Abstract：
BACKGROUND:Multiple primary tumors, especially quadruple primary neoplasms is extremely rare. Fibrous dysplasia (FD), osteosarcoma (OS), and giant cell tumor of bone (GCTB) are three bone tumors with low incidence while primary pulmonary meningioma is a rare disease. In this case report, we present a unique synchronous occurrence of these four separate pathological conditions. CASE PRESENTATION:A 53-year-old male previously underwent resection of OS of fifth rib and FD of eighth rib 1 year ago. Recently, a discontinuous pain at right knee developed. Serial X-ray films showed a progressively pure osteolytic lesion of proximal tibia which extended gradually. The incisional biopsy revealed that this tumor was confirmed as GCTB, and the tumor was successfully managed by extensive curettage and bone cement filling. The diagnosis of GCTB was re-confirmed by the postoperative histopathologic examinations. High-throughput sequencing from the GCTB exhibited a somatic mutation of H3.3A (G35W exon2). Germline testing revealed a germ-cell variant in gene of BRCA2 (exon 8 V220Ifs*4). CONCLUSIONS:This is a unique case with quadruple primary tumors. Germline mutation in gene of BRCA2 may be associated with the occurrence of multiple primary tumors in this patient.
journal_name
BMC Musculoskelet Disordjournal_title
BMC musculoskeletal disordersauthors
Zhao Z,Sun K,Yan T,Wei R,Guo Wdoi
10.1186/s12891-020-03426-8subject
Has Abstractpub_date
2020-06-22 00:00:00pages
394issue
1issn
1471-2474pii
10.1186/s12891-020-03426-8journal_volume
21pub_type
杂志文章abstract：BACKGROUND:We investigated the efficacy of annular ligament reconstruction by suture anchor in the treatment of radial head dislocation (RHD) in children. METHOD:A total of 20 RHD children nderwent annular ligament reconstruction surgery using suture anchor. Preoperative and postoperative elbow functions were evaluate...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-015-0642-y
更新日期：2015-08-05 00:00:00
abstract：BACKGROUND:The purpose of this systematic review and meta-analysis was to compare the direct anterior approach and posterior approach for primary total hip arthroplasty in terms of the clinical, functional and radiographic outcomes. METHODS:We searched the PubMed and EMBASE databases and Cochrane Library from their in...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-020-03318-x
更新日期：2020-06-02 00:00:00
abstract：BACKGROUND:Abnormal gluteus medius muscle activity is associated with a number of musculoskeletal conditions. Research investigating the effect of foot type and foot orthoses on gluteus medius muscle activity is both conflicting and limited. The primary aim was to investigate the relationship between foot type and glut...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-020-03683-7
更新日期：2020-10-07 00:00:00
abstract：BACKGROUND:Painful shoulders pose a substantial socioeconomic burden. A prospective cost-of-illness study was performed to assess the costs associated with healthcare use and loss of productivity in patients with shoulder pain in primary health care in Sweden. METHODS:The study was performed in western Sweden, in a re...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-13-17
更新日期：2012-02-10 00:00:00
abstract：BACKGROUND:The efficacy, safety and tolerability of lumiracoxib, a novel selective cyclooxygenase-2 (COX-2) inhibitor, has been demonstrated in previous studies of patients with osteoarthritis (OA). As it is important to establish the long-term safety and efficacy of treatments for a chronic disease such as OA, the pre...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/1471-2474-9-32
更新日期：2008-03-07 00:00:00
abstract：BACKGROUND:Data about minimally invasive surgery for the treatment of patients with degenerative disc disease (DDD) has been reported. However, no quantitative knowledge about the biomechanical characteristics of the spinous processes in patients with DDD after operation was reported in the literature. METHODS:Fourtee...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-017-1504-6
更新日期：2017-04-04 00:00:00
abstract：BACKGROUND:An arthroscopic narrow posteromedial gap of the knee may cause failure of a meniscus operation. The posteromedial complex (PMC) of the knee, including the posterior part of the medial collateral ligament (MCL) and the posterior oblique ligament (POL), has a restrictive effect on the opening of the posteromed...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-020-03336-9
更新日期：2020-05-14 00:00:00
abstract：BACKGROUND:The purpose of this study was to determine whether a specific threshold per lifting movement, the accumulation above which best predicts lumbar disk protrusion, exists or the total lifting load should be considered. METHODS:This was a retrospective study. Subjects with various lifting exposures were recruit...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-020-3167-y
更新日期：2020-03-16 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-016-0913-2
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Evaluating the strength of the small muscles of the foot may be useful in a variety of clinical applications but is challenging from a methodology standpoint. Previous efforts have focused primarily on the functional movement of toe flexion, but clear methodology guidelines are lacking. A novel foot doming t...
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pub_type： 杂志文章,随机对照试验
doi：10.1186/s12891-019-2981-6
更新日期：2019-12-14 00:00:00
abstract：BACKGROUND:Musculoskeletal complaints of arm, neck, and shoulder (CANS) can lead to loss of work productivity. To assess the functional consequences of impairments in work, patient-reported outcomes can be important. The Hand Function Sort (HFS) is a 62-item pictorial questionnaire that focuses on work task performance...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
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更新日期：2019-06-07 00:00:00
abstract：BACKGROUND:Low back pain (LBP) is a common problem that can contribute to motor dysfunction. Previous studies reporting the changes in kinematic characteristics caused by LBP present conflicting results. This study aimed to apply the multisegmental spinal model to investigate the kinematic changes in patients with lumb...
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pub_type： 杂志文章
doi：10.1186/s12891-017-1572-7
更新日期：2017-05-25 00:00:00
abstract：BACKGROUND:En bloc excision has been increasingly used for the management of giant cell tumors (GCTs) in the distal radius. An osteoarticular allograft has been used extensively for decades, and custom-made prosthesis reconstruction has been more recently applied. We aimed to compare the clinical outcomes of the two pr...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-020-3084-0
更新日期：2020-02-03 00:00:00
abstract：BACKGROUND:The identification of clinically relevant subgroups of low back pain (LBP) is considered the number one LBP research priority in primary care. One subgroup of LBP patients are those with back related leg pain. Leg pain frequently accompanies LBP and is associated with increased levels of disability and highe...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章,评审
doi：10.1186/s12891-016-1074-z
更新日期：2016-05-23 00:00:00
abstract：BACKGROUND:Recurrent severe Dupuytren contracture of the small finger's proximal interphalangeal (PIP) joint is a difficult problem. Further surgery carries high risk of complications and poor outcome. Patients are often offered finger amputation. We have devised a novel surgical procedure consisting of middle phalanx ...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-019-2701-2
更新日期：2019-07-09 00:00:00
abstract：BACKGROUND:The 6-minute walk test (6MWT) is a commonly used metric for measuring change in mobility after knee arthroplasty, however, what is considered an improvement after surgery has not been defined. The determination of important change in an outcome assessment tool is controversial and may require more than one a...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12891-016-1249-7
更新日期：2016-09-13 00:00:00
abstract：BACKGROUND:Ballet dancers have been shown to have a relatively high incidence of stress fractures of the foot and ankle. It was our objective to examine MR imaging patterns of bone marrow edema (BME) in the ankles of high performance professional ballet dancers, to evaluate clinical relevance. METHODS:MR Imaging was p...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-9-39
更新日期：2008-03-28 00:00:00
abstract：BACKGROUND:There has been no consensus regarding what is the optimal means of treating lumbosacral segment tuberculosis. The aim of this study was to evaluate the clinical outcomes of our newly developed one-stage anterior debridement and fusion combined with dual screw-rod construct anterior instrument underneath the ...
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doi：10.1186/s12891-016-0902-5
更新日期：2016-02-01 00:00:00
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journal_title：BMC musculoskeletal disorders
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-018-2159-7
更新日期：2018-07-25 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-14-126
更新日期：2013-04-05 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章,多中心研究
doi：10.1186/s12891-016-0870-9
更新日期：2016-01-13 00:00:00
abstract：BACKGROUND:There is a wide range of mechanical properties of spinal ligaments documented in literature. Due to the fact that ligaments contribute in stabilizing the spine by limiting excessive intersegmental motion, those properties are of particular interest for the implementation in musculoskeletal models. The aim of...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-016-0942-x
更新日期：2016-02-22 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-020-3065-3
更新日期：2020-01-29 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-018-2314-1
更新日期：2018-11-10 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-14-149
更新日期：2013-04-26 00:00:00
abstract：OBJECTIVE:This study aimed to describe the changes in spinopelvic sagittal alignment in the sitting position after posterior lumbar fusion, and to identify the factors influencing unfused adjacent segment lordosis. METHODS:Consecutive patients with lumbar degenerative disease who underwent posterior lumbar interbody f...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/s12891-020-03777-2
更新日期：2020-11-18 00:00:00
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journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2474-14-28
更新日期：2013-01-16 00:00:00
abstract：BACKGROUND:Macrophages expressing the pro-angiogenic transcription factor hypoxia-inducible factor (HIF)-1alpha have been demonstrated in rheumatoid arthritis (RA) in the synovial tissue. Aim of the present study was to investigate intracellular signal transduction regulation of pro-inflammatory HIF-1 alpha expression ...
journal_title：BMC musculoskeletal disorders
pub_type： 杂志文章
doi：10.1186/1471-2474-11-61
更新日期：2010-03-30 00:00:00
