Alterations of regional homogeneity in pediatric bipolar depression: a resting-state fMRI study.

Abstract:

BACKGROUND:Pediatric bipolar disorder (PBD) has attracted increasing attentions due to its high prevalence and great influence on social functions of children and adolescents. However, the pathophysiology underlying PBD remains unclear. In the present study, the resting-state functional magnetic resonance imaging (fMRI) was used to detect abnormalities of baseline brain functions in depressed PBD youth. METHODS:Seventeen youth with PBD-depression aged 10 - 18 years old and 18 age- and sex-matched normal controls were recruited in this study. The fMRI data under resting state were obtained on a Siemens 3.0 Tesla scanner and were analyzed using the regional homogeneity (ReHo) method. Correlations between the ReHo values of each survived area and the severity of depression symptoms in patients were further analyzed. RESULTS:As compared with the control group, PBD-depression patients showed decreased ReHo in the medial frontal gyrus, bilateral middle frontal gyrus and middle temporal gyrus, and the right putamen. Significant negative correlations of the mood and feelings questionnaire scores with mean ReHo values in the medial frontal gyrus and the right middle frontal gyrus in PBD-depression patients were observed. CONCLUSION:Our results suggest that extensive regions with altered baseline brain activities are existed in PBD-depression and these brain regions mainly locate in the fronto-limbic circuit and associated striatal structures. Moreover, the present findings also add to our understanding that there could be unique neuropathophysiological mechanisms underlying PBD-depression.

journal_name

BMC Psychiatry

journal_title

BMC psychiatry

authors

Gao W,Jiao Q,Lu S,Zhong Y,Qi R,Lu D,Xiao Q,Yang F,Lu G,Su L

doi

10.1186/s12888-014-0222-y

subject

Has Abstract

pub_date

2014-08-06 00:00:00

pages

222

issn

1471-244X

pii

s12888-014-0222-y

journal_volume

14

pub_type

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