Abstract：
PURPOSE/OBJECTIVES:To describe the pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency, which predisposes patients with cancer to potentially lethal adverse reactions following 5-fluorouracil (5-FU)-based chemotherapy. DATA SOURCES:Published articles, abstracts, and conference proceedings. DATA SYNTHESIS:Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU. Diagnosis of DPD deficiency must be confirmed by specialized laboratory tests. The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma. CONCLUSIONS:Early recognition of this serious pharmacogenetic syndrome may allow for the modification of future chemotherapy, thus avoiding further life-threatening toxicities. IMPLICATIONS FOR NURSING PRACTICE:Nurses must understand the pharmacology, mechanism of action, clinical presentation, potentially lethal risks, and traumatic psychosocial stresses experienced by DPD-deficient patients with cancer receiving 5-FU therapy in order to develop timely interventions and alternative plans of care.
journal_name
Oncol Nurs Forumjournal_title
Oncology nursing forumauthors
Morrison GB,Bastian A,Dela Rosa T,Diasio RB,Takimoto CHsubject
Has Abstractpub_date
1997-01-01 00:00:00pages
83-8issue
1eissn
0190-535Xissn
1538-0688journal_volume
24pub_type
杂志文章,评审abstract：PURPOSE/OBJECTIVES:To measure and compare oncology clinical nurse specialists' (OCNSs) perceptions of patient outcomes influenced through their practice and barriers to outcome production. DESIGN:Descriptive survey. SETTING:National. SAMPLE:104 members of the Oncology Nursing Society Clinical Nurse Specialist Specia...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：PURPOSE/OBJECTIVES:To examine relationships between coping resources and self-rated health among Latina breast cancer survivors. DESIGN:Cross-sectional telephone survey. SETTING:Four northern California counties. SAMPLE:330 Latina breast cancer survivors within one to five years of diagnosis. METHODS:Telephone surv...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：10.1188/11.ONF.523-531
更新日期：2011-09-01 00:00:00
abstract：PURPOSE/OBJECTIVES:To review clinical applications and nursing care activities for patients receiving cladribine, a synthetic antineoplastic agent used to treat lymphoid malignancies. DATA SOURCES:Clinical trial data, published articles, reports from oncology nurses, and personal observations. DATA SYNTHESIS:Cladribi...
journal_title：Oncology nursing forum
pub_type： 杂志文章,评审
doi：
更新日期：1995-10-01 00:00:00
abstract：PURPOSE/OBJECTIVES:To explore the meaning of the illness to the family and family quality of life (QOL) for survivors and family members and to describe similarities and differences between survivors' and family members' meaning of the illness and family QOL. RESEARCH APPROACH:Descriptive, qualitative. SETTING:Homes ...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：10.1188/02.ONF.1117-1125
更新日期：2002-08-01 00:00:00
abstract：PURPOSE/OBJECTIVES:To determine whether perceptions of quality of life (QOL) change over time in patients with non-small cell lung cancer (NSCLC) who receive curative radiation therapy (XRT). DESIGN:Descriptive, longitudinal. SETTING:Radiotherapy clinic of a comprehensive cancer center. SAMPLE:23 patients with NSCLC...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
abstract：:A recent post on The Scholarly Kitchen website got me thinking about the role of social media in my professional life. I have young adult children who keep me in the loop about social trends to some extent. They instructed me to join Facebook many years ago and, since then, I have remembered friends' and relatives' bi...
journal_title：Oncology nursing forum
pub_type： 社论
doi：10.1188/19.ONF.517-518
更新日期：2019-09-01 00:00:00
abstract：PURPOSE/OBJECTIVES:To measure the association between physical activity and social cognitive theory constructs during breast cancer treatment. DESIGN:Cross-sectional survey. SETTING:Midwestern, academic oncology clinic. SAMPLE:21 primarily Caucasian (90%) female patients with breast cancer undergoing treatment. 76% ...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：10.1188/05.ONF.807-815
更新日期：2005-07-01 00:00:00
abstract：PURPOSE/OBJECTIVES:To compare the effectiveness of two low-intensity approaches for distressed patients with cancer and caregivers who had called cancer helplines seeking support. Baseline distress was hypothesized as a moderator of intervention effect. DESIGN:Randomized trial. SETTING:Community-based cancer helpline...
journal_title：Oncology nursing forum
pub_type： 杂志文章,随机对照试验
doi：10.1188/14.ONF.E256-E266
更新日期：2014-07-01 00:00:00
abstract：PURPOSE/OBJECTIVES:To explore perceptions of spirituality in women who had undergone a breast diagnostic experience. RESEARCH APPROACH:Qualitative, phenomenologic study using Giorgi's approach. SETTING:An outpatient comprehensive breast assessment center. PARTICIPANTS:20 Caucasian women, aged 30-89, who had just com...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：10.1188/06.ONF.121-126
更新日期：2006-01-01 00:00:00
abstract：:Chemotherapy-induced nausea and vomiting (CINV) is a phenomenon common to patients being treated for a solid or hematologic malignancy. This adverse effect to cancer treatment persists in about half of all patients receiving highly emetogenic treatment, despite prophylaxis with serotonin (5-hydroxytryptamine-3 [5-HT3]...
journal_title：Oncology nursing forum
pub_type： 杂志文章,评审
doi：10.1188/16.ONF.389-393
更新日期：2016-05-01 00:00:00
abstract：PURPOSE/OBJECTIVES:to describe the types of pain patients in palliative care at home experience and how family caregivers assess them and intervene. RESEARCH APPROACH:qualitative using grounded theory. SETTING:family caregivers' homes. PARTICIPANTS:24 family caregivers of patients with advanced cancer receiving pall...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：10.1188/11.ONF.E37-E45
更新日期：2011-01-01 00:00:00
abstract：:Little is known about how/why women who receive adjuvant chemotherapy treatment, hormone therapy, or radiation for nonmetastatic breast cancer gain weight. This study's purpose was to use the restraint-disinhibition model to understand susceptibility to weight gain, and the potential impact of exercise and dysphoria. ...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：PROBLEM IDENTIFICATION:Oral anticancer medication (OAM) use has been steadily increasing, leading to several patient benefits. A notable challenge for nurses is accurate monitoring of patient OAM regimens because nonadherence is associated with poor health outcomes and decreased survival. Currently, no gold standard me...
journal_title：Oncology nursing forum
pub_type： 杂志文章,评审
doi：10.1188/16.ONF.576-582
更新日期：2016-09-01 00:00:00
abstract：PURPOSE/OBJECTIVES:To examine perceptions, attitudes, and beliefs regarding barriers and facilitators to prostate cancer screening, and to identify potential interventional strategies to promote prostate cancer screening among Filipino men in Hawaii. DESIGN:Exploratory, qualitative. SETTING:Community-based settings i...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：10.1188/11.ONF.227-233
更新日期：2011-03-01 00:00:00
abstract：:One goal of oncology nursing is to help patients achieve the best possible quality of life. In the conventional care perspective, quality of life has four aspects: physical, emotional, social, and spiritual. From the complementary care perspective, it is defined as harmony of body, mind, and spirit. Integrating these ...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：10.1188/02.ONF.25-27
更新日期：2002-01-01 00:00:00
abstract：PURPOSES/OBJECTIVES:To describe the importance of a professional code of ethics and values in guiding and supporting the practice of nurses and to present the proposed Oncology Nursing Society (ONS) Statement of Core Values. DATA SOURCES:Published articles and books on nursing ethics and bioethics, as well as authors'...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：:Purpose/Objectives: To examine relationships between capacity to direct attention and the quality-of-life (QOL) domains of psychological and physical well-being in breast cancer survivors.Design: Descriptive, correlational.Setting: National Cancer Institute-designated oncology and county hospital outpatient clinics in...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：10.1188/09.ONF.326-334
更新日期：2009-05-01 00:00:00
abstract：:Adapting to a cancer diagnosis requires much time, energy, and effort. Patients, who often feel stressed and vulnerable, use several cognitive processes to help protect themselves and adapt to the illness. Denial, attributions, downward comparison, reappraisal of life, and developing a sense of mastery are some of the...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：OBJECTIVES:To explore symptom clusters during proton beam therapy in patients with primary brain tumors and investigate associations among symptom clusters, demographic variables, and comorbidity in this patient population. SAMPLE & SETTING:Data were collected from 187 adult patients with primary brain tumors duri...
journal_title：Oncology nursing forum
pub_type： 杂志文章,多中心研究
doi：10.1188/19.ONF.349-363
更新日期：2019-05-01 00:00:00
abstract：:The complexity inherent in the inpatient oncology population requires effective interprofessional collaboration and integrated evidence-based practice (EBP), drawing from each of the disciplines to achieve desired outcomes. Each member of the team lends a strength and expertise that, when combined, often results in ou...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：10.1188/14.ONF.548-550
更新日期：2014-09-01 00:00:00
abstract：PURPOSE/OBJECTIVES:To describe women's representations of fatigue and fatigue-related coping efforts by women receiving chemotherapy. DESIGN:Descriptive, correlational. SETTING:Outpatient gynecologic oncology clinic. SAMPLE:Women receiving chemotherapy for gynecologic cancers. Fifty-four women were recruited; 49 (91...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：10.1188/05.ONF.113-116
更新日期：2005-01-19 00:00:00
abstract：PURPOSE/OBJECTIVES:To assess and describe health beliefs, level of knowledge about skin cancer, current skin cancer prevention practices, and cues to preventive action of Wisconsin dairy farmers. DESIGN:Descriptive survey. SETTING:Rural Wisconsin. SAMPLE:A stratified random sample of 535 male dairy farmers from the ...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：PURPOSE/OBJECTIVES:To identify overall perceptions of burnout within the inpatient oncology nursing population, how they perceived that burnout affected the care they provided, and how they perceived that burnout could be decreased. . DESIGN:A quantitative descriptive study using questionnaires to describe perceptions...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：10.1188/16.ONF.103-109
更新日期：2016-01-01 00:00:00
abstract：PROBLEM IDENTIFICATION:Genetic counseling is vital in helping people at high risk for hereditary breast and ovarian cancer (HBOC) make informed decisions to undergo BRCA testing. Many people, particularly those in rural locations, lack access to these services. This review examines evidence to determine if remotely del...
journal_title：Oncology nursing forum
pub_type： 杂志文章,评审
doi：10.1188/18.ONF.96-105
更新日期：2018-01-01 00:00:00
abstract：PROBLEM IDENTIFICATION:Survivorship care plans (SCPs) and treatment summaries (TSs) have been recommended by the Institute of Medicine as ways to facilitate the delivery of holistic survivorship care. An integrative literature review was undertaken to identify current use of SCPs and TSs to meet the needs of survivors ...
journal_title：Oncology nursing forum
pub_type： 杂志文章,评审
doi：10.1188/15.ONF.283-291
更新日期：2015-05-01 00:00:00
abstract：PURPOSE/OBJECTIVES:To investigate the relationships among physiologic variables, fatigue, and quality of life (QOL) in patients with multiple myeloma. DESIGN:Cross-sectional, descriptive, exploratory. SETTING:Outpatient ambulatory care clinics at a tertiary oncology center. SAMPLE:56 patients with multiple myeloma w...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：10.1188/09.ONF.209-216
更新日期：2009-03-01 00:00:00
abstract：:This study explored the relationships among medical fears, coping behaviors, and acute pain perceptions in 17 children with cancer who were encountering a painful medical procedure. The children completed the Child Medical Fear Scale (CMFS) before undergoing a lumbar puncture (LP), which was videotaped. The children's...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：PURPOSE/OBJECTIVES:To analyze predictors of adjustment and growth in women who had experienced recurrent ovarian cancer using components of the Resiliency Model of Family Stress, Adjustment, and Adaptation as a conceptual framework. DESIGN:Cross-sectional. SETTING:Participants were recruited from national cancer advo...
journal_title：Oncology nursing forum
pub_type： 杂志文章
doi：10.1188/10.ONF.357-364
更新日期：2010-05-01 00:00:00
abstract：:This paper explores the existence and effects of ageism on cancer care of the elderly. Cancer-related care for the elderly patient has not been given appropriate attention. Many of our present attitudes are based on how history has treated the elderly. Screening programs often neglect individuals over 65 despite the i...
journal_title：Oncology nursing forum
pub_type： 杂志文章,评审
doi：
更新日期：1991-07-01 00:00:00
abstract：PURPOSE/OBJECTIVES:To assess pain and activity limitations and to determine realistic goals for recovery after a transverse rectus abdominis myocutaneous (TRAM) flap breast reconstruction in a standard rehabilitation and recovery program. Assessing patient satisfaction with educational information is a secondary object...
journal_title：Oncology nursing forum
pub_type： 临床试验,杂志文章
doi：10.1188/08.ONF.189-196
更新日期：2008-03-01 00:00:00
