Abstract:
OBJECTIVE:To describe the characteristics of and trends in nosocomial infection among human immunodeficiency virus (HIV)-infected patients. DESIGN:Multicenter prospective cohort study. SETTING/PATIENTS:HIV-infected patients were enrolled at time of first inpatient admission at five Veterans' Administration Medical Centers (VAMCs). RESULTS:As of March 1995, 2,541 patients with 6,625 inpatient admissions had been monitored in the five VAMCs. A total of 530 nosocomial infections were detected using standard Centers for Disease Control and Prevention definitions. Overall distribution by infection site was 31% for primary bloodstream infections (BSIs), 28% for urinary tract infections, 15% for pneumonia, and 26% for all other sites. Of BSIs, 63% were central line-associated bloodstream infections (CLABs). The rate of CLABs per 1,000 central line days was 6.5 (range, 2.3-8.3) for all patients from participating hospitals, similar to the median CLAB rate of 6.0 for patients in medical intensive-care units (ICUs) of National Nosocomial Infections Surveillance (NNIS) System hospitals from January 1990 through September 1994. For ICU-specific CLABs, the rate from hospitals reporting at least one ICU CLAB was 12.7 (range, 12.1-13.1), comparable to the 90th percentile of NNIS hospital medical ICUs (13.1). Staphylococcus aureus, associated with 35% of BSIs, was the most common nosocomial BSI pathogen. Our data demonstrated the following: 13 (10%) of 134 patients with CD4 counts > or = 200 cells/mm3 had a CLAB, compared with 61 (6%) of 1,011 patients with CD4 counts < 200 cells/mm3, P = .08; the per-day risk of CLABs did not change with increased duration of catheterization (P = .4); and the per-day risk of a temporary (ie, short-term) CLAB was greater than that of a permanent CLAB (P < .001). CONCLUSIONS:The data suggest that HIV-infected patients were at higher risk of acquiring a BSI than were patients in the NNIS population; patients with CD4 counts > or = 200 cell/mm3 and temporary central lines were at increased risk for BSI, perhaps reflecting widespread prophylaxis with trimethoprim-sulfamethoxazole among patients with CD4 counts < 200 cells/mm3, and, in contrast to most studies, S aureus, not coagulase-negative Staphylococcus, was the most common BSI pathogen.
journal_name
Infect Control Hosp Epidemioljournal_title
Infection control and hospital epidemiologyauthors
Stroud L,Srivastava P,Culver D,Bisno A,Rimland D,Simberkoff M,Elder H,Fierer J,Martone W,Gaynes Rdoi
10.1086/647652subject
Has Abstractpub_date
1997-07-01 00:00:00pages
479-85issue
7eissn
0899-823Xissn
1559-6834journal_volume
18pub_type
杂志文章,多中心研究abstract::Infection control in British nursing homes is different from that in U.S. nursing homes in seveal ways. Most British nursing homes, for example, do not have a designated on-site infection control nurse, and several agencies are responsible for regulatory oversight. This article discusses the state of infection control...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/502198
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:To evaluate clonal dissemination of methicillin-resistant coagulase-negative staphylococci (CNS). SETTING:Neonatal intensive care unit of a 180-bed, university-affiliated general hospital. PATIENTS:Neonates admitted to the neonatal intensive care unit between March 1999 and October 2000, from whom CNS were ...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/502083
更新日期:2002-08-01 00:00:00
abstract::During an insidious outbreak of salmonellosis in a long-term care facility, residents who were treated with acid-suppressing medications were 8 times more likely than other residents to develop Salmonella infection. Among vulnerable populations, the risks and benefits of acid-suppressing medications should be consider...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/520736
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Clostridium difficile infection (CDI) is a reportable hospital metric associated with significant healthcare expenditures. The epidemiology of CDI is pivotal to the implementation of preventative measures. OBJECTIVE:To portray temporal CDI trends in Veterans Health Administration (VA) hospitals. DESIGN:A r...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1017/ice.2019.281
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To characterize the probability and duration of viral shedding among adults given trivalent live attenuated influenza vaccine (LAIV). DESIGN:Prospective surveillance study. METHODS:Nasal wash samples were collected from adult volunteers at baseline and on days 3, 7, and 10 and between days 17 and 21 followi...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/502574
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the antimicrobial efficacy of and risk of organisms developing resistance to 2 novel hand soaps: (1) a soap containing triclosan, polyhexamethylene biguanide, and benzethonium chloride added to a soap base (TPB soap); and (2) a soap containing farnesol, polyhexamethylene biguanide, and benzethoniu...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/589723
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of detergent and friction on removal of traditional biofilm and cyclic-buildup biofilm (CBB) from polytetrafluoroethylene (PTFE) channels and to evaluate the efficacy of glutaraldehyde to kill residual bacteria after cleaning. METHODS:PTFE channels were exposed to artificial test soi...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1017/ice.2019.306
更新日期:2020-02-01 00:00:00
abstract::Due to the rapid transfer of patients from the acute-care setting, the intensity of nursing care among residents in long-term-care facilities (LTCFs) has increased, transforming today's LTCFs into subacute healthcare facilities. Given the increased risk of infection among residents in LTCFs and the associated morbidit...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/501581
更新日期:1999-11-01 00:00:00
abstract::OBJECTIVE Recerntly, the role of the healthcare network, defined as a set of hospitals linked by patient transfers, has been increasingly considered in the control of antimicrobial resistance. Here, we investigate the potential impact of nursing homes on the spread of antimicrobial-resistant pathogens across the healt...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1017/ice.2016.59
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To assess the safety, sustainability, and effectiveness of a laboratory intervention to reduce processing of midstream urine (MSU) cultures. DESIGN:Prospective observational cohort. SETTING:Medical and surgical inpatients in a tertiary-care hospital. PARTICIPANTS:The study included 1,678 adult inpatients w...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1017/ice.2020.385
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:The investigation and control of an outbreak of nosocomial Pseudomonas cepacia respiratory tract colonization and infection. DESIGN:Epidemiologic investigation based on infection control surveillance data, including definition and characterization of case patients, environmental cultures based on epidemiolog...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/646642
更新日期:1993-10-01 00:00:00
abstract::Using samples collected for VRE surveillance, we evaluated unit admission prevalence of carbapenem-resistant Enterobacteriaceae (CRE) perirectal colonization and whether CRE carriers (unknown to staff) were on contact precautions for other indications. CRE colonization at unit admission was infrequent (3.9%). Most CRE...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1017/ice.2018.236
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:To investigate the potential role of blood pressure (BP) cuffs in the spread of bacterial infections in hospitals. DESIGN:A comprehensive, prospective study quantitatively and qualitatively evaluating the bacterial contamination on BP cuffs of 203 sphygmomanometers in use in 18 hospital units from January th...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/507284
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:To investigate and control an outbreak of epidemic keratoconjunctivitis (EKC) occurring in a neonatal intensive care unit (NICU) and to determine signs specific for EKC in newborns. DESIGN:Outbreak investigation and case-control study. SETTING:NICU of a 1,600-bed university hospital in Heidelberg, Germany....
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/502247
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:To curtail the prevalence and cross-transmission of methicillin-resistant Staphylococcus aureus (MRSA) in a rural healthcare setting. DESIGN:Before-after, quasi-experimental quality improvement study. SETTING:A regional-referral hospital, 5 affiliated nursing homes, and an outpatient MRSA clinic. INTERVENT...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/650445
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To investigate trends in plasmid types of methicillin-resistant Staphylococcus aureus over a 3-year period and determine the clinical impact of plasmid typing. DESIGN:Restriction endonuclease analysis of plasmid DNA (REAP) was used to type 270 clinical isolates. SETTING:A Veterans Affairs Medical Center. R...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/646627
更新日期:1993-01-01 00:00:00
abstract::Malassezia furfur, a lipophilic yeast, has become recognized as a cause of sepsis in infants receiving parenteral fat emulsions via indwelling deep venous catheters. Colonization of infants' skin may be a prerequisite to colonization of the intravascular catheter and subsequent infection with M furfur. Three hundred n...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/645819
更新日期:1988-04-01 00:00:00
abstract:OBJECTIVE:To describe the use of laminar airflow, body exhaust, and ultraviolet lights during total knee replacement (TKR) in four U.S. states. DESIGN:Survey of healthcare facilities. SETTING:Hospitals in Illinois, North Carolina, Ohio, and Tennessee that performed TKR during 2000 as identified by Medicare claims dat...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1086/505452
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of a positive deviance strategy for the improvement of hand hygiene compliance in 2 adult step-down units. DESIGN:A 9-month, controlled trial comparing the effect of positive deviance on compliance with hand hygiene. SETTING:Two 20-bed step-down units at a tertiary care private...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/649224
更新日期:2010-01-01 00:00:00
abstract::SHEA and the American Society for Quality's Health Care Division have been collaborating in areas of common concern to improve healthcare quality. We each possess a heritage of different but complementary approaches and stand a better chance of success together than apart. This presentation describes rapid growth of o...
journal_title:Infection control and hospital epidemiology
pub_type:
doi:10.1086/501957
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of a standardized regimen for decolonization of methicillin-resistant Staphylococcus aureus (MRSA) carriers and to identify factors influencing decolonization treatment failure. DESIGN:Prospective cohort study from January 2002 to April 2007, with a mean follow-up period of 36 months...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/588201
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Treatment of Staphylococcus aureus colonization before surgery reduces risk of surgical site infection (SSI). The regimen of nasal mupirocin ointment and topical chlorhexidine gluconate is effective, but cost and patient compliance may be a barrier. Nasal povidone-iodine solution may provide an alternative t...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1086/676872
更新日期:2014-07-01 00:00:00
abstract::We investigated a cluster of methicillin-resistant Staphylococcus aureus infections in college football players. Risk factors included a history of recurrent skin infections and contact with the skin lesions of persons outside college. The infections were controlled through treatment of carriers with topical mupirocin...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/587971
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:Laboratory-based characterization and traceback of Clostridium butyricum isolates linked to outbreak cases of neonatal necrotizing enterocolitis (NEC) in a hospital in China. METHODS:In total, 37 samples were collected during the NEC outbreak. Classical bacteriological methods were applied to isolate and ide...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1017/ice.2019.289
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:Viruses are more common than bacteria in patients hospitalized with community-acquired pneumonia. Little is known, however, about the frequency of respiratory viral testing and its associations with antimicrobial utilization. DESIGN:Retrospective cohort study. SETTING:The study included 179 US hospitals. P...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1017/ice.2020.1312
更新日期:2020-12-01 00:00:00
abstract::Whether healthcare-associated infection data should be presented using indirect (current CMS/CDC methodology) or direct standardization remains controversial. We applied both methods to central-line-associated bloodstream infection data from 45 acute-care hospitals in Maryland from 2012 to 2014. We found that the 2 me...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1017/ice.2017.120
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Interventions that prevent healthcare-associated infection should lead to fewer deaths and shorter hospital stays. Cleaning hands (with soap or alcohol) is an effective way to prevent the transmission of organisms, but rates of compliance with hand hygiene are sometimes disappointingly low. The National Hand...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/677160
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Hand hygiene noncompliance is a major cause of nosocomial infection. Nosocomial infection cost data exist, but the effect of hand hygiene noncompliance is unknown. OBJECTIVE:To estimate methicillin-resistant Staphylococcus aureus (MRSA)-related cost of an incident of hand hygiene noncompliance by a healthca...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/651096
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Despite contact isolation precautions for patients with methicillin-resistant Staphylococcus aureus (MRSA), MRSA infections are increasing in many countries. OBJECTIVE:To evaluate the role of a potential unrecognized reservoir of MRSA carried by patients in acute care wards, we determined the prevalence of ...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/502514
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:To study the molecular epidemiology of vancomycin-resistant Enterococcus (VRE) colonization and to identify modifiable risk factors among patients with hematologic malignancies. SETTING:A hematology-oncology unit with high prevalence of VRE colonization. PARTICIPANTS:Patients with hematologic malignancies a...
journal_title:Infection control and hospital epidemiology
pub_type: 杂志文章
doi:10.1086/659408
更新日期:2011-05-01 00:00:00