Abstract：
BACKGROUND:Hmg-CoA reductase inhibitors (statins) are widely used to prevent disease associated with vascular disease and hyperlipidemia. Although side effects are uncommon, clinical observations suggest statin exposure may exacerbate neuromuscular diseases, including peripheral neuropathy and amyotrophic lateral sclerosis. Although some have postulated class-effects, prior studies of hepatocytes and myocytes indicate that the statins may exhibit differential effects. Studies of neuronal cells have been limited. METHODS:We examined the effects of statins on cultured neurons and Schwann cells. Cultured spinal motor neurons were grown on transwell inserts and assessed for viability using immunochemical staining for SMI-32. Cultured cortical neurons and Schwann cells were assessed using dynamic viability markers. RESULTS:7 days of exposure to fluvastatin depleted spinal motor neurons in a dose-dependent manner with a KD of < 2 μM. Profound neurite loss was observed after 4 days exposure in culture. Other statins were found to produce toxic effects at much higher concentrations. In contrast, no such toxicity was observed for cultured Schwann cells or cortical neurons. CONCLUSIONS:It is known from pharmacokinetic studies that daily treatment of young adults with fluvastatin can produce serum levels in the single micromolar range. We conclude that specific mechanisms may explain neuromuscular disease worsening with statins and further study is needed.
journal_name
BMC Musculoskelet Disordjournal_title
BMC musculoskeletal disordersauthors
Murinson BB,Haughey NJ,Maragakis NJdoi
10.1186/1471-2474-13-100subject
Has Abstractpub_date
2012-06-15 00:00:00pages
100issn
1471-2474pii
1471-2474-13-100journal_volume
13pub_type
杂志文章abstract：BACKGROUND:We investigated whether Body Mass Index (BMI) at 11 years old has a direct effect on bone mass at age 18 operating through alterations to bone growth and development, or whether the association is mediated by concurrent BMI, fat mass (FM), and fat free mass (FFM). METHODS:Path analysis was used to explore t...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-015-0529-y
更新日期：2015-03-29 00:00:00
abstract：BACKGROUND:Clinicians and patients lack an evidence-based framework by which to judge individual-level recovery following total knee arthroplasty (TKA) surgery, thus impeding personalized treatment approaches for this elective surgery. Our study aimed to develop and validate a reference chart for monitoring recovery of...
journal_title：BMC musculoskeletal disorders
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doi：10.1186/s12891-020-03493-x
更新日期：2020-07-22 00:00:00
abstract：BACKGROUND:Valid measures of physical activity are critical research tools. The objective of this study was to develop a Spanish translation of the Yale Physical Activity Survey, and to provide preliminary evidence of its validity in a population of Dominican patients with lower extremity arthritis. METHODS:A Dominica...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-15-120
更新日期：2014-04-07 00:00:00
abstract：BACKGROUND:Variations in corticosteroid/anesthetic doses for injecting shoulder conditions were examined among orthopaedic surgeons, rheumatologists, and primary-care sports medicine (PCSMs) and physical medicine and rehabilitation (PMRs) physicians to provide data needed for documenting inter-group differences for est...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-8-63
更新日期：2007-07-06 00:00:00
abstract：BACKGROUND:Meniscal allograft transplantation (MAT) may improve symptoms and function, and may limit premature knee degeneration in patients with symptomatic meniscal loss. The aim of this retrospective study was to examine patient outcomes after MAT and to explore the different potential definitions of 'success' and '...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-020-3165-0
更新日期：2020-03-12 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-14-327
更新日期：2013-11-20 00:00:00
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journal_title：BMC musculoskeletal disorders
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doi：10.1186/1471-2474-10-6
更新日期：2009-01-14 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-9-24
更新日期：2008-02-25 00:00:00
abstract：BACKGROUND:One of the characteristics of lumbar spinal stenosis (LSS) is elastin degradation and fibrosis in the ligamentum flavum (LF). However, the biochemical factors that cause these histologic changes is unclear. P16 and S100 participate in scar formation and collagen development in wound healing and fibrosis dise...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-019-2825-4
更新日期：2019-10-22 00:00:00
abstract：BACKGROUND:Avulsion fractures of the pelvic apophyses typically occur in adolescent athletes due to a sudden strong muscle contraction while growth plates are still open. The main goals of this systematic review with meta-analysis were to summarize the evidence on clinical outcome and determine the rate of return to sp...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1186/s12891-017-1527-z
更新日期：2017-04-19 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-9-39
更新日期：2008-03-28 00:00:00
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pub_type： 杂志文章
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更新日期：2011-10-12 00:00:00
abstract：BACKGROUND:To examine whether number of physical therapy (PT) visits or amount of use of an internet-based exercise training (IBET) program is associated with differential improvement in outcomes for participants with knee osteoarthritis (OA). METHODS:A secondary analysis was performed using data from participants in ...
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pub_type： 杂志文章
doi：10.1186/s12891-018-2139-y
更新日期：2018-07-19 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
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更新日期：2015-09-04 00:00:00
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journal_title：BMC musculoskeletal disorders
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更新日期：2018-06-09 00:00:00
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pub_type： 杂志文章
doi：10.1186/1471-2474-8-31
更新日期：2007-04-03 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-14-74
更新日期：2013-02-28 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-018-2035-5
更新日期：2018-04-25 00:00:00
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pub_type： 杂志文章,随机对照试验
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pub_type： 临床试验,杂志文章
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更新日期：2019-01-08 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 临床试验,杂志文章
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更新日期：2011-01-10 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-020-03336-9
更新日期：2020-05-14 00:00:00
abstract：BACKGROUND:Multiple primary tumors, especially quadruple primary neoplasms is extremely rare. Fibrous dysplasia (FD), osteosarcoma (OS), and giant cell tumor of bone (GCTB) are three bone tumors with low incidence while primary pulmonary meningioma is a rare disease. In this case report, we present a unique synchronous...
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pub_type： 杂志文章
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更新日期：2020-06-22 00:00:00
abstract：BACKGROUND:Fibromyalgia syndrome (FMS) presents a challenge for patients and health care staff across many medical specialities. The aetiology is multi-dimensional, involving somatic, psychological and social factors. Patients' views were obtained to understand their experience of living with this long-term condition, ...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
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更新日期：2009-10-07 00:00:00
abstract：BACKGROUND:Open dislocations are infrequent, often associated with damage to the neuro vascular structures. We present an unusual case of an open antero-lateral dislocation of the elbow, which was not associated with any vascular or neural injury. CASE PRESENTATION:A 34 year female dance instructor sustained an open d...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-3-1
更新日期：2002-01-01 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-015-0603-5
更新日期：2015-06-05 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
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更新日期：2018-09-25 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
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更新日期：2018-08-02 00:00:00
