Abstract：
:Contamination of water by cyanobacteria (blue-green algae) is a serious health problem around the world, largely due to the toxic effects of microcystins, a group of potent hepatotoxins. However, the mechanisms responsible for the cytotoxicity of microcystins have not been fully elucidated. In the present study, oxidative damage caused by lyophilized freshwater cyanobacteria extract was evaluated on primary cultured rat hepatocytes. A time- and dose-dependent increase of lactate dehydrogenase (LDH) leakage was observed in hepatocytes treated with cyanobacteria extract. Lipid peroxidation, a main manifestation of oxidative damage, was also studied and a time- and dose-dependent increase in malondiadehyde was observed. In addition, by using a fluorescent probe, 2',7'-dichlorofluorescein diacetate, it was found that cyanobacteria extract was able to enhance intracellular production of reactive oxygen species (ROS) in a dose- and time-dependent manner. Moreover, desferrioxamine, a specific iron chelator, could significantly decrease LDH leakage and ROS production caused by cyanobacteria extract treatment. These findings thus provide experimental evidence that oxidative damage is involved in cyanobacteria extract-induced hepatotoxicity. The understanding of this mechanism is believed to be beneficial to the prevention and control of the toxicity of microcystin and cyanobacteria contamination.
journal_name
Environ Resjournal_title
Environmental researchauthors
Ding WX,Shen HM,Zhu HG,Ong CNdoi
10.1006/enrs.1998.3843subject
Has Abstractpub_date
1998-07-01 00:00:00pages
12-8issue
1eissn
0013-9351issn
1096-0953pii
S0013-9351(98)93843-9journal_volume
78pub_type
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