Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers.

Abstract:

BACKGROUND:Prefrontal repetitive transcranial magnetic stimulation (rTMS) has been used to induce side-specific mood changes in volunteers and patients. To clarify inconsistencies between reports that used different stimulation frequencies, we conducted a controlled study with a low (1 Hz) frequency, comparing left with right-sided stimulation METHODS:Nineteen healthy volunteers received randomised left or right prefrontal rTMS at a frequency of 1 Hz and 100% of motor threshold in two sessions two weeks apart. RESULTS:There were significant improvements with TMS for performance in the digit symbol substitution and verbal fluency tests, but no change of mood on a number of measures. There was also a reduction of pulse rate after TMS. The only side-specific TMS-effect was on mean arterial pressure, which decreased pressure after left, but not after right prefrontal TMS. CONCLUSIONS:Apart from the unexpected and so far unreplicated effect on mean arterial pressure, there were no side-specific effects on mood in volunteers. It is unlikely that a simple laterality model of mood together with the assumed activating effect of higher and 'quenching' effect of lower stimulation frequency can account for the effects of TMS on mood.

journal_name

BMC Psychiatry

journal_title

BMC psychiatry

authors

Jenkins J,Shajahan PM,Lappin JM,Ebmeier KP

doi

10.1186/1471-244x-2-1

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

1

issn

1471-244X

journal_volume

2

pub_type

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