The effects of pentobarbital on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats.


UNLABELLED:This study was performed to evaluate both the effects of pentobarbital on disruption of the blood-brain barrier (BBB) by hyperosmolar mannitol and the relationship between its effect on blood pressure and the integrity of the BBB. Under isoflurane anesthesia, rats in the control group were infused with 25% mannitol into the internal carotid artery before measuring the transfer coefficient (Ki) of 14C alpha-aminoisobutyric acid. Ten minutes before the administration of mannitol, rats received an infusion of pentobarbital: 20 mg/kg in the small-dose group and 50 mg/kg in the large-dose group. In another group of animals (hydralazine group), hydralazine was administered to maintain the mean arterial blood pressure (MAP) at 65 mm Hg during the experimental period. The MAP of the control group (113 +/- 14 mm Hg) was significantly higher (P < 0.002) than that of the small-dose pentobarbital group (78 +/- 13 mm Hg) or the large-dose pentobarbital group (68 +/- 14 mm Hg). In the control group, the Ki of the cortex ipsilateral to the mannitol injection was increased to 4.5 times that of the contralateral cortex (14.5 +/- 7.7 vs 3.2 +/- 0.6 microL x g(-1) x min(-1); P < 0.002). The Ki of the ipsilateral cortex of the small-dose pentobarbital group was 9.7 +/- 5.6 microL x g(-1) x min(-1). The Ki of the ipsilateral cortex of the large-dose pentobarbital group was 5.5 +/- 2.9 microL x g(-1) x min(-1), and lower (-9.0 microL x g(-1) x min(-1)) than that of the control animals (P < 0.05). There was no significant difference in the Ki of the contralateral cortex among any of the three groups of animals. At the same MAP, the Ki of the ipsilateral cortex of the large-dose pentobarbital group was lower (-4.3 microL x g(-1) x min(-1)) than that of the hydralazine group (9.8 +/- 4.6 microL x g(-1) x min(-1)) (P < 0.05). Pentobarbital attenuated the BBB disruption induced by hyperosmolar mannitol. This may be attributed, at least in part, to the blood pressure effect of pentobarbital. IMPLICATIONS:When the blood-brain barrier (BBB) was disrupted by a hyperosmolar solution, pentobarbital attenuated the degree of leakage of the BBB. Systemic hypotension caused by pentobarbital played a significant role in decreasing the leakage. Our study suggests that when the BBB is disrupted, pentobarbital may be effective in protecting the BBB. Furthermore, systemic blood pressure plays an important role in determining the degree of disruption.


Anesth Analg


Anesthesia and analgesia


Chi OZ,Chun TW,Liu X,Weiss HR




Has Abstract


1998-06-01 00:00:00












  • Management of 1-Lung Ventilation-Variation and Trends in Clinical Practice: A Report From the Multicenter Perioperative Outcomes Group.

    abstract:BACKGROUND:Lung-protective ventilation (LPV) has been demonstrated to improve clinical outcomes in surgical patients. There are very limited data on the current use of LPV for patients undergoing 1-lung ventilation (1LV) despite evidence that 1LV may be a particularly important setting for its use. In this multicenter ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究


    authors: Colquhoun DA,Naik BI,Durieux ME,Shanks AM,Kheterpal S,Bender SP,Blank RS,MPOG Investigators.

    更新日期:2018-02-01 00:00:00

  • Hypercapnia improves tissue oxygenation in morbidly obese surgical patients.

    abstract::Risk of wound infection is increased in morbidly obese surgical patients, in part because a major determinant of wound infection risk, tissue oxygenation, is marginal. Unlike in lean patients, supplemental inspired oxygen (Fio2) only slightly improves tissue oxygenation in obese patients. Mild hypercapnia improves tis...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Hager H,Reddy D,Mandadi G,Pulley D,Eagon JC,Sessler DI,Kurz A

    更新日期:2006-09-01 00:00:00

  • The effect of breath termination criterion on breathing patterns and the work of breathing during pressure support ventilation.

    abstract:UNLABELLED:With pressure support ventilation (PSV), each PSV breath is flow-cycled, and the breath termination criterion (TC) is usually nonadjustable. When TC does not match the interaction between the patient's inspiratory-expiratory efforts to the opening and closing of the inspiratory and expiratory valves, patient...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Tokioka H,Tanaka T,Ishizu T,Fukushima T,Iwaki T,Nakamura Y,Kosogabe Y

    更新日期:2001-01-01 00:00:00

  • Perioperative goal-directed hemodynamic optimization using noninvasive cardiac output monitoring in major abdominal surgery: a prospective, randomized, multicenter, pragmatic trial: POEMAS Study (PeriOperative goal-directed thErapy in Major Abdominal Surg

    abstract:BACKGROUND:In this study, our objective was to determine whether a perioperative hemodynamic protocol based on noninvasive cardiac output monitoring decreases the incidence of postoperative complications and hospital length of stay in major abdominal surgery patients requiring intensive care unit admission. Secondary o...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Pestaña D,Espinosa E,Eden A,Nájera D,Collar L,Aldecoa C,Higuera E,Escribano S,Bystritski D,Pascual J,Fernández-Garijo P,de Prada B,Muriel A,Pizov R

    更新日期:2014-09-01 00:00:00

  • Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes.

    abstract:BACKGROUND:Capsaicin, the active component of chili peppers, can produce sensory-selective peripheral nerve blockade. Coadministration of capsaicin and tetrodotoxin, a site-1 sodium channel blocker, can achieve a synergistic effect on duration of nerve blocks. However, capsaicin can be neurotoxic, and tetrodotoxin can ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Shomorony A,Santamaria CM,Zhao C,Rwei AY,Mehta M,Zurakowski D,Kohane DS

    更新日期:2019-09-01 00:00:00

  • A comparison of general anesthesia and lumbar epidural analgesia for elective cesarean section.

    abstract::Controversy exists concerning the choice of anesthetic technic for elective cesarean section. Several maternal and newborn parameters were compared during general anesthesia (GA) and lumbar epidural analgesia (LEA). High inspired maternal O2 levels were achieved with both technics. Vigorous, well-oxygenated infants wi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: James FM 3rd,Crawford JS,Hopkinson R,Davies P,Naiem H

    更新日期:1977-03-01 00:00:00

  • The effects of tramadol and morphine on immune responses and pain after surgery in cancer patients.

    abstract:UNLABELLED:There has been growing interest in determining the possible immune consequences of opioid administration for the management of postoperative pain. We studied the effects of morphine and tramadol on pain and immune function during the postoperative period in 30 patients undergoing abdominal surgery for uterin...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Sacerdote P,Bianchi M,Gaspani L,Manfredi B,Maucione A,Terno G,Ammatuna M,Panerai AE

    更新日期:2000-06-01 00:00:00

  • Serum cholinesterase levels in patients with cancer.

    abstract::Serum cholinesterase levels were determined in 180 patients with carcinoma and in 146 normal subjects. Serum cholinesterase activity was significantly lower in patients suffering from cancer than in normal controls, though still within the normal range. The degree of depression of serum cholinesterase activity was inf...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kaniaris P,Fassoulaki A,Liarmakopoulou K,Dermitzakis E

    更新日期:1979-03-01 00:00:00

  • Reversal of combination nondepolarized neuromuscular block.

    abstract::The antagonism of a pancuronium-curare (P + C) neuromuscular block was assessed and compared to the antagonism of a pancuronium (P) block. One group of seven patients received P + C (0.024 mg/kg + 0.144 mg/kg); another similar group of seven patients received P (0.07 mg/kg). Both groups were anesthetized with nitrous ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Vitez TS,Difrancesco LV

    更新日期:1983-12-01 00:00:00

  • Refinement of symptoms of neuropathic pain measurements after various transections of the nerve endings of the sciatic and femoral nerve in rats: an exploratory behavioral analysis.

    abstract:BACKGROUND:Many animal models can be used to study the underlying pathophysiological mechanisms of neuropathic pain. Most of these models rely on a partial denervation of the limb of the animal by ligating a selected nerve. In this study, we performed nerve lesions on three peripheral nerves supplying the plantar side ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Van Remoortere MP,Meert TF,Vissers KC,Coppenolle H,Adriaensen H

    更新日期:2007-05-01 00:00:00

  • The effects of sevoflurane and hyperventilation on electrocorticogram spike activity in patients with refractory epilepsy.

    abstract:UNLABELLED:We investigated the effects of sevoflurane and hyperventilation on intraoperative electrocorticogram (ECoG) spike activity in 13 patients with intractable epilepsy. Grid electrodes were placed on the brain surface and ECoG was recorded under the following conditions: 1) 0.5 minimal alveolar anesthetic concen...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Kurita N,Kawaguchi M,Hoshida T,Nakase H,Sakaki T,Furuya H

    更新日期:2005-08-01 00:00:00

  • The additive antinociceptive interaction between WIN 55,212-2, a cannabinoid agonist, and ketorolac.

    abstract::Combinations of nonsteroidal antiinflammatory drugs (NSAIDs) and opioids are widespread in the management of pain, allowing better analgesia with reduced side effects. Cannabinoids are promising analgesic drugs that have pharmacological properties similar to those of opioids. However, the beneficial effects of cannabi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Ulugöl A,Ozyigit F,Yesilyurt O,Dogrul A

    更新日期:2006-02-01 00:00:00

  • Assessment of Tricuspid Annular Motion by Speckle Tracking in Anesthetized Patients Using Transesophageal Echocardiography.

    abstract:BACKGROUND:The perioperative assessment of right ventricular (RV) function remains a challenge. Tricuspid annular plane systolic excursion (TAPSE) using M-mode is a widely used measure of RV function. However, accurate alignment of the ultrasound beam with the direction of annular movement can be difficult with transes...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Shen T,Picard MH,Hua L,Burns SM,Andrawes MN

    更新日期:2018-01-01 00:00:00

  • Hemodynamic and catecholamine stress responses to insertion of the Combitube, laryngeal mask airway or tracheal intubation.

    abstract:UNLABELLED:In a prospective, randomized, and controlled trial, we compared the stress responses after insertion of the Combitube (CT; Kendall-Sheridan Catheter Corp., Argyle, NY), the laryngeal mask airway (LMA), or endotracheal intubation (ET). Seventy-five patients scheduled for routine urological or gynecological su...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Oczenski W,Krenn H,Dahaba AA,Binder M,El-Schahawi-Kienzl I,Jellinek H,Schwarz S,Fitzgerald RD

    更新日期:1999-06-01 00:00:00

  • Lack of CNS depression from large doses of trimethaphan in sheep.

    abstract::It is not uncommon to observe prolonged CNS depression for several hours following controlled hypotension and halothane anesthesia for neurosurgery. The present study evaluates possible contribution of large doses of trimethaphan to CNS depression. Four adult sheep were placed on transapical left ventricular bypass (T...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Wong KC,Peters JL,Roberts TS,McRea JC,Fukumasu H

    更新日期:1977-01-01 00:00:00

  • Intraoperative monitoring of tibialis anterior muscle motor evoked responses to transcranial electrical stimulation during partial neuromuscular blockade.

    abstract::We studied the feasibility of recording motor evoked responses to transcranial electrical stimulation (tce-MERs) during partial neuromuscular blockade (NMB). In 11 patients, compound muscle action potentials were recorded from the tibialis anterior muscle in response to transcranial electrical stimulation during vario...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kalkman CJ,Drummond JC,Kennelly NA,Patel PM,Partridge BL

    更新日期:1992-10-01 00:00:00

  • Propofol preserves the viability of isolated rat hepatocyte suspensions under an oxidant stress.

    abstract:UNLABELLED:The purpose of this study was to investigate whether propofol protects rat hepatocyte suspensions against an oxidant attack by a free radical generator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). Rat hepatocyte suspensions (2 x 10(6) cells/mL) were prepared using Seglen's collagenase perfusion tec...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Navapurkar VU,Skepper JN,Jones JG,Menon DK

    更新日期:1998-11-01 00:00:00

  • Effects of Electrical Transcutaneous Vagus Nerve Stimulation on the Perceived Intensity of Repetitive Painful Heat Stimuli: A Blinded Placebo- and Sham-Controlled Randomized Crossover Investigation.

    abstract:BACKGROUND:Transcutaneous vagus nerve stimulation (TVNS) is a promising treatment for acute and chronic pain. However, experimental studies yielded controversial results. We examined if TVNS reduces the perceived intensity of repetitive painful heat stimulation and temporal summation of pain (TSP) in healthy volunteers...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Janner H,Klausenitz C,Gürtler N,Hahnenkamp K,Usichenko TI

    更新日期:2018-06-01 00:00:00

  • Accidental intraneural injection into the musculocutaneous nerve visualized with ultrasound.

    abstract::Ultrasound has become a widely used tool within the practice of regional anesthesia, offering real-time visualization of the nerves, needle, and local anesthetic during performance of a block. A successful ultrasound-guided axillary block was performed on a healthy adult male undergoing wrist surgery. Postoperative re...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Russon K,Blanco R

    更新日期:2007-11-01 00:00:00

  • Xenon/hypothermia neuroprotection regimes in spontaneously breathing neonatal rats after hypoxic-ischemic insult: the respiratory and sedative effects.

    abstract:BACKGROUND:Hypothermia (HT) reduces neuronal injury after perinatal asphyxia. The anesthetic gas xenon (XE) may enhance this effect. We investigated the sedative and respiratory effects of variable XE concentrations at 37 degrees C normothermia (NT) or 32 degrees C HT after a hypoxic-ischemic (HI) insult to determine t...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Dingley J,Hobbs C,Ferguson J,Stone J,Thoresen M

    更新日期:2008-03-01 00:00:00

  • Comparison of hypobaric, hyperbaric, and isobaric solutions of bupivacaine during continuous spinal anesthesia.

    abstract::This study was designed to compare the anesthetic properties of hypobaric bupivacaine with those of isobaric and hyperbaric solutions when administered in the supine position in an elderly population undergoing hip surgery using continuous spinal anesthesia. Plain bupivacaine (0.5%) was mixed with equal volumes of 10%...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Van Gessel EF,Forster A,Schweizer A,Gamulin Z

    更新日期:1991-06-01 00:00:00

  • Outcomes in Patients Undergoing Cardiac Surgery Who Decline Transfusion and Received Erythropoietin Compared to Patients Who Did Not: A Matched Cohort Study.

    abstract:BACKGROUND:Erythropoiesis-stimulating agents, such as erythropoietin (EPO), can be used to treat preoperative anemia. Some studies suggest an increased risk of mortality and thrombotic events, and use in cardiovascular surgery remains off-label. This study compares outcomes in cardiac surgery patients declining blood t...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Duce L,Cooter ML,McCartney SL,Lombard FW,Guinn NR

    更新日期:2018-08-01 00:00:00

  • Central nervous system effects of intrathecal muscle relaxants in rats.

    abstract::When given for a sufficient time and dose intravenously, neuromuscular blocking drugs eventually can enter the cerebrospinal fluid (CSF). To study the potential pharmacologic consequences of neuromuscular blocking drugs in the CSF, a model was developed in the rat by using an intrathecal infusion of these drugs. A can...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Szenohradszky J,Trevor AJ,Bickler P,Caldwell JE,Sharma ML,Rampil IJ,Miller RD

    更新日期:1993-06-01 00:00:00

  • Digital skin blood flow as an indicator for intravascular injection of epinephrine-containing simulated epidural test dose in sevoflurane-anesthetized adults.

    abstract:UNLABELLED:I designed this study to determine the efficacy of heart rate (HR), systolic blood pressure (SBP), and digital skin blood flow (DSBF) in detecting intravascular injection after a simulated epidural test dose containing 15 mug of epinephrine in sevoflurane-anesthetized adults. In addition, the testing thresho...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mowafi HA

    更新日期:2005-08-01 00:00:00

  • Comparison of regional ophthalmic anesthesia produced by pH-adjusted 0.75% and 0.5% bupivacaine and 1% and 1.5% etidocaine, all with hyaluronidase.

    abstract::Two concentrations of etidocaine (1 and 1.5%) and of pH-adjusted bupivacaine (0.5 and 0.75%, pH 6.8), all fortified with hyaluronidase, were compared as local anesthetics in regional ophthalmic surgery for cataract extraction. The series comprised 160 patients assigned randomly to four groups (n = 40). Each patient re...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sarvela PJ

    更新日期:1993-07-01 00:00:00

  • An assessment of the antinociceptive efficacy of intrathecal and epidural contulakin-G in rats and dogs.

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    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Allen JW,Hofer K,McCumber D,Wagstaff JD,Layer RT,McCabe RT,Yaksh TL

    更新日期:2007-06-01 00:00:00

  • The population problem: conceptions and misconceptions.

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    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Berelson B

    更新日期:1971-07-01 00:00:00

  • Dental sedation by dentists: a view from anesthesiologists working in central Western Brazil.

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    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Costa PS,Valadao WJ Jr,Costa LR

    更新日期:2010-01-01 00:00:00

  • Hematocrit and the solubility of volatile anesthetics in blood.

    abstract::To clarify the effect of hematocrit on the solubility of volatile anesthetics in blood, we measured the blood-gas partition coefficients of isoflurane, enflurane, halothane, and methoxyflurane concurrently at 37 degrees C in blood from four adults. We measured the blood-gas partition coefficients in the plasma (hemato...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Lerman J,Gregory GA,Eger EI 2nd

    更新日期:1984-10-01 00:00:00

  • Increasing halothane concentrations reduce nitroprusside dose requirement.

    abstract::There has been no description of the hemodynamic dose-response relationship between halothane and sodium nitroprusside (SNP), although these drugs are used together frequently for induction of deliberate hypotension. Utilizing aortic root cannulation and thermister-tipped pulmonary artery catheterization, this relatio...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Bedford RF

    更新日期:1978-07-01 00:00:00