Effect of a lathyrogen (aminoacetonitrile hydrochloride) on aortic physiosclerosis and skeletal mineralization in growing rats of different age.

Abstract:

:In one experiment, four groups of six-week-old-male PVG rats were, respectively, given tap water ('control group'), 0.00125M, 0.0025M, and 0.005M lathyrogen (aminoacetonitrile hydrochloride: AAN) solutions ad libitum for a period of 20 weeks. In a second experiment, 12-week-old male rats were similarly treated. It was found that the younger rats were far more susceptible to lathyrogenic influences than the older rats. For example, the rate of aortic physiosclerosis was significantly retarded in the six-week-old rats at dosages of 0.00125M and 0.0025M (the six-week-old rats exposed to 0.005M AAN were eliminated from the experiment before its completion), whilst physiosclerosis was unaffected even in those 12-week-old rats exposed to 0.005M AAN. The degree of mineralization of the femur (as reflected by its ash, Ca, Mg, Na, and K content) was retarded in approximately dose-dependent fashion in the rats of both ages, the effect being somewhat more pronounced in the younger animals. These results were discussed in the context of the known effects of lathyrogenic compounds on the biochemical maturation of connective tissue components, and also in the context of previous attempts to modify the lifespan of laboratory animals by lathyrogen administration.

journal_name

Age Ageing

journal_title

Age and ageing

authors

Morgan AJ,Bellamy D

doi

10.1093/ageing/5.3.155

subject

Has Abstract

pub_date

1976-08-01 00:00:00

pages

155-63

issue

3

eissn

0002-0729

issn

1468-2834

journal_volume

5

pub_type

杂志文章
  • Aged men and ischaemic heart disease: serum cholesterol and triglyceride levels.

    abstract::Fasting serum cholesterol and triglyceride levels, and lipoprotein electrophoretic patterns have been investigated in 42 men aged 67-92 years (mean 79 years). Although all the cholesterol and the majority of the triglyceride levels were within the normal range for younger people, both were significantly greater (P < 0...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/9.3.154

    authors: Horsey J,Livesley B,Dickerson JW

    更新日期:1980-08-01 00:00:00

  • Reproductive longevity and increased life expectancy.

    abstract:BACKGROUND:Female life expectancy in developed countries has increased by 30 years in the twentieth century. AIM:To determine if there has been an increase in reproductive longevity. METHODS:We analysed age-specific fertility data from birth statistics for the USA, Canada, Japan, France, Sweden, the UK and Australia....

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/29.1.75

    authors: Brody JA,Grant MD,Frateschi LJ,Miller SC,Zhang H

    更新日期:2000-01-01 00:00:00

  • The impact of first- and second-eye cataract surgery on injurious falls that require hospitalisation: a whole-population study.

    abstract:BACKGROUND:cataract is a leading cause of reversible vision impairment and may increase falls in older adults. OBJECTIVE:to assess the risk of an injury due to a fall among adults aged 60+, 2 years before first-eye cataract surgery, between first-eye surgery and second-eye surgery and 2 years after second-eye surgery....

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/aft177

    authors: Meuleners LB,Fraser ML,Ng J,Morlet N

    更新日期:2014-05-01 00:00:00

  • Catheter-associated urinary tract infection in primary and community health care.

    abstract:INTRODUCTION:Although often a last resort, urinary catheterisation is a relatively common management option for bladder dysfunction in older people and others cared for in community settings. Catheter-associated urinary tract infection (CAUTI) is a well-recognised source of increased morbidity and economic burden in ac...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afl052

    authors: Getliffe K,Newton T

    更新日期:2006-09-01 00:00:00

  • Spindle cell sarcoma: a rare cause of a large abdominal mass.

    abstract::A 73-year-old man presented with a huge intra-abdominal mass. Initially a gastrointestinal stromal tumour (GIST) was diagnosed, but his tumour was subsequently classified as a spindle cell sarcoma. Difficulties in the classification of rare intra-abdominal tumours are discussed. ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afi002

    authors: Bills V,Iqbal R,Haqqani M,Clague JE

    更新日期:2005-01-01 00:00:00

  • Reviews after one and five years in a longitudinal study of ageing persons.

    abstract::A simple random sample of older people composed of 215 men and 272 women aged 62 years and over was examined in Edinburgh in 1968-9. After one year, 86 per cent of the men and 79 per cent of the women were re-examined; 7 per cent of the men and 4 per cent of the women had died and the remainder were not re-examined fo...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/4.3.152

    authors: Milne JS,Chopin JM

    更新日期:1975-08-01 00:00:00

  • The decision to work after state pension age and how it affects quality of life: evidence from a 6-year English panel study.

    abstract:Background:despite an increasing proportion of older people working beyond State Pension Age (SPA), little is known about neither the motivations for this decision nor whether, and to what extent, working beyond SPA affects quality of life (QoL). Methods:QoL was measured using the CASP-19 scale. Respondents in paid wo...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afx181

    authors: Di Gessa G,Corna L,Price D,Glaser K

    更新日期:2018-05-01 00:00:00

  • Associations of fat and muscle tissue with cognitive status in older adults: the AGES-Reykjavik Study.

    abstract:Background/Objective:studies on the association of dementia with specific body composition (BC) components are scarce. Our aim was to investigate associations of BC measures with different levels of cognitive function in late-life. Methods:we studied 5,169 participants (mean age 76 years, 42.9% men) in the AGES-Reykja...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afw219

    authors: Spauwen PJ,Murphy RA,Jónsson PV,Sigurdsson S,Garcia ME,Eiriksdottir G,van Boxtel MP,Lopez OL,Gudnason V,Harris TB,Launer LJ

    更新日期:2017-03-01 00:00:00

  • Impact of endovascular reperfusion therapy in nonagenarians with anterior circulation large-vessel ischaemic stroke.

    abstract:BACKGROUND AND PURPOSE:The benefit of endovascular thrombectomy (EVT) among nonagenarians (90 years or older) is poorly documented. We aimed to investigate the clinical and imaging factors associated with good outcomes and mortality at 90 days in nonagenarians undergoing EVT for acute ischemic stroke (AIS). METHODS:Da...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa243

    authors: Derraz I,Benali A,Ahmed R,Cagnazzo F,Dargazanli C,Gascou G,Riquelme C,Corti L,Lefevre PH,Bonafe A,Arquizan C,Costalat V

    更新日期:2020-11-17 00:00:00

  • Is medication use by community-dwelling elderly people influenced by cognitive function?

    abstract::To determine whether medication use differs by cognitive status among community dwelling elderly, a survey was made of a stratified random sample of 4110 black and white participants, aged 65 or older from the Duke Established Populations for Epidemiologic Studies of the Elderly in five adjacent urban and rural counti...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/25.3.190

    authors: Hanlon JT,Landerman LR,Wall WE Jr,Horner RD,Fillenbaum GG,Dawson DV,Schmader KE,Cohen HJ,Blazer DG

    更新日期:1996-05-01 00:00:00

  • Optimal healthcare delivery to care homes in the UK: a realist evaluation of what supports effective working to improve healthcare outcomes.

    abstract:INTRODUCTION:care home residents have high healthcare needs not fully met by prevailing healthcare models. This study explored how healthcare configuration influences resource use. METHODS:a realist evaluation using qualitative and quantitative data from case studies of three UK health and social care economies select...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afx195

    authors: Gordon AL,Goodman C,Davies SL,Dening T,Gage H,Meyer J,Schneider J,Bell B,Jordan J,Martin FC,Iliffe S,Bowman C,Gladman JRF,Victor C,Mayrhofer A,Handley M,Zubair M

    更新日期:2018-07-01 00:00:00

  • Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease.

    abstract:BACKGROUND/OBJECTIVES:to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes. DESIGN:a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/aft191

    authors: Werner KB,Elmståhl S,Christensson A,Pihlsgård M

    更新日期:2014-05-01 00:00:00

  • Cognitive impairment in the elderly--a community survey.

    abstract::Previous studies have suggested that up to a fifth of people over the age of 80 years may suffer severe dementia-like illnesses. This total population survey of over a thousand people over the age of 75 suggests that the prevalence of marked cognitive impairment is much less than expected. However, differences in the ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/15.5.278

    authors: Clarke M,Lowry R,Clarke S

    更新日期:1986-09-01 00:00:00

  • Combined resistance and balance-jumping exercise reduces older women's injurious falls and fractures: 5-year follow-up study.

    abstract:BACKGROUND AND OBJECTIVE:previously, a randomised controlled exercise intervention study (RCT) showed that combined resistance and balance-jumping training (COMB) improved physical functioning and bone strength. The purpose of this follow-up study was to assess whether this exercise intervention had long-lasting effect...

    journal_title:Age and ageing

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/ageing/afv064

    authors: Karinkanta S,Kannus P,Uusi-Rasi K,Heinonen A,Sievänen H

    更新日期:2015-09-01 00:00:00

  • Hip fracture risk and subsequent mortality among Alzheimer's disease patients in the United Kingdom, 1988-2007.

    abstract:BACKGROUND:hip fractures result in a significant burden to the patient, their caregivers and the health care system. Patients with Alzheimer's disease (AD) have a higher incidence of hip fracture compared with other older people without AD, although it is not clear if AD is an independent risk factor for hip fracture. ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afq146

    authors: Baker NL,Cook MN,Arrighi HM,Bullock R

    更新日期:2011-01-01 00:00:00

  • Increased levels of soluble Receptor for Advanced Glycation End-products (RAGE) are associated with a higher risk of mortality in frail older adults.

    abstract:OBJECTIVE:to evaluate the relationship between serum levels of the soluble Receptor for Advanced Glycation End-products (sRAGE) and mortality in frail and non-frail older adults. METHODS:we studied 691 subjects (141 frail and 550 non-frail) with a median age of 75 years from two population-based cohorts, the Toledo St...

    journal_title:Age and ageing

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ageing/afz073

    authors: Butcher L,Carnicero JA,Gomez Cabrero D,Dartigues JF,Pérès K,Garcia-Garcia FJ,Rodriguez-Mañas L,Erusalimsky JD,FRAILOMIC Consortium.

    更新日期:2019-09-01 00:00:00

  • Teaching geriatric medicine to medical students--a summary.

    abstract::Within the wide range of topics embraced in the subject of geriatric medicine, a division may be made as far as teaching is concerned into: 1. those that could be taught by other people; 2. those that should be taught by other people; 3. those that cannot be taught by other people. If attitudes throughout the medical ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:

    authors: Millard PH

    更新日期:1983-01-01 00:00:00

  • Intravenous cannulation alters the specificity of head-up tilt testing for vasovagal syncope in elderly patients.

    abstract::Prolonged head-up tilt is increasingly used as a diagnostic test for vasovagal syncope. Its sensitivity is reported to increase with the concurrent administration of intravenous isoprenaline. False-positive responses are common in young controls particularly following intravascular instrumentation. We studied the infl...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/23.4.317

    authors: McIntosh SJ,Lawson J,Kenny RA

    更新日期:1994-07-01 00:00:00

  • The effect of a vinyl floor surface and a carpeted floor surface upon walking in elderly hospital in-patients.

    abstract::Fifty-eight elderly hospital patients walked along a 10-m length of carpeted corridor and a 10-m length of vinyl-tiled corridor. Gait speed and step length were significantly greater on the carpeted than on the vinyl surface. ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/15.2.119

    authors: Willmott M

    更新日期:1986-03-01 00:00:00

  • Refeeding syndrome.

    abstract:CASE REPORT:An elderly woman with poor nutritional intake developed profound hypophosphataemia and hypokalaemia following the institution of nasogastric feeding. DISCUSSION:Refeeding syndrome is well recognized in certain undernourished groups of patients, but may not be so well known to physicians looking after elder...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/31.1.65

    authors: Mallet M

    更新日期:2002-01-01 00:00:00

  • Acute confusion secondary to pneumocephalus in an elderly patient.

    abstract:PRESENTATION:an 83-year-old man was admitted to hospital with acute confusion 3 days after a direct flight from Australia. OUTCOME:computed tomography (CT) brain scan and magnetic resonance imaging head scan revealed the cause to be pneumocephalus, apparently the result of barotrauma caused by Valsalva manoeuvres when...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/29.4.365

    authors: Chan YP,Yau CY,Lewis RR,Kinirons MT

    更新日期:2000-07-01 00:00:00

  • Trends in hip fracture incidence and mortality in Chinese population from Hong Kong 2001-09.

    abstract:BACKGROUND:there is a suggestion that while the age-adjusted incidence of hip fracture in the West may be declining, the incidence may be rising in Asia. OBJECTIVE:this study examines the incidence and post-fracture mortality from 2001 to 2009 among the population aged 65 years and over. METHODS:hip fracture incidenc...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afs177

    authors: Chau PH,Wong M,Lee A,Ling M,Woo J

    更新日期:2013-03-01 00:00:00

  • Unexpected paracetamol (acetaminophen) hepatotoxicity at standard dosage in two older patients: time to rethink 1 g four times daily?

    abstract::We present two cases of acute hepatotoxicity associated with elevated paracetamol (acetaminophen) levels in older patients. Both patients were receiving a standard European dose of oral paracetamol (2 × 500 mg QDS) with no risk factors for slowed metabolism (weight <50 kg, interacting medications, hepatic enzyme induc...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afw067

    authors: Ging P,Mikulich O,O'Reilly KM

    更新日期:2016-07-01 00:00:00

  • Severity of age-related hearing loss is associated with impaired activities of daily living.

    abstract:BACKGROUND:age-related hearing loss is a common chronic condition; hence, it is important to understand its influence on the functional status of older adults. We assessed the association between hearing impairment with activity limitations as assessed by the activities of daily living (ADL) scale. METHODS:a total of ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afr155

    authors: Gopinath B,Schneider J,McMahon CM,Teber E,Leeder SR,Mitchell P

    更新日期:2012-03-01 00:00:00

  • Gastrointestinal investigations for anaemia in the elderly: a prospective study.

    abstract::Of 60 patients referred for geriatric assessment with clinically significant hypochromic anaemia, in the absence of frank bleeding, 44 underwent upper gastrointestinal and 27 lower gastrointestinal investigations. The probability of identifying a potential cause at upper gastrointestinal endoscopy was three times that...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/16.6.399

    authors: Calvey HD,Castleden CM

    更新日期:1987-11-01 00:00:00

  • Older age is associated with less cancer treatment: a longitudinal study of English cancer patients.

    abstract:Background:making informed decisions about cancer care provision for older cancer patients can be challenging and complex. Evidence suggests cancer care varies by age, however the relationship between age and care experiences from diagnosis to death for cancer patients within the UK has not previously been examined in ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afy094

    authors: Craigs CL,Bennett MI,Hurlow A,West RM,Ziegler LE

    更新日期:2018-11-01 00:00:00

  • Effect of intravenous iron on functional outcomes in hip fracture: a randomised controlled trial.

    abstract:OBJECTIVES:to determine the safety and effect of intravenous iron sucrose on functional outcomes, delirium, nosocomial infections and transfusion requirements in older patients with hip fracture. DESIGN:single-centre randomised, double-blind, placebo-controlled clinical trial. SETTING AND PARTICIPANTS:orthogeriatric ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa107

    authors: Bielza R,Llorente J,Thuissard IJ,Andreu-Vázquez C,Blanco D,Sanjurjo J,López N,Herráez MR,Molano C,Morales A,Arias E,Neira M,Lung A,Escalera J,Portillo L,Larrubia Y,García C,Zambrana F,Gómez Cerezo J

    更新日期:2021-01-08 00:00:00

  • Death: a foe to be conquered? Questioning the paradigm.

    abstract::There are few certainties in life-death is one of them. Yet death is often thought of today as the 'loss of the battle' against illness, where in traditional societies it was the natural, meaningful, end to life. Medical knowledge and technologies have extended the possibilities of medical care and increased our life ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afu116

    authors: Gellie A,Mills A,Levinson M,Stephenson G,Flynn E

    更新日期:2015-01-01 00:00:00

  • Bacterial surveillance cultures in a geriatric ward.

    abstract::A study was carried out to examine the prevalence of oropharyngeal and urinary tract colonization and to compare the colonizing bacteria with the strains causing nosocomial infections during patients' stays in a geriatric ward. Colonization with Gram-negative rods was not uncommon. Nosocomial infections frequently occ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/22.3.221

    authors: Michielsen W,Vandevondele D,Verschraegen G,Claeys G,Afschrift M

    更新日期:1993-05-01 00:00:00

  • The reliability and predictive accuracy of the falls risk for older people in the community assessment (FROP-Com) tool.

    abstract:BACKGROUND:the Falls Risk for Older People in the Community assessment (FROP-Com) tool was designed for use in targeted multi-factorial falls prevention programmes. It fills the gap between the short screening tools and the longer assessment tools, e.g. the physiological profile assessment (PPA). The aim of this study ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afn129

    authors: Russell MA,Hill KD,Blackberry I,Day LM,Dharmage SC

    更新日期:2008-11-01 00:00:00