Muscarinic regulation of intracellular signaling and neurosecretion in gonadotropin-releasing hormone neurons.

abstract：:Active immunization against GRF at 6 months of age delays puberty in beef heifers. The objectives of the present study were to determine whether active immunization against GRF at an earlier age would affect normal onset of puberty and follicular growth and to determine whether these changes were related to alteration...

journal_title：Endocrinology

authors： Cohick WS,Armstrong JD,Whitacre MD,Lucy MC,Harvey RW,Campbell RM

更新日期：1996-05-01 00:00:00

abstract：:Glucocorticoids are potent inhibitors of prostaglandin (PG) release in vitro, but they fail to influence basal PG production in vivo. To test one possible explanation for this apparent discrepancy in the present study we investigated the effect of dexamethasone (DEX) on basal and antidiuretic hormone-stimulated renal ...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Fejes-Tóth G

更新日期：1986-12-01 00:00:00

abstract：:Immune activation results in the activation of adrenal steroidogenesis and inhibition of gonadal steroidogenesis. Previous studies indicated that these effects were caused primarily by activation and suppression of the secretion of ACTH and LH, respectively. However, other evidence indicated a direct effect of the imm...

journal_title：Endocrinology

authors： Hales KH,Diemer T,Ginde S,Shankar BK,Roberts M,Bosmann HB,Hales DB

更新日期：2000-11-01 00:00:00

abstract：:Diagnostic tests of hypothalamic-pituitary-adrenocortical function in psychiatric illness largely report the interaction of hypothalamic secretagogues with glucocorticoids at the pituitary level. This study investigated whether the efficiency of glucocorticoid inhibition is subject to modulation by intracellular proce...

journal_title：Endocrinology

authors： Lim MC,Shipston MJ,Antoni FA

更新日期：2002-10-01 00:00:00

abstract：:RNA blot hybridization analysis with cloned rat CRF precursor (prepro-CRF) cDNA as a probe showed that prepro-CRF mRNA existed in rat hypothalamic and extrahypothalamic brain tissue, whereas it was undetectable in the pituitary and adrenal. To study the effect of glucocorticoid on the level of prepro-CRF mRNA in the h...

journal_title：Endocrinology

authors： Jingami H,Matsukura S,Numa S,Imura H

更新日期：1985-10-01 00:00:00

abstract：:Physiological concentrations of L-T4 were found previously to stimulate Ca2+-ATPase activity in vitro in reticulocyte membranes from female rabbits and to inhibit this enzyme in reticulocyte membranes from males. In these previous studies, preincubation of intact cells or ghosts with testosterone (5 X 10(-11) M) conve...

journal_title：Endocrinology

authors： Lawrence WD,Osawa YM,Davis PJ,Blas SD

更新日期：1986-12-01 00:00:00

abstract：:L-Asparaginase (ASNase), a drug widely used in the treatment of acute lymphoblastic leukemia, has been reported to decrease serum T4-binding globulin (TBG) levels, while results of serum albumin determinations were conflicting. This effect in vivo has been attributed to depressed liver protein synthesis, but this hypo...

journal_title：Endocrinology

authors： Bartalena L,Martino E,Antonelli A,Pacchiarotti A,Robbins J,Pinchera A

更新日期：1986-09-01 00:00:00

abstract：:The SMRT coregulator functions as a dual coactivator and corepressor for estrogen receptor-α (ERα) in a gene-specific manner, and in several studies its elevated expression correlates with poor outcome for breast cancer patients. A specific role of SMRT in breast cancer progression has not been elucidated, but SMRT kn...

journal_title：Endocrinology

authors： Blackmore JK,Karmakar S,Gu G,Chaubal V,Wang L,Li W,Smith CL

更新日期：2014-09-01 00:00:00

abstract：:The effect of constant infusions of bovine TSH in different concentrations on the pattern of T4 and T3 secretion was examined in perfused canine thyroids isolated in situ. Each of the thyroid lobes was isolated and perfused in each animal. It was thus possible to examine the effect of two different concentrations of T...

journal_title：Endocrinology

authors： Laurberg P

更新日期：1977-03-01 00:00:00

abstract：:Excess of glucocorticoids (GCs) is a leading cause of bone fragility, and therapeutic targets are sorely needed. We report that genetic deletion or pharmacological inhibition of proline-rich tyrosine kinase 2 (Pyk2) prevents GC-induced bone loss by overriding GC effects of detachment-induced bone cell apoptosis (anoik...

journal_title：Endocrinology

authors： Sato AY,Cregor M,McAndrews K,Li T,Condon KW,Plotkin LI,Bellido T

更新日期：2019-07-01 00:00:00

abstract：:In an attempt to purify the thyroid receptor for TSH and to study interaction with the thyroid-stimulating antibody (TSAb) of graves' disease, we used both bovine and human thyroid glands. With either tissue, the 10,000 X g pellet of homogenized material was solubilized with 0.5% Triton N-101; excess Triton was remove...

journal_title：Endocrinology

authors： Koizumi Y,Zakarija M,McKenzie JM

更新日期：1982-04-01 00:00:00

abstract：:Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II. We previously found marked down-regulation of cardiac CRH receptor type 2 expression following administration of bacterial endotoxin, lipopolysacc...

journal_title：Endocrinology

authors： Coste SC,Heldwein KA,Stevens SL,Tobar-Dupres E,Stenzel-Poore MP

更新日期：2001-08-01 00:00:00

abstract：:Mice with somatotrope-specific deletion of the Janus kinase binding site in leptin receptors are GH deficient as young adults and become obese by 6 months of age. This study focused on the metabolic status of young (3-4.5 month old) preobese mutant mice. These mutants had normal body weights, lean body mass, serum lep...

journal_title：Endocrinology

authors： Akhter N,Odle AK,Allensworth-James ML,Haney AC,Syed MM,Cozart MA,Chua S,Kineman R,Childs GV

更新日期：2012-10-01 00:00:00

abstract：:Bisphosphonates are effective for preventing and treating skeletal disorders associated with hyperresorption. Their safety and efficacy has been studied in adults where the growth plate is fused and there is no longitudinal bone growth and little appositional growth. Although bisphosphonate use in the pediatric popula...

journal_title：Endocrinology

authors： Zhu ED,Louis L,Brooks DJ,Bouxsein ML,Demay MB

更新日期：2014-04-01 00:00:00

abstract：:Cyclic somatostatin strongly stimulated secretion of histamine from rat peritoneal mast cells. The energy, temperature and calcium dependence of this effect indicate that the action of somatostatin on the mast cells is similar to that of the classic mast cell secretagogue compound 48/80 and is to induce exocytosis. ...

journal_title：Endocrinology

authors： Theoharides TC,Douglas WW

更新日期：1978-05-01 00:00:00

abstract：:The most significant increase in metabolic syndrome over the previous decade occurred in women of reproductive age, which is alarming given that metabolic syndrome is associated with reproductive problems including subfertility and early pregnancy loss. Individuals with metabolic syndrome often consume excess fructose...

journal_title：Endocrinology

authors： Saben JL,Asghar Z,Rhee JS,Drury A,Scheaffer S,Moley KH

更新日期：2016-02-01 00:00:00

abstract：:Neonatal thymectomy at 3 days of age in mice results in ovarian dysgenesis, characterized by early follicular and oocyte loss, followed by a high incidence of ovarian tumorigenesis. Thymectomized animals with dysgenetic ovaries had extremely high levels of circulating PRL and gonadotropins before the appearance of the...

journal_title：Endocrinology

authors： Michael SD,Taguchi O,Nishizuka Y

更新日期：1981-06-01 00:00:00

abstract：:There are many precedents for the production from a single precursor of multiple peptides, with independent receptors and different bioactivities. Gastrin-releasing peptide (GRP) is initially synthesized as amino acids 1-27 of a 125-residue precursor, proGRP, and is subsequently cleaved and amidated to form GRP18-27. ...

journal_title：Endocrinology

authors： Patel O,Dumesny C,Shulkes A,Baldwin GS

更新日期：2007-03-01 00:00:00

abstract：:Angiotensin II and extracellular potassium stimulate aldosterone production in adrenal glomerulosa cells by mobilizing the calcium messenger system. This response requires calcium influx across the plasma membrane, followed by calcium uptake into the mitochondria. It has been proposed that calcium is transported to th...

journal_title：Endocrinology

authors： Lalevée N,Resin V,Arnaudeau S,Demaurex N,Rossier MF

更新日期：2003-10-01 00:00:00

abstract：:The extensive colocalization of insulin receptor (IR) and insulin-like growth factor-I receptor (IGFR) messenger RNAs during central nervous system development, together with the effects of insulin and IGF-I in neurogenesis, raises the question of how stage- and factor-specific signaling occurs. Thus, it is necessary ...

journal_title：Endocrinology

authors： García-de Lacoba M,Alarcón C,de la Rosa EJ,de Pablo F

更新日期：1999-01-01 00:00:00

abstract：:Acromegaly is associated with an increased incidence of cardiovascular disease. Transgenic mice expressing bovine GH (bGH) gene have previously been used to examine the effects of chronic GH stimulation on cardiovascular function. Results concerning systolic blood pressure (SBP) in bGH mice are conflicting. We hypothe...

journal_title：Endocrinology

authors： Jara A,Benner CM,Sim D,Liu X,List EO,Householder LA,Berryman DE,Kopchick JJ

更新日期：2014-03-01 00:00:00

abstract：:Interleukin-1 (IL-1) greatly induces osteoclast formation and stimulates bone resorption of mouse calvaria in culture. In the presence of soluble IL-6 receptor (sIL-6R), IL-6 similarly induces osteoclast formation, but the potency of IL-6 in inducing bone resorption in organ culture is weaker than that of IL-1. To stu...

journal_title：Endocrinology

authors： Kusano K,Miyaura C,Inada M,Tamura T,Ito A,Nagase H,Kamoi K,Suda T

更新日期：1998-03-01 00:00:00

abstract：:It is known that renin is present in fetal membranes, with the highest concentration in the chorion laeve (reflected chorion). The purpose of this study was to identify and localize renin in human chorion laeve. Indirect immunofluorescent analysis, using antiserum against pure human kidney renin, revealed a single lay...

journal_title：Endocrinology

authors： Poisner AM,Wood GW,Poisner R,Inagami T

更新日期：1981-10-01 00:00:00

abstract：:N-methyl-D,L,-aspartate (NMA), an analog of the excitatory neurotransmitter aspartate, has been previously shown to acutely stimulate LH release in the rodent and primate. In this study, we examine the effect of NMA on LH secretion in the long term ovariectomized adult rhesus monkey. After a 3-h control period, three ...

journal_title：Endocrinology

authors： Reyes A,Luckhaus J,Ferin M

更新日期：1990-08-01 00:00:00

abstract：:The present study was undertaken to identify the mechanisms underlying the effect of insulin-like growth factor (IGF-I) on LH receptor in rat granulosa cells. Treatment with FSH, as expected, produced a substantial increase in LH receptor messenger RNA (mRNA) level, and concurrent treatment with increasing concentrati...

journal_title：Endocrinology

authors： Hirakawa T,Minegishi T,Abe K,Kishi H,Ibuki Y,Miyamoto K

更新日期：1999-11-01 00:00:00

abstract：:Notch signaling directs cell fate during embryogenesis by influencing cell proliferation, differentiation, and apoptosis. Notch genes are expressed in the adult mouse ovary, and roles for Notch in regulating folliculogenesis are beginning to emerge from mouse genetic models. We investigated how Notch signaling might i...

journal_title：Endocrinology

authors： Trombly DJ,Woodruff TK,Mayo KE

更新日期：2009-02-01 00:00:00

abstract：:Mineralocorticoid and glucocorticoid hormones are metabolized as glucuronide conjugates. Using labeled [(14)C]uridine diphosphate glucuronic acid and microsomal preparations from human embryonic kidney 293 cells stably expressing the different human and monkey uridine diphosphate glucuronosyltransferase (UGT)2B enzyme...

journal_title：Endocrinology

authors： Girard C,Barbier O,Veilleux G,El-Alfy M,Bélanger A

更新日期：2003-06-01 00:00:00

abstract：:Multiple forms of PRL differing in their physicochemical and biological characteristics have been described. We have analyzed the molecular forms of human (h) PRL released in culture by pure hPRL-secreting tumors with a particular attention to glycosylated hPRL. The prolactinoma cells from six different tumors release...

journal_title：Endocrinology

authors： Pellegrini I,Gunz G,Ronin C,Fenouillet E,Peyrat JP,Delori P,Jaquet P

更新日期：1988-06-01 00:00:00

abstract：:Angiogenic factors, including vascular endothelial growth factor (VEGF), are expressed during follicular development. Our objective was to investigate the role of VEGF in the early follicular phase to test whether early cyclic follicle development and selection are angiogenesis-dependent processes. After documentation...

journal_title：Endocrinology

authors： Zimmermann RC,Xiao E,Bohlen P,Ferin M

更新日期：2002-07-01 00:00:00

abstract：:We investigated the effect of glucocorticoid on the generation of osteoclasts. In mouse bone marrow culture systems, dexamethasone, a synthetic glucocorticoid analog, enhanced osteoclast-like cell formation induced by 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] in a dose-dependent manner. Conversely, dexamethasone inhibit...

journal_title：Endocrinology

authors： Shuto T,Kukita T,Hirata M,Jimi E,Koga T

更新日期：1994-03-01 00:00:00