Terminal spreading depolarizations causing electrocortical silencing prior to clinical brain death: case report.

Abstract:

:The authors report on a 57-year-old woman in whom progression to brain death occurred on day 9 after aneurysmal subarachnoid hemorrhage without evidence of significant brain edema or vasospasm. Neuromonitoring demonstrated that brain death was preceded by a series of cortical spreading depolarizations that occurred in association with progressive hypoxic episodes. The depolarizations induced final electrical silence in the cortex and ended with a terminal depolarization that persisted > 7 hours. To the authors' knowledge, this is the first report of terminal spreading depolarization in the human brain prior to clinical brain death and major cardiopulmonary failure.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Carlson AP,Shuttleworth CW,Major S,Lemale CL,Dreier JP,Hartings JA

doi

10.3171/2018.7.JNS181478

subject

Has Abstract

pub_date

2018-12-07 00:00:00

pages

1773-1779

issue

6

eissn

0022-3085

issn

1933-0693

pii

2018.7.JNS181478

journal_volume

131

pub_type

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