Resource utilization in patients with schizophrenia who initiated risperidone long-acting therapy: results from the Schizophrenia Outcomes Utilization Relapse and Clinical Evaluation (SOURCE).


BACKGROUND:Schizophrenia is a chronic mental health disorder associated with increased hospital admissions and excessive utilization of outpatient services and long-term care. This analysis examined health care resource utilization from a 24-month observational study of patients with schizophrenia initiated on risperidone long-acting therapy (RLAT). METHODS:Schizophrenia Outcomes Utilization Relapse and Clinical Evaluation (SOURCE) was a 24-month observational study designed to examine real-world treatment outcomes by prospectively following patients with schizophrenia initiated on RLAT. At baseline visit, prior hospitalization and ER visit dates were obtained for the previous 12 months and subsequent hospitalization visit dates were obtained at 3-month visits, if available. The health care resource utilization outcomes measures observed in this analysis were hospitalizations for any reason, psychiatric-related hospitalizations, and emergency room (ER) visits. Incidence density analysis was used to assess pre-event and postevent rates per person-year (PY). RESULTS:The primary medical resource utilization analysis included 435 patients who had a baseline visit, ≥1 postbaseline visits after RLAT initiation, and valid hospitalization dates. The number of hospitalizations and ER visits per PY declined significantly (p < .0001) after initiation with RLAT. A 41% decrease (difference of -0.29 hospitalizations per PY [95% CI: -0.39 to -0.18] from baseline) in hospitalizations for any reason, a 56% decrease (a difference of -0.35 hospitalizations per PY [95% CI: -0.44 to -0.26] from baseline) in psychiatric-related hospitalizations, and a 40% decrease (-0.26 hospitalizations per PY [95% CI: -0.44 to -0.10] from baseline) in ER visits were observed after the baseline period. The percentage of psychiatric-related hospitalizations decreased significantly after RLAT initiation, and patients had fewer inpatient hospitalizations and ER visits (all p < .0001). CONCLUSION:The results suggest that treatment with RLAT may result in decreased hospitalizations for patients with schizophrenia. TRIAL NCT00246194.


BMC Psychiatry


BMC psychiatry


Crivera C,DeSouza C,Kozma CM,Dirani RD,Mao L,Macfadden W




Has Abstract


2011-10-14 00:00:00










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    更新日期:2018-11-13 00:00:00

  • Schizophrenia and psychotic symptoms in families of two American Indian tribes.

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    abstract:BACKGROUND:The present study investigated the reliability and validity of a Japanese version of the Internalized Stigma of Mental Illness (ISMI) scale, designed to assess internalized stigma experienced by people with mental illness. METHODS:A survey was conducted with 173 outpatients with mental illness who attended ...

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    authors: Gregorowski C,Seedat S,Jordaan GP

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    更新日期:2019-07-05 00:00:00

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    更新日期:2019-05-28 00:00:00

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    pub_type: 杂志文章,多中心研究,随机对照试验


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    pub_type: 杂志文章


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    更新日期:2015-11-04 00:00:00