Mathematical model for early development of the sea urchin embryo.

Abstract:

:In Xenopus and Drosophila, the nucleocytoplasmic ratio controls many aspects of cell-cycle remodeling during the transitory period that leads from fast and synchronous cell divisions of early development to the slow, carefully regulated growth and divisions of somatic cells. After the fifth cleavage in sea urchin embryos, there are four populations of differently sized blastomeres, whose interdivision times are inversely related to size. The inverse relation suggests nucleocytoplasmic control of cell division during sea urchin development as well. To investigate this possibility, we developed a mathematical model based on molecular interactions underlying early embryonic cell-cycle control. Introducing the nucleocytoplasmic ratio explicitly into the molecular mechanism, we are able to reproduce many physiological features of sea urchin development.

journal_name

Bull Math Biol

authors

Ciliberto A,Tyson JJ

doi

10.1006/bulm.1999.0129

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

37-59

issue

1

eissn

0092-8240

issn

1522-9602

pii

S0092-8240(99)90129-5

journal_volume

62

pub_type

杂志文章
  • The effect of polar lipids on tear film dynamics.

    abstract::In this paper, we present a mathematical model describing the effect of polar lipids, excreted by glands in the eyelid and present on the surface of the tear film, on the evolution of a pre-corneal tear film. We aim to explain the interesting experimentally observed phenomenon that the tear film continues to move upwa...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-010-9555-y

    authors: Aydemir E,Breward CJ,Witelski TP

    更新日期:2011-06-01 00:00:00

  • Fitting a structured juvenile-adult model for green tree frogs to population estimates from capture-mark-recapture field data.

    abstract::We derive point and interval estimates for an urban population of green tree frogs (Hyla cinerea) from capture-mark-recapture field data obtained during the years 2006-2009. We present an infinite-dimensional least-squares approach which compares a mathematical population model to the statistical population estimates ...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-011-9682-0

    authors: Ackleh AS,Carter J,Deng K,Huang Q,Pal N,Yang X

    更新日期:2012-03-01 00:00:00

  • Experimental design for dynamics identification of cellular processes.

    abstract::We address the problem of using nonlinear models to design experiments to characterize the dynamics of cellular processes by using the approach of the Maximally Informative Next Experiment (MINE), which was introduced in W. Dong et al. (PLoS ONE 3(8):e3105, 2008) and independently in M.M. Donahue et al. (IET Syst. Bio...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-014-9935-9

    authors: Dinh V,Rundell AE,Buzzard GT

    更新日期:2014-03-01 00:00:00

  • Mathematical models for the Aedes aegypti dispersal dynamics: travelling waves by wing and wind.

    abstract::Biological invasion is an important area of research in mathematical biology and more so if it concerns species which are vectors for diseases threatening the public health of large populations. That is certainly the case for Aedes aegypti and the dengue epidemics in South America. Without the prospect of an effective...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1016/j.bulm.2004.08.005

    authors: Takahashi LT,Maidana NA,Ferreira WC Jr,Pulino P,Yang HM

    更新日期:2005-05-01 00:00:00

  • Comparing approximations to spatio-temporal models for epidemics with local spread.

    abstract::Analytical methods for predicting and exploring the dynamics of stochastic, spatially interacting populations have proven to have useful application in epidemiology and ecology. An important development has been the increasing interest in spatially explicit models, which require more advanced analytical techniques tha...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1006/bulm.2001.0234

    authors: Filipe JA,Gibson GJ

    更新日期:2001-07-01 00:00:00

  • Modeling optimal intervention strategies for cholera.

    abstract::While cholera has been a recognized disease for two centuries, there is no strategy for its effective control. We formulate a mathematical model to include essential components such as a hyperinfectious, short-lived bacterial state, a separate class for mild human infections, and waning disease immunity. A new result ...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-010-9521-8

    authors: Miller Neilan RL,Schaefer E,Gaff H,Fister KR,Lenhart S

    更新日期:2010-11-01 00:00:00

  • On the fractal geometry of DNA by the binary image analysis.

    abstract::The multifractal analysis of binary images of DNA is studied in order to define a methodological approach to the classification of DNA sequences. This method is based on the computation of some multifractality parameters on a suitable binary image of DNA, which takes into account the nucleotide distribution. The binar...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-013-9859-9

    authors: Cattani C,Pierro G

    更新日期:2013-09-01 00:00:00

  • A mathematical model for the effects of HER2 over-expression on cell cycle progression in breast cancer.

    abstract::In this paper, we present a mathematical model predicting the fraction of proliferating cells in G1, S, and G2/M phases of the cell cycle as a function of EGFR and HER2. We show that it is possible to find parameters for the mathematical model so that its predictions agree with the experimental observations that HER2 ...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-011-9663-3

    authors: Eladdadi A,Isaacson D

    更新日期:2011-12-01 00:00:00

  • A jump-growth model for predator-prey dynamics: derivation and application to marine ecosystems.

    abstract::This paper investigates the dynamics of biomass in a marine ecosystem. A stochastic process is defined in which organisms undergo jumps in body size as they catch and eat smaller organisms. Using a systematic expansion of the master equation, we derive a deterministic equation for the macroscopic dynamics, which we ca...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-009-9496-5

    authors: Datta S,Delius GW,Law R

    更新日期:2010-08-01 00:00:00

  • Modeling the Transmission Dynamics of Rabies for Dog, Chinese Ferret Badger and Human Interactions in Zhejiang Province, China.

    abstract::Human rabies is one of the major public health problems in China with an average of 1977 cases per year. It is estimated that 95% of these human rabies cases are due to dog bites. In recent years, the number of wildlife-associated human rabies cases has increased, particularly in the southeast and northeast regions of...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-018-00537-1

    authors: Huang J,Ruan S,Shu Y,Wu X

    更新日期:2019-04-01 00:00:00

  • Modeling the effects of varicella vaccination programs on the incidence of chickenpox and shingles.

    abstract::Two possible dangers of an extensive varicella vaccination program are more varicella (chickenpox) cases in adults, when the complication rates are higher, and an increase in cases of zoster (shingles). Here an age-structured epidemiologic-demographic model with vaccination is developed for varicella and zoster. Param...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1006/bulm.1999.0126

    authors: Schuette MC,Hethcote HW

    更新日期:1999-11-01 00:00:00

  • Pulse Generation in the Quorum Machinery of Pseudomonas aeruginosa.

    abstract::Pseudomonas aeruginosa is a Gram-negative bacterium that is responsible for a wide range of infections in humans. Colonies employ quorum sensing (QS) to coordinate gene expression, including for virulence factors, swarming motility and complex social traits. The QS signalling system of P. aeruginosa is known to involv...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-017-0288-z

    authors: Alfiniyah C,Bees MA,Wood AJ

    更新日期:2017-06-01 00:00:00

  • Mathematical Modeling of Learning from an Inconsistent Source: A Nonlinear Approach.

    abstract::Continuing the discussion of how children can modify and regularize linguistic inputs from adults, we present a new interpretation of existing algorithms to model and investigate the process of a learner learning from an inconsistent source. On the basis of this approach is a (possibly nonlinear) function (the update ...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-017-0250-0

    authors: Ma T,Komarova NL

    更新日期:2017-03-01 00:00:00

  • Modeling Glucose Metabolism in the Kidney.

    abstract::The mammalian kidney consumes a large amount of energy to support the reabsorptive work it needs to excrete metabolic wastes and to maintain homeostasis. Part of that energy is supplied via the metabolism of glucose. To gain insights into the transport and metabolic processes in the kidney, we have developed a detaile...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-016-0188-7

    authors: Chen Y,Fry BC,Layton AT

    更新日期:2016-06-01 00:00:00

  • Optimizing the Timing and Composition of Therapeutic Phage Cocktails: A Control-Theoretic Approach.

    abstract::Viruses that infect bacteria, i.e., bacteriophage or 'phage,' are increasingly considered as treatment options for the control and clearance of bacterial infections, particularly as compassionate use therapy for multi-drug-resistant infections. In practice, clinical use of phage often involves the application of multi...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-020-00751-w

    authors: Li G,Leung CY,Wardi Y,Debarbieux L,Weitz JS

    更新日期:2020-06-12 00:00:00

  • Competing effects of toxin-producing phytoplankton on overall plankton populations in the bay of Bengal.

    abstract::The coexistence of a large number of phytoplankton species on a seemingly limited variety of resources is a classical problem in ecology, known as 'the paradox of the plankton'. Strong fluctuations in species abundance due to the external factors or competitive interactions leading to oscillations, chaos and short-ter...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-006-9109-5

    authors: Roy S,Alam S,Chattopadhyay J

    更新日期:2006-11-01 00:00:00

  • Evolution of dispersal toward fitness.

    abstract::It is widely believed that the slowest dispersal strategy is selected in the evolutional if the environment is temporally invariant but spatially heterogeneous. Authors claim in this paper that this belief is true only if random dispersals with constant motility are considered. However, if a dispersal strategy with fi...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-013-9904-8

    authors: Kim YJ,Kwon O,Li F

    更新日期:2013-12-01 00:00:00

  • Analyzing the fitch method for reconstructing ancestral states on ultrametric phylogenetic trees.

    abstract::The accuracy of the Fitch method for reconstructing ancestral states on ultrametric phylogenetic trees is studied. Two recurrence relations for computing the accuracy are given here. Using these relations, we analyze the convergence of the accuracy of the Fitch method for reconstructing the root state on a complete bi...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-010-9505-8

    authors: Zhang L,Shen J,Yang J,Li G

    更新日期:2010-10-01 00:00:00

  • An evolution model for sequence length based on residue insertion-deletion independent of substitution: an application to the GC content in bacterial genomes.

    abstract::We introduce here a gene evolution model which is an extension of the time-continuous stochastic IDIS model (Lèbre and Michel in J. Comput. Biol. Chem. 34:259-267, 2010) to sequence length. This new IDISL (Insertion Deletion Independent of Substitution based on sequence Length) model gives an analytical expression of ...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-012-9735-z

    authors: Lèbre S,Michel CJ

    更新日期:2012-08-01 00:00:00

  • A Model for Interstitial Drainage Through a Sliding Lymphatic Valve.

    abstract::This study investigates fluid flow and elastic deformation in tissues that are drained by the primary lymphatic system. A model is formulated based on the Rossi hypothesis that states that the primary lymphatic valves, which are formed by overlapping endothelial cells around the circumferential lining of lymphatic cap...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-015-0078-4

    authors: Heppell C,Roose T,Richardson G

    更新日期:2015-06-01 00:00:00

  • Estimation of cell proliferation dynamics using CFSE data.

    abstract::Advances in fluorescent labeling of cells as measured by flow cytometry have allowed for quantitative studies of proliferating populations of cells. The investigations (Luzyanina et al. in J. Math. Biol. 54:57-89, 2007; J. Math. Biol., 2009; Theor. Biol. Med. Model. 4:1-26, 2007) contain a mathematical model with fluo...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-010-9524-5

    authors: Banks HT,Sutton KL,Thompson WC,Bocharov G,Roose D,Schenkel T,Meyerhans A

    更新日期:2011-01-01 00:00:00

  • Proliferation and competition in discrete biological systems.

    abstract::We study the emergence of collective spatio-temporal objects in biological systems by representing individually the elementary interactions between their microscopic components. We use the immune system as a prototype for such interactions. The results of this detailed explicit analysis are compared with the tradition...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1016/S0092-8240(03)00007-7

    authors: Louzoun Y,Solomon S,Atlan H,Cohen IR

    更新日期:2003-05-01 00:00:00

  • An Alternative to Moment Closure.

    abstract::Moment closure methods are widely used to analyze mathematical models. They are specifically geared toward derivation of approximations of moments of stochastic models, and of similar quantities in other models. The methods possess several weaknesses: Conditions for validity of the approximations are not known, magnit...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-017-0321-2

    authors: Nåsell I

    更新日期:2017-09-01 00:00:00

  • A new model for laser-induced thermal damage in the retina.

    abstract::We describe a new model for laser-induced retinal damage. Our treatment is prompted by the failure of the traditional approach to accurately describe the image size dependence of laser-induced retinal injuries and by a recently reported study which demonstrated that laser injuries to the retina might not appear for up...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1016/S0092-8240(03)00028-4

    authors: Till SJ,Till J,Milsom PK,Rowlands G

    更新日期:2003-07-01 00:00:00

  • Bistability, oscillations, and traveling waves in frog egg extracts.

    abstract::Mathematical modeling is a powerful tool for unraveling the complexities of the molecular regulatory networks underlying all aspects of cell physiology. To support this claim, we review our experiences modeling the cyclin-dependent kinase (CDK) network that controls events of the eukaryotic cell cycle. The model was d...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-014-0009-9

    authors: Tyson JJ,Novak B

    更新日期:2015-05-01 00:00:00

  • Uni-directional interaction and plant-pollinator-robber coexistence.

    abstract::A mathematical model for the plant-pollinator-robber interaction is studied to understand the factors leading to the widespread occurrence and stability of such interactions. In the interaction, a flowering plant provides resource for its pollinator and the pollinator has both positive and negative effects on the plan...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-012-9750-0

    authors: Wang Y,DeAngelis DL,Holland JN

    更新日期:2012-09-01 00:00:00

  • Inferring the dynamics of a spatial epidemic from time-series data.

    abstract::Spatial interactions are key determinants in the dynamics of many epidemiological and ecological systems; therefore it is important to use spatio-temporal models to estimate essential parameters. However, spatially-explicit data sets are rarely available; moreover, fitting spatially-explicit models to such data can be...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1016/j.bulm.2003.09.002

    authors: Filipe JA,Otten W,Gibson GJ,Gilligan CA

    更新日期:2004-03-01 00:00:00

  • Mechanical-statistical modeling in ecology: from outbreak detections to pest dynamics.

    abstract::Knowledge about large-scale and long-term dynamics of (natural) populations is required to assess the efficiency of control strategies, the potential for long-term persistence, and the adaptability to global changes such as habitat fragmentation and global warming. For most natural populations, such as pest population...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-008-9363-9

    authors: Soubeyrand S,Neuvonen S,Penttinen A

    更新日期:2009-02-01 00:00:00

  • An example of model structure differences using sensitivity analyses in physiologically based pharmacokinetic models of trichloroethylene in humans.

    abstract::Trichloroethylene (TCE) is an industrial chemical and an environmental contaminant. TCE and its metabolites may be carcinogenic and affect human health. Physiologically based pharmacokinetic (PBPK) models that differ in compartmentalization are developed for TCE metabolism in humans, and the focus of this investigatio...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1007/s11538-007-9233-x

    authors: Yokley KA,Evans MV

    更新日期:2007-11-01 00:00:00

  • Diverse ideas on the growth kinetics of disseminated cancer cells.

    abstract::Theoretical and empirical arguments are used to support the growth kinetics of disseminated tumors. Employing viable hypotheses, it is established that Gompertzian growth of disseminated cancer cells can be derived from a number of theoretical considerations. Empirical methods are used to validate and confirm the theo...

    journal_title:Bulletin of mathematical biology

    pub_type: 杂志文章

    doi:10.1006/bulm.1999.0165

    authors: Afenya EK,Calderón CP

    更新日期:2000-05-01 00:00:00