Abstract:
:A series of [2-(omega-phenylalkyl)phenoxy]alkylamines was synthesized and their 5-hydroxytryptamine2 (5-HT2) and/or dopamine2 (D2) receptor antagonistic activities were examined in vitro. [2-(4-Phenylbutyl)phenoxy]alkylamines showed strong inhibition of both 5-HT2 and D2 receptors. In particular, [2-(4-Phenylbutyl)phenoxy]-methylpiperidine derivatives, 10b, 10i and 10q, exhibited potent inhibition. The structure-activity relationships in this series of compounds are discussed.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Tanaka N,Goto R,Ito R,Hayakawa M,Ogawa T,Fujimoto Kdoi
10.1248/cpb.46.639subject
Has Abstractpub_date
1998-04-01 00:00:00pages
639-46issue
4eissn
0009-2363issn
1347-5223journal_volume
46pub_type
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