Abstract：
:A high-performance chromatographic method is described for simultaneous determination of ambroxol in the presence of different preservatives in syrups. The method separates ambroxol from methyl- ethyl-, propyl- and butyl paraben and from other multi-component mixtures. The retention behaviour of ambroxol and parabens as a function of both pH and mobile phase composition was investigated. The eluents were monitored with a UV detector at 247 nm. Linear relationships between the amount of pharmaceutical compounds and peak heights were confirmed at the concentrations of 0.74-14.08 microg ml(-1). The high recovery (no extraction of the samples is required) and the low %RSD confirm the suitability of the proposed method for the determination of ambroxol in different pharmaceutical preparations.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Koundourellis JE,Malliou ET,Broussali TAdoi
10.1016/s0731-7085(00)00318-6subject
Has Abstractpub_date
2000-08-15 00:00:00pages
469-75issue
2-3eissn
0731-7085issn
1873-264Xpii
S0731-7085(00)00318-6journal_volume
23pub_type
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