Influence of age on the presentation and outcome of choledochal cyst.

Abstract:

PURPOSE:The aim of this study was to identify the most appropriate timing for surgery in newborns with choledochal cysts. METHODS:The clinical and histological data of 8 newborn cases of choledochal cysts (newborn group) were compared with 45 cases that were diagnosed later than the newborn period (late group). RESULTS:The mean and standard deviation of age at diagnosis was 0.4+/-0.4 months and 43.4+/-37.8 months in the newborn and late group, respectively. The age at operation was significantly earlier in the newborn group than in the late group (4.9+/-4.5 months v54.7+/-47.0 months). Although no significant difference in the time that elapsed between the operation and the onset of symptoms between the newborn and late groups (4.5+/-4.7 months v11.3+/-21.1 months), the serum bilirubin level (4.6+/-3.8 mg/dL v1.8+/-3.4 mg/dL) and the grade of liver fibrosis (2.0+/-0.8 v1.1+/-0.8) were significantly higher in the newborn group than in the late group. CONCLUSION:The newborn group should be considered as a special group of patients with different clinical course and pathology than those of the late group, which necessitate the early surgical intervention to prevent progression of liver fibrosis.

journal_name

J Pediatr Surg

authors

Suita S,Shono K,Kinugasa Y,Kubota M,Matsuo S

doi

10.1016/s0022-3468(99)90308-1

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

1765-8

issue

12

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(99)90308-1

journal_volume

34

pub_type

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