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Respiratory viral testing and antibacterial treatment in patients hospitalized with community-acquired pneumonia.

Abstract：

OBJECTIVE:Viruses are more common than bacteria in patients hospitalized with community-acquired pneumonia. Little is known, however, about the frequency of respiratory viral testing and its associations with antimicrobial utilization. DESIGN:Retrospective cohort study. SETTING:The study included 179 US hospitals. PATIENTS:Adults admitted with pneumonia between July 2010 and June 2015. METHODS:We assessed the frequency of respiratory virus testing and compared antimicrobial utilization, mortality, length of stay, and costs between tested versus untested patients, and between virus-positive versus virus-negative patients. RESULTS:Among 166,273 patients with pneumonia on admission, 40,787 patients (24.5%) were tested for respiratory viruses, 94.8% were tested for influenza, and 20.7% were tested for other viruses. Viral assays were positive in 5,133 of 40,787 tested patients (12.6%), typically for influenza and rhinovirus. Tested patients were younger and had fewer comorbidities than untested patients, but patients with positive viral assays were older and had more comorbidities than those with negative assays. Blood cultures were positive for bacterial pathogens in 2.7% of patients with positive viral assays versus 5.3% of patients with negative viral tests (P < .001). Antibacterial courses were shorter for virus-positive versus -negative patients overall (mean 5.5 vs 6.4 days; P < .001) but varied by bacterial testing: 8.1 versus 8.0 days (P = .60) if bacterial tests were positive; 5.3 versus 6.1 days (P < .001) if bacterial tests were negative; and 3.3 versus 5.2 days (P < .001) if bacterial tests were not obtained (interaction P < .001). CONCLUSIONS:A minority of patients hospitalized with pneumonia were tested for respiratory viruses; only a fraction of potential viral pathogens were assayed; and patients with positive viral tests often received long antibacterial courses.

journal_name

Infect Control Hosp Epidemiol

journal_title

Infection control and hospital epidemiology

authors

Klompas M,Imrey PB,Yu PC,Rhee C,Deshpande A,Haessler S,Zilberberg MD,Rothberg MB

doi

10.1017/ice.2020.1312

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

1-9

eissn

0899-823X

issn

1559-6834

pii

S0899823X20013124

pub_type

杂志文章

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Respiratory viral testing and antibacterial treatment in patients hospitalized with community-acquired pneumonia.