Heart transplantation for end-stage heart failure caused by iron overload.

abstract：:A 30-year-old woman was diagnosed as having an acute promyelocytic leukaemia in September 1981. Chemotherapeutic courses of daunomycin, ara-C, thioguanine and prednisolone were administered, resulting in a complete remission. A relapse occurred in January 1982, and chemotherapy did not lead to a second complete remiss...

journal_title：British journal of haematology

authors： Nilsson B

更新日期：1984-07-01 00:00:00

abstract：:Dendritic cells (DC) are attractive candidates for use in vaccine-based immunotherapy. We have analysed the functional capability of DC generated in vitro from blood CD14(+) cells of chronic lymphocytic leukaemia (CLL) patients and healthy donors by culturing for 10 d with granulocyte-macrophage colony-stimulating fac...

journal_title：British journal of haematology

authors： Rezvany MR,Jeddi-Tehrani M,Biberfeld P,Söderlund J,Mellstedt H,Osterborg A,Rabbani H

更新日期：2001-11-01 00:00:00

abstract：:The inv(8)(p11q13) chromosomal abnormality, described in acute myeloid leukaemias (AML), fuses the histone acetyl-transferase (HAT) MYST3 (MOZ) gene with another HAT gene, NCOA2 (TIF2). We generated a transgenic zebrafish in which the MYST3/NCOA2 fusion gene was expressed under control of the spi1 promoter. An AML dev...

journal_title：British journal of haematology

authors： Zhuravleva J,Paggetti J,Martin L,Hammann A,Solary E,Bastie JN,Delva L

更新日期：2008-11-01 00:00:00

abstract：:Two children affected by severe aplastic anaemia (SAA) underwent allogeneic bone marrow transplantation (BMT) using partially matched family donors. In both cases there was a successful engraftment of donor haemopoietic stem cells. However, after an initial erythropoietic recovery, 5 months following BMT both children...

journal_title：British journal of haematology

authors： Locatelli F,Pedrazzoli P,Barosi G,Zecca M,Porta F,Liberato L,Gambarana D,Nespoli L,Cazzola M

更新日期：1992-04-01 00:00:00

abstract：:Aggregation, exposure of procoagulant phospholipids and shedding of microparticles are platelet responses that depend on activating conditions. To determine how these different responses are interconnected, we simultaneously measured fibrinogen (Fg) binding and aminophospholipid exposure on activated platelets by mean...

journal_title：British journal of haematology

authors： Bachelot-Loza C,Badol P,Brohard-Bohn B,Fraiz N,Cano E,Rendu F

更新日期：2006-05-01 00:00:00

abstract：:Both the 2001 World Health Organisation (WHO) classification of haematopoietic neoplasms and the 2008 WHO classification revision include a distinctive diagnostic category, refractory anaemia with ring sideroblasts and thrombocytosis (RARS-T), to describe those rare patients who have both >or=15% ring sideroblasts and...

journal_title：British journal of haematology

authors： Wardrop D,Steensma DP

更新日期：2009-03-01 00:00:00

abstract：:Kidney iron deposition measured by R2* (magnetic resonance imaging) MRI is posited to result from tubular reabsorption of filtered haemoglobin due to intravascular haemolysis. In chronically transfused sickle cell disease (SCD), R2* is elevated and positively correlated with lactate dehydrogenase (LDH). To account for...

journal_title：British journal of haematology

authors： Denton CC,Detterich JA,Coates TD,Wood JC

更新日期：2020-11-20 00:00:00

abstract：:The peripheral T-cell neoplasms are a biologically and clinically heterogeneous group of rare disorders that result from clonal proliferation of mature post-thymic lymphocytes. Natural killer (NK) cell neoplasms are included in this group. The World Health Organization classification of haemopoietic malignancies has d...

journal_title：British journal of haematology

authors： Dearden CE,Johnson R,Pettengell R,Devereux S,Cwynarski K,Whittaker S,McMillan A,British Committee for Standards in Haematology.

更新日期：2011-05-01 00:00:00

abstract：:Platelets in an infant with Chediak-Higashi (C-H) syndrome without bleeding manifestations and not in the accelerated phase showed abnormal function consistent with storage pool disorder as shown by abnormal aggregation, decreased storage capacity and release of [14C]5-HT, low endogenous 5-HT, reduced ATP and ADP with...

journal_title：British journal of haematology

authors： Boxer GJ,Holmsen H,Robkin L,Bang NU,Boxer LA,Baehner RL

更新日期：1977-04-01 00:00:00

abstract：:Venesection of 10% of whole blood volume or plateletpheresis was performed in nine patients with chronic myeloproliferative disorders and in five normal control subjects. Before venesection, the patients showed impaired platelet aggregation in 33% of tests, most often in response to stimulation with 9 mumol adrenaline...

journal_title：British journal of haematology

authors： Boughton BJ

更新日期：1978-08-01 00:00:00

abstract：:Reducing infectious morbidity is an important goal to improve childhood acute lymphoblastic leukaemia (ALL) survival. To explore the impact of chemotherapy reduction on infectious morbidity, we compared outpatient and inpatient infectious morbidity of reduced versus intensive (conventional) chemotherapy. One hundred a...

journal_title：British journal of haematology

authors： van Tilburg CM,Sanders EA,Nibbelke EE,Pieters R,Revesz T,Westers P,Wolfs TF,Bierings MB

更新日期：2011-02-01 00:00:00

abstract：:Investigations of the purine degradative enzymes adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), and ecto-5'-nucleotidase (5'NT) have been shown to be of value in defining subsets of lymphoid malignancies. We have studied the activities of these enzymes in the circulating malignant cells of 35 patien...

journal_title：British journal of haematology

authors： Ho AD,Dörken B,Ma DD,Pezzutto A,Hunstein W,Hoffbrand AV

更新日期：1986-03-01 00:00:00

abstract：:Acute graft-versus-host disease (GVHD) remains a major complication after allogeneic haematopoietic stem cell transplantation (allo-HSCT). The emergence of different immuno-prophylaxis strategies, such as post-transplant cyclophosphamide or anti-thymocyteglobulin has reduced the incidence of acute GVHD in recent years...

journal_title：British journal of haematology

authors： Zeiser R

更新日期：2019-12-01 00:00:00

abstract：:Radiolabelled antiCD-20 antibodies have demonstrated single agent activity in relapsed diffuse large B-cell lymphoma (DLBCL). The S0433 clinical trial enrolled patients with newly diagnosed, advanced stage or bulky stage II, histologically confirmed DLBCL. Patients received six cycles of R-CHOP (rituximab, cyclophosph...

journal_title：British journal of haematology

authors： Friedberg JW,Unger JM,Burack WR,Gopal AK,Raju RN,Nademanee AP,Kaminski MS,Li H,Press OW,Miller TP,Fisher RI

更新日期：2014-08-01 00:00:00

abstract：:We have identified a novel polymorphism located in intron 1a of the human factor VII gene, caused by the nucleotide change G to A at position + 73. In a population of 128 healthy individuals from northern Italy, the variant A73 allele had a frequency of 0.21, whereas the frequency of the previously reported 10 bp inse...

journal_title：British journal of haematology

authors： Peyvandi F,Mannucci PM,Bucciarelli P,Zeinali S,Akhavan S,Sacchi E,Merlini PA,Perry DJ

更新日期：2000-02-01 00:00:00

abstract：:This study was designed to investigate the ability of long-term primary cultures of adult human hepatocytes to secrete the main haemostasis proteins. Factors II, V, VII, VIII, PIVKA-II (protein induced by vitamin K 1 absence or antagonist II), fibrinogen and antithrombin were quantified in culture medium by immunologi...

journal_title：British journal of haematology

authors： Biron-Andréani C,Bezat-Bouchahda C,Raulet E,Pichard-Garcia L,Fabre JM,Saric J,Baulieux J,Schved JF,Maurel P

更新日期：2004-06-01 00:00:00

abstract：:Relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) in those unfit or ineligible for autologous stem cell transplantation is associated with a poor outcome and new treatment approaches are needed. Pixantrone is a novel aza-anthracenedione which is structurally similar to anthracyclines and is licenced i...

journal_title：British journal of haematology

authors： Eyre TA,Linton KM,Rohman P,Kothari J,Cwynarski K,Ardeshna K,Bailey C,Osborne WL,Rowntree C,Eden D,Shankara P,Eyre DW,Jasani P,Chaidos A,Collins GP,Hatton CS

更新日期：2016-06-01 00:00:00

abstract：:Physiological parameters such as pH and oxygen tension probably play significant roles in the regulation of haemopoiesis in the bone marrow microenvironment, but these roles have yet to be characterized in detail. We have found that changes in culture pH (0.2 units) can cause significant changes in the culture composi...

journal_title：British journal of haematology

authors： McAdams TA,Miller WM,Papoutsakis ET

更新日期：1998-11-01 00:00:00

abstract：:We report a case of persistent infection with human parvovirus B19 (PVB19), manifesting clinically as recurrent agranulocytosis and in bone marrow biopsy as recurrent pure granulocytic aplasia. Persistence of parvovirus infection was documented by the presence of PVB19 DNA and anti-PVB19-IgM antibodies in the serum fo...

journal_title：British journal of haematology

authors： Pont J,Puchhammer-Stöckl E,Chott A,Popow-Kraupp T,Kienzer H,Postner G,Honetz N

更新日期：1992-02-01 00:00:00

abstract：:Our study aimed to determine the expression pattern and clinical relevance of CD99 in paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). Our findings demonstrate that high expression levels of CD99 are mainly found in high-risk BCP-ALL, e.g. BCR-ABL1 and CRLF2Re/Hi, and that high CD99 mRNA levels are...

journal_title：British journal of haematology

authors： Chen D,Camponeschi A,Wu Q,Gerasimcik N,Li H,Shen X,Tan Y,Sjögren H,Nordlund J,Lönnerholm G,Abrahamsson J,Fogelstrand L,Mårtensson IL

更新日期：2019-02-01 00:00:00

abstract：:Asparaginase (ASNase) is an important anti-leukaemic drug in the treatment of childhood acute lymphoblastic leukaemia (ALL) and non-Hodgkin lymphoma (NHL). A substantial proportion of patients develop hypersensitivity reactions with anti-ASNase neutralising antibodies, resulting in allergic reactions or silent inactiv...

journal_title：British journal of haematology

authors： Mondelaers V,Ferster A,Uyttebroeck A,Brichard B,van der Werff Ten Bosch J,Norga K,Francotte N,Piette C,Vandemeulebroecke K,Verbeke C,Schmidt S,Benoit Y,Lammens T,De Moerloose B

更新日期：2020-07-01 00:00:00

abstract：:The expression of the VAV proto-oncogene in 57 patients with chronic myeloproliferative disease (CMD), B-cell acute lymphoblastic leukaemia (B-ALL) and B-cell non-Hodgkin Lymphoma (B-NHL), and 61 with B-cell chronic lymphocytic leukaemia (B-CLL) was analysed. VAV overexpression was observed in 19.5% of cases and 81% o...

journal_title：British journal of haematology

authors： Prieto-Sánchez RM,Hernández JA,García JL,Gutiérrez NC,San Miguel J,Bustelo XR,Hernández JM

更新日期：2006-06-01 00:00:00

abstract：:Pentose phosphate shunt activity was studied by the release of 14CO2 from 14C-1-glucose and 14C-2-glucose in the red cells of five patients with pyruvate kinase deficiency and found to be significantly decreased after new methylene blue stimulation when compared to high reticulocyte controls. Incubated Heinz body form...

journal_title：British journal of haematology

authors： Tomoda A,Lachant NA,Noble NA,Tanaka KR

更新日期：1983-07-01 00:00:00

abstract：:The combination of tumour necrosis factor alpha (TNF alpha) and gamma-interferon induced transcription of class I HLA genes in chronic myelogenous leukaemia (CML) cell lines through the formation of a complex between nuclear proteins and the transcriptional enhancers associated with these genes. Although gamma-interfe...

journal_title：British journal of haematology

authors： Seong D,Sims S,Johnson E,Lyding J,Lopez A,Garovoy M,Talpaz M,Kantarjian H,Lopez-Berestein G,Reading C

更新日期：1991-07-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a distinct lymphoma subtype with a particularly poor clinical outcome. The clinical relevance of the morphological characteristics of these tumours remains uncertain. The European MCL Network reviewed 304 cases of MCL to determine the prognostic significance of histopathological character...

journal_title：British journal of haematology

authors： Tiemann M,Schrader C,Klapper W,Dreyling MH,Campo E,Norton A,Berger F,Kluin P,Ott G,Pileri S,Pedrinis E,Feller AC,Merz H,Janssen D,Hansmann ML,Krieken H,Möller P,Stein H,Unterhalt M,Hiddemann W,Parwaresch R,Europ

更新日期：2005-10-01 00:00:00

abstract：:High-dose chemotherapy with melphalan followed by autologous haematopoietic cell transplantation (AHCT) is a standard of care in young patients (<65 years) with multiple myeloma. Most myeloma patients, however, are older than 65 years at the time of diagnosis, and the findings of numerous single-centre and registry st...

journal_title：British journal of haematology

authors： Auner HW,Garderet L,Kröger N

更新日期：2015-11-01 00:00:00

abstract：:The question as to whether autologous stem cell transplantation (SCT) after consolidation chemotherapy improves the probability of survival of patients with acute myeloid leukaemia (AML) in first remission has not been settled. Here, we present the results of a phase III study conducted in newly diagnosed adult AML pa...

journal_title：British journal of haematology

authors： Breems DA,Boogaerts MA,Dekker AW,Van Putten WL,Sonneveld P,Huijgens PC,Van der Lelie J,Vellenga E,Gratwohl A,Verhoef GE,Verdonck LF,Löwenberg B

更新日期：2005-01-01 00:00:00

abstract：:Mature (peripheral) T-cell lymphoma (PTCL) other than anaplastic large cell lymphoma is a heterogeneous group of diseases and exceedingly rare in children and adolescents. Survival rates range between 46% and 85%. This study reports the disease characteristics, treatment and outcome of all patients with the diagnosis ...

journal_title：British journal of haematology

authors： Kontny U,Oschlies I,Woessmann W,Burkhardt B,Lisfeld J,Salzburg J,Janda A,Attarbaschi A,Niggli F,Zimmermann M,Reiter A,Klapper W

更新日期：2015-03-01 00:00:00

abstract：:We report on a 62-year-old female initially suffering from extreme pain in both her lower extremities. Plain radiographs revealed multiple osteolytic lesions. Laboratory analyses indicated high levels of serum calcium and parathyroid hormone related protein (PTHrP) and detected HTLV-1 antibody. Histological examinatio...

journal_title：British journal of haematology

authors： Yamaguchi T,Hirano T,Kumagai K,Tsurumoto T,Shindo H,Majima R,Arima N

更新日期：1999-12-01 00:00:00

abstract：:To assess and define the effects of heterocellular hereditary persistence of fetal haemoglobin (HPFH) on the haematological phenotype of heterozygous beta-thalassaemia, we have studied a large kindred that included a total of 204 subjects with 60 beta-thalassaemia carriers, of whom 35 were also heterozygous, and five ...

journal_title：British journal of haematology

authors： Garner C,Dew TK,Sherwood R,Rees D,Thein SL

更新日期：2003-10-01 00:00:00