Aberrant p21 regulation in radioresistant primary glioblastoma multiforme cells bearing wild-type p53.

abstract：OBJECT:Patients with gliomas frequently have cognitive deficits, and surgery can exacerbate these deficits. Preoperative assessment is therefore crucial in patients undergoing surgery for glioma in eloquent areas, because the proximity of functional areas increases the risk of permanent postoperative cognitive disturba...

journal_title：Journal of neurosurgery

authors： Satoer D,Vork J,Visch-Brink E,Smits M,Dirven C,Vincent A

更新日期：2012-11-01 00:00:00

abstract：OBJECT:High-frequency stimulation (HFS) delivered through implanted electrodes in the subthalamic nucleus (STN) has become an established treatment for Parkinson disease (PD). The precise mechanism of action of deep brain stimulation (DBS) in the STN is unknown, however. In the present study, the authors tested the hyp...

journal_title：Journal of neurosurgery

authors： Lee KH,Chang SY,Roberts DW,Kim U

更新日期：2004-09-01 00:00:00

abstract：OBJECT:The authors describe their initial results obtained using a skull-mounted trajectory guide for intraoperative magnetic resonance (MR) imaging-guided brain biopsy sampling. The device was used in conjunction with a new methodology known as prospective stereotaxis for surgical trajectory alignment. METHODS:Betwee...

journal_title：Journal of neurosurgery

authors： Hall WA,Liu H,Martin AJ,Maxwell RE,Truwit CL

更新日期：2001-01-01 00:00:00

abstract：OBJECT:Emergency access to the ventricular system is sometimes necessary for the treatment of raised intracranial pressure with ensuing herniation. One procedure described in the literature is a transorbital approach performed using a spinal needle. Because past publications have been case reports with minimal definiti...

journal_title：Journal of neurosurgery

authors： Tubbs RS,Loukas M,Shoja MM,Cohen-Gadol AA

更新日期：2009-12-01 00:00:00

abstract：:Analysis of the authors' experience over the last 10 years has indicated that excellent pain control has rarely been obtained by thalamic relay nucleus stimulation in patients with thalamic pain. In the present study, 11 patients with thalamic pain were treated by chronic stimulation of the precentral gyrus. In eight ...

journal_title：Journal of neurosurgery

authors： Tsubokawa T,Katayama Y,Yamamoto T,Hirayama T,Koyama S

更新日期：1993-03-01 00:00:00

abstract：OBJECT:Microangiopathy associated with hypertension is a notable cause of cerebral small vessel disease (SVD), including deep intracerebral hemorrhage (ICH) and lacunar infarct. Dotlike low-intensity spots (dotlike hemosiderin spots: dotHSs) on T2*-weighted magnetic resonance (MR) images have been histologically diagno...

journal_title：Journal of neurosurgery

authors： Imaizumi T,Horita Y,Hashimoto Y,Niwa J

更新日期：2004-12-01 00:00:00

abstract：OBJECT:Preoperative anemia may be treated with a blood transfusion. Both are associated with adverse outcomes in various surgical procedures, but this has not been clearly elucidated in surgery for cerebral aneurysms. In this study the authors assessed the association of preoperative anemia and perioperative blood tran...

journal_title：Journal of neurosurgery

authors： Seicean A,Alan N,Seicean S,Neuhauser D,Selman WR,Bambakidis NC

更新日期：2015-07-01 00:00:00

abstract：:OBJECTIVE A subset of patients with Chiari I malformation demonstrate patent subarachnoid spaces around the cerebellum, indicating that reduced posterior fossa volume alone does not account for tonsillar descent. The authors distinguish two subsets of Chiari I malformation patients based on the degree of "posterior fo...

journal_title：Journal of neurosurgery

authors： Taylor DG,Mastorakos P,Jane JA Jr,Oldfield EH

更新日期：2017-06-01 00:00:00

abstract：OBJECT:Brain metastases from gastrointestinal cancers are rare. However, the incidence is increasing because patients with gastrointestinal carcinoma tend to live longer due to earlier diagnosis and more effective treatment of systemic disease. The purpose of this study was to evaluate the efficacy of Gamma Knife surge...

journal_title：Journal of neurosurgery

authors： Da Silva AN,Nagayama K,Schlesinger DJ,Sheehan JP

更新日期：2009-09-01 00:00:00

abstract：:The authors report the successful staged stenting and coil embolization of a large vertebral artery-posterior inferior cerebellar artery (VA-PICA) aneurysm using the contralateral VA for access. A 67-year-old woman presented with a large ruptured VA-PICA aneurysm. Initial attempts to stent the wide-necked aneurysm fro...

journal_title：Journal of neurosurgery

authors： Ecker RD,Hanel RA,Levy EI,Hopkins LN

更新日期：2007-12-01 00:00:00

abstract：OBJECT:The authors have treated intractable pain, particularly cancer pain related to bone metastasis, with various protocols. Cancer pain has been treated by gamma knife radiosurgery (GKS), targeted to the pituitary gland-stalk, as an alternative new pain control method. The purpose of this study was to investigate a ...

journal_title：Journal of neurosurgery

authors： Hayashi M,Taira T,Chernov M,Fukuoka S,Liscak R,Yu CP,Ho RT,Regis J,Katayama Y,Kawakami Y,Hori T

更新日期：2002-12-01 00:00:00

abstract：:Eradication of malignant brain tumors by in situ intratumoral, retrovirally mediated transfer of the herpes simplex virus thymidine kinase (HSVtk) gene, which sensitizes the tumor cells to ganciclovir, has recently been demonstrated in animal models. The observation that tumors studied in vitro and in animals can be c...

journal_title：Journal of neurosurgery

authors： Ram Z,Walbridge S,Shawker T,Culver KW,Blaese RM,Oldfield EH

更新日期：1994-08-01 00:00:00

abstract：:The authors report on a 57-year-old woman in whom progression to brain death occurred on day 9 after aneurysmal subarachnoid hemorrhage without evidence of significant brain edema or vasospasm. Neuromonitoring demonstrated that brain death was preceded by a series of cortical spreading depolarizations that occurred in...

journal_title：Journal of neurosurgery

authors： Carlson AP,Shuttleworth CW,Major S,Lemale CL,Dreier JP,Hartings JA

更新日期：2018-12-07 00:00:00

abstract：OBJECT:Surgical indications for patients with pineal cysts are controversial. While the majority of patients harboring a pineal cyst require no treatment, surgery is a well-accepted option for a subset of those patients with secondary hydrocephalus or Parinaud's syndrome. The majority of pineal cysts are identified inc...

journal_title：Journal of neurosurgery

authors： Kalani MY,Wilson DA,Koechlin NO,Abuhusain HJ,Dlouhy BJ,Gunawardena MP,Nozue-Okada K,Teo C

更新日期：2015-08-01 00:00:00

abstract：:A patient with glioblastoma multiforme of the brain was treated with both intravenous and oral glycerol as well as intravenous mannitol in an attempt to reduce increased intracranial pressure. After an initial lowering of the cerebrospinal fluid (CSF) pressure to near normal values during continuous glycerol administr...

journal_title：Journal of neurosurgery

authors： Guisado R,Tourtellotte WW,Arieff AI,Tomiyasu U,Mishra SK,Schotz MC

更新日期：1975-02-01 00:00:00

abstract：OBJECTIVE:One of the goals in this study was to set up a semiautomatic method to estimate blood-brain barrier disruption obtained in patients with glioblastoma by using an implantable, unfocused, ultrasound device. Another goal was to correlate the probability of significant ultrasound-induced signal enhancement (SUISE...

journal_title：Journal of neurosurgery

authors： Asquier N,Bouchoux G,Canney M,Martin C,Law-Ye B,Leclercq D,Chapelon JY,Lafon C,Idbaih A,Carpentier A

更新日期：2019-02-01 00:00:00

abstract：:The surgical indication for spontaneous cerebellar hemorrhage is not as controversial as the operative management of intracranial hemorrhage. Timing of the operation is crucial: intervening too early can produce an additional strain on the patient and an increased risk, while waiting too long to evacuate the hematoma ...

journal_title：Journal of neurosurgery

authors： Mohadjer M,Eggert R,May J,Mayfrank L

更新日期：1990-08-01 00:00:00

abstract：OBJECT:The goal of this study was to assess the accuracy of the routine clinical use of transcranial Doppler (TCD) ultrasonography and SPECT in predicting angiographically demonstrated vasospasm. METHODS:Following receipt of institutional review board approval, the authors reviewed the records of patients with subarac...

journal_title：Journal of neurosurgery

authors： Kincaid MS,Souter MJ,Treggiari MM,Yanez ND,Moore A,Lam AM

更新日期：2009-01-01 00:00:00

abstract：:Verbal memory deficits remain a major complication of dominant hemisphere temporal lobectomy for epilepsy. The extent of this deficit was assessed preoperatively and 1 month and 1 year postoperatively with the Wechsler Verbal Memory Scale (WMSV) in 14 adults undergoing left temporal lobectomy. Intraoperative localizat...

journal_title：Journal of neurosurgery

authors： Ojemann GA,Dodrill CB

更新日期：1985-01-01 00:00:00

abstract：:The aim of this study was to establish a standard method for determining the pressure setting of the Codman Hakim valve (CHV) in patients with hydrocephalus. The authors' investigation was twofold. It focused on: 1) the relationships among CHV setting, intracranial pressure (ICP), intraabdominal pressure (IAP), hydros...

journal_title：Journal of neurosurgery

authors： Miyake H,Ohta T,Kajimoto Y,Nagao K

更新日期：2000-01-01 00:00:00

abstract：:Leukotrienes derive from arachidonic acid metabolism via the lipoxygenase pathway and modulate several cellular events. In the central nervous system, leukotrienes are mainly synthesized in the gray matter and in vascular tissues. Their production is enhanced in ischemic conditions and in experimental subarachnoid hem...

journal_title：Journal of neurosurgery

authors： Paoletti P,Gaetani P,Grignani G,Pacchiarini L,Silvani V,Rodriguez y Baena R

更新日期：1988-10-01 00:00:00

abstract：:Heterotopic new bone formation, associated with head injuries, usually affects the shoulder, elbow, and hip joints. The authors present a case with an unusual involvement of the cervical spine, confirmed by bone scanning and computerized tomography. Although the etiology of heterotopic new bone formation is not well u...

journal_title：Journal of neurosurgery

authors： Groswasser Z,Reider-Groswasser I

更新日期：1986-03-01 00:00:00

abstract：:An analysis of Motor Index score, pinprick sensory score, joint position sense score, somatosensory evoked potential (SSEP) grade in the ulnar (SSEPu) and posterior tibial (SSEPt) regions, and overall SSEP grade (mean SSEPu + t) was conducted in 36 patients with cervical spinal cord injuries to determine the relations...

journal_title：Journal of neurosurgery

authors： Li C,Houlden DA,Rowed DW

更新日期：1990-04-01 00:00:00

abstract：OBJECT:The goal of this study was to establish the therapeutic window during which delayed therapy with MgSO4 improves neurological motor outcome in rats that have suffered severe traumatic axonal brain injury. METHODS:Severe brain injury was induced in male Sprague-Dawley rats by using the impact-acceleration model o...

journal_title：Journal of neurosurgery

authors： Heath DL,Vink R

更新日期：1999-03-01 00:00:00

abstract：:Tail-like caudal appendages may be associated with spinal dysraphism, particularly with spinal lipomas or lipomyelomeningoceles. An unusual case is presented of a patient with a myelomeningocele and a thick filum terminale with tethered spinal cord, which presented with the external appearance of a human tail. A revie...

journal_title：Journal of neurosurgery

authors： Chakrabortty S,Oi S,Yoshida Y,Yamada H,Yamaguchi M,Tamaki N,Matsumoto S

更新日期：1993-06-01 00:00:00

abstract：:A Remington humane stunner was used to deliver a blow to the left side of the surgically-exposed skull in ketamine-anesthetized cats. At 15 minutes after the trauma, brain tissue was frozen in situ. In animals without visible tissue hemorrhage (Grade 0) and in those with unilateral cerebral contusions involving the ce...

journal_title：Journal of neurosurgery

authors： Wagner KR,Tornheim PA,Eichhold MK

更新日期：1985-07-01 00:00:00

abstract：:A new model producing diffuse brain injury, without focal brain lesions, has been developed in rats. This has been achieved by allowing a weight of 450 gm to fall onto a metallic disc fixed to the intact skull of the animal which is supported by a foam bed. Two levels of injury were examined by adjusting the height of...

journal_title：Journal of neurosurgery

authors： Foda MA,Marmarou A

更新日期：1994-02-01 00:00:00

abstract：:OBJECTIVE Despite persisting questions regarding its appropriateness, 30-day readmission is an increasingly common quality metric used to influence hospital compensation in the United States. However, there is currently insufficient evidence to identify which patients are at highest risk for readmission after aneurysm...

journal_title：Journal of neurosurgery

authors： Greenberg JK,Guniganti R,Arias EJ,Desai K,Washington CW,Yan Y,Weng H,Xiong C,Fondahn E,Cross DT,Moran CJ,Rich KM,Chicoine MR,Dhar R,Dacey RG Jr,Derdeyn CP,Zipfel GJ

更新日期：2017-06-01 00:00:00

abstract：:The use of surgical treatment for depressed skull fractures that are located over major venous sinuses is a matter of controversy. However, if clinical and radiological findings of sinus obliteration and related intracranial hypertension are present, surgical decompression is indicated. The authors present the case of...

journal_title：Journal of neurosurgery

authors： Uzan M,Ciplak N,Dashti SG,Bozkus H,Erdinçler P,Akman C

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:It is well known that larger aneurysm size is a risk factor for poor outcome after surgical treatment of unruptured saccular intracranial aneurysms (USIAs). However, the authors have occasionally observed poor outcome in the surgical treatment of small USIAs and hypothesized that size ratio has a negative imp...

journal_title：Journal of neurosurgery

authors： Matsukawa H,Kamiyama H,Kinoshita Y,Saito N,Hatano Y,Miyazaki T,Ota N,Noda K,Shonai T,Takahashi O,Tokuda S,Tanikawa R

更新日期：2018-09-21 00:00:00