Efficacy and side-effects of cyclosporine dose monitoring with levels 6 h after the morning dose in heart transplant patients.

Abstract:

:The purpose of this study was to compare CsA dose monitoring with trough levels (T0) vs. levels obtained 6 h after the morning dose of CsA (T6), with respect to the incidence of acute rejection and renal dysfunction, and the cumulative dose, as well as the cost of CsA after heart transplantation. Twenty consecutive adult heart transplant patients receiving quadruple sequential immunosuppression were prospectively randomized into CsA monitoring with T0 (Group I) vs. T6 levels (Group II). Oral CsA was started at a dosage of 2 mg/kg/d, 1-4 d after transplantation. The target range for either T0 or T6 was 150 to 250 ng/ml (enzyme multiplied immunologic technique), respectively. The CsA dose was increased or decreased by 0.5-1 mg/kg/d if the measured level was outside of the target range. Throughout the follow-up period (Group I, 11 +/- 2 months; Group II, 10 +/- 3 months), the incidence of acute rejection (ISHLT grade > or = 2) was 50% in each group. The left ventricular ejection fraction and serum creatinine were similar in both groups at 1 month and at the end of the follow-up. The maximal dose of CsA (mg/kg/d): 3.8 +/- 1 vs. 5 +/- 0.6 (P = 0.002), the minimal dose: 2.2 +/- 0.7 vs. 3.4 +/- 0.8 (P = 0.003), and the current dose: 2.6 +/- 0.6 vs. 3.5 +/- 1 (P = 0.02), were lower in Group II, as well as the cumulative dose of CsA (mg): 61,790 +/- 19,754 vs. 88,524 +/- 18,082 (P = 0.005), and its cost (CDN$): 3,589 +/- 1,116 vs. 5,106 +/- 1,045 (P = 0.005). In conclusion, CsA dose monitoring with T6 was associated with a 30% lower CsA dose and cost compared to T0, with the same effectiveness in the prevention of acute rejection, and similar cardiac and renal function.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Cantarovich M,Besner JG,Fitchett DH,Latter DA

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

399-405

issue

5 Pt 1

eissn

0902-0063

issn

1399-0012

journal_volume

11

pub_type

临床试验,杂志文章,随机对照试验
  • Care of international living kidney donor candidates in the United States: A survey of contemporary experience, practice, and challenges.

    abstract::The evaluation and care of non-US citizen, non-US residents who wish to come to the United States to serve as international living kidney donors (ILKDs) can pose unique challenges. We surveyed US transplant programs to better understand practices related to ILKD care. We distributed the survey by email and professiona...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14064

    authors: Lentine KL,Motter JD,Henderson ML,Hays RE,Shukhman E,Hunt J,Al Ammary F,Kumar V,LaPointe Rudow D,Van Pilsum Rasmussen SE,Nishio-Lucar AG,Schaefer HM,Cooper M,Mandelbrot DA

    更新日期:2020-11-01 00:00:00

  • Peritoneal metastasis of intracranial glioblastoma via a ventriculoperitoneal shunt preventing organ retrieval: case report and review of the literature.

    abstract::The case of patient with glioblastoma metastatic to the peritoneal cavity 9 months after ventriculoperitoneal shunt surgery precluding cadaver organ procurement is presented. Even though central nervous tumors rarely metastasize spontaneously, the literature indicates that systemic metastases are related to previous s...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Fecteau AH,Penn I,Hanto DW

    更新日期:1998-08-01 00:00:00

  • Current principles and practice in autologous intraportal islet transplantation: a meta-analysis of the technical considerations.

    abstract:OBJECTIVES:Autologous islet transplantation (IAT) following pancreatectomy is now a recognized, albeit highly specialized procedure carried out in a small number of centers worldwide. Current clinical principles and best practice with emphasis on examining the technical aspects of surgery in centers with significant IA...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/ctr.12695

    authors: Kumar R,Chung WY,Dennison AR,Garcea G

    更新日期:2016-04-01 00:00:00

  • Marijuana use should not preclude consideration for kidney transplantation.

    abstract::Transplant eligibility for tobacco and/or marijuana using candidates varies among transplant centers. This study compared the impact of marijuana use and tobacco use on kidney transplant recipient outcomes. Kidney transplant recipients at a single center from 2001 to 2015 were reviewed for outcomes of all-cause graft ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13706

    authors: Fabbri KR,Anderson-Haag TL,Spenningsby AM,Israni A,Nygaard RM,Stahler PA

    更新日期:2019-10-01 00:00:00

  • Hospital admissions and emergency department visits among kidney transplant recipients.

    abstract::Reducing acute care utilization is a means of improving long-term patient outcomes. We sought to assess high inpatient (IP) admission and standalone emergency department (ED) utilization within a 9-month period post-kidney transplantation and to identify mutable factors to reduce utilization. In this ten-year retrospe...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13522

    authors: Weeda ER,Su Z,Taber DJ,Bian J,Morinelli TA,Pilch NA,Mauldin PD,DuBay DA

    更新日期:2019-05-01 00:00:00

  • Prognostic role of pre-transplantation serum C-reactive protein levels in patients with acute leukemia undergoing myeloablative allogeneic stem cell transplantation.

    abstract::The aim of this study was to identify indicators of outcome prior to transplantation in allogeneic hematopoietic stem cell transplantation (HCT). Clinical data of 106 patients with acute leukemia were retrospectively analyzed. We examined the role of pre-conditioning serum C-reactive protein (CRP) and ferritin levels,...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12028

    authors: Akı ŞZ,Suyanı E,Bildacı Y,Çakar MK,Baysal NA,Sucak GT

    更新日期:2012-09-01 00:00:00

  • Role of 99mTc-labeled DISIDA scan in the assessment of marginal liver grafts after orthotopic transplantation.

    abstract::Accurate prognostic indicators are lacking for livers with early marginal graft function, making the decision to re-transplant a difficult one. Therefore, we studied 99mTc-labeled DISIDA scanning as a predictor of recovery of marginal grafts. Records of 28 liver transplant recipients with prolonged periods of marginal...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Karademir S,Csete ME,Jurim O,Finstad T,Hawkins R,Bussuttil RW,Shaked A

    更新日期:1994-02-01 00:00:00

  • Comparative effects of renal transplantation and maintenance dialysis on arterial stiffness and left ventricular mass index.

    abstract:BACKGROUND:Arterial stiffness and left ventricular hypertrophy (LVH) are major independent risk factors for cardiovascular disease in healthy and renal population. In this study, we aimed to investigate comparative long-term effects of renal transplantation (RTx) and of hemodialysis (HD) on both arterial stiffness and ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00794.x

    authors: Keven K,Calayoglu R,Sengul S,Dincer I,Kutlay S,Erturk S,Erbay B,Nergizoglu G

    更新日期:2008-05-01 00:00:00

  • Kidney transplant referral practices in southeastern dialysis units.

    abstract:BACKGROUND:The Southeastern Kidney Transplant Coalition was created in 2010 to improve kidney transplant (KTx) rates in Georgia, North Carolina, and South Carolina. To identify dialysis staff-reported barriers to transplant, the Coalition developed a survey of dialysis providers in the region. METHODS:All dialysis uni...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12693

    authors: Browne T,Patzer RE,Gander J,Amamoo MA,Krisher J,Sauls L,Pastan S

    更新日期:2016-04-01 00:00:00

  • Outcome of lung transplantation in non-idiopathic pulmonary fibrosis interstitial lung disease.

    abstract::Lung transplantation remains the only curative treatment option for selected patients with end-stage interstitial lung disease (ILD). Candidate selection is impeded by patient heterogeneity, particularly in the subgroup of non-idiopathic pulmonary fibrosis (non-IPF) interstitial lung diseases. We performed a descripti...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13661

    authors: Bode H,Verleden SE,Wuyts WA,Yserbyt J,Verleden GM,Vos R

    更新日期:2019-10-01 00:00:00

  • Pleural catheter placement and intrapleural fibrinolysis following lung transplantation.

    abstract:BACKGROUND:This study aimed to investigate the characteristics of lung transplant recipients requiring additional pleural drainage catheters early post-lung transplantation and to determine the safety and efficacy of intrapleural fibrinolytics in these patients. METHODS:A retrospective review of lung transplant recipi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13592

    authors: Kao CC,Cuevas JF,Tuthill S,Parulekar AD

    更新日期:2019-06-01 00:00:00

  • Combination of pancreas volume and HbA1c level predicts islet yield in patients undergoing total pancreatectomy and islet autotransplantation.

    abstract::Islet yield is an important predictor of acceptable glucose control after total pancreatectomy with islet autotransplantation (TP-IAT). We assessed if pancreas volume calculated with preoperative MRI could assess islet yield and postoperative outcomes. We reviewed dynamic MRI studies from 154 adult TP-IAT patients (20...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.14008

    authors: Nanno Y,Wilhelm JJ,Heller D,Schat R,Freeman ML,Trikudanathan G,Kirchner VA,Pruett TL,Beilman GJ,Hering BJ,Bellin MD

    更新日期:2020-08-01 00:00:00

  • Everolimus leads to a lower risk of BKV viremia than mycophenolic acid in de novo renal transplantation patients: a single-center experience.

    abstract:BACKGROUND:There are limited published data concerning the effects of different immunosuppressive regimens on the development of polyomavirus (BKV) viremia. We examined the risk of developing BKV viremia in kidney transplant recipients receiving everolimus (EVR) or mycophenolic acid (MPA) as maintenance therapy. METHO...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.12151

    authors: Moscarelli L,Caroti L,Antognoli G,Zanazzi M,Di Maria L,Carta P,Minetti E

    更新日期:2013-07-01 00:00:00

  • Use of G-CSF-stimulated marrow in allogeneic hematopoietic stem cell transplantation settings: a comprehensive review.

    abstract::In recent years, several researchers have unraveled the previously unrecognized effects of granulocyte colony-stimulating factor (G-CSF) on hematopoiesis and the immune cell functions of bone marrow in healthy donors. In human leukocyte antigen-matched or haploidentical transplant settings, available data have establi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2010.01298.x

    authors: Chang YJ,Huang XJ

    更新日期:2011-01-01 00:00:00

  • Post-transplant changes of segment 4 after living related liver transplantation.

    abstract::The purpose of this study was to evaluate the outcome of the medial segment of the graft after living related liver transplantation (LRLT). Of the 12 pediatric recipients who underwent LRLT, 2 received whole left liver graft, 1 left lateral segment graft, and 9 extended left lateral segment grafts. The hepatic veins o...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Cheng YF,Chen CL,Haung TL,Lee TY,Chen TY,Chen YS,Liu PP,Chiang YC,Eng HL,Wang CC,Cheung HK,Jawan B,Goto S

    更新日期:1998-10-01 00:00:00

  • Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients.

    abstract:BACKGROUND:We performed a study to identify differences in the urinary microbiome associated with chronic allograft dysfunction (CAD) and compared the urinary microbiome of male and female transplant recipients with CAD. METHODS:This case-control study enrolled 67 patients within the Deterioration of Kidney Allograft ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13436

    authors: Wu JF,Muthusamy A,Al-Ghalith GA,Knights D,Guo B,Wu B,Remmel RP,Schladt DP,Alegre ML,Oetting WS,Jacobson PA,Israni AK

    更新日期:2018-12-01 00:00:00

  • Does comfort therapy during controlled donation after circulatory death shorten the life of potential donors?

    abstract:INTRODUCTION:Controlled donation after circulatory death (DCD) remains ethically controversial. The authors developed a controlled DCD protocol in which comfort therapy is regularly used. The aim of this study was to determine whether this policy shortens the DCD donors' life. METHODS:The authors retrospectively analy...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12276

    authors: Ledoux D,Delbouille MH,Deroover A,Lambermont B,Meurisse M,Damas P,Joris J,Detry O

    更新日期:2014-01-01 00:00:00

  • Impact of dose reductions on efficacy outcome in heart transplant patients receiving enteric-coated mycophenolate sodium or mycophenolate mofetil at 12 months post-transplantation.

    abstract::Mycophenolic acid (MPA) dose reduction is associated with increased risk of rejection and graft loss in renal transplantation. This analysis investigated the impact of MPA dose changes with enteric-coated mycophenolate sodium (EC-MPS) or mycophenolate mofetil (MMF) in de novo heart transplant recipients. In a 12-month...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1399-0012.2008.00887.x

    authors: Segovia J,Gerosa G,Almenar L,Livi U,Viganò M,Arizón JM,Yonan N,Di Salvo TG,Renlund DG,Kobashigawa JA,ERL 2401 Study Group.

    更新日期:2008-11-01 00:00:00

  • Calcification score evaluation in patients listed for renal transplantation.

    abstract::Based on native CT scans of the pelvic region using a standardized calcification score, evaluation of iliac vascular calcification was performed between 2008 and 2012 prior to listing for renal transplantation in 205 patients with chronic kidney disease. Vascular calcification showed a decrease from proximal to distal...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12888

    authors: Kahn J,Ram LM,Eberhard K,Groselj-Strele A,Obermayer-Pietsch B,Müller H

    更新日期:2017-03-01 00:00:00

  • Recurrent allograft HCV presenting as acute cellular rejection: successful management with interferon and ribavirin alone.

    abstract::Hepatitis C virus (HCV) is currently the leading indication worldwide for orthotopic liver transplantation. However, the majority of patients receiving transplant for HCV eventually develop histopathologic evidence of recurrent allograft HCV and approximately 10% die or require retransplantation within the first 5 pos...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2003.00049.x

    authors: Leung JY,Abraczinskas DR,Bhan AK,Terella AM,Pascual M,Cosimi AB,Chung RT

    更新日期:2003-06-01 00:00:00

  • Bone mineral density and osteoporosis in heart transplanted patients: A single-center retrospective study at Skåne University Hospital in Lund 1988-2016.

    abstract::Bone mineral density (BMD) in the lumbar spine and femoral neck, the incidence of osteoporosis, and survival up to 10 years after heart transplantation (HT) were investigated in 169 patients who underwent HT at Skåne University Hospital in Lund, Sweden, 1988-2016. Within the first year post-transplantation, mean (SD) ...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13477

    authors: Löfdahl E,Söderlund C,Rådegran G

    更新日期:2019-03-01 00:00:00

  • Limitations of pediatric donor kidneys for transplantation.

    abstract:BACKGROUND:The shortage of grafts for kidney transplantation (Tx) has resulted in an expansion of criteria for pediatric donors. However, the limitations of pediatric donors for kidney Tx are not yet clearly established. We investigated the outcomes of recipients with pediatric kidney grafts from Colorado to elucidate ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Yagisawa T,Kam I,Chan L,Springer JW,Dunn S

    更新日期:1998-12-01 00:00:00

  • Optimal timing for living-related liver transplantation in children.

    abstract:BACKGROUND:The pediatric end stage liver disease (PELD) score has been used widely to prioritize children awaiting cadaveric liver transplantation (LTx). To establish the objective parameter for optimal timing of living-related LTx (LRLTx), we have assessed our cases using the PELD score. METHODS:From 1997 to 2002, 24...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2004.00194.x

    authors: Kimura T,Hasegawa T,Sasaki T,Shimizu Y,Mushiake S,Fukuzawa M,Okada A

    更新日期:2004-10-01 00:00:00

  • Differential contribution of graft and recipient to perioperative TNF-alpha, IL-1 beta, IL-6 and IL-8 levels and correlation with early graft function in clinical liver transplantation.

    abstract::Cytokines, produced by both the recipient and the newly vascularized allograft, are central mediators in the inflammatory response to allografted tissue. This study examines the relationship between pre- and intraoperative levels of TNF, IL-1, IL-6, and IL-8 and hepatic allograft function in the early postoperative pe...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Boros P,Suehiro T,Curtiss S,Sheiner P,Emre S,Guy S,Schwartz ME,Miller CM

    更新日期:1997-12-01 00:00:00

  • Short- and midterm results for internal jugular vein extension for short right renal vein kidney transplant.

    abstract::Renal transplantation remains the definitive treatment for end-stage renal disease (ESRD). The shorter renal vein in right donor nephrectomies is associated with higher incidence of technical failure. We present here our experience with autologous internal jugular vein (IJV) conduits to facilitate living-donor transpl...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13312

    authors: Lu T,Yi SG,Bismuth J,Knight RJ,Gaber AO,Bechara CF

    更新日期:2018-08-01 00:00:00

  • Influence of immunosuppressive regimens on short-term morbidity and mortality in heart transplantation.

    abstract:BACKGROUND:The goal of immunosuppressive therapy in heart transplantation is to maximize safety and efficacy while minimizing morbidity and mortality. We now have numerous drug combinations, but few have been compared with each other. AIM:To compare various immunosuppressive regimens assessing morbidity and mortality ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00751.x

    authors: Aguero J,Almenar L,Martínez-Dolz L,Moro JA,Rueda J,Raso R,Chamorro C,Sanchez JM,Salvador A

    更新日期:2008-01-01 00:00:00

  • Immunosuppressive standards in simultaneous kidney-pancreas transplantation.

    abstract::Simultaneous pancreas-kidney transplantation is an established procedure for patients with type I diabetes and end-stage renal disease. Continuous advances in the operation techniques with consequent reduction of perioperative morbidity and mortality and the introduction of modern immunosuppressive agents improved not...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2006.00599.x

    authors: Schmied BM,Müller SA,Mehrabi A,Welsch T,Büchler MW,Zeier M,Schmidt J

    更新日期:2006-01-01 00:00:00

  • Long-term outcomes of dual kidney transplantation-a single center experience.

    abstract::The shortage of kidney donors has led to broadening of the acceptance criteria for deceased donor organs beyond the traditional use of young donors. We determined long-term post-transplant outcomes in recipients of dual expanded criteria donor kidneys (dECD, n = 44) and compared them to recipients of standard criteria...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.00956.x

    authors: Salifu MO,Norin AJ,O'Mahony C,Sumrani N,Apel A,Ikram M,Alam A,Hayat A,Jindal RM,Friedman EA,Distant DA

    更新日期:2009-06-01 00:00:00

  • Analysis of local versus imported expanded criteria donor kidneys: A single-center experience with 497 ECD kidney transplants.

    abstract:BACKGROUND:The value of importing expanded criteria donor (ECD) kidneys is uncertain. METHODS:We retrospectively reviewed our single-center experience with ECD kidney transplants (KT). RESULTS:Over 12.8 years, we performed 497 ECD KTs including 247 local and 250 imported from other donor service areas. The import ECD...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13029

    authors: Khan MA,El-Hennawy H,Farney AC,Rogers J,Orlando G,Reeves-Daniel A,Palanisamy A,Gautreaux M,Iskandar S,Doares W,Kaczmorski S,Stratta RJ

    更新日期:2017-08-01 00:00:00

  • The role of biomechanical anatomical modeling via computed tomography for identification of restrictive allograft syndrome.

    abstract::Chronic lung allograft dysfunction (CLAD) reduces long-term graft survival. It is important to distinguish CLAD subtypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS) as RAS has a worse prognosis and accurate subtyping could facilitate targeted treatments. However, the current diagn...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13027

    authors: Horie M,Saito T,Moseley J,D'Errico L,Salazar P,Nakajima D,Brock K,Yasufuku K,Binnie M,Keshavjee S,Paul N

    更新日期:2017-08-01 00:00:00