Increased IL-4 mRNA expression and poly-aromatic hydrocarbon concentrations from children with asthma.

Abstract:

BACKGROUND:Asthma is the most common chronic childhood disease. Imbalance of cytokines released from T helper cells and environmental factors, such as exposure to poly-aromatic hydrocarbon (PAH), play pivotal roles in the pathogenesis of asthma. The aim of this study was to compare the mRNA expression patterns of Interleukin (IL)-4, interferon (IFN)-γ and Acyl Co A long chain 3 (ACSL3) in peripheral blood leukocytes of children with and without asthma. To correlate the obtained mRNA data with serum IL-4, IFN-γ and PAH levels. Further, to determine the effect of in vivo exposure to PAH on mRNA expression of IL-4, IFN-γ and ACSL3 genes in a rat model. METHODS:A total of 170 children below 16 years (85 pediatric asthma patients and 85 matched healthy controls) were randomly selected from the Riyadh Cohort, Saudi Arabia. Gene expression analysis was performed using qRTPCR. Serum IL-4, IFN-γ and PAH were measured using LINCOplex (human multiplex immunoassay kit) and HPLC respectively. RESULTS:IL-4 mRNA expression was significantly increased (P < 0.05) in children with asthma compared to healthy control group whereas no differences were observed for either IFN-γ or ACSL3 mRNA. Similarly, serum IL- 4 and PAHs concentration was significantly higher as well in children with asthma in whom IFN-γ was also significantly lower. Results obtained in rats showed that exposure to the benzopyrene prototype PAH resulted in a 2.6 fold (P < 0.001) increased IL-4 mRNA expression in blood. CONCLUSION:Peripheral blood IL-4 mRNA levels, serum concentration of this cytokine are elevated in children with asthma. Also, elevated levels of PAH were observed in children with asthma. Additionally, PAH administration in rodents resulted in an increased IL-4 mRNA which is supposed to partly mediate the inflammatory response noted in asthma.

journal_name

BMC Pediatr

journal_title

BMC pediatrics

authors

Al-Daghri NM,Abd-Alrahman S,Draz H,Alkharfy K,Mohammed AK,Clerici MS,Alokail MS

doi

10.1186/1471-2431-14-17

subject

Has Abstract

pub_date

2014-01-23 00:00:00

pages

17

issn

1471-2431

pii

1471-2431-14-17

journal_volume

14

pub_type

杂志文章
  • Characteristics and risk factors of children with sleep-disordered breathing in Wuxi, China.

    abstract:BACKGROUND:Sleep-disordered breathing (SDB) is a common syndrome in children, related to their immune responses, cardiovascular function, and neurocognitive function. This study aimed to determine the prevalence of SDB among children in Wuxi, China, and to evaluate the protective and risk factors of SDB in children. M...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-020-02207-5

    authors: Guo Y,Pan Z,Gao F,Wang Q,Pan S,Xu S,Hui Y,Li L,Qian J

    更新日期:2020-06-26 00:00:00

  • Effectiveness of physical therapy interventions for children with cerebral palsy: a systematic review.

    abstract:BACKGROUND:To assess the effectiveness of physical therapy (PT) interventions on functioning in children with cerebral palsy (CP). METHODS:A search was made in Medline, Cinahl, PEDro and the Cochrane library for the period 1990 to February 2007. Only randomized controlled trials (RCTs) on PT interventions in children ...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2431-8-14

    authors: Anttila H,Autti-Rämö I,Suoranta J,Mäkelä M,Malmivaara A

    更新日期:2008-04-24 00:00:00

  • Health related quality of life of Dutch children: psychometric properties of the PedsQL in the Netherlands.

    abstract:BACKGROUND:Knowledge about psychometric properties of the Pediatric Quality of Life Inventory (PedsQL) in the Netherlands is limited and Dutch reference data are lacking. Aim of the current study is to collect Dutch reference data of the PedsQL and subsequently assess reliability, socio-demographic within-group differe...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-9-68

    authors: Engelen V,Haentjens MM,Detmar SB,Koopman HM,Grootenhuis MA

    更新日期:2009-11-03 00:00:00

  • Evaluation of neuropsychiatric comorbidities and their clinical characteristics in Chinese children with asthma using the MINI kid tool.

    abstract:BACKGROUND:The mental health and quality of life in children with asthma have attracted widespread attention. This study focused on the evaluation of mental health conditions and their clinical characteristics in Chinese children with asthma. METHODS:A total of 261 children with asthma aged 6 to 16 years old and 261 a...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-019-1834-7

    authors: Zhou H,Chen Z,Zhao W,Liu Y,Cui Y

    更新日期:2019-11-22 00:00:00

  • High level of treatment failure and drug resistance to first-line antiretroviral therapies among HIV-infected children receiving decentralized care in Senegal.

    abstract:BACKGROUND:In Senegal in 2015, an estimated 4800 children were living with HIV, with 1200 receiving ARV treatment, of whom half had follow-up care in decentralized sites outside Dakar. However, until now no studies have determined the efficacy of pediatric treatment in decentralized settings, even though the emergence ...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-019-1420-z

    authors: Cissé AM,Laborde-Balen G,Kébé-Fall K,Dramé A,Diop H,Diop K,FatouNiasse-Traoré,Coulibaly M,Have NN,Vidal N,Thiam S,Wade AS,Peeters M,Taverne B,Msellati P,Touré-Kane C

    更新日期:2019-02-05 00:00:00

  • Mutations in the PIGW gene associated with hyperphosphatasia and mental retardation syndrome: a case report.

    abstract:BACKGROUND:Mutations in the PIGV, PIGO, PIGL, PIGY, PGAP2, PGAP3, and PIGW genes have recently been reported to cause hyperphosphatasia accompanied by mental retardation syndrome (HPMRS); the latter is an autosomal-recessive neurological disorder typically characterised by recurrent seizures, intellectual disability, a...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-019-1440-8

    authors: Fu L,Liu Y,Chen Y,Yuan Y,Wei W

    更新日期:2019-02-27 00:00:00

  • Mode of delivery and other risk factors for Escherichia coli infections in very low birth weight infants.

    abstract:BACKGROUND:Infections in newborns remain one of the most significant problems in modern medicine. Escherichia coli is an important cause of neonatal bloodstream and respiratory tract infections and is associated with high mortality. The aim of our study was to investigate the epidemiology of E. coli infection in Polish...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-14-274

    authors: Chmielarczyk A,Wójkowska-Mach J,Romaniszyn D,Adamski P,Helwich E,Lauterbach R,Pobiega M,Borszewska-Kornacka M,Gulczyńska E,Kordek A,Heczko PB

    更新日期:2014-10-18 00:00:00

  • Reducing neonatal infections in south and south central Vietnam: the views of healthcare providers.

    abstract:BACKGROUND:Infection causes neonatal mortality in both high and low income countries. While simple interventions to prevent neonatal infection are available, they are often poorly understood and implemented by clinicians. A basic understanding of healthcare providers' perceptions of infection control provides a platfor...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-13-51

    authors: Trevisanuto D,Arnolda G,Chien TD,Xuan NM,Thu le TA,Kumara D,Lincetto O,Moccia L

    更新日期:2013-04-09 00:00:00

  • Obliterative cholangiopathy in acquired cystic biliary atresia type III after cyst perforation: a case report.

    abstract:BACKGROUND:In biliary atresia, the disease process of obliterative cholangiopathy may begin in the perinatal period; however, no chronological evidence exists on how the cholangiopathy progresses to biliary obliteration. This is the first acquired case with the final diagnosis of type III cystic biliary atresia with an...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-018-1125-8

    authors: Koshinaga T,Ohashi K,Ono K,Kaneda H,Furuya T

    更新日期:2018-05-11 00:00:00

  • Dietary intake in 6-year-old children from southern Poland: part 1--energy and macronutrient intakes.

    abstract:BACKGROUND:The studies on dietary intake in Polish children are sparse and the information about dietary intake in 6-year-olds in Europe is limited. The published studies on dietary intake in children rarely provide information on the intake of animal protein, plant protein and water. The purpose of the study was to an...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-14-197

    authors: Merkiel S

    更新日期:2014-08-03 00:00:00

  • Nasal carriage and antimicrobial susceptibility of Staphylococcus aureus in healthy preschool children in Ujjain, India.

    abstract:BACKGROUND:There is increasing evidence that community acquired S. aureus infections are spreading among healthy children. Nasal colonization with S. aureus plays pivotal role in the increasing prevalence of resistant community acquired S. aureus infections worldwide. A regular surveillance system is important in ensur...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-10-100

    authors: Pathak A,Marothi Y,Iyer RV,Singh B,Sharma M,Eriksson B,Macaden R,Lundborg CS

    更新日期:2010-12-29 00:00:00

  • Early versus delayed cord clamping in small for gestational age infants and iron stores at 3 months of age - a randomized controlled trial.

    abstract:BACKGROUND:Delayed cord clamping is the standard of care in infants not requiring resuscitation; however effects of cord clamping strategies have not been evaluated systematically in small for gestational age (SGA) infants. The primary objective was to compare effects of delayed cord clamping (DCC) and early cord clamp...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12887-018-1214-8

    authors: Chopra A,Thakur A,Garg P,Kler N,Gujral K

    更新日期:2018-07-18 00:00:00

  • Low cyclosporine concentrations in children and time to acute graft versus host disease.

    abstract:BACKGROUND:Achievement of target blood concentrations of cyclosporine (CsA) early after transplantation is known to be highly effective for reducing the incidence of acute graft versus host disease (aGVHD). However, no research has been conducted for predicting aGVHD occurrence with low CsA concentrations at different ...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-020-02125-6

    authors: Chung EK,Yee J,Kim JY,Gwak HS

    更新日期:2020-05-11 00:00:00

  • NEOnatal Central-venous Line Observational study on Thrombosis (NEOCLOT): evaluation of a national guideline on management of neonatal catheter-related thrombosis.

    abstract:BACKGROUND:In critically ill (preterm) neonates, central venous catheters (CVCs) are increasingly used for administration of medication or parenteral nutrition. A serious complication, however, is the development of catheter-related thrombosis (CVC-thrombosis), which may resolve by itself or cause severe complications....

    journal_title:BMC pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12887-018-1000-7

    authors: Sol JJ,van de Loo M,Boerma M,Bergman KA,Donker AE,van der Hoeven MAHBM,Hulzebos CV,Knol R,Djien Liem K,van Lingen RA,Lopriore E,Suijker MH,Vijlbrief DC,Visser R,Veening MA,van Weissenbruch MM,van Ommen CH

    更新日期:2018-02-23 00:00:00

  • Reduced anogenital distance, hematuria and left renal hypoplasia in a patient with 13q33.1-34 deletion: case report and literature review.

    abstract:BACKGROUND:13q33-q34 microdeletions are rare chromosomal aberrations associated with a high risk of developmental disability, facial dysmorphism, cardiac defects and other malformation of organs. It is necessary to collect and report evidence of this rare chromosome mutation to improve the prognosis of this rare diseas...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-020-02205-7

    authors: He X,Shen H,Fu H,Feng C,Liu Z,Jin Y,Mao J

    更新日期:2020-07-02 00:00:00

  • High-dose of intravenous immunoglobulin modulates immune tolerance in premature infants.

    abstract:BACKGROUND:Intravenous immunoglobulin (IVIG) is commonly used to improve the immunomodulatory effects, although its regulatory effect on premature Treg cells is unclear. The purpose of this study is to study the effect of high dose of IVIG (HD-IVIG) on Treg cells expression and cytokine profile in premature birth. MET...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-018-1055-5

    authors: Liu P,Li L,Fan P,Zheng J,Zhao D

    更新日期:2018-02-21 00:00:00

  • Negative exploration for pyloric stenosis--is it preventable?

    abstract:BACKGROUND:The diagnosis of infantile hypertrophic pyloric stenosis (IHPS), although traditionally clinical, is now increasingly dependent on radiological corroboration. The rate of negative exploration in IHPS has been reported as 4%. The purpose of our study was to look at elements of supportive clinical evidence lea...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-8-37

    authors: Mullassery D,Mallappa S,Shariff R,Craigie RJ,Losty PD,Kenny SE,Pilling D,Baillie CT

    更新日期:2008-09-24 00:00:00

  • Predictors of breastfeeding duration in a predominantly Māori population in New Zealand.

    abstract:BACKGROUND:Although breastfeeding duration in New Zealand's indigenous Māori is shorter than in non-Māori, we know little about barriers or motivators of breastfeeding in this community. The aim of this analysis was to identify predictors for extended duration of breastfeeding amongst participants drawn from predominan...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-018-1274-9

    authors: Manhire KM,Williams SM,Tipene-Leach D,Baddock SA,Abel S,Tangiora A,Jones R,Taylor BJ

    更新日期:2018-09-12 00:00:00

  • Assessing an isiZulu questionnaire with educators in primary schools in Pietermaritzburg to establish a baseline of knowledge of Autism Spectrum Disorder.

    abstract:BACKGROUND:Autism Spectrum Disorder (ASD) is a significant childhood disorder and has a growing prevalence rate across the world. It has been identified in children from a wide range of racial groups, ethnicities and socio-economic groups, making it a globally relevant disorder. However, a lack of research on ASD in Af...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-016-0721-8

    authors: Hutton NK,Mitchell C,van der Riet M

    更新日期:2016-11-14 00:00:00

  • Impact of birthweight on health-care utilization during early childhood - a birth cohort study.

    abstract:BACKGROUND:Comprehensive data are needed to evaluate the burden of low birthweight. Analysis of routine data on health-care utilization during early childhood were used to test the hypothesis that infants with low birthweight have (i) increased inpatient health-care utilization, (ii) higher hospital costs and (iii) dif...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-019-1424-8

    authors: Rüdiger M,Heinrich L,Arnold K,Druschke D,Reichert J,Schmitt J

    更新日期:2019-03-01 00:00:00

  • Treatment outcomes of severe acute malnutrition and predictors of recovery in under-five children treated within outpatient therapeutic programs in Ethiopia: a systematic review and meta-analysis.

    abstract:BACKGROUND:Severe acute malnutrition affects around 17 million under-five children in the world, of which the highest burden is accounted by Sub-Saharan Africa where Ethiopia is found. Though there are few individual, inconsistent and inconclusive studies, there is no nationally representative study on treatment outcom...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-020-02188-5

    authors: Bitew ZW,Alemu A,Worku T

    更新日期:2020-07-07 00:00:00

  • Neonatal hematological parameters and the risk of moderate-severe bronchopulmonary dysplasia in extremely premature infants.

    abstract:OBJECTIVE:To evaluate the association between hematological parameters at birth and the risk of moderate-severe bronchopulmonary dysplasia (BPD) in a cohort of extremely preterm infants. METHODS:This is a retrospective study of all extremely premature infants admitted to the neonatal intensive care unit, Shenzhen Mate...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-019-1515-6

    authors: Chen X,Li H,Qiu X,Yang C,Walther FJ

    更新日期:2019-04-30 00:00:00

  • Neonatal sepsis and its association with birth weight and gestational age among admitted neonates in Ethiopia: systematic review and meta-analysis.

    abstract:BACKGROUND:Neonatal sepsis is an invasive infection, usually bacterial, and often occurring during the neonatal period (0-28 days). Neonatal sepsis causes a high burden of morbidity and mortality in developing countries like Ethiopia. There are fragmented, inconsistency, and no review has been conducted to report the m...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-020-1949-x

    authors: Belachew A,Tewabe T

    更新日期:2020-02-05 00:00:00

  • Perception and management of fever in infants up to six months of age: a survey of US pediatricans.

    abstract:BACKGROUND:A fever is an increase in the body's temperature above normal. This study examined how US pediatricians perceive and manage fever generally versus fever occurring after vaccination in infants up to six months of age. METHODS:A web-based survey of 400 US pediatricians subscribing to the Physician Desk Refere...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-10-95

    authors: El Khoury AC,Durden E,Ma L,Markson LE,Lee AW,Duan Y,Foley K

    更新日期:2010-12-22 00:00:00

  • Association between altered placental human chorionic gonadotrophin (hCG) production and the occurrence of cryptorchidism: a retrospective study.

    abstract:BACKGROUND:An increase in cryptorchidism has been reported in many countries. One mechanism could be low fetal testosterone production possibly secondary to altered placental human chorionic gonadotrophin (hCG) release. Our Objective was to compare hCG values from maternal blood between boys with cryptorchidism and nor...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-14-191

    authors: Chedane C,Puissant H,Weil D,Rouleau S,Coutant R

    更新日期:2014-07-26 00:00:00

  • Neonatal mortality in the neonatal intensive care unit of Debre Markos referral hospital, Northwest Ethiopia: a prospective cohort study.

    abstract:BACKGROUND:Neonatal mortality remains a serious global public health problem, but Sub-Saharan Africa (SSA), in particular, is largely affected. Current evidence on neonatal mortality is essential to inform programs and policies, yet there is a scarcity of information concerning neonatal mortality in our study area. The...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-020-1963-z

    authors: Alebel A,Wagnew F,Petrucka P,Tesema C,Moges NA,Ketema DB,Yismaw L,Melkamu MW,Hibstie YT,Temesgen B,Bitew ZW,Tadesse AA,Kibret GD

    更新日期:2020-02-15 00:00:00

  • Necrotizing enterocolitis leads to disruption of tight junctions and increase in gut permeability in a mouse model.

    abstract:BACKGROUND:Necrotizing enterocolitis (NEC) is a leading cause of death in preterm infants. Neonates weighing <1500 grams are at the highest risk for acquiring NEC, with a prevalence of nearly 7-10%, mortality up to 30%, and several long-term complications among survivors. Despite advancements in neonatal medicine, this...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-018-1346-x

    authors: Ravisankar S,Tatum R,Garg PM,Herco M,Shekhawat PS,Chen YH

    更新日期:2018-11-27 00:00:00

  • Early Check: translational science at the intersection of public health and newborn screening.

    abstract:BACKGROUND:Newborn screening (NBS) occupies a unique space at the intersection of translational science and public health. As the only truly population-based public health program in the United States, NBS offers the promise of making the successes of translational medicine available to every infant with a rare disorde...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/s12887-019-1606-4

    authors: Bailey DB Jr,Gehtland LM,Lewis MA,Peay H,Raspa M,Shone SM,Taylor JL,Wheeler AC,Cotten M,King NMP,Powell CM,Biesecker B,Bishop CE,Boyea BL,Duparc M,Harper BA,Kemper AR,Lee SN,Moultrie R,Okoniewski KC,Paquin RS,Pe

    更新日期:2019-07-17 00:00:00

  • Subacute sclerosing panencephalitis: results of the Canadian Paediatric Surveillance Program and review of the literature.

    abstract:BACKGROUND:Subacute Sclerosing Panencephalitis (SSPE) is so rare in developed countries with measles immunization programs that national active surveillance is now needed to capture sufficient number of cases for meaningful analysis of data. Through the Canadian Paediatric Surveillance Program (CPSP), the SSPE study wa...

    journal_title:BMC pediatrics

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2431-5-47

    authors: Campbell C,Levin S,Humphreys P,Walop W,Brannan R

    更新日期:2005-12-15 00:00:00

  • EPIPAGE 2: a preterm birth cohort in France in 2011.

    abstract:BACKGROUND:Children born at low gestational ages face a range of risks and number of neonates surviving very preterm birth is increasing. We present the objectives and methods of a French national cohort of very and moderately preterm children, the EPIPAGE 2 study. It aims to examine short- and long-term outcomes of ve...

    journal_title:BMC pediatrics

    pub_type: 杂志文章

    doi:10.1186/1471-2431-14-97

    authors: Ancel PY,Goffinet F,EPIPAGE 2 Writing Group.

    更新日期:2014-04-09 00:00:00