The relationship of weight change trajectory with medial temporal lobe atrophy in patients with mild Alzheimer's disease: results from a cohort study.

abstract：:Lewy body dementia (LBD), including dementia with Lewy bodies and Parkinson's disease dementia, affects over a million people in the USA and has a substantial impact on patients, caregivers, and society. Symptomatic treatments for LBD, which can include cognitive, neuropsychiatric, autonomic, sleep, and motor features...

journal_title：Alzheimer's research & therapy

authors： Goldman JG,Forsberg LK,Boeve BF,Armstrong MJ,Irwin DJ,Ferman TJ,Galasko D,Galvin JE,Kaufer D,Leverenz J,Lippa CF,Marder K,Abler V,Biglan K,Irizarry M,Keller B,Munsie L,Nakagawa M,Taylor A,Graham T

更新日期：2020-10-29 00:00:00

abstract：BACKGROUND:Amyloid pathology, which is one of the characteristics of Alzheimer's disease (AD), results from altered metabolism of the beta-amyloid (Aβ) peptide in terms of synthesis, clearance, or aggregation. A decrease in cerebrospinal fluid (CSF) level Aβ1-42 is evident in AD, and the CSF ratio Aβ42/Aβ40 has recentl...

journal_title：Alzheimer's research & therapy

authors： Lehmann S,Dumurgier J,Ayrignac X,Marelli C,Alcolea D,Ormaechea JF,Thouvenot E,Delaby C,Hirtz C,Vialaret J,Ginestet N,Bouaziz-Amar E,Laplanche JL,Labauge P,Paquet C,Lleo A,Gabelle A,Alzheimer’s Disease Neuroimaging Initi

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Theory of mind (ToM) refers to the ability to attribute mental states, thoughts (cognitive component) or feelings (affective component) to others. This function has been studied in many neurodegenerative diseases; however, to our knowledge, no studies investigating ToM in dementia with Lewy bodies (DLB) have...

journal_title：Alzheimer's research & therapy

authors： Heitz C,Noblet V,Phillipps C,Cretin B,Vogt N,Philippi N,Kemp J,de Petigny X,Bilger M,Demuynck C,Martin-Hunyadi C,Armspach JP,Blanc F

更新日期：2016-03-16 00:00:00

abstract：BACKGROUND:Cerebrovascular pathology, quantified by white matter lesions (WML), is known to affect cognition in aging, and is associated with an increased risk of dementia. The present study aimed to investigate whether higher functional connectivity in cognitive control networks mitigates the detrimental effect of WML...

journal_title：Alzheimer's research & therapy

authors： Benson G,Hildebrandt A,Lange C,Schwarz C,Köbe T,Sommer W,Flöel A,Wirth M

更新日期：2018-10-27 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by neuropathologic changes involving beta-amyloid (Aβ), tau, neuronal loss, and other associated biological events. While levels of cerebrospinal fluid (CSF) Aβ and tau peptides have enhanced the antemortem detection of AD-specifi...

journal_title：Alzheimer's research & therapy

authors： Gangishetti U,Christina Howell J,Perrin RJ,Louneva N,Watts KD,Kollhoff A,Grossman M,Wolk DA,Shaw LM,Morris JC,Trojanowski JQ,Fagan AM,Arnold SE,Hu WT

更新日期：2018-09-25 00:00:00

abstract：BACKGROUND:Dementia has been presenting an imminent public health challenge worldwide. Studies have shown a combination of cognitive and physical trainings may have synergistic value for improving cognitive functions. Daily functional tasks are innately cognitive demanding and involve components found in common exercis...

journal_title：Alzheimer's research & therapy

authors： Law LLF,Mok VCT,Yau MMK

更新日期：2019-12-04 00:00:00

abstract：INTRODUCTION:There have been recent reports about a decline in dementia incidence, but only little is known about trends in the mortality of patients with dementia. Only the simultaneous analysis of both trends can inform whether the reported decline in dementia has led to a compression of dementia into higher ages. M...

journal_title：Alzheimer's research & therapy

authors： Doblhammer G,Fink A,Zylla S,Willekens F

更新日期：2015-11-05 00:00:00

abstract：INTRODUCTION:There are no empiric data to support guidelines for duration of therapy with antidementia drugs. This study examined whether persistent use of antidementia drugs slows clinical progression of Alzheimer disease (AD) assessed by repeated measures on serial tests of cognition and function. METHODS:Six hundre...

journal_title：Alzheimer's research & therapy

authors： Rountree SD,Chan W,Pavlik VN,Darby EJ,Siddiqui S,Doody RS

更新日期：2009-10-21 00:00:00

abstract：:Sports-related concussions are one of the major causes of mild traumatic brain injury. Although most patients recover completely within days to weeks, those who experience repetitive brain trauma (RBT) may be at risk for developing a condition known as chronic traumatic encephalopathy (CTE). While this condition is mo...

journal_title：Alzheimer's research & therapy

authors： Ng TS,Lin AP,Koerte IK,Pasternak O,Liao H,Merugumala S,Bouix S,Shenton ME

更新日期：2014-02-24 00:00:00

abstract：BACKGROUND:Antidepressant use has been associated with an increased risk of falling, but no studies have been conducted on whether antidepressant use is associated with an increased risk of head injuries which often result from falling among older persons. The objective of this study was to investigate the risk of head...

journal_title：Alzheimer's research & therapy

authors： Taipale H,Koponen M,Tanskanen A,Lavikainen P,Sund R,Tiihonen J,Hartikainen S,Tolppanen AM

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:Alzheimer's disease (AD) is increasing in frequency as the global population ages. Five drugs are approved for treatment of AD, including four cholinesterase inhibitors and an N-methyl-D-aspartate (NMDA)-receptor antagonist. We have an urgent need to find new therapies for AD. METHODS:We examined Clinical...

journal_title：Alzheimer's research & therapy

authors： Cummings JL,Morstorf T,Zhong K

更新日期：2014-07-03 00:00:00

abstract：BACKGROUND:Widespread implementation of Alzheimer's disease biomarkers in routine clinical practice requires the establishment of standard operating procedures for pre-analytical handling of cerebrospinal fluid (CSF). METHODS:Here, CSF collection and storage protocols were optimized for measurements of β-amyloid (Aβ)....

journal_title：Alzheimer's research & therapy

authors： Janelidze S,Stomrud E,Brix B,Hansson O

更新日期：2019-07-19 00:00:00

abstract：:Symptomatic treatments for Alzheimer's disease should retain a place in the advanced stages of disease since their actions on these symptoms, even if not modifying the course of disease, are critical for improving patients' comfort and reducing the burden felt by caregivers, especially those facing behavioral disorder...

journal_title：Alzheimer's research & therapy

authors： Ousset PJ,Delrieu J,Vellas B

更新日期：2013-12-11 00:00:00

abstract：:The strongest known risk factors for late-onset Alzheimer disease (LOAD) remain a positive family history and the APOE epsilon4 allele. van Exel and colleagues used these known risk factors to identify high- and low-risk samples of middle-aged persons in whom they compared levels of inflammatory and vascular risk fact...

journal_title：Alzheimer's research & therapy

authors： Tan ZS,Seshadri S

更新日期：2010-04-12 00:00:00

abstract：:In May 2012, the Fourth Canadian Consensus Conference on the Diagnosis and Treatment of Dementia brought together in Montreal experts from around Canada to update Canadian recommendations for the diagnosis and management of patients with neurodegenerative conditions associated with deterioration of cognition. Multiple...

journal_title：Alzheimer's research & therapy

authors： Soucy JP,Bartha R,Bocti C,Borrie M,Burhan AM,Laforce R,Rosa-Neto P

更新日期：2013-07-08 00:00:00

abstract：:Following publication of the original article [1], the authors reported that Fig. 6 contains a mistake. The Fig. 6F is a duplicate of Fig. 6E of Braak 5. ...

journal_title：Alzheimer's research & therapy

authors： Hishimoto A,Pletnikova O,Lang DL,Troncoso JC,Egan JM,Liu QR

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Determination of β-amyloid (Aβ) positivity and likelihood of underlying Alzheimer's disease (AD) relies on dichotomous biomarker cut-off values. Individuals with mild cognitive impairment (MCI) and Aβ within the normal range may still have a substantial risk of developing dementia, primarily of Alzheimer typ...

journal_title：Alzheimer's research & therapy

authors： Rosenberg A,Solomon A,Jelic V,Hagman G,Bogdanovic N,Kivipelto M

更新日期：2019-12-05 00:00:00

abstract：INTRODUCTION:The goal was to identify which neurochemicals differ in professional athletes with repetitive brain trauma (RBT) when compared to healthy controls using a relatively new technology, in vivo Localized COrrelated SpectroscopY (L-COSY). METHODS:To achieve this, L-COSY was used to examine five former professi...

journal_title：Alzheimer's research & therapy

authors： Lin AP,Ramadan S,Stern RA,Box HC,Nowinski CJ,Ross BD,Mountford CE

更新日期：2015-03-15 00:00:00

abstract：:Identification of therapeutic targets based on novel mechanistic studies is urgently needed for neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and prion disease. Multiple lines of evidence have emerged to suggest that inhibition of the stress-induced endoplasmic reticulum kinase PERK (pro...

journal_title：Alzheimer's research & therapy

authors： Ma T,Klann E

更新日期：2014-05-29 00:00:00

abstract：INTRODUCTION:The diagnosis of mild cognitive impairment (MCI) refers to cognitive impairment not meeting dementia criteria. A survey among members of the American Association of Neurology (AAN) showed that MCI was considered a useful diagnosis. Recently, research criteria have been proposed for the diagnosis of Alzheim...

journal_title：Alzheimer's research & therapy

authors： Bertens D,Vos S,Kehoe P,Wolf H,Nobili F,Mendonça A,van Rossum I,Hort J,Molinuevo JL,Heneka M,Petersen R,Scheltens P,Visser PJ

更新日期：2019-08-22 00:00:00

abstract：BACKGROUND:Down syndrome (DS), caused by chromosome 21 trisomy, is associated with an ultra-high risk of dementia due to Alzheimer's disease (AD), driven by amyloid precursor protein (APP) gene triplication. Understanding relevant molecular differences between those with DS, those with sporadic AD (sAD) without DS, and...

journal_title：Alzheimer's research & therapy

authors： Startin CM,Ashton NJ,Hamburg S,Hithersay R,Wiseman FK,Mok KY,Hardy J,Lleó A,Lovestone S,Parnetti L,Zetterberg H,Hye A,LonDownS Consortium.,Strydom A

更新日期：2019-03-21 00:00:00

abstract：:Therapeutic products that depend on the use of an in vitro diagnostic biomarker test to confirm their effectiveness are increasingly being developed. Use of biomarkers is particularly meaningful in the context of selecting the patient population where the therapeutic treatment is believed to be efficacious (patient en...

journal_title：Alzheimer's research & therapy

authors： Vanderstichele H,Stoops E,Vanmechelen E,Jeromin A

更新日期：2012-10-17 00:00:00

abstract：BACKGROUND:Our objectives were to develop a disease progression model for cognitive decline in Alzheimer's disease (AD) and to determine whether disease progression of AD is related to the year of publication, add-on trial design, and geographical regions. METHODS:Placebo-controlled randomized AD clinical trials were ...

journal_title：Alzheimer's research & therapy

authors： Zhang N,Zheng X,Liu H,Zheng Q,Li L

更新日期：2020-05-26 00:00:00

abstract：INTRODUCTION:Depression and psychosis are two of the most severe neuropsychiatric symptoms (NPS) in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Both NPS have negative effects on cognitive performance and life expectancy. The current study aimed to investigate and compare monoaminergic etiologies betwe...

journal_title：Alzheimer's research & therapy

authors： Vermeiren Y,Van Dam D,Aerts T,Engelborghs S,Martin JJ,De Deyn PP

更新日期：2015-02-11 00:00:00

abstract：BACKGROUND:Synapse damage and loss are fundamental to the pathophysiology of Alzheimer's disease (AD) and lead to reduced cognitive function. The goal of this review is to address the challenges of forging new clinical development approaches for AD therapeutics that can demonstrate reduction of synapse damage or loss. ...

journal_title：Alzheimer's research & therapy

authors： Colom-Cadena M,Spires-Jones T,Zetterberg H,Blennow K,Caggiano A,DeKosky ST,Fillit H,Harrison JE,Schneider LS,Scheltens P,de Haan W,Grundman M,van Dyck CH,Izzo NJ,Catalano SM,Synaptic Health Endpoints Working Group.

更新日期：2020-03-02 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) pathophysiology is mostly (>95%) not inherited in a Mendelian fashion. Such sporadic AD (sAD) forms do not exhibit familial aggregation and are characterized by complex genetic inheritance. Growing evidence indicates that multiple genes contribute to sAD-characteristic endophenotypes...

journal_title：Alzheimer's research & therapy

authors： Hampel H,Lista S

更新日期：2013-03-18 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disorder affecting older people worldwide. It is a progressive disorder mainly characterized by the presence of amyloid-beta (Aβ) plaques and neurofibrillary tangles within the brain parenchyma. It is now well accepted that neuroinflammation constitutes an ...

journal_title：Alzheimer's research & therapy

authors： Thériault P,ElAli A,Rivest S

更新日期：2015-04-15 00:00:00

abstract：:Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between...

journal_title：Alzheimer's research & therapy

authors： Bateman RJ,Aisen PS,De Strooper B,Fox NC,Lemere CA,Ringman JM,Salloway S,Sperling RA,Windisch M,Xiong C

更新日期：2011-01-06 00:00:00

abstract：BACKGROUND:Optical coherence tomography (OCT) of the retina is a fast and easily accessible tool for the quantification of retinal structural measurements. Multiple studies show that patients with Alzheimer's disease (AD) exhibit thinning in several retinal layers compared to age-matched controls. Subjective cognitive ...

journal_title：Alzheimer's research & therapy

authors： Marquié M,Valero S,Castilla-Marti M,Martínez J,Rodríguez-Gómez O,Sanabria Á,Tartari JP,Monté-Rubio GC,Sotolongo-Grau O,Alegret M,Pérez-Cordón A,Roberto N,de Rojas I,Moreno-Grau S,Montrreal L,Hernández I,Rosende-Roca M,M

更新日期：2020-03-31 00:00:00

abstract：:The oligomer cascade hypothesis, which states that oligomers are the initiating pathologic agents in Alzheimer's disease, has all but supplanted the amyloid cascade hypothesis, which suggested that fibers were the key etiologic agents in Alzheimer's disease. We review here the results of in vivo, in vitro and in silic...

journal_title：Alzheimer's research & therapy

authors： Hayden EY,Teplow DB

更新日期：2013-11-29 00:00:00