Rebound phenomenon complicating cerebral dehydration with glycerol. Case report.

Abstract:

:A patient with glioblastoma multiforme of the brain was treated with both intravenous and oral glycerol as well as intravenous mannitol in an attempt to reduce increased intracranial pressure. After an initial lowering of the cerebrospinal fluid (CSF) pressure to near normal values during continuous glycerol administration, a secondary rise in CSF pressure above the initial level occurred despite a persistent elevation of plasma osmolality (315 mOsm/kg) and glycerol level (30 mmole/l). Similarly, 4 hours after the administration of a single oral dose of glycerol, CSF pressure increased to levels higher (700 mm H2O) than the original baseline (400 mm H2O).

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Guisado R,Tourtellotte WW,Arieff AI,Tomiyasu U,Mishra SK,Schotz MC

doi

10.3171/jns.1975.42.2.0226

subject

Has Abstract

pub_date

1975-02-01 00:00:00

pages

226-8

issue

2

eissn

0022-3085

issn

1933-0693

journal_volume

42

pub_type

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