Abstract:
BACKGROUND AND OBJECTIVES:The pathogenesis of chancroid is currently unclear. There are discrepancies between the virulence of Haemophilus ducreyi in the human and animal experiments. Iron availability influences the virulence of many pathogens. The objective of this study was to investigate the role of iron in virulence of H. ducreyi. STUDY DESIGN:Intradermal inoculation of the primate Macaca mulatta was studied as an animal model for pathogenesis of chancroid. This model then was used to study the influence of iron availability on virulence of H. ducreyi. Eleven strains of H. ducreyi with proven avirulence in the rabbit intradermal test and one virulent control strain were used. Two of the strains had been shown to cause ulcers in a human inoculation experiment. Strains were suspended in fluid with different iron compounds before intradermal injection. Other monkeys were treated with injectable iron before inoculation with bacteria suspended. RESULTS:All but one of the test strains produced a chancroid-like ulcer from which H. ducreyi could be isolated. The minimal ulcerative dose was 10(5) cfu. Iron in the injection fluid decreased this dose 10-fold. In animals pretreated with intramuscular iron, the minimal ulcerative dose decreased to 10(4) cfu and all eleven strains became ulcerative. CONCLUSIONS:The availability of iron increases virulence of H. ducreyi. The iron pretreated primate model is useful for the study of virulence factors of H. ducreyi because of its ability to produce lesions with strains that avirulent in other animal models but pathogenic to humans.
journal_name
Sex Transm Disjournal_title
Sexually transmitted diseasesauthors
Sturm AWdoi
10.1097/00007435-199702000-00002subject
Has Abstractpub_date
1997-02-01 00:00:00pages
64-8issue
2eissn
0148-5717issn
1537-4521journal_volume
24pub_type
杂志文章abstract:BACKGROUND:Community Approaches to Reducing Sexually Transmitted Disease (CARS), a unique initiative of the US Centers for Disease Control and Prevention, promotes the use of community engagement to increase sexually transmitted disease (STD) prevention, screening, and treatment and to address locally prioritized STD-r...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001267
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Since 2003, outbreaks of lymphogranuloma venereum (LGV) with anorectal syndrome have been increasingly recognized in many Western countries. All of them have been classified as LGV serovar L2b, mainly occurring in human immunodeficiency virus (HIV)-infected men who have had sex with men (MSM). We describe a ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000459
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To describe demographic and geographic trends in gonorrhea incidence in the United States from 1981 through 1996. STUDY DESIGN:We analyzed aggregate gonorrhea cases reported to the Centers for Disease Control and Prevention by the 50 states, District of Columbia, and 63 large cities. Annual incidence rates (...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199808000-00011
更新日期:1998-08-01 00:00:00
abstract::A previously healthy 19-year-old nonpregnant woman had disseminated infection with herpes simplex virus. The disseminated disease was accompanied by hepatitis. The patient was treated with parenteral acyclovir (5 mg/kg) given every 8 hr. The patient's symptoms resolved after three days of therapy. A review of five sim...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198607000-00014
更新日期:1986-07-01 00:00:00
abstract::Neisseria gonorrhoeae and Chlamydia trachomatis screening was performed in a cohort of 100 men who have sex with men. A nucleic acid amplification test on a pooled sample of first-pass urine, pharyngeal, and anorectal specimens was compared with results on nonpooled samples. Despite an excellent agreement (Cohen κ, 0....
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000722
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Herpes simplex virus (HSV) infection is one of the most common viral infections worldwide. Genital herpes is associated with other sexually transmitted infections (STIs) including HIV. Data on prevalence of HSV infections and other STIs in the Kingdom of Saudi Arabia are limited. METHODS:We conducted the fi...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000336
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Sexual concurrency is associated with higher prevalence of sexually transmitted diseases (STDs) including HIV. However, most studies have focused only on the concurrency of the individual participant (individual concurrency) and not on concurrency of their sexual partners (partner concurrency). Furthermore, ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318205e449
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Enzyme-linked immunosorbent assay (ELISA) is the most popular method used by blood banks in China to screen for antibodies to Treponema pallidum (TP). However, this method produces a high percentage of false-positive reactions.The current study aimed to propose a more effective procedure for screening anti-T...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31819db594
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVES:To determine the attitudes of male and female patients to the use of chaperones during genital examination within a sexually transmitted diseases clinic. STUDY DESIGN:An anonymous, self-completed questionnaire was administered to patients attending the Melbourne Sexual Health Centre, Australia, between Sept...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3180ca8f3a
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Although there is evidence for heightened sexually transmitted disease (STD) acquisition among women who experienced sexual violence, little is known about their patterns of STD testing, STD diagnosis, and STD treatment. METHODS:Data was drawn from cycle eight of the National Survey of Family Growth (2011-2...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000651
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:To examine practices of general practitioners' (GPs) in relation to partner notification for chlamydia and identify the supports they would find most useful to assist them. GOAL:To identify innovative resources that could improve partner notification for chlamydia in primary care. STUDY DESIGN:A postal surv...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181b357f6
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The Cuban Ministry of Public Health plans to implement the syndromic approach to sexually transmitted diseases in persons with urethral or vaginal syndrome in Cuba using 500 mg ciprofloxacin as therapy. Although the emergence of clinical isolates of Neisseria gonorrhoeae with decreased suscept...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200102000-00004
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVES:This study examined serologic markers of hepatitis B virus (HBV) infection and immunity among young Asian/Pacific Islander men who have sex with men (API MSM) in San Francisco. METHODS:Participants were 496 API MSM, aged 18 to 29 years, recruited to participate in a cross-sectional survey using a random, ve...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000148296.93945.53
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Since the early 1980s, the Bahamas has experienced sequential epidemics of freebase/crack cocaine use, genital ulcer-inguinal adenopathy disease (GUD), and heterosexual HIV infection. GOAL:To prospectively define the etiology of GUD in patients at the Princess Margaret Hospital during outbreaks of crack coc...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200205000-00001
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Bacterial vaginosis is the most common cause of vaginal symptoms in women and has potential complications. Efforts to improve treatment of this disease process are warranted. GOAL OF THIS STUDY:The goal of this study was to compare the safety and efficacy of once-daily intravaginal administra...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00007435-199903000-00003
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:Adolescents and young adults comprise disproportionately high percentages of individuals living with human immunodeficiency virus (HIV) and those with undiagnosed HIV. Our objective was to determine factors associated with history of HIV testing and receipt of results among a sample of urban, high-risk, sexu...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318214bb70
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Sexually transmitted infections (STIs) continue to exert a tremendous health burden on women in developing countries. Poor socioeconomic status, inadequate knowledge, lack of diagnostic facilities, and shortages of effective treatment all contribute to the high incidence of STIs. The use of clinical algorith...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199909000-00010
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:The integration of HPV-16 DNA into the host genome is considered an important event in the progression of premalignant cervical lesions to cervical cancer. The aim of our study was to assess the prevalence of HPV-16 integration in anal cytologic specimens of HIV-1 infected men and its association with risk f...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181c9c23f
更新日期:2010-05-01 00:00:00
abstract::Heretofore most people affected by warts of the oral cavity were children, but during the past decade adults have become the most frequently seen patients with warts in the mouth. The popularity of fellatio among heterosexuals, teenagers, and adults has contributed to the spread of oral warts. Of epidemiologic interes...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198410000-00001
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Calls for increased investment in sexually transmitted infection (STI) treatment across the developing world have been made to address the high disease burden and the association with HIV transmission. GOALS:The goals of this study were to systematically review evidence on the cost of treating curable STIs ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/01.olq.0000235177.30718.84
更新日期:2006-10-01 00:00:00
abstract:GOAL:To determine prevalence and incidence of Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) infection and assess risk factors predictive for such infections in a middle school-based clinic sample. STUDY DESIGN:170 female students and 43 male students making 256 and 47 visits, respectively, > or = 30 days a...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199809000-00001
更新日期:1998-09-01 00:00:00
abstract::This report describes the cases of seven patients who had primary genital infection with herpes simplex virus and whose initial nontreponemal and treponemal tests for syphilis were nonreactive. On routine posttreatment examination, a change in the consistency of the ulcers was noticed, and the inguinal nodes, which ha...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198007000-00008
更新日期:1980-07-01 00:00:00
abstract::Pelvic inflammatory disease (PID), one of the major sequelae of the current epidemic of sexually transmitted diseases, has been shown to be a polymicrobial infection. This study compares the efficacy and safety of two broad-spectrum combination drug regimens, cefotetan with doxycycline and cefoxitin with doxycycline, ...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007435-199118020-00012
更新日期:1991-04-01 00:00:00
abstract:OBJECTIVES:To evaluate the incidence of early syphilis based on time from initiation of highly active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV)-infected patients. STUDY DESIGN:Five hundred thirty-nine HIV-positive patients undergoing HAART were followed up to 4 years to identify early (prima...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31815b0148
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Nucleic acid amplification tests (NAATs) allow chlamydia screening in asymptomatic women who otherwise may not have pelvic examinations. How often these women have examination findings that may prompt empiric therapy is unclear. OBJECTIVE:The objective of this study was to assess the relationship of chlamyd...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,多中心研究
doi:10.1097/01.olq.0000240344.20665.63
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:The prevalence of gonorrhea (GC) among adolescent and young women attending some urban emergency departments (EDs) ranges from 1% to 7%, but historically screening has not been logistically practical. GOAL:The primary goal of the study was to assess the cost effectiveness of GC screening in women ages 15 to...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000154501.22566.fa
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:A dye-based method for determining applicator usage in microbicide trials has been developed to assess whether applicators have been exposed to vaginal fluid. Our objective was to evaluate this method on polypropylene HTI applicators that are being widely used in several effectiveness trials of microbicides....
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,多中心研究
doi:10.1097/OLQ.0b013e3181972397
更新日期:2009-06-01 00:00:00
abstract::We describe the effects of multiple freeze and thaw cycles on the sensitivity of the immunoglobulins IgG and IgM measured by enzyme-linked immunoassays in the sera of patients with syphilis. Stored frozen sera can withstand repeated freezing and thawing cycles with a minimal detrimental effect on the sensitivity of th...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000036
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:American Indian and Alaska Natives suffer pervasive health disparities, including disproportionately high rates of HIV. Sexual network dynamics, including concurrency and sexual mixing patterns, are key determinants of HIV disparities. METHODS:We analyzed data from the first national study of gay, lesbian, ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181c37e3e
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:The prevalence of human papillomavirus (HPV) infection and the distribution of different HPV genotypes vary greatly within different geographical and ethnic populations, especially in Asia. The HPV infection data based on regional population are extremely important for researchers to develop new efficient HP...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000201
更新日期:2014-12-01 00:00:00