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Comparing the performance characteristics of CSF-TRUST and CSF-VDRL for syphilis: a cross-sectional study.

Abstract：

OBJECTIVE:In this study, we aimed to determine the performance characteristics of toluidine red unheated serum test on cerebrospinal fluids (CSF-TRUST) as compared to venereal disease research laboratory test on cerebrospinal fluids (CSF-VDRL) for laboratory the diagnosis of neurosyphilis. DESIGN:A cross-sectional study. SETTING:Sexually transmitted infections (STIs) clinics. PARTICIPANTS AND METHODS:CSF and serum samples were collected from 824 individual STD clinic patients who have syphilis and are suspected to progress to neurosyphilis within a 9-month period. CSF-VDRL and CSF-TRUST were performed parallelly on the same day when collected. Treponema pallidum particle agglutination (TPPA) tests were also performed on the CSF and the serum samples, and biochemical analysis of the CSF samples was also performed. RESULTS:The overall agreement between CSF-TRUST and CSF-VDRL was 97.3%. The reactive ratios of the CSF samples were 22.1% by CSF-TRUST and 24.8% by CSF-VDRL, respectively. All CSF-TRUST-reactive cases were reactive in the CSF-VDRL. Twenty-two samples with CSF-TRUST-negative were tested CSF-VDRL-reactive with low titres (1 : 1 to 1 : 4). Over 97% of the double-reactive CSF samples (CSF-VDRL and CSF-TRUST) had an identical titre or a titre within a two-fold difference. The agreement of CSF-TPPA and CSF-VDRL was 71.9%. Similarly, the agreement of CSF-TPPA and CSF-TRUST was 69.2%. CONCLUSIONS:Our results revealed that CSF-TRUST could be used as an option for CSF examination in settings without CSF-VDRL in place.

journal_name

BMJ Open

journal_title

BMJ open

authors

Gu W,Yang Y,Wu L,Yang S,Ng LK

doi

10.1136/bmjopen-2012-002204

subject

Has Abstract

pub_date

2013-02-21 00:00:00

issue

2

issn

2044-6055

pii

bmjopen-2012-002204

journal_volume

3

pub_type

杂志文章

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