Iron and virulence of Haemophilus ducreyi in a primate model.

Abstract:

BACKGROUND AND OBJECTIVES:The pathogenesis of chancroid is currently unclear. There are discrepancies between the virulence of Haemophilus ducreyi in the human and animal experiments. Iron availability influences the virulence of many pathogens. The objective of this study was to investigate the role of iron in virulence of H. ducreyi. STUDY DESIGN:Intradermal inoculation of the primate Macaca mulatta was studied as an animal model for pathogenesis of chancroid. This model then was used to study the influence of iron availability on virulence of H. ducreyi. Eleven strains of H. ducreyi with proven avirulence in the rabbit intradermal test and one virulent control strain were used. Two of the strains had been shown to cause ulcers in a human inoculation experiment. Strains were suspended in fluid with different iron compounds before intradermal injection. Other monkeys were treated with injectable iron before inoculation with bacteria suspended. RESULTS:All but one of the test strains produced a chancroid-like ulcer from which H. ducreyi could be isolated. The minimal ulcerative dose was 10(5) cfu. Iron in the injection fluid decreased this dose 10-fold. In animals pretreated with intramuscular iron, the minimal ulcerative dose decreased to 10(4) cfu and all eleven strains became ulcerative. CONCLUSIONS:The availability of iron increases virulence of H. ducreyi. The iron pretreated primate model is useful for the study of virulence factors of H. ducreyi because of its ability to produce lesions with strains that avirulent in other animal models but pathogenic to humans.

journal_name

Sex Transm Dis

authors

Sturm AW

doi

10.1097/00007435-199702000-00002

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

64-8

issue

2

eissn

0148-5717

issn

1537-4521

journal_volume

24

pub_type

杂志文章
  • Critical Elements of Community Engagement to Address Disparities and Related Social Determinants of Health: The Centers of Disease Control and Prevention Community Approaches to Reducing Sexually Transmitted Disease Initiative.

    abstract:BACKGROUND:Community Approaches to Reducing Sexually Transmitted Disease (CARS), a unique initiative of the US Centers for Disease Control and Prevention, promotes the use of community engagement to increase sexually transmitted disease (STD) prevention, screening, and treatment and to address locally prioritized STD-r...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000001267

    authors: Rhodes SD,Daniel-Ulloa J,Wright SS,Mann-Jackson L,Johnson DB,Hayes NA,Valentine JA

    更新日期:2021-01-01 00:00:00

  • Anorectal Lymphogranuloma Venereum in Madrid: A Persistent Emerging Problem in Men Who Have Sex With Men.

    abstract:BACKGROUND:Since 2003, outbreaks of lymphogranuloma venereum (LGV) with anorectal syndrome have been increasingly recognized in many Western countries. All of them have been classified as LGV serovar L2b, mainly occurring in human immunodeficiency virus (HIV)-infected men who have had sex with men (MSM). We describe a ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000459

    authors: Cabello Úbeda A,Fernández Roblas R,García Delgado R,Martínez García L,Sterlin F,Fernández Guerrero ML,Górgolas M

    更新日期:2016-07-01 00:00:00

  • Gonorrhea in the United States, 1981-1996. Demographic and geographic trends.

    abstract:OBJECTIVE:To describe demographic and geographic trends in gonorrhea incidence in the United States from 1981 through 1996. STUDY DESIGN:We analyzed aggregate gonorrhea cases reported to the Centers for Disease Control and Prevention by the 50 states, District of Columbia, and 63 large cities. Annual incidence rates (...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199808000-00011

    authors: Fox KK,Whittington WL,Levine WC,Moran JS,Zaidi AA,Nakashima AK

    更新日期:1998-08-01 00:00:00

  • Hepatitis due to herpes simplex virus in a nonpregnant patient: treatment with acyclovir.

    abstract::A previously healthy 19-year-old nonpregnant woman had disseminated infection with herpes simplex virus. The disseminated disease was accompanied by hepatitis. The patient was treated with parenteral acyclovir (5 mg/kg) given every 8 hr. The patient's symptoms resolved after three days of therapy. A review of five sim...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198607000-00014

    authors: Baxter RP,Phillips LE,Faro S,Hoffman L

    更新日期:1986-07-01 00:00:00

  • Screening for Chlamydia trachomatis and Neisseria gonorrhoeae Infections in Men Who Have Sex With Men: Diagnostic Accuracy of Nucleic Acid Amplification Test on Pooled Urine, Anorectal, and Pharyngeal Specimens.

    abstract::Neisseria gonorrhoeae and Chlamydia trachomatis screening was performed in a cohort of 100 men who have sex with men. A nucleic acid amplification test on a pooled sample of first-pass urine, pharyngeal, and anorectal specimens was compared with results on nonpooled samples. Despite an excellent agreement (Cohen κ, 0....

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000722

    authors: Thielemans E,Wyndham-Thomas C,Henrard S,De Vleeschouwer A,Steensels D,Montesinos I,Debaisieux L,Delforge ML,Van Vooren JP,Goffard JC

    更新日期:2018-03-01 00:00:00

  • Seroprevalence of Herpes Simplex Virus Type 1 and Type 2 and Coinfection With HIV and Syphilis: The First National Seroprevalence Survey in Saudi Arabia.

    abstract:BACKGROUND:Herpes simplex virus (HSV) infection is one of the most common viral infections worldwide. Genital herpes is associated with other sexually transmitted infections (STIs) including HIV. Data on prevalence of HSV infections and other STIs in the Kingdom of Saudi Arabia are limited. METHODS:We conducted the fi...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000336

    authors: Memish ZA,Almasri M,Chentoufi AA,Al-Tawfiq JA,Al-Shangiti AM,Al-Kabbani KM,Otaibi B,Assirri A,Yezli S

    更新日期:2015-09-01 00:00:00

  • Concurrent sexual partnerships and sexually transmitted diseases in Russia.

    abstract:BACKGROUND:Sexual concurrency is associated with higher prevalence of sexually transmitted diseases (STDs) including HIV. However, most studies have focused only on the concurrency of the individual participant (individual concurrency) and not on concurrency of their sexual partners (partner concurrency). Furthermore, ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e318205e449

    authors: Zhan W,Krasnoselskikh TV,Niccolai LM,Golovanov S,Kozlov AP,Abdala N

    更新日期:2011-06-01 00:00:00

  • Evaluation of immunoglobulin M and G Western blot and ELISA for screening antibodies to Treponema pallidum in blood donors.

    abstract:BACKGROUND:Enzyme-linked immunosorbent assay (ELISA) is the most popular method used by blood banks in China to screen for antibodies to Treponema pallidum (TP). However, this method produces a high percentage of false-positive reactions.The current study aimed to propose a more effective procedure for screening anti-T...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e31819db594

    authors: Wang LN,Li JM

    更新日期:2009-07-01 00:00:00

  • The differing views of male and female patients toward chaperones for genital examinations in a sexual health setting.

    abstract:OBJECTIVES:To determine the attitudes of male and female patients to the use of chaperones during genital examination within a sexually transmitted diseases clinic. STUDY DESIGN:An anonymous, self-completed questionnaire was administered to patients attending the Melbourne Sexual Health Centre, Australia, between Sept...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3180ca8f3a

    authors: Teague R,Newton D,Fairley CK,Hocking J,Pitts M,Bradshaw C,Chen M

    更新日期:2007-12-01 00:00:00

  • Understanding the Effects of Forced Sex on Sexually Transmitted Disease Acquisition and Sexually Transmitted Disease Care: Findings From the National Survey of Family Growth (2011-2013).

    abstract:BACKGROUND:Although there is evidence for heightened sexually transmitted disease (STD) acquisition among women who experienced sexual violence, little is known about their patterns of STD testing, STD diagnosis, and STD treatment. METHODS:Data was drawn from cycle eight of the National Survey of Family Growth (2011-2...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000651

    authors: Brookmeyer KA,Beltran O,Abad N

    更新日期:2017-10-01 00:00:00

  • Innovative resources could help improve partner notification for chlamydia in primary care.

    abstract:OBJECTIVE:To examine practices of general practitioners' (GPs) in relation to partner notification for chlamydia and identify the supports they would find most useful to assist them. GOAL:To identify innovative resources that could improve partner notification for chlamydia in primary care. STUDY DESIGN:A postal surv...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3181b357f6

    authors: Bilardi JE,Hopkins CA,Fairley CK,Hocking JS,Tomnay JE,Pavlin NL,Parker RM,Temple-Smith MJ,Bowden FJ,Russell DB,Pitts M,Chen MY

    更新日期:2009-12-01 00:00:00

  • Neisseria gonorrhoeae resistant to ciprofloxacin: first report in Cuba.

    abstract:BACKGROUND AND OBJECTIVES:The Cuban Ministry of Public Health plans to implement the syndromic approach to sexually transmitted diseases in persons with urethral or vaginal syndrome in Cuba using 500 mg ciprofloxacin as therapy. Although the emergence of clinical isolates of Neisseria gonorrhoeae with decreased suscept...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200102000-00004

    authors: Llanes R,Sosa J,Guzmán D,Gutiérrez Y,Llop A,Ricardo O

    更新日期:2001-02-01 00:00:00

  • High level of hepatitis B infection and ongoing risk among Asian/Pacific Islander men who have sex with men, San Francisco, 2000-2001.

    abstract:OBJECTIVES:This study examined serologic markers of hepatitis B virus (HBV) infection and immunity among young Asian/Pacific Islander men who have sex with men (API MSM) in San Francisco. METHODS:Participants were 496 API MSM, aged 18 to 29 years, recruited to participate in a cross-sectional survey using a random, ve...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000148296.93945.53

    authors: Choi KH,McFarland W,Neilands TB,Nguyen S,Secura G,Behel S,Mackellar D,Valleroy L

    更新日期:2005-01-01 00:00:00

  • Epidemic Lymphogranuloma venereum during epidemics of crack cocaine use and HIV infection in the Bahamas.

    abstract:BACKGROUND:Since the early 1980s, the Bahamas has experienced sequential epidemics of freebase/crack cocaine use, genital ulcer-inguinal adenopathy disease (GUD), and heterosexual HIV infection. GOAL:To prospectively define the etiology of GUD in patients at the Princess Margaret Hospital during outbreaks of crack coc...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-200205000-00001

    authors: Bauwens JE,Orlander H,Gomez MP,Lampe M,Morse S,Stamm WE,Cone R,Ashley R,Swenson P,Holmes KK

    更新日期:2002-05-01 00:00:00

  • Comparison of once-daily and twice-daily dosing of 0.75% metronidazole gel in the treatment of bacterial vaginosis.

    abstract:BACKGROUND AND OBJECTIVES:Bacterial vaginosis is the most common cause of vaginal symptoms in women and has potential complications. Efforts to improve treatment of this disease process are warranted. GOAL OF THIS STUDY:The goal of this study was to compare the safety and efficacy of once-daily intravaginal administra...

    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00007435-199903000-00003

    authors: Livengood CH 3rd,Soper DE,Sheehan KL,Fenner DE,Martens MG,Nelson AL,Ismail M,Thorp JM,Lappin M,Long BJ,Blackwelder T,Sweet RL,Sagov S

    更新日期:1999-03-01 00:00:00

  • Correlates of HIV testing history among urban youth recruited through venue-based testing in 15 US cities.

    abstract:BACKGROUND:Adolescents and young adults comprise disproportionately high percentages of individuals living with human immunodeficiency virus (HIV) and those with undiagnosed HIV. Our objective was to determine factors associated with history of HIV testing and receipt of results among a sample of urban, high-risk, sexu...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e318214bb70

    authors: Straub DM,Arrington-Sanders R,Harris DR,Willard N,Kapogiannis B,Emmanuel P,Futterman D,Ellen JM,Adolescent Trials Network for HIV\/AIDS Interventions.

    更新日期:2011-08-01 00:00:00

  • Predicting Neisseria gonorrhoeae and Chlamydia trachomatis infection using risk scores, physical examination, microscopy, and leukocyte esterase urine dipsticks among asymptomatic women attending a family planning clinic in Kenya.

    abstract:BACKGROUND:Sexually transmitted infections (STIs) continue to exert a tremendous health burden on women in developing countries. Poor socioeconomic status, inadequate knowledge, lack of diagnostic facilities, and shortages of effective treatment all contribute to the high incidence of STIs. The use of clinical algorith...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199909000-00010

    authors: Tyndall MW,Kidula N,Sande J,Ombette J,Temmerman M

    更新日期:1999-09-01 00:00:00

  • Human papillomavirus 16 integration and risk factors associated in anal samples of HIV-1 infected men.

    abstract:BACKGROUND:The integration of HPV-16 DNA into the host genome is considered an important event in the progression of premalignant cervical lesions to cervical cancer. The aim of our study was to assess the prevalence of HPV-16 integration in anal cytologic specimens of HIV-1 infected men and its association with risk f...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3181c9c23f

    authors: Cañadas MP,Darwich L,Sirera G,Bofill M,Piñol M,Garcia-Cuyas F,Llatjos M,Corbasi P,Clotet B,Videla S,HIV-HPV Can Ruti Study Group.

    更新日期:2010-05-01 00:00:00

  • The management of warts of the oral cavity.

    abstract::Heretofore most people affected by warts of the oral cavity were children, but during the past decade adults have become the most frequently seen patients with warts in the mouth. The popularity of fellatio among heterosexuals, teenagers, and adults has contributed to the spread of oral warts. Of epidemiologic interes...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198410000-00001

    authors: Fiumara NJ

    更新日期:1984-10-01 00:00:00

  • The costs of treating curable sexually transmitted infections in low- and middle-income countries: a systematic review.

    abstract:BACKGROUND:Calls for increased investment in sexually transmitted infection (STI) treatment across the developing world have been made to address the high disease burden and the association with HIV transmission. GOALS:The goals of this study were to systematically review evidence on the cost of treating curable STIs ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,评审

    doi:10.1097/01.olq.0000235177.30718.84

    authors: Terris-Prestholt F,Vyas S,Kumaranayake L,Mayaud P,Watts C

    更新日期:2006-10-01 00:00:00

  • Screening for gonorrhea and chlamydia by DNA amplification in adolescents attending middle school health centers. Opportunity for early intervention.

    abstract:GOAL:To determine prevalence and incidence of Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) infection and assess risk factors predictive for such infections in a middle school-based clinic sample. STUDY DESIGN:170 female students and 43 male students making 256 and 47 visits, respectively, > or = 30 days a...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-199809000-00001

    authors: Burstein GR,Waterfield G,Joffe A,Zenilman JM,Quinn TC,Gaydos CA

    更新日期:1998-09-01 00:00:00

  • Primary herpes simplex and primary syphilis: a description of seven cases.

    abstract::This report describes the cases of seven patients who had primary genital infection with herpes simplex virus and whose initial nontreponemal and treponemal tests for syphilis were nonreactive. On routine posttreatment examination, a change in the consistency of the ulcers was noticed, and the inguinal nodes, which ha...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/00007435-198007000-00008

    authors: Fiumara NJ,Schmidt-Ulrick B,Comite H

    更新日期:1980-07-01 00:00:00

  • Comparison of cefotetan plus doxycycline with cefoxitin plus doxycycline in the inpatient treatment of acute salpingitis.

    abstract::Pelvic inflammatory disease (PID), one of the major sequelae of the current epidemic of sexually transmitted diseases, has been shown to be a polymicrobial infection. This study compares the efficacy and safety of two broad-spectrum combination drug regimens, cefotetan with doxycycline and cefoxitin with doxycycline, ...

    journal_title:Sexually transmitted diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007435-199118020-00012

    authors: Walker CK,Landers DV,Ohm-Smith MJ,Robbie MO,Luft J,Schachter J,Sweet RL

    更新日期:1991-04-01 00:00:00

  • Effect of highly active antiretroviral therapy on incidence of early syphilis in HIV-infected patients.

    abstract:OBJECTIVES:To evaluate the incidence of early syphilis based on time from initiation of highly active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV)-infected patients. STUDY DESIGN:Five hundred thirty-nine HIV-positive patients undergoing HAART were followed up to 4 years to identify early (prima...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e31815b0148

    authors: Park WB,Jang HC,Kim SH,Kim HB,Kim NJ,Oh MD,Choe KW

    更新日期:2008-03-01 00:00:00

  • Pelvic examination findings and Chlamydia trachomatis infection in asymptomatic young women screened with a nucleic acid amplification test.

    abstract:BACKGROUND:Nucleic acid amplification tests (NAATs) allow chlamydia screening in asymptomatic women who otherwise may not have pelvic examinations. How often these women have examination findings that may prompt empiric therapy is unclear. OBJECTIVE:The objective of this study was to assess the relationship of chlamyd...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.olq.0000240344.20665.63

    authors: Geisler WM,Chow JM,Schachter J,McCormack WM

    更新日期:2007-06-01 00:00:00

  • The cost effectiveness of gonorrhea screening in urban emergency departments.

    abstract:BACKGROUND:The prevalence of gonorrhea (GC) among adolescent and young women attending some urban emergency departments (EDs) ranges from 1% to 7%, but historically screening has not been logistically practical. GOAL:The primary goal of the study was to assess the cost effectiveness of GC screening in women ages 15 to...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/01.olq.0000154501.22566.fa

    authors: Aledort JE,Hook EW 3rd,Weinstein MC,Goldie SJ

    更新日期:2005-07-01 00:00:00

  • Limitations of the dye-based method for determining vaginal applicator use in microbicide trials.

    abstract:BACKGROUND:A dye-based method for determining applicator usage in microbicide trials has been developed to assess whether applicators have been exposed to vaginal fluid. Our objective was to evaluate this method on polypropylene HTI applicators that are being widely used in several effectiveness trials of microbicides....

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1097/OLQ.0b013e3181972397

    authors: Austin MN,Rabe LK,Hillier SL

    更新日期:2009-06-01 00:00:00

  • Effect of multiple freeze and thaw cycles on the sensitivity of IgG and IgM immunoglobulins in the sera of patients with syphilis.

    abstract::We describe the effects of multiple freeze and thaw cycles on the sensitivity of the immunoglobulins IgG and IgM measured by enzyme-linked immunoassays in the sera of patients with syphilis. Stored frozen sera can withstand repeated freezing and thawing cycles with a minimal detrimental effect on the sensitivity of th...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000036

    authors: Castro AR,Jost HA

    更新日期:2013-11-01 00:00:00

  • Sexual partner concurrency and sexual risk among gay, lesbian, bisexual, and transgender American Indian/Alaska natives.

    abstract:BACKGROUND:American Indian and Alaska Natives suffer pervasive health disparities, including disproportionately high rates of HIV. Sexual network dynamics, including concurrency and sexual mixing patterns, are key determinants of HIV disparities. METHODS:We analyzed data from the first national study of gay, lesbian, ...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0b013e3181c37e3e

    authors: Cassels S,Pearson CR,Walters K,Simoni JM,Morris M

    更新日期:2010-04-01 00:00:00

  • Prevalence of human papillomavirus infection in Guangdong Province, China: a population-based survey of 78,355 women.

    abstract:BACKGROUND:The prevalence of human papillomavirus (HPV) infection and the distribution of different HPV genotypes vary greatly within different geographical and ethnic populations, especially in Asia. The HPV infection data based on regional population are extremely important for researchers to develop new efficient HP...

    journal_title:Sexually transmitted diseases

    pub_type: 杂志文章

    doi:10.1097/OLQ.0000000000000201

    authors: Jing L,Zhong X,Zhong Z,Huang W,Liu Y,Yang G,Zhang X,Zou J,Jing C,Wei X

    更新日期:2014-12-01 00:00:00