Safety and immunogenicity of hepatitis B vaccine ButaNG in adults

Abstract:

:Recombinant yeast-derived hepatitis B vaccine manufactured by Instituto Butantan was administered in two groups of adult volunteers (I, II) following two different schedules of immunization. In the first trial (10 &mgr;g doses and 0, 1, 3 months vaccination schedule) 106 individuals completed the full immunization program. The results of seroconversion by age group varied from 70 to 100% and the GMT from 46.5 to 124.9 mIU mL-1. In the second trial with 68 individuals (for dosage comparison and 0, 1, 6 months vaccination schedule) indicated that the vaccine formulated in 20 &mgr;g was more effective than in 10 &mgr;g. The adverse reactions observed in the vaccinees were less frequent than the ones previously found since the introduction of similar vaccines.

authors

Ioshimoto LM,Rissato ML,Bonilha VS,Miyaki C,Raw I I,Granovski N

doi

10.1590/s0036-46651999000300011

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

191-3

issue

3

eissn

0036-4665

issn

1678-9946

pii

S0036-4665(99)04100311

journal_volume

41

pub_type

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