Abstract:
:A total of 752 individuals from The Gambia, west Africa who are representative of the major ethnic groups in the capital, Banjul, were serologically typed for HLA-A, -B, and -C antigens. Although all were typically "African" in their antigenic profiles, some marked frequency differences were found between the ethnic groups. Genetic distance comparisons with several other African populations showed that, although these west African populations clustered closely together, the positions of the various ethnic groups in The Gambia were consistent with historical and linguistic evidence of their affinities with one another and with other African populations. Despite the potential confounding effects both of selection by infectious diseases and of genetic drift caused by local differences in population structure, HLA frequencies appear to be of value in measuring inter- and intraregional population affinities in sub-Saharan Africa.
journal_name
Am J Hum Genetjournal_title
American journal of human geneticsauthors
Allsopp CE,Harding RM,Taylor C,Bunce M,Kwiatkowski D,Anstey N,Brewster D,McMichael AJ,Greenwood BM,Hill AVsubject
Has Abstractpub_date
1992-02-01 00:00:00pages
411-21issue
2eissn
0002-9297issn
1537-6605journal_volume
50pub_type
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更新日期:1994-07-01 00:00:00
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journal_title:American journal of human genetics
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更新日期:1997-03-01 00:00:00
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