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A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus.

Abstract：

:Previously, we demonstrated evidence of linkage to bipolar affective disorder (BP) in a single large, multigenerational family with a LOD score of 3.41 at the PFKL locus on chromosome 21q22.3. Additional families showed little support for linkage to PFKL under homogeneity or heterogeneity, in that study. We have expanded on that analysis, with 31 microsatellite markers at an average marker spacing of

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Aita VM,Liu J,Knowles JA,Terwilliger JD,Baltazar R,Grunn A,Loth JE,Kanyas K,Lerer B,Endicott J,Wang Z,Penchaszadeh G,Gilliam TC,Baron M

doi

10.1086/302185

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

210-7

issue

1

eissn

0002-9297

issn

1537-6605

pii

S0002-9297(07)61674-7

journal_volume

64

pub_type

杂志文章

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