Abstract:
:The effects of combined antibiotics (pefloxacin-doxycycline and pefloxacin-ceftriaxone) were tested on the most prevalent European Lyme spirochete species, Borrelia garinii by checkerboard dilution. The influence was judged both microscopically and by the measurement of the pH of the culture medium on the 5th day after inoculation. Borreliae propagated quite well at the concentration of 4 mg/l pefloxacin but the motility and the metabolism of the spirochete injured. Neither synergetic nor additive effect of the combination could be registered. Surprisingly, the pefloxacin at a concentration less than 4 mg/l activated both the propagation and the metabolism of borreliae, showing a clear antagonistic effect with doxycycline and ceftriaxone. Unless well-controlled animal model will prove the contrary, quinolones neither alone nor in combination should be used in Lyme borreliosis.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Lakos A,Nagy Gsubject
Has Abstractpub_date
1999-07-04 00:00:00pages
1529-32issue
27eissn
0030-6002issn
1788-6120journal_volume
140pub_type
杂志文章相关文献
ORVOSI HETILAP文献大全abstract::Two cases of arrhythmogenic right ventricular dysplasia are described. The most important clinical features of the disease are malignant ventricular arrhythmia and sudden death. It is characterized by the loss of right ventricular musculature and by the fatty and connective tissue infiltration of the right ventricular...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1993-12-19 00:00:00
abstract:INTRODUCTION:Recent data suggest that the copper-containing semicarbazide-sensitive amine oxidase enzyme (SSAO) may play a role in vascular endothelial damage through conversion of certain endogenous monoamines, like methylamine into cytotoxic aldehydes, hydrogen peroxide and ammonia. SSAO is present in various human t...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2002-11-24 00:00:00
abstract::Family centralised delivery model program in the Department of Obstetrics of Borsod County Hospital in Miskolc is reviewed. This program has been started since 1986. Significance and positive emotional effects are emphasized. Preparation for the birth, the presence of the husband in the labour ward, the alternative de...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1992-10-18 00:00:00
abstract:INTRODUCTION:Congenital heart defects are frequently present in patients with Down syndrome. AIM:The authors analyzed the impact of changing approach in surgical management of congenital heart defect on the life expectancy of patients with Down syndrome. METHOD:Between 1974 and 1997 the data of 359 children with Down...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2016.30529
更新日期:2016-10-01 00:00:00
abstract::Two cases of patients with benign biliary strictures (one with anastomotic and another with iatrogen stenosis of the common bile duct) successfully treated by percutaneous transhepatic balloon dilatation are presented. The patients have been symptom-free for 24 and 14 months, respectively. The author deals with the in...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1992-09-13 00:00:00
abstract::Incidence of gastrointestinal tuberculosis increases in the western world. Exact epidemiological data about this rare extrapulmonological disease are not available in Hungary. Three advanced cases with intestinal tuberculosis have been reported, all of them recognised during surgery due to complications. The clinicopa...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1998-02-01 00:00:00
abstract::Authors report effective treatment of T-cell large granular lymphocyte (LGL) leukaemia and secondary pure cell aplasia with cyclophosphamide. The current classification of LGL proliferations is presented, with emphasis on the issues of diagnosis, clinical course and treatment. LGL proliferations are not so rare that p...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1997-08-17 00:00:00
abstract::The first decade after the announcement of the draft sequence of human genome has brought spectacular advances in basic science, however, the fact that human health did not benefit that much caused disappointment, as well. In order to explore the causes of the absence of revolution in medicine, beside the extension of...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2010.29014
更新日期:2010-12-19 00:00:00
abstract:INTRODUCTION:Human metapneumovirus was identified in 2001 as a respiratory-tract pathogen that has been classified as a new genera in family Paramyxoviridae. AIMS:Molecular detection of human metapneumovirus in Hungary. MATERIALS AND METHODS:Human metapneumovirus was identified in nasopharyngeal aspirate amplificatio...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2006-12-03 00:00:00
abstract::The authors review the case of a 30 years old female patient presenting with a 48 hours-standing anuria, who permanently used products of grist of a virtuous plant, Guarana and occasionally used a parenteral non-steroid painkiller. The clinical history and laboratory results showed acute renal and hepatic failure. The...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2007.27954
更新日期:2007-03-04 00:00:00
abstract:AIM:The authors show human immunodeficiency virus positive cases among Hungarian intravenous drug users. PATIENTS/METHOD:The cases were identified by self-admittance (by the results of HIV screening), and by objective methods. The persons were studied by questionnaire on their risk behaviours (injecting and sexual beh...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2002-01-20 00:00:00
abstract::Optical Coherence Tomography (OCT) is a novel, non invasive imaging method, which enables in vivo assessment of living tissues, providing near histological resolution images. The first description of its clinical introduction was in ophthalmology, which substantially changed our view of specific retinal diseases. OCT ...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2005-05-22 00:00:00
abstract::The aim of this article is to introduce the automatic, implantable cardioverter-defibrillator (AICD) device in connection with the first two cases in Hungary. At present time, the indications of the AICD implantation in the European Community are as follows: recurrent sustained episodes of ventricular tachycardia vent...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1995-02-05 00:00:00
abstract::Introduction: Uveitis is characterized by inflammation of the middle layer of the eye. Its overall incidence is low. Autoimmune diseases and infections are the most common underlying diseases. Out of the autoimmune diseases, juvenile idiopathic arthritis is associated most frequently with uveitis. The topical ophthalm...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2019.31459
更新日期:2019-08-01 00:00:00
abstract::In primary immunodeficiencies, the malfunction of the immune system is caused by genetic alterations. The physician proposes the most probable diagnosis based on symptoms, clinical signs, the family history and the results of the pathogen identification. To confirm this clinical suspicion, it is essential that the imm...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2018.31261
更新日期:2018-12-01 00:00:00
abstract::Összefoglaló. Bevezetés: A diffúz aortobiiliacalis érszakasz occlusiv betegségének kezelésére alkalmazott aortobifemoralis bypass szerepe csökken az endovascularis műtétek térnyerése miatt. Célkitűzés: A vizsgálat célja volt a modern invazív kezelés korszakában a perioperatív és a hosszú távú eredmények elemzése aorto...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2021.31970
更新日期:2021-01-17 00:00:00
abstract::Generalized (systemic) secondary amyloidosis was a post mortem finding recorded in 28 patients (25.2%) by amyloid specific Congored staining according to Romhányi, from 111 randomized autopsy cases with rheumatoid arthritis. Amyloidosis was present most frequently in the gastro-intestinal tract, the heart, kidney, thy...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1993-11-21 00:00:00
abstract:INTRODUCTION:Healthcare associated infections and antimicrobial use are common among residents of long-term care facilities. Faced to the lack of standardized data, the European Centre for Disease Prevention and Control funded a project with the aim of estimating prevalence of infections and antibiotic use in European ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2014.29876
更新日期:2014-06-08 00:00:00
abstract::Vasculitis is a heterogeneous group of rare disorders in which inflammation of blood vessels is the common feature. Due to the increasing number of diseases as well as overlaps and gaps in the definition and nomenclature, the classification criteria were constantly changing in the past decades. The classifications wer...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2013.29704
更新日期:2013-10-06 00:00:00
abstract::Patients seeking help from gastroenterologist have frequent complaints of changes in the quality and quantity of stool as well in the frequency of bowel movements. Definition of diarrhea includes: more than three bowel movements daily, more than 200 grams of the stool daily, and its water content exceeding 75-85%. Dia...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2009.28709
更新日期:2009-08-30 00:00:00
abstract::The authors present the results of allergologic investigations in 54 infants and children with atopic dermatitis. To demonstrate the food and inhalative allergies, which are most important etiologic factors in this disease, different methods have been administered. Besides these in vitro and in vivo methods oral food ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1993-03-14 00:00:00
abstract::Antibodies against ENA (Extractable Nuclear Antigens), SSA/Ro and SSB/La were investigated in parallel in the serum and the immune complex precipitates of 41 patients with autoimmune disease (10 systemic lupus erythematosus, 23 discoid lupus erythematosus, 3 subacute cutaneous lupus erythematosus, and 5 progressive sy...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1992-05-03 00:00:00
abstract::In a period of 18 months the authors performed 359 scrotal ultrasonographies, of which 93 were done because of acute scrotum. The ultrasound-diagnosis failed only in two cases. The ultrasound proved to be a significant aid in the differential diagnostics, and the number of diagnostic explorations decreased especially ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1989-11-19 00:00:00
abstract::Introduction: Autologous hemopoietic stem cell transplantation remains a promising therapy in certain malignant and non-malignant conditions. The procedure, however, will increase the risk of complications, most notably early and late infections. Aim: To analyze the frequency and spectrum of pathogens in early (<+100 ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2020.31638
更新日期:2020-01-01 00:00:00
abstract::Three-dimensional speckle-tracking echocardiography is a new cardiac imaging methodology, which allows three-dimensional non-invasive evaluation of the myocardial mechanics. The aim of this review is to present this new tool emphasizing its diagnostic potentials and demonstrating its limitations, as well. ...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2012.29466
更新日期:2012-10-07 00:00:00
abstract::The authors survey the application of polymerase chain reaction (PCR)-based DNA polymorphisms in the Hungarian forensic practice. The combined application of the presented 17 PCR-based sequence- or length-polymorphic DNA systems to criminal cases gives the power of individualization to the hand of the forensic scienti...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1997-12-21 00:00:00
abstract::The authors report the medical history of a 19-year-old male patient, who had been admitted to the department of infectious diseases three times with recurrent icterus of unknown origin, suspected of viral hepatitis before his internal examination. The clinical picture and the histological results of liver biopsy perf...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1995-04-16 00:00:00
abstract:INTRODUCTION:Mutations in Janus kinase 2, calreticulin and thrombopoietin receptor genes have been identified in the genetic background of Philadelphia chromosome negative, "classic" myeloproliferative neoplasms. AIM:The aim of the authors was to identify driver mutations in a large myeloproliferative cohort of 949 pa...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2014.30051
更新日期:2014-12-28 00:00:00
abstract:INTRODUCTION:Gleason grading is the most common method of prostate cancer classification. AIM:The aim of the authors was to assess the reproducibility of Gleason grading among pathologists using the same needle biopsy samples. METHOD:23 pathologists examined 37 prostate cancer biopsies stained with hematoxylin and eo...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2013.29659
更新日期:2013-08-04 00:00:00
abstract::Rickettsia helvetica belonging to spotted fever group rickettsiae was recently detected by polymerase chain reaction followed by sequencing in European sheep ticks (Ixodes ricinus) from Hungary. Current knowledge on these rickettsiae and the clinical and diagnostic aspects of R. helvetica infection is summarized. In a...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2005-12-11 00:00:00