Characterization of a specific binding site for angiotensin II in chicken liver.

abstract：:This study investigated the effects of prolonged exercise on muscle sarcoplasmic reticulum (SR) Ca2+ cycling properties and the metabolic responses with and without a session of exercise designed to reduce muscle glycogen reserves while on a normal carbohydrate (CHO) diet. Eight untrained males (VO(2peak) = 3.81 +/- 0...

journal_title：Canadian journal of physiology and pharmacology

authors： Duhamel TA,Green HJ,Perco JG,Ouyang J

更新日期：2005-07-01 00:00:00

abstract：:The effect of varying dietary levels of zinc was evaluated in mice fed T-2 toxin. A semipurified diet was used to produce a low zinc (less than 2 parts per million (ppm], a zinc replete (100 ppm), and a high zinc (2500 ppm) diet. T-2 toxin was added to the three zinc diets at a concentration of 10 ppm. The mice were f...

journal_title：Canadian journal of physiology and pharmacology

authors： Chanin BE,Hamilton DL,Hancock DS,Schiefer HB

更新日期：1984-10-01 00:00:00

abstract：:Normal mammalian sexual maturation and reproductive functions require the integration and precise coordination of hormones at the hypothalamic, pituitary, and gonadal levels. Hypothalamic gonadotropin-releasing hormone (GnRH) is a key regulator in this system; after binding to its receptor (GnRHR), it stimulates de no...

journal_title：Canadian journal of physiology and pharmacology

authors： Cheng KW,Leung PC

更新日期：2000-12-01 00:00:00

abstract：:This review updates our current knowledge on the regulation of Na+/H+ exchanger, Na+,K+,Cl- cotransporter, Na+,Pi cotransporter, and Na+,K+ pump in isolated epithelial cells from mammalian kidney by protein kinase C (PKC). In cells derived from different tubule segments, an activator of PKC, 4beta-phorbol 12-myristate...

journal_title：Canadian journal of physiology and pharmacology

authors： Gagnon F,Hamet P,Orlov SN

更新日期：1999-05-01 00:00:00

abstract：:Our knowledge of the effects of exercise on the heart is limited by the predominant use of rats as an animal model. The rabbit has many advantages over the rat as an animal model to study. However, little work has characterized its capacity to exercise. The purposes of the present study were to determine if the rabbit...

journal_title：Canadian journal of physiology and pharmacology

authors： Meng H,Pierce GN

更新日期：1990-07-01 00:00:00

abstract：:The effect of adrenaline on the membrane transport of 3-methylglucose was studied in perifused isolated rat left atria that had been fully arrested. In this preparation a high concentration of adrenaline stimulated and a low one decreased sugar transport. The stimulatory effect was strongly inhibited by the beta-adren...

journal_title：Canadian journal of physiology and pharmacology

authors： Bihler I,Sawh PC

更新日期：1976-10-01 00:00:00

abstract：:Although ATP-MgCl2 enhances the recovery of renal function after ischemia and reperfusion, it is not known whether this agent has any beneficial effects on renal microcirculation and function in a nonheparinized model of trauma and severe hemorrhage. To study this, a midline laparotomy was performed (i.e., trauma indu...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang P,Zhou M,Rana MW,Singh G,Ba ZF,Ayala A,Chaudry IH

更新日期：1992-03-01 00:00:00

abstract：:Recent evidence suggests that some Ca2+ channels are regulated by a tyrosine kinase pathway. The possibility that Ca2+ entry is regulated by tyrosine kinase was investigated in canine vascular muscles. Functional studies were carried out in the dog mesenteric arteries and saphenous veins. Nicardipine-insensitive refil...

journal_title：Canadian journal of physiology and pharmacology

authors： Low AM

更新日期：1996-03-01 00:00:00

abstract：:Single ventricular cells have been isolated from adult guinea pig heart using a collagenase enzyme method. The procedure is straightforward, takes about 20 min, and yields 40-65% rod-shaped cells which are quiescent in millimolar Ca2+ solution. Electrophysiological studies involving external ion changes and ionic chan...

journal_title：Canadian journal of physiology and pharmacology

authors： Bustamante JO,Watanabe T,McDonald TF

更新日期：1981-08-01 00:00:00

abstract：:Obesity is associated with autonomic nervous system dysfunction. The aim of the study was to evaluate baroreflex sensitivity, an indicator of autonomic nervous function, in 20 obese children and adolescents in comparison with 20 age- and sex-matched nonobese subjects. All subjects were examined in the supine position ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lazarova Z,Tonhajzerova I,Trunkvalterova Z,Brozmanova A,Honzíková N,Javorka K,Baumert M,Javorka M

更新日期：2009-07-01 00:00:00

abstract：:In anesthetized dogs, 60-min occlusions of either the proximal (n = 14), distal (n = 8) left circumflex (LCX), or left anterior descending (LAD, n = 10) arteries were followed by reperfusion. Coronary sinus and aortic norepinephrine and epinephrine plasma concentrations were measured. The ventricular arrhythmias were ...

journal_title：Canadian journal of physiology and pharmacology

authors： Godin D,Campeau N,Nadeau R,Cardinal R,de Champlain J

更新日期：1985-09-01 00:00:00

abstract：:Excitation-contraction coupling in crab muscle fibers was studied in voltage-clamp conditions. Extracellular calcium is essential for the mechanical activity. Two calcium influxes induced by membrane depolarization contribute to tension development: one is the inward calcium current responsible for the phasic tension,...

journal_title：Canadian journal of physiology and pharmacology

authors： Mounier Y,Goblet C

更新日期：1987-04-01 00:00:00

abstract：:The objective of the present study was to assess the cardioprotective effect of dual NEP-ACE inhibition in relation to endogenous cardiac bradykinin (BK), its active metabolite des-Arg9-BK, endogenous brain natriuretic peptides (BNP), and cGMP. Rats were treated with the dual metallopeptidase inhibitor, omapatrilat, o...

journal_title：Canadian journal of physiology and pharmacology

authors： Dumoulin MJ,Adam A,Burnett J,Heublein D,Yamaguchi N,Lamontagne D

更新日期：2005-02-01 00:00:00

abstract：:A striking feature of the mammalian respiratory rhythm generator is the abruptness of the transitions between the inspiratory (I) and expiratory (E) phases ("phase-switching"). Although reciprocal inhibitory actions between I and E neurons are important for maintaining the alternation of respiratory phases, phase-swit...

journal_title：Canadian journal of physiology and pharmacology

authors： Cohen MI

更新日期：1981-07-01 00:00:00

abstract：:The synthesis, receptor binding, and agonist activity of a series of truncated atrial natriuretic analogs (ANF) are described. These analogs incorporate two portions of the native 28 amino peptide, the eight amino acids C-terminal to Cys7, and two amino acids from the C-terminus (phenylalanine and arginine), into disu...

journal_title：Canadian journal of physiology and pharmacology

authors： Holleman WH,Budzik GP,Devine EM,Pollock DM,Opgenorth TJ,Thomas AM,von Geldern TW,Rockway TW

更新日期：1991-10-01 00:00:00

abstract：:Rats received a daily injection of 2, 6, or 12 mg kg-1 bethanechol for 7 or 14 days. Pancreatic weight and content of protein, amylase, and chymotrypsinogen were increased in a dose and time dependent fashion by bethanechol. After 14 days of treatment with the highest dose, pancreatic weight and total pancreatic DNA c...

journal_title：Canadian journal of physiology and pharmacology

authors： Morisset J,Jolicoeur L,Caussignac Y,Solomon TE

更新日期：1982-07-01 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), a polyphenol in green tea, is an effective antioxidant and possesses neuroprotective effects. Brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB) are crucial for neurogenesis and synaptic plasticity. In this study, we aimed to assess the pr...

journal_title：Canadian journal of physiology and pharmacology

authors： Ding ML,Ma H,Man YG,Lv HY

更新日期：2017-12-01 00:00:00

abstract：:Acetylcholine (ACh) is an important regulator of intestinal epithelial ion transport via muscarinic or nicotinic ACh receptors. Previous studies emphasize the role of the M3 muscarinic receptor subtype in mediating the effects of cholinergic agonists on intestinal ion transport. With the prevalence of mouse models to ...

journal_title：Canadian journal of physiology and pharmacology

authors： Hirota CL,McKay DM

更新日期：2006-11-01 00:00:00

abstract：:In open-chest pentothal-chloralose anesthetized dogs, plasma catecholamine and cyclic AMP levels were evaluated in the aortic and coronary sinus blood, during stimulations of the left ansa subclavia (1, 2, and 4 Hz). Basal aortic and coronary sinus catecholamine levels were respectively 0.373 +/- 0.090 and 0.259 +/- 0...

journal_title：Canadian journal of physiology and pharmacology

authors： Lavallée M,Laurencin C,de Champlain J,Nadeau RA

更新日期：1981-06-01 00:00:00

abstract：:The effects of estrogen and progesterone domination, achieved by administering estrogen (E) and estrogen plus progesterone (E + P), on rat uterine reactivity to Ca2+ and to Ca2+ channel ligands (antagonist and activator) were compared. The inhibitory activities of nifedipine, diltiazem, and D 600 against K+ depolariza...

journal_title：Canadian journal of physiology and pharmacology

authors： Ruzycky AL,Crankshaw DJ,Triggle DJ

更新日期：1987-10-01 00:00:00

abstract：:Metaiodobenzylguanidine, which is used in the diagnosis and treatment of pheochromocytoma, produced 50% inhibition of monoamine oxidase at a concentration of 8 X 10(-6) M in vitro. These results suggest that a careful study of the structure of a new radiodiagnostic agent should be done to anticipate and prepare for po...

journal_title：Canadian journal of physiology and pharmacology

authors： Burba JV

更新日期：1985-02-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) and CNTF analogs were reported to have hepatoprotective effect and ameliorate hepatic steatosis in db/db or high-fat-diet-fed mice. Because hepatic steatosis and injury are also commonly induced by hepatotoxin, the aim of the present study is to clarify whether CNTF could alleviate h...

journal_title：Canadian journal of physiology and pharmacology

authors： Cui MX,Jiang JF,Min GN,Han W,Wu YJ

更新日期：2017-05-01 00:00:00

abstract：:The mechanisms responsible for microbially induced epithelial apoptosis and increased intestinal permeability remain unclear. This study assessed whether purified bacterial lipopolysaccharide (LPS) increases epithelial apoptosis and permeability and whether these changes are dependent on caspase-3 activation. In nontu...

journal_title：Canadian journal of physiology and pharmacology

authors： Chin AC,Flynn AN,Fedwick JP,Buret AG

更新日期：2006-10-01 00:00:00

abstract：:Rapamycin, a new antifungal antibiotic, was found to inhibit the immune response in rats. It totally prevented the development of two experimental immunopathies (experimental allergic encephalomyelitis (EAE) and adjuvant arthritis (AA)) and the formation of humoral (IgE-like) antibody. It was about half as potent as c...

journal_title：Canadian journal of physiology and pharmacology

authors： Martel RR,Klicius J,Galet S

更新日期：1977-02-01 00:00:00

abstract：:Magnesium concentrations in erythrocyte ghosts and arterial tissue of male, spontaneously hypertensive rats (SHR) were significantly less than in these tissues of male normotensive controls (Wistar-Kyoto; WKY) of the same age, which were also fed rat chow and tap water. The magnesium concentration in SHR erythrocyte g...

journal_title：Canadian journal of physiology and pharmacology

authors： Wells IC,Agrawal DK

更新日期：1992-09-01 00:00:00

abstract：:In this study, we aimed to investigate the protective effects of androgens, using letrozole (LET; an aromatase inhibitor), grape seed extract (GSE; a naturally occurring aromatase inhibitor and antioxidant), and testosterone propionate (Tp), against methotrexate (MTX)-induced testicular toxicity in adult male rats. MT...

journal_title：Canadian journal of physiology and pharmacology

authors： Makary S,Abdo M,Fekry E

更新日期：2018-04-01 00:00:00

abstract：:Induced ketosis may acutely prolong hypoxic tolerance by altering glucose and (or) beta-hydroxybutyrate extraction by the brain. Anesthetized dogs were ventilated and instrumental for arterial and cerebral venous blood sampling, taken during baseline, infusion, test, and recovery periods. Each dog received one of four...

journal_title：Canadian journal of physiology and pharmacology

authors： Chang AS,D'Alecy LG

更新日期：1993-07-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a multifactorial disease characterized by left ventricular dilation that is associated with systolic dysfunction and increased action potential duration. The Kir2.x K⁺ channels (encoded by KCNJ genes) regulate the inward rectifier current (IK1) contributing to the final repolarization i...

journal_title：Canadian journal of physiology and pharmacology

authors： Szuts V,Ménesi D,Varga-Orvos Z,Zvara Á,Houshmand N,Bitay M,Bogáts G,Virág L,Baczkó I,Szalontai B,Geramipoor A,Cotella D,Wettwer E,Ravens U,Deák F,Puskás LG,Papp JG,Kiss I,Varró A,Jost N

更新日期：2013-08-01 00:00:00

abstract：:Complexes of vanadyl(IV) with 4 monosaccharides and 5 disaccharides were tested in 2 osteoblast-like cell lines (MC3T3E1 and UMR106). Many complexes caused stimulation of UMR106 proliferation (120% basal) in the range of 2.5 to 25 micromol/L. In the nontransformed osteoblasts, some vanadyl-saccharide complexes stimula...

journal_title：Canadian journal of physiology and pharmacology

authors： Barrio DA,Cattáneo ER,Apezteguía MC,Etcheverry SB

更新日期：2006-07-01 00:00:00

abstract：:Pathogenic mechanisms for essential hypertension are unclear despite striking efforts from numerous research teams over several decades. Increased production of reactive oxygen species (ROS) has been associated with the development of hypertension and the role of ROS in hypertension has been well documented in recent ...

journal_title：Canadian journal of physiology and pharmacology

authors： Chang T,Wu L

更新日期：2006-12-01 00:00:00