Abstract：
OBJECT:Stereotactic radiosurgery is an increasingly used and the least invasive surgical option for patients with trigeminal neuralgia. In this study, the authors investigate the clinical outcomes in patients treated with this procedure. METHODS:Independently acquired data from 220 patients with idiopathic trigeminal neuralgia who underwent gamma knife radiosurgery were reviewed. The median age was 70 years (range 26-92 years). Most patients had typical features of trigeminal neuralgia, although 16 (7.3%) described additional atypical features. One hundred thirty-five patients (61.4%) had previously undergone surgery and 80 (36.4%) had some degree of sensory disturbance related to the earlier surgery. Patients were followed for a maximum of 6.5 years (median 2 years). Complete or partial relief was achieved in 85.6% of patients at 1 year. Complete pain relief was achieved in 64.9% of patients at 6 months, 70.3% at 1 year, and 75.4% at 33 months. Patients with an atypical pain component had a lower rate of pain relief (p = 0.025). Because of recurrences, only 55.8% of patients had complete or partial pain relief at 5 years. The absence of preoperative sensory disturbance (p = 0.02) or previous surgery (p = 0.01) correlated with an increased proportion of patients who experienced complete or partial pain relief over time. Thirty patients (13.6%) reported pain recurrence 2 to 58 months after initial relief (median 15.4 months). Only 17 patients (10.2% at 2 years) developed new or increased subjective facial paresthesia or numbness, including one who developed deaf-ferentation pain. CONCLUSIONS:Radiosurgery for idiopathic trigeminal neuralgia was safe and effective, and it provided benefit to a patient population with a high frequency of prior surgical intervention.
journal_name
J Neurosurgjournal_title
Journal of neurosurgeryauthors
Kao MCdoi
10.3171/jns.2002.96.1.0160subject
Has Abstractpub_date
2002-01-01 00:00:00pages
160-1issue
1eissn
0022-3085issn
1933-0693journal_volume
96pub_type
评论,信件abstract：OBJECT:Selective dorsal rhizotomy (SDR) has been shown to provide considerable benefit to children with spastic cerebral palsy (CP). The authors sought to evaluate the risks of postoperative spinal deformities in patients following SDR. METHODS:All patients who underwent SDR at McGill University between 1991 and 2001 ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/ped.2007.106.6.441
更新日期：2007-06-01 00:00:00
abstract：:The authors describe two patients in whom tumor swelling and brain swelling (and possible tumor swelling), respectively, developed after undergoing gamma knife surgery. One had a skull defect with a palpable parasagittal tumor. One had neurofibromatosis Type 2 with multiple tumors, one of which was parasagittal. ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.2005.102.s_supplement.0001
更新日期：2005-01-01 00:00:00
abstract：:Neurosurgery has played an important role in the development of neuroscience and the science of consciousness. In this paper, the authors reflect on some of the historical contributions of neurosurgeons to the science of consciousness and discuss the ways in which clinical neurosurgery can contribute to the science of...
journal_title：Journal of neurosurgery
pub_type： 历史文章,杂志文章
doi：10.3171/2012.6.JNS112136
更新日期：2012-09-01 00:00:00
abstract：:The usefulness of electroencephalographic (EEG) monitoring as well as the significance of the period of cross clamping in carotid endarterectomy have not been completely defined. In particular, the clinical importance of major EEG changes has not been fully investigated and some recent studies seem to indicate that th...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1986.65.6.0815
更新日期：1986-12-01 00:00:00
abstract：:OBJECTIVE Outpatient craniotomy has many advantages to the psychological and physical well-being of patients, as well as benefits to the health care system. Its efficacy and safety have been well demonstrated, but barriers to its widespread adoption remain. Among the challenges is a perception that its application is ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/2015.11.JNS152151
更新日期：2016-11-01 00:00:00
abstract：:Up to now, navigated transcranial magnetic stimulation (nTMS) has been used for motor mapping in the vicinity of rolandic brain lesions. Recently, nTMS has also been suggested to be useful in mapping human language areas. The authors describe the case of a left-handed patient with a left-side glioblastoma within the...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/2012.9.JNS121053
更新日期：2013-01-01 00:00:00
abstract：OBJECT:The purpose of this study was to identify the causes of failed temporal lobe resection in patients with mesial temporal sclerosis (MTS) and the role of repeat surgery for seizure control. METHODS:This is a retrospective study of 105 patients who underwent temporal lobe resection for MTS with unilateral electroe...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/2009.1.JNS08638
更新日期：2009-06-01 00:00:00
abstract：:Intracranial extraaxial cavernous angiomas are rare vascular malformations. Their occurrence at the geniculate ganglion of the facial nerve within the temporal bone is exceptional. The authors describe a 35-year-old man who developed a slowly progressing facial palsy. Initial cranial MR imaging showed no pathological ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/JNS/2008/109/11/0893
更新日期：2008-11-01 00:00:00
abstract：:OBJECTIVE Access to the third ventricle is a veritable challenge to neurosurgeons. In this context, anatomical and morphometric studies are useful for establishing the limitations and advantages of a particular surgical approach. The transchoroidal approach is versatile and provides adequate exposure of the middle and...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/2016.8.JNS16403
更新日期：2017-07-01 00:00:00
abstract：OBJECT:Glial cell line-derived neurotrophic factor (GDNF) has been shown to confer neuroprotective effects on dopaminergic neurons. The authors investigated the effects of GDNF on 6-hydroxydopamine (6-OHDA)-treated dopaminergic neurons in vitro and in vivo. METHODS:First, the authors examined how 1, 10, or 100 ng/ml o...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.2005.102.1.0080
更新日期：2005-01-01 00:00:00
abstract：:Procedures for relief of coronal synostosis and metopic synostosis have resulted in some undesirable sequelae. The authors present combined neurological and plastic surgical modifications to prevent additional synostoses, forehead ridging, and lateral orbital wall step-off. They recommend bifrontal craniotomy with lat...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1983.59.2.0245
更新日期：1983-08-01 00:00:00
abstract：:The criteria by which acromegalic patients are considered "cured" after surgical therapy are still controversial. Since the abnormal growth hormone (GH) increase after the administration of some agents has been demonstrated to be characteristic of the tumoral somatotrophs, its disappearance after surgery may be taken ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1983.59.3.0402
更新日期：1983-09-01 00:00:00
abstract：:A patient is presented who had neck pain and transient episodes of visual-field defect followed by unconsciousness when he hyperextended his neck. Radiographic examination revealed atlantooccipital instability on flexion and extension views. Treatment by fusion of the occiput to C-2 resulted in relief of symptoms. ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1978.48.4.0636
更新日期：1978-04-01 00:00:00
abstract：:The humoral immune response to autologous gliomas has been investigated in 16 patients using immune adherence and anti-C3 immunofluorescence assays of serum samples. Significant antiglioma antibody activity was detected in 56% of these sera. Fractionation experiments demonstrated that IgM class antibodies were more ef...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1981.55.1.0019
更新日期：1981-07-01 00:00:00
abstract：:In patients with pineal tumors, clinical symptoms are due to direct compression of adjacent structures. The most common signs include increased intracranial pressure (80%) caused by obstruction of the sylvian aqueduct, and Parinaud syndrome (50%) caused by direct compression of the superior colliculi. Hearing loss is ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.2003.99.3.0587
更新日期：2003-09-01 00:00:00
abstract：:Verbal memory deficits remain a major complication of dominant hemisphere temporal lobectomy for epilepsy. The extent of this deficit was assessed preoperatively and 1 month and 1 year postoperatively with the Wechsler Verbal Memory Scale (WMSV) in 14 adults undergoing left temporal lobectomy. Intraoperative localizat...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1985.62.1.0101
更新日期：1985-01-01 00:00:00
abstract：OBJECT:Although nucleus ventralis intermedius stimulation has been shown to be safe and efficacious in the treatment of essential tremor, there is a subset of patients who eventually lose benefit from their stimulation. Proposed causes for this phenomenon include tolerance, disease progression, and suboptimal location....
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/JNS/2008/109/10/0640
更新日期：2008-10-01 00:00:00
abstract：:Leukotrienes derive from arachidonic acid metabolism via the lipoxygenase pathway and modulate several cellular events. In the central nervous system, leukotrienes are mainly synthesized in the gray matter and in vascular tissues. Their production is enhanced in ischemic conditions and in experimental subarachnoid hem...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1988.69.4.0488
更新日期：1988-10-01 00:00:00
abstract：:The avian sarcoma virus-induced glioma model in rats was used to evaluate radiation dose response (survival curves), giving fractionated treatments to the whole head. Groups of 14 to 20 rats received total doses of 2300, 4600, or 5750 rads over 2, 4, or 5 weeks, respectively. Median group survival times were compared ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1980.53.1.0068
更新日期：1980-07-01 00:00:00
abstract：:Acute cerebellar hemorrhages, treated medically with subsequent complete recovery, have been designated "benign cerebellar hemorrhages." Ordinarily, acute cerebellar hemorrhage does require early surgical intervention and reported surgical mortality is relatively low (17%) in awake patients with this lesion. Clinical ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1979.50.3.0374
更新日期：1979-03-01 00:00:00
abstract：OBJECT:Renal cell carcinoma (RCC) is an aggressive malignancy that frequently metastasizes. When RCC metastasizes to the spine, significant pain and neurological dysfunction often follow. Because systemic therapy and radiotherapy have a limited effect in controlling spinal disease, surgery is frequently required; howev...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/spi.2001.94.1.0018
更新日期：2001-01-01 00:00:00
abstract：OBJECT:Patients with fusiform aneurysms can present with subarachnoid hemorrhage (SAH), mass effect, ischemia, or unrelated symptoms. The absence of an aneurysm neck impedes the direct application of a clip and endovascular coil deployment. To evaluate the effects of their treatments, the authors retrospectively analyz...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.2007.106.5.855
更新日期：2007-05-01 00:00:00
abstract：:Melanocytomas are rare tumors of the central nervous system that are believed to arise from leptomeningeal melanocytes. A young girl presented with a contrast-enhancing cystic mass in the temporal horn of the left lateral ventricle. Microsurgical resection of a black-colored vascular tumor supplied by the anterior cho...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/JNS/2008/109/9/0480
更新日期：2008-09-01 00:00:00
abstract：:The author, while a research illustrator at the Smithsonian Institution National Museum of Natural History, studied two ancient skulls from the Incan period in Peru, both with trephination. Her conclusions and illustrations of the skulls are included in this paper. ...
journal_title：Journal of neurosurgery
pub_type： 历史文章,杂志文章
doi：10.3171/jns.1992.76.3.0550
更新日期：1992-03-01 00:00:00
abstract：:A consecutive series of 82 acromegalic patients who underwent transsphenoidal surgery during a 5-year period is presented. Preoperative and postoperative values for human growth hormone (HGH) were available in 80 cases. Microadenomas were present in 18 patients with a mean preoperative HGH value of 25.2 ng/ml, diffuse...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1979.50.4.0454
更新日期：1979-04-01 00:00:00
abstract：:Arachnoid cysts are commonly thought to arise from either congenital defects or trauma. In this article the authors report the spontaneous development of a suprasellar third ventricular arachnoid cyst whose origin was not clearly congenital or traumatic. At the age of 4 months, the patient presented with hypertonia, a...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/ped.2006.104.6.426
更新日期：2006-06-01 00:00:00
abstract：:The authors describe the first documented case of transplacental transmission of metastatic melanoma to the neuraxis. The patient was a 7-month-old boy who presented with signs and symptoms of elevated intracranial pressure. Magnetic resonance imaging revealed an inhomogeneously enhancing posterior fossa mass measurin...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/ped.2005.103.2.0191
更新日期：2005-08-01 00:00:00
abstract：:Cushing's experience with the surgical treatment of pituitary adenomas and other lesions producing the chiasmal syndrome is reviewed. The conclusion is that his ultimate rejection of the transsphenoidal route was not due to his dissatisfaction with this procedure, but rather came about because of the transfrontal rout...
journal_title：Journal of neurosurgery
pub_type： 传,历史文章,杂志文章
doi：10.3171/jns.1981.54.4.0448
更新日期：1981-04-01 00:00:00
abstract：:A 55-year-old man, who had previously had a left atrial myxoma excised, developed recurrent hematomas of the left occipital lobe. Microscopic examination revealed the presence of metastatic myxoma. ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章,评审
doi：10.3171/jns.1990.72.2.0295
更新日期：1990-02-01 00:00:00
abstract：OBJECT:The purpose of this study was to analyze patient outcomes and to define the role of radiosurgery in patients who have undergone prior microsurgical resection of their vestibular schwannoma. METHODS:The authors evaluated the pre- and postoperative clinical and neuroimaging characteristics of 76 consecutive patie...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1998.89.6.0944
更新日期：1998-12-01 00:00:00
