Abstract:
:We reported HTLV-1 uveitis (HU) as the third distinct clinical entity associated with HTLV-1 infection. Uveitis has advantages for studying the pathogenetic mechanisms of inflammatory diseases caused by HTLV-1, since observation of the disease process is relatively easy and clinical samples from the lesion can be obtained. Results of our clinical, virological and epidemiological studies of HU patients will be first summarized. Then we present results on in vitro studies that showed transactivation of HTLV-1 LTR by thyroid hormone and discuss the significance in the context of pathogenesis of HTLV-1-related inflammatory diseases.
journal_name
Leukemiajournal_title
Leukemiaauthors
Watanabe T,Mochizuki M,Yamaguchi Ksubject
Has Abstractpub_date
1997-04-01 00:00:00pages
582-4eissn
0887-6924issn
1476-5551journal_volume
11 Suppl 3pub_type
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