Abstract:
:The monocyte/macrophage plays a key role in the network of immune reactions. Dependent on activation, it is able to produce various cytokines which act on other cells of the immune system in the sense of upregulation or downregulation. In addition, it presents antigens by the HLA-DR molecule as an initial trigger of an antigen-specific T-cell response. Monocyte function is affected by surgical disease and further affected by surgical trauma. We found the monocyte to be activated in a subgroup of patients before the operation, related to an increased rate of postoperative septic complications. After the operation, plasma concentrations of IL-6 and IL-10 were increased indicating the activation of an immune response. After surgery HLA-DR expression decreased as well as LPS-stimulated TNFalpha and IL-6 production, the latter indicating a hyporesponsiveness of peripheral blood cells (presumably monocytes) to further stimulation. On the other hand, continuously high plasma concentrations of activation markers like neopterin and IL-6 in the postoperative course were associated with complications and poor outcome. In postoperative septic shock monocytes may be almost areactive towards natural stimuli like bacteria and endotoxin, since IL-6 and TNFalpha production decreased to very low amounts. Adequate pre- and postoperative monocyte function is related to an uneventful postoperative course after major surgical operations. Surgical trauma affects monocyte function rendering it less reactive, which is a potential risk factor for postoperative septic complications.
journal_name
Dig Surgjournal_title
Digestive surgeryauthors
Haupt W,Riese J,Mehler C,Weber K,Zowe M,Hohenberger Wdoi
10.1159/000018601subject
Has Abstractpub_date
1998-01-01 00:00:00pages
102-4issue
2eissn
0253-4886issn
1421-9883pii
dsu15102journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Management of leakages of the gastrojejunal anastomosis after laparoscopic Roux-en-Y gastric bypass (LRYGB) can be complex. New endoscopic techniques such as covered stents and over-the-scope clips (OTCs) have been developed and are valuable alternative therapeutic options to reoperation and drainage. The ai...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000358849
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the early postoperative hematological changes after spleen-preserving distal pancreatectomy (SpDP) with preservation of the splenic artery and vein (PSAV). METHODS:We reviewed 53 patients who underwent SpDP with PSAV (n = 21) or distal pancreatectomy with splenectomy (...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000337312
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIM:In the present study, we investigated the acute and late phases of splenic circulation after spleen-preserving distal pancreatectomy (SPDP) involving the division of splenic vessels. METHODS:An acute phase of splenic circulation was evaluated by laser flow meter and the late phase was estimated by (99m)...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000051952
更新日期:2000-01-01 00:00:00
abstract::One of the possible long-term complications following an ileoanal pouch procedure is the development of malignancy in the mucosa of the rectal stump. Only 10 such cases have been reported so far. We report the case of a 23-year-old male who had ulcerative colitis with high-grade dysplasia and underwent an ileoanal pou...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000068855
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Long-term functional results of ileal pouch-anal anastomosis (IPAA) with mucosal proctectomy (MP) for ulcerative colitis (UC) are satisfactory but may be compromised by perianal fistulae. METHODS:We analyzed the effect of the level of MP (above or below the dentate line) on the risk of perianal fistulae in ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000351443
更新日期:2013-01-01 00:00:00
abstract::A case of carcinoma of the colon that metastasized to the lower gingiva is described. The patient who had carcinoma of the colon developed a proliferating lesion at the site of a recent tooth extraction. A few days later, the primary site of the malignancy appeared. The clinical features in such cases were reviewed in...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000050166
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:In the last one hundred years much has been written on peptic ulcer disease and the treatment options for one of its most common complications: perforation. The reason for reviewing the literature was evaluating most common ideas on how to treat perforated peptic ulcers (PPU) in general, opinions on conserva...
journal_title:Digestive surgery
pub_type: 历史文章,杂志文章,评审
doi:10.1159/000264653
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND/AIMS:Graft failure is a critical complication associated with vascular occlusion in esophageal reconstruction with a free jejunal graft following pharyngolaryngoesophagectomy. In this study, we evaluated the usefulness of intramucosal pH (pHi) measurement using a tonometer to assess the graft viability. MET...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000102902
更新日期:2007-01-01 00:00:00
abstract::The authors reported the magnetic resonance imaging (MRI) detection of manganese (Mn) deposition in the basal ganglia of a pancreatoduodenectomized patient following 30-day parenteral nutrition. A multi-trace element supplement solution including 20 micromol Mn/day was parenterally administered for 30 days postoperati...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018830
更新日期:2000-01-01 00:00:00
abstract:AIMS:To assess the safety and feasibility of minimally invasive esophagectomy and selected three-field lymphadenectomy with the right bronchial occlusion in left semi-prone position under artificial pneumothorax. METHODS:Thoracoscopic-laparoscopic subtotal esophagectomy and selected three-field lymphadenectomy were pe...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000371747
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:In the management of pancreatic cystic neoplasms (PCN), size plays a crucial role as the expression of disease progression. While many evidences regarding the natural history of growing pancreatic cysts exist, almost no data are available regarding cysts with a reduction in size. METHODS:Radiological and ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000485199
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Chyle leaks are a rare complication following abdominal surgery. The aim of this study is to describe the management of chyle leaks following surgery for pancreatico-duodenal malignancy. METHODS:Data were collated from a consecutive series of 105 patients who had undergone a pancreatico-duodenectomy for mal...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000108324
更新日期:2007-01-01 00:00:00
abstract:AIMS:To evaluate the role of the Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (POSSUM), the Portsmouth variant (p-POSSUM) and the Glasgow Prognostic Score (GPS) in predicting outcome after pancreatic surgery with reference to the International Study Group of Pancreatic Surge...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000313693
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Surgery for patients with malignant obstructive jaundice carries high morbidity and mortality rates. Preoperative biliary drainage (PBD) has been used in an attempt to improve the outcome in these patients. AIM:To review the evidence in the literature on whether PBD improves postoperative morbidity and mort...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000050105
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND/AIMS:Primary distal bile duct adenocarcinomas (DBDAs) are unusual neoplasms, necessitating pancreaticoduodenectomy for cure. The aims of this study were to evaluate the prognostic importance of lymphatic and perineural invasion, long-term outcome of patients after resection, and differences in outcome with h...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018798
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Hilar resection in combination with extended liver resections has resulted in a higher rate of R0 resections and increased survival in patients with hilar cholangiocarcinoma (HCCA). This aggressive surgical approach is, however, associated with high rates of operative morbidity and mortality, largely due to ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000323825
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Tata Memorial Centre (TMC) is a high-volume centre for pancreatic tumour resections. We found a continually increasing referral of pancreatic tumours for re-evaluation for surgery, after an initial unsuccessful attempt at resection. AIM:To evaluate reasons of initial in-operability, the feasibility of re-op...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000489275
更新日期:2019-01-01 00:00:00
abstract::This study was designed to evaluate the efficacy of preoperative chemotherapy and to investigate the relationship between the histopathologic response and prognosis in patients with colorectal carcinoma. Thirty-six previously untreated patients with advanced colorectal carcinoma were consecutively enrolled in this stu...
journal_title:Digestive surgery
pub_type: 临床试验,杂志文章
doi:10.1159/000018649
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND/AIMS:The management of patients with silent or asymptomatic gallstones remains controversial. The objective of this study is to determine the complications of laparoscopic cholecystectomy performed to treat patients under 50 years of age with asymptomatic gallstones. METHOD:207 patients, 13-49 years of age ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018876
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:It is unclear whether total gastrectomy (TG) is always necessary for gastric cancer of the cardia. We therefore investigated whether cardiac cancers treated by TG would have been cured by proximal gastrectomy (PG). METHODS:Photocopies of the resected stomachs of 55 patients who had received TG for cardiac c...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000052000
更新日期:2002-01-01 00:00:00
abstract::Partial liver resections are the treatment of choice for patients with a malignant liver or bile duct tumor. The most frequent indications for partial liver resections are colorectal metastasis, hepatocellular carcinoma (HCC) and cholangiocarcinoma. Liver resection is the only therapy with a chance for cure in these p...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000103656
更新日期:2007-01-01 00:00:00
abstract::One of the main reasons for the dismal prognosis of pancreatic ductal adenocarcinoma (PDAC) is its late diagnosis. At the time of presentation, only approximately 15-20% of all patients with PDAC are considered resectable and around 30% are considered borderline resectable. A surgical approach, which is the only curat...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000493466
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The optimal management approach to pancreatic serous cystic neoplasms (SCNs) is still evolving. METHODS:Consecutive patients with SCN managed at the Liverpool Pancreas Cancer Centre between 2000 and 2013 were retrospectively reviewed. RESULTS:There were 64 patients consisting of 39 women (60.9%) and 25 men...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000442094
更新日期:2016-01-01 00:00:00
abstract::Ectopic pancreas is an uncommon condition and is usually found in the gastrointestinal tract, such as stomach, duodenum and jejunum. However, ectopic pancreas in the ampulla of Vater is rare and its clinical presentations may be similar to periampullary cancer. It is difficult to diagnose preoperatively. We present su...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000096158
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Mexican health system structure allows us to study the differences in bile duct injury (BDI) management. The study aimed to assess the differences in patients with complex BDI in 2 different public sector institutions using a new proposed standard terminology. METHODS:Retrospective review (2008-2019) in 2 p...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000509706
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Little data is available on the prognosis of esophageal cancer (EC) in Iran. We studied the short- and long-term survival of EC patients treated at the Cancer Institute of Iran. METHODS:619 patients were followed who had been operated in the years 1997-2006. The 1-month to 5-year survival rates of EC and ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000354854
更新日期:2013-01-01 00:00:00
abstract::The surgical management of gastroesophageal reflux disease has been simplified by the availability of minimally invasive techniques to treat this condition. The indications and selection of patients remain the same as for open surgery and initial results with laparoscopic antireflux surgery show long-term results equa...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000018686
更新日期:1999-01-01 00:00:00
abstract::In this review, the function of the sphincter of Oddi (SO) is detailed in terms of normal motility, neural and hormonal control of SO function, coordination between gallbladder and SO motility, and correlation of motility of the SO and the duodenum. In addition, SO function tests, such as the morphine Prostigmin test ...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000286464
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Little information from prospective clinical trials is available on the influences of surgical approaches on postoperative body compositions and nutritional status. We designed a prospective non-randomized trial to compare postoperative chronological changes in body composition and nutritional status between...
journal_title:Digestive surgery
pub_type: 杂志文章,多中心研究
doi:10.1159/000458714
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:In order to diagnose an unsuspected gallbladder carcinoma and to examine whether a differential diagnosis could be made between cancer and noncancerous lesions during surgery, we evaluated the findings of fine structures of various types of gallbladder mucosa. METHODS:We used stereomicroscopy with a dye-con...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000050156
更新日期:2001-01-01 00:00:00