The effects of pentobarbital on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats.

Abstract:

UNLABELLED:This study was performed to evaluate both the effects of pentobarbital on disruption of the blood-brain barrier (BBB) by hyperosmolar mannitol and the relationship between its effect on blood pressure and the integrity of the BBB. Under isoflurane anesthesia, rats in the control group were infused with 25% mannitol into the internal carotid artery before measuring the transfer coefficient (Ki) of 14C alpha-aminoisobutyric acid. Ten minutes before the administration of mannitol, rats received an infusion of pentobarbital: 20 mg/kg in the small-dose group and 50 mg/kg in the large-dose group. In another group of animals (hydralazine group), hydralazine was administered to maintain the mean arterial blood pressure (MAP) at 65 mm Hg during the experimental period. The MAP of the control group (113 +/- 14 mm Hg) was significantly higher (P < 0.002) than that of the small-dose pentobarbital group (78 +/- 13 mm Hg) or the large-dose pentobarbital group (68 +/- 14 mm Hg). In the control group, the Ki of the cortex ipsilateral to the mannitol injection was increased to 4.5 times that of the contralateral cortex (14.5 +/- 7.7 vs 3.2 +/- 0.6 microL x g(-1) x min(-1); P < 0.002). The Ki of the ipsilateral cortex of the small-dose pentobarbital group was 9.7 +/- 5.6 microL x g(-1) x min(-1). The Ki of the ipsilateral cortex of the large-dose pentobarbital group was 5.5 +/- 2.9 microL x g(-1) x min(-1), and lower (-9.0 microL x g(-1) x min(-1)) than that of the control animals (P < 0.05). There was no significant difference in the Ki of the contralateral cortex among any of the three groups of animals. At the same MAP, the Ki of the ipsilateral cortex of the large-dose pentobarbital group was lower (-4.3 microL x g(-1) x min(-1)) than that of the hydralazine group (9.8 +/- 4.6 microL x g(-1) x min(-1)) (P < 0.05). Pentobarbital attenuated the BBB disruption induced by hyperosmolar mannitol. This may be attributed, at least in part, to the blood pressure effect of pentobarbital. IMPLICATIONS:When the blood-brain barrier (BBB) was disrupted by a hyperosmolar solution, pentobarbital attenuated the degree of leakage of the BBB. Systemic hypotension caused by pentobarbital played a significant role in decreasing the leakage. Our study suggests that when the BBB is disrupted, pentobarbital may be effective in protecting the BBB. Furthermore, systemic blood pressure plays an important role in determining the degree of disruption.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Chi OZ,Chun TW,Liu X,Weiss HR

doi

10.1097/00000539-199806000-00018

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

1230-5

issue

6

eissn

0003-2999

issn

1526-7598

journal_volume

86

pub_type

杂志文章
  • Intraoperative Data Enhance the Detection of High-Risk Acute Kidney Injury Patients When Added to a Baseline Prediction Model.

    abstract:BACKGROUND:Aspects of intraoperative management (eg, hypotension) are associated with acute kidney injury (AKI) in noncardiac surgery patients. However, it is unclear if and how the addition of intraoperative data affects a baseline risk prediction model for postoperative AKI. METHODS:With institutional review board (...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000005057

    authors: Kim M,Li G,Mohan S,Turnbull ZA,Kiran RP,Li G

    更新日期:2021-02-01 00:00:00

  • Evaluation of an on-demand, ex vivo bedside blood gas monitor on pulmonary artery blood gas determinations.

    abstract::Critically ill patients often have cardiopulmonary perturbations that require rapid and frequent assessment for optimal care, including cardiac output determinations, measurement of cardiac filling pressures, and arterial and mixed venous blood gas determinations. We evaluated the performance of a rapid, on-demand bed...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199609000-00010

    authors: Franklin ML,Peruzzi WT,Moen SG,Shapiro BA

    更新日期:1996-09-01 00:00:00

  • An advanced specialty training program in anesthesiology: a special educational fellowship designed to return community anesthesiologists to clinical practice.

    abstract::We describe a program for community anesthesiologists designed to evaluate clinical skills and provide additional training in the latest technologies in anesthesiology. This educational program was established for previously trained anesthesiologists who require additional training for either remedial purposes or beca...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000220903.33100.15

    authors: Larson CP Jr,Steadman RH

    更新日期:2006-07-01 00:00:00

  • Effects of 6% hydroxyethyl starch and 3% modified fluid gelatin on intravascular volume and coagulation during intraoperative hemodilution.

    abstract::In the perioperative period, artificial colloids are most often infused in doses of 500-1000 mL intravenously. This randomized study compared the effects on intravascular volume and coagulation of approximately 2000 mL of two isooncotic artificial colloids: 6% hydroxyethyl starch (HES; MW 200,000; substitution ratio 0...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199512000-00020

    authors: Mortelmans YJ,Vermaut G,Verbruggen AM,Arnout JM,Vermylen J,Van Aken H,Mortelmans LA

    更新日期:1995-12-01 00:00:00

  • Effects of spinal needle type on lateral distribution of 0.5% hyperbaric bupivacaine.

    abstract:UNLABELLED:To evaluate the influence of needle type on the lateral distribution of 0.5% hyperbaric bupivacaine, 30 patients undergoing lower limb surgery were placed in the lateral position with the side to be operated on dependent and underwent dural puncture by either a 25-gauge Whitacre (n = 15) or a 25-gauge Quinck...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199808000-00022

    authors: Casati A,Fanelli G,Cappelleri G,Aldegheri G,Leoni A,Casaletti E,Torri G

    更新日期:1998-08-01 00:00:00

  • A randomized, double-blinded study of remifentanil versus fentanyl for tonsillectomy and adenoidectomy surgery in pediatric ambulatory surgical patients.

    abstract:UNLABELLED:We compared, in a double-blinded manner, the anesthetic maintenance and recovery properties of remifentanil with a clinically comparable fentanyl-based anesthetic technique in pediatric ambulatory surgical patients. Anesthesia was induced with either halothane or sevoflurane and nitrous oxide and oxygen. Pat...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00000539-200004000-00017

    authors: Davis PJ,Finkel JC,Orr RJ,Fazi L,Mulroy JJ,Woelfel SK,Hannallah RS,Lynn AM,Kurth CD,Moro M,Henson LG,Goodman DK,Decker MD

    更新日期:2000-04-01 00:00:00

  • Effects of Obesity and Leptin Deficiency on Morphine Pharmacokinetics in a Mouse Model.

    abstract:BACKGROUND:Obesity causes multiorgan dysfunction, specifically metabolic abnormalities in the liver. Obese patients are opioid-sensitive and have high rates of respiratory complications after surgery. Obesity also has been shown to cause resistance to leptin, an adipose-derived hormone that is key in regulating hunger,...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001578

    authors: Dalesio NM,Hendrix CW,McMichael DH,Thompson CB,Lee CK,Pho H,Arias RS,Lynn RR,Galinkin J,Yaster M,Brown RH,Schwartz AR

    更新日期:2016-12-01 00:00:00

  • Analgetic contribution of sufentanil during halothane anesthesia: a mechanism involving serotonin.

    abstract::Catecholamine and serotonin concentrations in the cord, medulla, and hypothalamus were measured in rats after saline, after sufentanil sufficient to reduce the minimum alveolar concentration (MAC) of halothane by 30% or less, or after sufentanil sufficient to reduce the MAC of halothane by 80% or more. In the cord, hi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Althaus JS,Miller ED Jr,Moscicki JC,Hecker BR,DiFazio CA

    更新日期:1985-09-01 00:00:00

  • Effects of H2-receptor blockers on response of cerebral blood flow to normocapnic hypoxia.

    abstract::Cimetidine blunts the increase in cerebral blood flow (CBF) normally observed during hypoxia. It is important, therefore, to know whether other H2-blockers also affect the cerebral circulation adaptation to hypoxia. Cerebral blood flow was measured in 24 awake dogs after an intravenous injection of either saline (cont...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199104000-00020

    authors: Audibert G,Saunier C,Hartemann D,Bigard O,Haberer JP

    更新日期:1991-04-01 00:00:00

  • Postoperative intravenous morphine consumption, pain scores, and side effects with perioperative oral controlled-release oxycodone after lumbar discectomy.

    abstract:BACKGROUND:Oral opioid formulations contribute to postoperative analgesia. In this study, we evaluated the perioperative application of oral controlled-release oxycodone to reduce postoperative IV morphine consumption and opioid side effects after lumbar discectomy. METHODS:Forty patients scheduled for elective lumbar...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000266451.77524.0d

    authors: Blumenthal S,Min K,Marquardt M,Borgeat A

    更新日期:2007-07-01 00:00:00

  • Anesthetic concerns for robot-assisted laparoscopy in an infant.

    abstract::A 2-mo-old infant with biliary atresia was scheduled for laparoscopic Kasai with robot assistance. Before surgery, a practice trial maneuvering the cumbersome robotic equipment was performed to ensure rapid access to the patient in case of emergency. IV access, tracheal intubation, and arterial line placement followed...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000137394.99683.66

    authors: Mariano ER,Furukawa L,Woo RK,Albanese CT,Brock-Utne JG

    更新日期:2004-12-01 00:00:00

  • Role of Micro-RNA for Pain After Surgery: Narrative Review of Animal and Human Studies.

    abstract::One of the most prevalent symptoms after major surgery is pain. When postoperative pain treatment is unsatisfactory, it can lead to poor surgical recovery, decreased quality of life, and increased health care costs. Current analgesics, single or in combination, have limited efficacy due to low potency, limited duratio...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000004767

    authors: Cata JP,Gorur A,Yuan X,Berg NK,Sood AK,Eltzschig HK

    更新日期:2020-06-01 00:00:00

  • A low approach to interscalene brachial plexus block results in more distal spread of sensory-motor coverage compared to the conventional approach.

    abstract::A low approach to the interscalene block (LISB) deposits local anesthetic farther caudad on the brachial plexus compared with the conventional interscalene block (ISB). We compared the efficacy of LISB and ISB in achieving anesthesia of the distal extremity in 254 patients having upper extremity surgery. The most freq...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e31820b5e8e

    authors: Kim JH,Chen J,Bennett H,Lesser JB,Resta-Flarer F,Barczewska-Hillel A,Byrnes P,Santos AC

    更新日期:2011-04-01 00:00:00

  • Hemodynamic dose-responses to halothane and isoflurane are different in swine with and without critical coronary artery stenosis.

    abstract::This study examined global hemodynamic responses to increasing concentrations of halothane and isoflurane in pigs with an acute critical coronary stenosis (CCS) on the left anterior descending coronary artery (LAD). The CCS was caused by graded inflation of an hydraulic occluder to the point where no hyperemic respons...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Gilbert M,Mori M,Myhre ES

    更新日期:1989-06-01 00:00:00

  • Immediate tracheal extubation after liver transplantation: experience of two transplant centers.

    abstract::Early tracheal extubation has been safely performed after large operative procedures, questioning the need for routine postoperative ventilation. Because immediate postoperative tracheal extubation of liver transplantation patients has not been previously reported, we performed preliminary studies at two institutions ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199702000-00003

    authors: Mandell MS,Lockrem J,Kelley SD

    更新日期:1997-02-01 00:00:00

  • Percutaneous pulsed radiofrequency reduces mechanical allodynia in a neuropathic pain model.

    abstract:BACKGROUND:Neuropathic pain is a result of a primary lesion or dysfunction of the peripheral or central nervous system, and its treatment is challenging. Animal models have been helpful in understanding mechanisms of neuropathic pain and in developing new treatment strategies. In this study, we examined the effect of p...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e31818060e1

    authors: Ozsoylar O,Akçali D,Cizmeci P,Babacan A,Cahana A,Bolay H

    更新日期:2008-10-01 00:00:00

  • The effect of remifentanil on cerebral blood flow velocity.

    abstract:UNLABELLED:In the present study, we investigated the effect of remifentanil on cerebral blood flow velocity (CBFV). We investigated 20 patients (ASA physical status III) scheduled for elective coronary artery bypass graft surgery. Anesthesia was induced with remifentanil 5 microg/kg IV (Group 1, n = 10) or 2 microg/kg ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-199809000-00013

    authors: Paris A,Scholz J,von Knobelsdorff G,Tonner PH,Schulte am Esch J

    更新日期:1998-09-01 00:00:00

  • Tramadol added to 1.5% mepivacaine for axillary brachial plexus block improves postoperative analgesia dose-dependently.

    abstract:UNLABELLED:Adjuncts to local anesthetics for peripheral plexus blockade may enhance the quality and duration of anesthesia and postoperative analgesia. The analgesic, tramadol, has a unique mechanism of action that suggests efficacy as such an adjunct. It displays a central analgesic and peripheral local anesthetic eff...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ane.0000108966.84797.72

    authors: Robaux S,Blunt C,Viel E,Cuvillon P,Nouguier P,Dautel G,Boileau S,Girard F,Bouaziz H

    更新日期:2004-04-01 00:00:00

  • Elevated Presepsin Is Associated With Perioperative Major Adverse Cardiovascular and Cerebrovascular Complications in Elevated-Risk Patients Undergoing Noncardiac Surgery: The Leukocytes and Cardiovascular Perioperative Events Study.

    abstract:BACKGROUND:Perioperative major adverse cardiovascular and cerebrovascular events (MACCEs) are incompletely understood, and risk prediction is imprecise. Atherogenic leukocytes are crucial in cardiovascular events. However, it is unclear if surgical interventions affect leukocyte counts or activation status. Therefore, ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000003738

    authors: Handke J,Scholz AS,Gillmann HJ,Janssen H,Dehne S,Arens C,Kummer L,Uhle F,Weigand MA,Motsch J,Larmann J

    更新日期:2019-06-01 00:00:00

  • Role of intracellular Ca2+ pools in the effects of halothane and isoflurane on vascular smooth muscle contraction.

    abstract::We examined the effect of halothane and isoflurane on contraction in the vascular smooth muscle of rat thoracic aorta simultaneously with the cytosolic Ca2+ levels ([Ca2+]i). Isolated spiral strips of rat thoracic aorta were suspended for isometric tension recordings in physiologic salt solution. The [Ca2+]i was measu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199406000-00006

    authors: Tsuchida H,Namba H,Seki S,Fujita S,Tanaka S,Namiki A

    更新日期:1994-06-01 00:00:00

  • Regional cerebral oxygen saturation during electroconvulsive therapy: monitoring by near-infrared spectrophotometry.

    abstract::Electroconvulsive therapy (ECT) increases neuronal energy consumption and alters systemic hemodynamics. We examined the effects of ECT on regional cerebral oxygen saturation (rSo2) using a near-infrared spectro-photometer. Heart rate (HR), mean arterial blood pressure (MAP), and rSo2 were continuously monitored throug...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199610000-00011

    authors: Saito S,Miyoshi S,Yoshikawa D,Shimada H,Morita T,Kitani Y

    更新日期:1996-10-01 00:00:00

  • Noninfectious serious hazards of transfusion.

    abstract::As infectious complications from blood transfusion have decreased because of improved donor questionnaires and sophisticated infectious disease blood screening, noninfectious serious hazards of transfusion (NISHOTs) have emerged as the most common complications of transfusion. The category of NISHOTs is very broad, in...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ane.0b013e3181930a6e

    authors: Hendrickson JE,Hillyer CD

    更新日期:2009-03-01 00:00:00

  • The modified nasal trumpet maneuver.

    abstract:UNLABELLED:The last decade has witnessed a proliferation of devices or methods that facilitate intubation in difficult circumstances, maintain ventilation, or which do both. These all require properly functioning and specially designed apparatus, the use of which requires variable degrees of expertise. This technical c...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200202000-00045

    authors: Beattie C

    更新日期:2002-02-01 00:00:00

  • Functional residual capacity changes after different endotracheal suctioning methods.

    abstract:BACKGROUND:Our primary objective was to investigate the effects of three different endotracheal suctioning procedures on functional residual capacity (FRC). METHODS:Using a crossover design, postoperative cardiac surgery patients (n = 20) received three different suctioning methods in randomized order: closed suctioni...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ane.0b013e3181804a5d

    authors: Heinze H,Sedemund-Adib B,Heringlake M,Gosch UW,Eichler W

    更新日期:2008-09-01 00:00:00

  • Somatosensory evoked potential quantification of ulnar nerve blockade.

    abstract::We investigated the appropriateness of the somatosensory evoked potentials (SSEPs) as an objective monitor of sensory blockade of the ulnar nerve by comparing the effects of saline and lidocaine infiltration of the ulnar nerve at the elbow, with and without epinephrine. The four treatments were administered in random ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Benzon HT,Toleikis JR,Shanks C,Ramseur A,Sloan T

    更新日期:1986-08-01 00:00:00

  • Prevention of hypotension after spinal anesthesia for cesarean section: six percent hetastarch versus lactated Ringer's solution.

    abstract::This study was designed to determine whether preoperative administration of 6% hetastarch decreases the incidence and severity of hypotension after spinal anesthesia for cesarean section. Forty nonlaboring ASA class I and II women having nonurgent cesarean sections were randomized to receive either 500 mL of 6% hetast...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199510000-00031

    authors: Riley ET,Cohen SE,Rubenstein AJ,Flanagan B

    更新日期:1995-10-01 00:00:00

  • Protein binding and the metabolism of thiamylal enantiomers in vitro.

    abstract:UNLABELLED:Thiamylal, a chiral thiobarbiturate, is marketed as a racemic product. We studied the serum protein binding and microsomal metabolism of thiamylal enantiomers in vitro. The unbound fraction of R(+)-thiamylal was greater than that of S(-)-thiamylal. The analysis of binding data revealed that both enantiomers ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200009000-00045

    authors: Sueyasu M,Fujito K,Shuto H,Mizokoshi T,Kataoka Y,Oishi R

    更新日期:2000-09-01 00:00:00

  • Perioperative neurotoxicity in the elderly: summary of the 4th International Workshop.

    abstract::To learn the latest developments in the various forms of postoperative cognitive dysfunction, a group of scientists and physicians met in Stockholm for a full day of presentations and interactive discussions. This article summarizes the discussion; highlighting progress, challenges, and new directions in the area of p...

    journal_title:Anesthesia and analgesia

    pub_type:

    doi:10.1213/ANE.0000000000000624

    authors: Terrando N,Eriksson LI,Eckenhoff RG

    更新日期:2015-03-01 00:00:00

  • Differential changes of alveolar gas concentrations during anesthetic induction of a patient with an absent right pulmonary artery.

    abstract::A 38-yr-old man with congenital right pulmonary artery agenesis, whose right lung was perfused with collateral systemic arterial blood, presented for right pneumonectomy. Because of a likely difference in gas exchange between the two lungs, we sampled end-tidal gases from each lung individually, as well as from the co...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000226089.53300.7a

    authors: Jiang Y,Wain JC,Chang AW,Zapol WM,Xie Z

    更新日期:2006-08-01 00:00:00

  • Predictors of Delayed Postoperative Respiratory Depression Assessed from Naloxone Administration.

    abstract:BACKGROUND:The aim of this study was to identify patient and procedural characteristics associated with postoperative respiratory depression or sedation requiring naloxone intervention. METHODS:We identified patients who received naloxone to reverse opioid-induced respiratory depression or sedation within 48 hours aft...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000000792

    authors: Weingarten TN,Herasevich V,McGlinch MC,Beatty NC,Christensen ED,Hannifan SK,Koenig AE,Klanke J,Zhu X,Gali B,Schroeder DR,Sprung J

    更新日期:2015-08-01 00:00:00