BART inhibits pancreatic cancer cell invasion by Rac1 inactivation through direct binding to active Rac1.

abstract：:PX-478 is a new agent known to inhibit the hypoxia-responsive transcription factor, HIF-1alpha, in experimental tumors. The current study was undertaken in preparation for clinical trials to determine which noninvasive imaging endpoint(s) is sensitive to this drug's actions. Dynamic contrast-enhanced (DCE) and diffusi...

journal_title：Neoplasia (New York, N.Y.)

authors： Jordan BF,Runquist M,Raghunand N,Baker A,Williams R,Kirkpatrick L,Powis G,Gillies RJ

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:Upregulation of Bcl-2 family members is a well-established mechanism in the development of androgen-independent prostate cancer. Inhibition of the antiapoptotic proteins Bcl-2 and Mcl-1 may delay the transition to androgen-independent growth. EXPERIMENTAL DESIGN:We have established a prostate cancer model with...

journal_title：Neoplasia (New York, N.Y.)

authors： Loberg RD,McGregor N,Ying C,Sargent E,Pienta KJ

更新日期：2007-12-01 00:00:00

abstract：:Numerous human tumor types, including ovarian cancer, display a significant expression of the CD44 family of cell surface proteoglycans. To develop tumor-targeted drugs, we have initially evaluated whether the CD44 ligand hyaluronic acid (HA) could serve as a backbone for paclitaxel (TXL) prodrugs. HA-TXL was prepared...

journal_title：Neoplasia (New York, N.Y.)

authors： Auzenne E,Ghosh SC,Khodadadian M,Rivera B,Farquhar D,Price RE,Ravoori M,Kundra V,Freedman RS,Klostergaard J

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:This study was performed to evaluate the safety and efficacy of paclitaxel with cisplatin as salvage therapy in patients previously treated with gemcitabine and cisplatin (G/C) for advanced transitional cell carcinoma (TCC) of the urothelial tract. METHODS:Twenty-eight patients with metastatic or locally ad...

journal_title：Neoplasia (New York, N.Y.)

authors： Uhm JE,Lim HY,Kim WS,Choi HY,Lee HM,Park BB,Park K,Kang WK

更新日期：2007-01-01 00:00:00

abstract：:Recent studies have established that a significant fraction of prostate cancers harbor a signature gene fusion between the 5' region of androgen-regulated TMPRSS2 and an ETS family transcription factor, most commonly ERG. Studies on the molecular mechanisms and functional consequences of this important chromosomal rea...

journal_title：Neoplasia (New York, N.Y.)

authors： Mertz KD,Setlur SR,Dhanasekaran SM,Demichelis F,Perner S,Tomlins S,Tchinda J,Laxman B,Vessella RL,Beroukhim R,Lee C,Chinnaiyan AM,Rubin MA

更新日期：2007-03-01 00:00:00

abstract：:Identification of the cell types capable of initiating and sustaining growth of the neoplastic clone in vivo is a fundamental problem in cancer research. It is likely that tumor growth can be sustained both by rare cancer stem-like cells and selected aggressive clones and that the nature of the mutations, the cell of ...

journal_title：Neoplasia (New York, N.Y.)

authors： Tysnes BB

更新日期：2010-07-01 00:00:00

abstract：:Since loss of VHL is frequently detected early phase genetic event in human renal cell carcinoma, pVHL is assumed to be indispensable for suppression of tumor initiation step. However, induction of HIF-1α, target of pVHL E3 ligase, is more adequate to angiogenesis step after tumor mass formation. Concerning this, it h...

journal_title：Neoplasia (New York, N.Y.)

authors： Jung YS,Chun HY,Yoon MH,Park BJ

更新日期：2014-12-01 00:00:00

abstract：:It has long been a puzzle in cancer treatment that despite the initial appearance of apoptosis, the process could be reversed in some cancer cells and often results in more aggressive tumors and metastasis. The mechanism for this recurrence is yet unknown. Here we report that human mammary carcinoma cells induced to u...

journal_title：Neoplasia (New York, N.Y.)

authors： Xu Y,So C,Lam HM,Fung MC,Tsang SY

更新日期：2018-03-01 00:00:00

abstract：:We investigated the epigenetic silencing and genetic changes of the RAS-associated domain family 1A (RASSF1A) gene and the O6-methylguanine-DNA methyltransferase (MGMT) gene in retinoblastoma. We extracted DNA from microdissected tumor and normal retina tissues of the same patient in 68 retinoblastoma cases. Promoter ...

journal_title：Neoplasia (New York, N.Y.)

authors： Choy KW,Lee TC,Cheung KF,Fan DS,Lo KW,Beaverson KL,Abramson DH,Lam DS,Yu CB,Pang CP

更新日期：2005-03-01 00:00:00

abstract：:p300/CBP-associated factor (PCAF) is a coactivator of the tumor suppressor, p53. PCAF participates in p53's transactivation of target genes through acetylation of both bound p53 and histones within p53 target promoters. Using microarrays, we discovered that PCAF itself is induced by p53 in a panel of breast tumor cell...

journal_title：Neoplasia (New York, N.Y.)

authors： Watts GS,Oshiro MM,Junk DJ,Wozniak RJ,Watterson S,Domann FE,Futscher BW

更新日期：2004-05-01 00:00:00

abstract：:Mutations of the NF2 gene on chromosome 22q are thought to initiate tumorigenesis in nearly 50% of meningiomas, and 22q deletion is the earliest and most frequent large-scale chromosomal abnormality observed in these tumors. In aggressive meningiomas, 22q deletions are generally accompanied by the presence of large-sc...

journal_title：Neoplasia (New York, N.Y.)

authors： Yang HW,Kim TM,Song SS,Shrinath N,Park R,Kalamarides M,Park PJ,Black PM,Carroll RS,Johnson MD

更新日期：2012-01-01 00:00:00

abstract：:Sporadic ovarian cancer is a particularly aggressive tumor characterized by highly abnormal karyotypes exhibiting many features of genomic instability. More complex genomic changes in tumors arise as a consequence of chromosomal instability (CIN), which can generate both numerical [(N)-CIN] and structural chromosomal ...

journal_title：Neoplasia (New York, N.Y.)

authors： Bayani J,Paderova J,Murphy J,Rosen B,Zielenska M,Squire JA

更新日期：2008-10-01 00:00:00

abstract：:The term mucositis is coined to describe the adverse effects of radiation and chemotherapy treatments. Mucositis is one of the most common adverse reactions encountered in radiation therapy for head and neck cancers, as well as in chemotherapy, in particular with drugs affecting DNA synthesis (S-phase-specific agents ...

journal_title：Neoplasia (New York, N.Y.)

authors： Naidu MU,Ramana GV,Rani PU,Mohan IK,Suman A,Roy P

更新日期：2004-09-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is an important process of tumor progression associated with increased metastatic potential. EMT can be activated by external triggers such as cytokines or metabolic parameters (e.g. hypoxia). Since extracellular acidosis is a common finding in tumors, the aim of the study is...

journal_title：Neoplasia (New York, N.Y.)

authors： Riemann A,Rauschner M,Gießelmann M,Reime S,Haupt V,Thews O

更新日期：2019-05-01 00:00:00

abstract：:The sequence of genomic alterations acquired by cancer cells during tumor progression and metastasis is poorly understood. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that integrates cytoskeleton remodeling, mitogenic signaling and cell survival. FAK has previously been reported to undergo nuclear lo...

journal_title：Neoplasia (New York, N.Y.)

authors： Constanzo JD,Tang KJ,Rindhe S,Melegari M,Liu H,Tang X,Rodriguez-Canales J,Wistuba I,Scaglioni PP

更新日期：2016-05-01 00:00:00

abstract：:It is widely accepted that a deranged immune system plays a key role in the onset and evolution of classic Kaposi sarcoma (CKS). Nevertheless, the usage of the T-cell receptor (TCR) β-variable (BV) chain repertoire expressed by peripheral blood lymphocytes in patients with CKS is still unknown. With the aim of providi...

journal_title：Neoplasia (New York, N.Y.)

authors： Galleu A,Fozza C,Simula MP,Contini S,Virdis P,Corda G,Pardini S,Cottoni F,Pruneddu S,Angeloni A,Ceccarelli S,Longinotti M

更新日期：2012-06-01 00:00:00

abstract：:We characterized the molecular genetic consequences of a balanced chromosome translocation t(8;22)(p21;q12), which occurred as the sole cytogenetic aberration in short-term cultured cells from an intrathoracic mature teratoma in a 15-year-old girl. Fluorescence in situ hybridization and reverse transcription-polymeras...

journal_title：Neoplasia (New York, N.Y.)

authors： Jin Y,Mertens F,Kullendorff CM,Panagopoulos I

更新日期：2006-05-01 00:00:00

abstract：:The tumor-selective cytotoxic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) makes TRAIL an attractive candidate as an anticancer agent. However, resistance to TRAIL poses a challenge in anticancer therapy with TRAIL. Therefore, characterizing the mechanisms of resistance and developing stra...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhang L,Zhu H,Teraishi F,Davis JJ,Guo W,Fan Z,Fang B

更新日期：2005-06-01 00:00:00

abstract：:We previously demonstrated the synergistic therapeutic effect of the cetuximab (anti-epidermal growth factor receptor [EGFR] monoclonal antibody, mAb)-trastuzumab (anti-HER2 mAb) combination (2mAbs therapy) in HER2(low) human pancreatic carcinoma xenografts. Here, we compared the 2mAbs therapy, the erlotinib (EGFR tyr...

journal_title：Neoplasia (New York, N.Y.)

authors： Larbouret C,Gaborit N,Chardès T,Coelho M,Campigna E,Bascoul-Mollevi C,Mach JP,Azria D,Robert B,Pèlegrin A

更新日期：2012-02-01 00:00:00

abstract：:A step toward the molecular classification of prostate cancer was the discovery of recurrent erythroblast transformation-specific rearrangements, most commonly fusing the androgen-regulated TMPRSS2 promoter to ERG. The TMPRSS2-ERG fusion is observed in around 90% of tumors that overexpress the oncogene ERG. The goal o...

journal_title：Neoplasia (New York, N.Y.)

authors： Pflueger D,Rickman DS,Sboner A,Perner S,LaFargue CJ,Svensson MA,Moss BJ,Kitabayashi N,Pan Y,de la Taille A,Kuefer R,Tewari AK,Demichelis F,Chee MS,Gerstein MB,Rubin MA

更新日期：2009-08-01 00:00:00

abstract：:One of the challenges of tailored antiangiogenic therapy is the ability to adequately monitor the angiogenic activity of a malignancy in response to treatment. The α(v)β(3) integrin, highly overexpressed on newly formed tumor vessels, has been successfully used as a target for Arg-Gly-Asp (RGD)-functionalized nanopart...

journal_title：Neoplasia (New York, N.Y.)

authors： Jarzyna PA,Deddens LH,Kann BH,Ramachandran S,Calcagno C,Chen W,Gianella A,Dijkhuizen RM,Griffioen AW,Fayad ZA,Mulder WJ

更新日期：2012-10-01 00:00:00

abstract：:Direct tumor injections of (CpG ODN) into murine colon tumor 26 (CT-26) tumors can induce a potent antitumor response. Tumor size at the beginning of treatment determines the final therapeutic outcome, with smaller tumors responding favorably to CpG ODN therapy whereas large tumors do not. CpG ODN injections in small ...

journal_title：Neoplasia (New York, N.Y.)

authors： Sharma S,Karakousis CP,Takita H,Shin K,Brooks SP

更新日期：2004-09-01 00:00:00

abstract：:For improved tumor staging and therapy control, imaging biomarkers are of great interest allowing a noninvasive characterization of invasiveness. In squamous epithelial skin and cervix lesions, transition to invasive stages is associated with enhanced matrix metalloproteinase (MMP) activity, increased angiogenesis, an...

journal_title：Neoplasia (New York, N.Y.)

authors： Al Rawashdeh W,Arns S,Gremse F,Ehling J,Knüchel-Clarke R,Kray S,Spöler F,Kiessling F,Lederle W

更新日期：2014-03-01 00:00:00

abstract：:Even with increasing evidence for roles of glycolytic enzymes in controlling cancerous characteristics, the best target of candidate metabolic enzymes for lessening malignancy remains under debate. Pyruvate is a main glycolytic metabolite that could be mainly converted into either lactate by Lactate Dehydrogenase A (L...

journal_title：Neoplasia (New York, N.Y.)

authors： Chen TY,Hsieh YT,Huang JM,Liu CJ,Chuang LT,Huang PC,Kuo TY,Chia HY,Chou CY,Chang CW,Chen YF,Chen HM,Lo JF,Li WC

更新日期：2019-07-01 00:00:00

abstract：:The WNT/beta-catenin (CTNNB1) pathway is commonly activated in the carcinogenic process. Cross-talks between the WNT and cyclooxygenase-2 (COX-2 or PTGS2)/prostaglandin pathways have been suggested. The relationship between beta-catenin activation and microsatellite instability (MSI) in colorectal cancer has been cont...

journal_title：Neoplasia (New York, N.Y.)

authors： Kawasaki T,Nosho K,Ohnishi M,Suemoto Y,Kirkner GJ,Dehari R,Meyerhardt JA,Fuchs CS,Ogino S

更新日期：2007-07-01 00:00:00

abstract：:To survive and metastasize, tumors interact with surrounding tissues by secreting growth factors and cytokines. In return, surrounding host tissues respond by changing their secretome. Numerous factors theoretically function as therapeutic targets or biomarkers of cancer growth and metastatic risk. However, it is uncl...

journal_title：Neoplasia (New York, N.Y.)

authors： Kerr BA,Miocinovic R,Smith AK,Klein EA,Byzova TV

更新日期：2010-05-01 00:00:00

abstract：:Heparanase-1 (HPR1), an endoglycosidase that specifically degrades heparan sulfate (HS) proteoglycans, is overexpressed in a variety of malignancies. Our present study sought to determine whether oncogene BRAF and RAS mutations lead to increased HPR1 expression. Reverse transcription-polymerase chain reaction analysis...

journal_title：Neoplasia (New York, N.Y.)

authors： Rao G,Liu D,Xing M,Tauler J,Prinz RA,Xu X

更新日期：2010-11-01 00:00:00

abstract：:Signaling events leading to Schwann cell tumor initiation have been extensively characterized in the context of neurofibromatosis (NF). Similar tumors are also observed in patients with the endocrine neoplasia syndrome Carney complex, which results from inactivating mutations in PRKAR1A. Loss of PRKAR1A causes enhance...

journal_title：Neoplasia (New York, N.Y.)

authors： Jones GN,Tep C,Towns WH 2nd,Mihai G,Tonks ID,Kay GF,Schmalbrock PM,Stemmer-Rachamimov AO,Yoon SO,Kirschner LS

更新日期：2008-11-01 00:00:00

abstract：:The bcl-2 and c-myc oncogenes cooperate to transform multiple cell types. In the pediatric malignancy NB(2), Bcl-2 is highly expressed. In tumors with a poor prognosis, N-Myc, a protein homologous to c-Myc, is overexpressed as a result of gene amplification. The present study was designed to determine whether Bcl-2 co...

journal_title：Neoplasia (New York, N.Y.)

authors： Jasty R,van Golen C,Lin HJ,Solomon G,Heidelberger K,Polverini P,Opipari A,Feldman E,Castle VP

更新日期：2001-07-01 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy originating from T-cell precursors. The genetic landscape of T-ALL has been largely characterized by next-generation sequencing. Yet, the transcriptome of miRNAs (miRNome) of T-ALL has been less extensively studied. Using small RNA sequencing, we ...

journal_title：Neoplasia (New York, N.Y.)

authors： Dawidowska M,Jaksik R,Drobna M,Szarzyńska-Zawadzka B,Kosmalska M,Sędek Ł,Machowska L,Lalik A,Lejman M,Ussowicz M,Kałwak K,Kowalczyk JR,Szczepański T,Witt M

更新日期：2019-03-01 00:00:00