HLA-DQB1 and HLA-DPB1 genotypes in severe preeclampsia.

Abstract:

OBJECTIVE:To clarify whether there are susceptible HLA-DQB1 or HLA-DPB1 alleles in women with preeclampsia. METHODS:The frequency of HLA-DQB1 and HLA-DPB1 alleles was analyzed in 47 women with previous severe preeclampsia and compared with that in 85 normal fertile women. The types of HLA-DQB1 and HLA-DPB1 alleles were assessed using a polymerase chain reaction-restriction fragment length polymorphism method. RESULTS:The frequency of HLA-DQB1*04 allele in previously preeclamptic women was 21.3% (20 of 94 loci) and in the controls was 11.2% (19 of 170 loci). Thus, the HLA-DQB1*04 allele frequency was significantly higher in preeclamptic women compared with controls (P <.05 by chi(2) test, OR 2.15, 95% confidence interval 1.08, 4.27). The frequency of other HLA-DQB1 alleles and all HLA-DPB1 alleles was not significantly different between groups. The incidence of homozygosity of HLA-DQB1 or HLA-DPB1 alleles in preeclamptic women was not significantly different compared with that of normal fertile women. CONCLUSION:These data suggest that women who have the HLA-DQB1*04 allele might be susceptible to preeclampsia.

journal_name

Obstet Gynecol

authors

Honda K,Takakuwa K,Hataya I,Yasuda M,Kurabayashi T,Tanaka K

doi

10.1016/s0029-7844(00)00918-2

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

385-9

issue

3

eissn

0029-7844

issn

1873-233X

pii

S0029-7844(00)00918-2

journal_volume

96

pub_type

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