Herpes zoster-associated mortality in Europe: a systematic review.


BACKGROUND:Reactivation of latent varicella zoster virus, partly due to age-related immunosenescence and immunosuppressive conditions, results in herpes zoster (HZ) and its associated complications. The management of the most important complication, post-herpetic neuralgia (PHN), is challenging, particularly in the elderly, and is generally unsatisfactory. No previous reviews have reported the incidence of HZ-associated mortality. METHODS:We carried out a systematic literature review to identify studies and databases providing data for HZ-associated mortality in adults aged ≥ 50 years in Europe. RESULTS:We identified 12 studies: Belgium (1); France (1); Germany (1); the Netherlands (2); Portugal (1); Spain (4) and England/Wales (2) and 4 databases from Europe: France; Germany and England/Wales. The incidence was available from eight studies; it was highest in those aged ≥ 95 in France (19.48/100,000). In the European (WHO) database, the overall mortality ranged from 0 to > 0.07/100,000. The age- and gender-specific HZ mortality rates from the other databases showed that while in younger age groups the HZ mortality rate was higher in males, in older patients the rate was much higher in women. The case fatality rate was 2 and 61/100,000 in those 45-65 and ≥ 65 years, respectively. A similar increase with age was seen for the hospital fatality rate; 0.6% in those 45-65 years in the UK and 7.1% in those ≥ 80 in Spain. CONCLUSIONS:Although the data were sparse and heterogeneous, HZ-associated mortality clearly increases with age. In addition, the elderly who develop HZ often have underlying diseases and are at increased risk of functional decline and loss of independence. Mortality should be taken into account in health-economics models.


BMC Public Health


BMC public health


Bricout H,Haugh M,Olatunde O,Prieto RG




Has Abstract


2015-05-05 00:00:00










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    authors: Suhrcke M,Boluarte TA,Niessen L

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    abstract:BACKGROUND:Diabetes as being a chronic disease with a number of complications deteriorates the quality of life among the people with type 2 diabetes. Health related quality of life is widely used as an important health outcome measure worldwide. This study assessed the quality of life among the people living with type ...

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    更新日期:2015-04-01 00:00:00

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    更新日期:2016-05-26 00:00:00

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    abstract:BACKGROUND:Relatively few studies have examined survival by pharmacotherapy level and the effects of patient characteristics on mortality by pharmacotherapy level in older chronic respiratory disease (CRD) patients. This study aimed to investigate these issues in older (> or = 65) CRD patients in Western Australia. ME...

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    authors: Einarsdóttir K,Preen DB,Sanfilippo FM,Reeve R,Emery JD,Holman CD

    更新日期:2010-07-01 00:00:00

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    更新日期:2008-09-19 00:00:00

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    authors: Frieze JB,Yadav RP,Sokhan K,Ngak S,Khim TB

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    authors: Garin N,Olaya B,Lara E,Moneta MV,Miret M,Ayuso-Mateos JL,Haro JM

    更新日期:2014-08-08 00:00:00

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    更新日期:2009-12-10 00:00:00

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    更新日期:2018-04-19 00:00:00

  • Social support and Quality of Life: a cross-sectional study on survivors eight months after the 2008 Wenchuan earthquake.

    abstract:BACKGROUND:The 2008 Wenchuan earthquake resulted in extensive loss of life and physical and psychological injuries for survivors. This research examines the relationship between social support and health-related quality of life for the earthquake survivors. METHODS:A multistage cluster sampling strategy was employed t...

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    authors: Ke X,Liu C,Li N

    更新日期:2010-09-24 00:00:00

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    abstract:BACKGROUND:Health care providers (HCPs) play an important role in public health emergency preparedness and response (PHEPR) so need to be aware of public health threats and emergencies. To inform HCPs, public health issues PHEPR messages that provide guidelines and updates, and facilitate surveillance so HCPs will reco...

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    authors: Hempler NF,Krasnik A,Pisinger C,Jørgensen T

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  • Effect of preventive zinc supplementation on linear growth in children under 5 years of age in developing countries: a meta-analysis of studies for input to the lives saved tool.

    abstract:INTRODUCTION:Zinc plays an important role in cellular growth, cellular differentiation and metabolism. The results of previous meta-analyses evaluating effect of zinc supplementation on linear growth are inconsistent. We have updated and evaluated the available evidence according to Grading of Recommendations, Assessme...

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    authors: Imdad A,Bhutta ZA

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  • Evaluating the technical efficiency of care among long-term care facilities in Xiamen, China: based on data envelopment analysis and Tobit model.

    abstract:BACKGROUND:The technical efficiency (TE) of care among the elderly in long-term care facilities (LTCF) have become increasingly crucial policy concerns faced by developing countries and Asia, especially China. The purpose of this study was to evaluate the TE and the quality of care and identify its influencing factors ...

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  • Prevalence and determinants of childhood mortality in Nigeria.

    abstract:BACKGROUND:Childhood mortality has remained a major challenge to public health amongst families in Nigeria and other developing countries. The menace of incessant childhood mortality has been a major concern and this calls for studies to generate new scientific evidence to determine its prevalence and explore predispos...

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    authors: Yaya S,Ekholuenetale M,Tudeme G,Vaibhav S,Bishwajit G,Kadio B

    更新日期:2017-05-22 00:00:00

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    authors: van Eeden M,van Heugten CM,Evers SM

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  • Comparison of two statistical indicators in communicating epidemiological results to the population: a randomized study in a high environmental risk area of Italy.

    abstract:BACKGROUND:When communicating risks to the general population, the format of the epidemiological results may affect individual reactions. In environmental epidemiology, no study has compared the use of different statistical formats in communicating results to the population. The aim of this paper is to investigate whet...

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    pub_type: 杂志文章,随机对照试验


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    abstract:BACKGROUND:Haze leads to many direct serious public health impacts. Understanding haze related knowledge can not only help adolescents organize health protection awareness to prevent the harmful effects that haze has on the body, but also promote their normal growth and development. METHODS:By considering, as the theo...

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    更新日期:2018-06-14 00:00:00

  • Early childhood caries trends and surveillance shortcomings in the Czech Republic.

    abstract:BACKGROUND:Despite the decline in childhood caries prevalence, seen particularly in 1980s, in recent years there have been reports that the declining trend has stopped or even reversed in some countries. The aim of the study was to analyse data from previous epidemiological studies on early childhood caries in the Czec...

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    pub_type: 杂志文章


    authors: Lenčová E,Pikhart H,Broukal Z

    更新日期:2012-07-24 00:00:00

  • Seasonality in diabetes in Yaounde, Cameroon: a relation with precipitation and temperature.

    abstract:BACKGROUND:Diabetes is a growing health concern in developing countries, with Cameroon population having an estimated 6% affected. Of note, hospital attendees appear to be increasing all over the country, with fluctuating numbers throughout the annual calendar. The aim of the study was to investigate the relationship b...

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    pub_type: 杂志文章,多中心研究


    authors: Lontchi-Yimagou E,Tsalefac M,Tapinmene LM,Noubiap JJ,Balti EV,Nguewa JL,Dehayem M,Sobngwi E

    更新日期:2016-06-06 00:00:00

  • Social-cognitive determinants of the tick check: a cross-sectional study on self-protective behavior in combatting Lyme disease.

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    journal_title:BMC public health

    pub_type: 杂志文章


    authors: van der Heijden A,Mulder BC,Poortvliet PM,van Vliet AJH

    更新日期:2017-11-25 00:00:00

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    pub_type: 杂志文章


    authors: Riddell MA,Dunbar JA,Absetz P,Wolfe R,Li H,Brand M,Aziz Z,Oldenburg B,Australasian Peers for Progress Diabetes Project Investigators.

    更新日期:2016-08-24 00:00:00

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    journal_title:BMC public health

    pub_type: 杂志文章


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    更新日期:2017-10-18 00:00:00

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    pub_type: 杂志文章


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    更新日期:2015-01-31 00:00:00

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    pub_type: 杂志文章


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    更新日期:2019-05-02 00:00:00

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    journal_title:BMC public health

    pub_type: 杂志文章


    authors: Vong S,Perz JF,Sok S,Som S,Goldstein S,Hutin Y,Tulloch J

    更新日期:2005-06-02 00:00:00