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Endothelial damage caused by uncoated and fluorocarbon-coated poly(methyl methacrylate) intraocular lenses.

Abstract：

PURPOSE:To assess endothelial damage induced by poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) coated with a fluorocarbon polymer, Teflon AF, to make them highly hydrophobic. SETTING:Department of Ophthalmology. Hôtel-Dieu Hospital, Paris, France. METHODS:Ten Teflon-coated and 10 uncoated PMMA IOLs were used in an in vitro static touch model. The corneal endothelium was placed in direct contact with the IOL for 15 seconds and then stained with trypan blue and alizarin red. The endothelial damage produced by each IOL in the area of contact was assessed semiquantitatively and quantitatively. RESULTS:Teflon-coated IOLs produced significantly less endothelial damage than uncoated PMMA IOLs (P < .0001). Endothelial cells in contact with Teflon-coated IOLs did not usually adhere to the IOL surface. In contrast, the uncoated IOLs produced large areas of endothelial cell loss. CONCLUSION:Teflon-coated PMMA IOLs have an antiadhesive effect that reduced endothelial damage after IOL insertion in an in vitro model.

journal_name

J Cataract Refract Surg

journal_title

Journal of cataract and refractive surgery

authors

Werner LP,Legeais JM,Durand J,Savoldelli M,Legeay G,Renard G

doi

10.1016/s0886-3350(97)80073-9

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

1013-9

issue

7

eissn

0886-3350

issn

1873-4502

pii

S0886-3350(97)80073-9

journal_volume

23

pub_type

杂志文章

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