Distribution of genes for bone morphogenetic protein-4, -6, growth differentiation factor-5, and bone morphogenetic protein receptors in the process of experimental spondylosis in mice.

Abstract:

OBJECT:Because little is known about the molecular mechanisms underlying the process of spondylosis, the authors examined the extent of genetic localization of several members of bone morphogenetic protein (BMP) and BMP receptors in chondrogenesis during the process of inducing spondylosis in their previously established experimental mice model. METHODS:Experimental spondylosis was induced in 5-week-old ICR mice. The cervical spine was harvested chronologically, and histological sections were prepared. Messenger RNA for BMP-4, growth and differentiation (GDF)-5, BMP-6, and BMP receptors (ALK-3, -6, and BMP-RII) was localized in the tissue sections by in situ hybridization. In the early stage, BMP-4-derived mRNA was localized mainly in cells in the anterior margin of the cervical discs, together with ALK-6 and BMP-RII mRNA. No GDF-5 and BMP-6 mRNA was detected at this stage. In the late stage, cells positive for BMP-4 decreased, whereas GDF-5 and BMP-6 mRNA were localized in cells undergoing chondrogenesis. The ALK-3 mRNA began to appear in this stage, as did ALK-6 and BMP-RII. CONCLUSIONS:The localization of transcripts for BMP-4, -6, and GDF-5 as well as BMP receptors shown during the present experimental model indicate the possible involvement of molecular signaling by these BMPs in the chondrogenic progress in spondylosis.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Nakase T,Ariga K,Miyamoto S,Okuda S,Tomita T,Iwasaki M,Yonenobu K,Yoshikawa H

doi

10.3171/spi.2001.94.1.0068

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

68-75

issue

1 Suppl

eissn

0022-3085

issn

1933-0693

journal_volume

94

pub_type

杂志文章
  • Neuroprotective and neurorestorative effects of thymosin β4 treatment initiated 6 hours after traumatic brain injury in rats.

    abstract:OBJECT:Thymosin β4 (Tβ4) is a regenerative multifunctional peptide. The aim of this study was to test the hypothesis that Tβ4 treatment initiated 6 hours postinjury reduces brain damage and improves functional recovery in rats subjected to traumatic brain injury (TBI). METHODS:Traumatic brain injury was induced by con...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2012.1.JNS111729

    authors: Xiong Y,Zhang Y,Mahmood A,Meng Y,Zhang ZG,Morris DC,Chopp M

    更新日期:2012-05-01 00:00:00

  • Anterior thoracic myelomeningocele presenting as a retromediastinal mass. Case report.

    abstract::Myelomeningocele presenting as a retromediastinal mass originating from the midline defect through the fused T-4, T-5, and T-6 VBs is described. An 11-year-old boy with a completely normal systemic and neurological examination suffering pulmonary problems such as effort dyspnea and severe kyphosis was evaluated and an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2005.103.1.0079

    authors: Börcek AO,Ergün E,Emmez H,Kurt G,Dogulu F,Baykaner MK

    更新日期:2005-07-01 00:00:00

  • Cortical motor and somatosensory representation: effect of cerebral lesions.

    abstract:OBJECT:Changes in cortical representation in patients with cerebral lesions may alter the correlation between cortical anatomy and function. This is of potential clinical significance when the extent of cortical resection is based on surface anatomical landmarks. METHODS:Fifty-one patients with supratentorial lesions ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2000.92.2.0242

    authors: Bittar RG,Olivier A,Sadikot AF,Andermann F,Reutens DC

    更新日期:2000-02-01 00:00:00

  • Outcomes of decompressive surgery for cavernous sinus meningiomas: long-term follow-up in 50 patients.

    abstract:OBJECTIVE:Cavernous sinus meningiomas are complex tumors that offer a perpetual challenge to skull base surgeons. The senior author has employed a management strategy for these lesions aimed at maximizing tumor control while minimizing neurological morbidity. This approach emphasizes combining "safe" tumor resection an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.10.JNS181480

    authors: Gozal YM,Alzhrani G,Abou-Al-Shaar H,Azab MA,Walsh MT,Couldwell WT

    更新日期:2020-02-01 00:00:00

  • Neurological manifestations of pediatric achondroplasia.

    abstract::The neurological and neuroradiological manifestations of pediatric achondroplasia are analyzed on the basis of 10 cases. In addition to the classical symptomatology of an enlarging head, with or without increased intracranial pressure, several patients presented symptoms related to a small foramen magnum. Respiratory ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1981.54.1.0049

    authors: Yamada H,Nakamura S,Tajima M,Kageyama N

    更新日期:1981-01-01 00:00:00

  • Dural-cortical anastomosis in pial arteriovenous malformation. Case report.

    abstract::A patient is reported with a purely pial arteriovenous malformation (AVM) supplied from the posterior parietal artery. The prominent middle meningeal artery contributed to opacification of the angular branches distal to the AVM, but did not contribute to the AVM. After total removal of the AVM, the angular branches be...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1979.50.4.0522

    authors: Waga S,Morikawa A,Kojima T

    更新日期:1979-04-01 00:00:00

  • A more potent bystander cytocidal effect elicited by tumor cells expressing the herpes simplex virus-thymidine kinase gene than by fibroblast virus-producer cells in vitro.

    abstract::Retrovirus-mediated herpes simplex virus-thymidine kinase (HSV-tk) gene therapy is a promising approach in the treatment of brain tumors. Previous in vitro and in vivo studies have demonstrated a bystander effect in which nonmodified tumor cells in proximity to HSV-tk-modified tumor cells are killed with the modified ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.83.4.0698

    authors: Vrionis FD,Wu JK,Qi P,Cano W,Cherington V

    更新日期:1995-10-01 00:00:00

  • Deep brain stimulation for treatment of hemichorea-hemiballism after craniopharyngioma resection: long-term follow-up.

    abstract::Hemichorea-hemiballism is a rare movement disorder that has various causes. In treatment-resistant cases, both thalamic and pallidal functional procedures have been shown to yield beneficial results. Until now it has not been clarified whether the thalamus or the pallidum would yield a superior outcome. After resect...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2011.6.JNS101388

    authors: Capelle HH,Kinfe TM,Krauss JK

    更新日期:2011-11-01 00:00:00

  • Effects of experimental fluid-percussion injury of the brain on cerebrovascular reactivity of hypoxia and to hypercapnia.

    abstract::To test the hypothesis that concussive brain injury interferes with the normal vasodilator response of the cerebral circulation to hypoxemia, 30 cats were subjected to mild (PaO2 50 mm Hg) and severe (PaO2 30 mm Hg) hypoxemia while measurements were made of arterial and intracranial pressure, regional cerebral blood f...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1982.56.3.0332

    authors: Lewelt W,Jenkins LW,Miller JD

    更新日期:1982-03-01 00:00:00

  • Efficacy of deep rTMS for neuropathic pain in the lower limb: a randomized, double-blind crossover trial of an H-coil and figure-8 coil.

    abstract::OBJECTIVE Electrical motor cortex stimulation can relieve neuropathic pain (NP), but its use requires patients to undergo an invasive procedure. Repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex (M1) using a figure-8 coil can relieve NP noninvasively, but its ability to relieve lower limb...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,随机对照试验

    doi:10.3171/2016.9.JNS16815

    authors: Shimizu T,Hosomi K,Maruo T,Goto Y,Yokoe M,Kageyama Y,Shimokawa T,Yoshimine T,Saitoh Y

    更新日期:2017-11-01 00:00:00

  • Real-time detection of vascular occlusion and reperfusion of the brain during surgery by using infrared imaging.

    abstract:OBJECT:Application of sensitive infrared imaging is ideally suited to observe blood vessels and blood flow in exposed organs, including the brain. Temporary vascular occlusion is an important part of neurosurgery, but the capacity to monitor the effects of these occlusions in real time is limited. In surgical procedure...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2002.96.5.0918

    authors: Watson JC,Gorbach AM,Pluta RM,Rak R,Heiss JD,Oldfield EH

    更新日期:2002-05-01 00:00:00

  • Mycotic aneurysms of the internal carotid artery. Case report.

    abstract::The authors report a case with two mycotic aneurysms in the cavernous portion of the internal carotid artery, presumably secondary to a transient bacteremia from pneumonia. The strikingly rapid development of the aneurysms was demonstrated by angiography. Painful total ophthalmoplegia and extophthalmos were the main c...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1976.44.1.0105

    authors: Shibuya S,Igarashi S,Amo T,Sato H,Fukumitsu T

    更新日期:1976-01-01 00:00:00

  • Dural arteriovenous malformations of the spine. Clinical features and surgical results in 55 cases.

    abstract::The clinical and angiographic findings of 55 patients with a spinal dural arteriovenous malformation (AVM) are reviewed, and the results of surgery assessed. The symptoms of dural AVM are usually gradual in onset, and hemorrhage from this type of AVM is less common than in true spinal cord angiomas. Other clinical fea...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.2.0238

    authors: Symon L,Kuyama H,Kendall B

    更新日期:1984-02-01 00:00:00

  • Tenascin-C-coated platinum coils for acceleration of organization of cavities and reduction of lumen size in a rat aneurysm model.

    abstract:OBJECT:Detachable platinum coils are widely used in the endovascular treatment of intracranial aneurysms. The use of coil placement produces a higher incidence of aneurysm recurrence compared with surgical clipping. To reduce the incidence of recurrence by promoting clot organization, the authors designed a platinum co...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.103.4.0681

    authors: Toma N,Imanaka-Yoshida K,Takeuchi T,Matsushima S,Iwata H,Yoshida T,Taki W

    更新日期:2005-10-01 00:00:00

  • Acute subdural hematoma: morbidity, mortality, and operative timing.

    abstract::Traumatic acute subdural hematoma remains one of the most lethal of all head injuries. Since 1981, it has been strongly held that the critical factor in overall outcome from acute subdural hematoma is timing of operative intervention for clot removal; those operated on within 4 hours of injury may have mortality rates...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1991.74.2.0212

    authors: Wilberger JE Jr,Harris M,Diamond DL

    更新日期:1991-02-01 00:00:00

  • Brain tissue oxygen tension response to induced hyperoxia reduced in hypoperfused brain.

    abstract:OBJECTIVES:Increasing PaO2 can increase brain tissue PO2 (PbtO2). Nevertheless, the small increase in arterial O2 content induced by hyperoxia does not increase O2 delivery much, especially when cerebral blood flow (CBF) is low, and the effectiveness of hyperoxia as a therapeutic intervention remains controversial. The...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/108/01/0053

    authors: Hlatky R,Valadka AB,Gopinath SP,Robertson CS

    更新日期:2008-01-01 00:00:00

  • Spinal cord injury without radiographic abnormality and Chiari malformation.

    abstract::Spinal cord injury without radiographic abnormality and asymptomatic Chiari I malformation have an unusual coincidence. A young boy who had recently fallen from his porch was transferred to the neurosurgery service with a high cervical central cord syndrome. Careful study demonstrated no radiographic abnormality and, ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.1993.79.6.0833

    authors: Bondurant CP,Oró JJ

    更新日期:1993-12-01 00:00:00

  • Potentiating effects of extraluminal oxyhemoglobin to intraluminal 5-hydroxytryptamine in isolated canine internal carotid arteries.

    abstract::The interaction between oxyhemoglobin (oxyHb) and 5-hydroxytryptamine (5-HT) was investigated in an experimental model of isolated canine internal and common carotid arteries with insertion of stainless steel cannulae. Extraluminal application of 10(-5) M oxyHb induced marked and long-lasting vasoconstriction in the i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1988.69.2.0263

    authors: Tanaka Y,Chiba S

    更新日期:1988-08-01 00:00:00

  • Clinical outcome of radiosurgery for cerebral arteriovenous malformations.

    abstract::The clinical outcomes are described for 247 consecutive cases of arteriovenous malformation (AVM) treated with the gamma knife between April, 1970, and December 31, 1983. Headache resolved in 65 (66.3%) of the 98 patients presenting with this symptom and improved in an additional nine (9.2%). Of 59 patients admitted w...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1992.77.1.0001

    authors: Steiner L,Lindquist C,Adler JR,Torner JC,Alves W,Steiner M

    更新日期:1992-07-01 00:00:00

  • Endovascular occlusion of intracranial vessels for curative treatment of unclippable aneurysms: report of 16 cases.

    abstract::Among 121 intracerebral aneurysms presenting at one institution between 1984 and 1989, 16 were treated by endovascular means. All 16 lesions were intradural and intracranial, and had failed either surgical or endovascular attempts at selective exclusion with parent vessel preservation. The lesions included four giant ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1991.75.5.0694

    authors: Hodes JE,Aymard A,Gobin YP,Rüfenacht D,Bien S,Reizine D,Gaston A,Merland JJ

    更新日期:1991-11-01 00:00:00

  • Treatment by specialist surgical neurooncologists improves survival times for patients with malignant glioma.

    abstract:OBJECT:Surgeries for CNS tumors are frequently performed by general neurosurgeons and by those who specialize in surgical neurooncology. Subspecialization in neurosurgical practice has become common and may improve patient morbidity and mortality rates. However, the potential benefits for patients of having their surge...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.10.JNS132057

    authors: Khan UA,Bhavsar A,Asif H,Karabatsou K,Leggate JR,Sofat A,Kamaly-Asl ID

    更新日期:2015-02-01 00:00:00

  • Distribution of hematoporphyrin derivative in canine glioma following intraneoplastic and intraperitoneal injection.

    abstract::Hematoporphyrin derivative (HPD) is a photosensitizing agent that has been used to locate and kill tumors. The distribution of tritiated (3H)-HPD was studied in a transplantable canine glioma model following intraperitoneal or direct intraneoplastic injection. Compared to intraperitoneal administration of 3H-HPD, dire...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.65.3.0364

    authors: Steichen JD,Dashner K,Martuza RL

    更新日期:1986-09-01 00:00:00

  • Brain biopsy sampling by using prospective stereotaxis and a trajectory guide.

    abstract:OBJECT:The authors describe their initial results obtained using a skull-mounted trajectory guide for intraoperative magnetic resonance (MR) imaging-guided brain biopsy sampling. The device was used in conjunction with a new methodology known as prospective stereotaxis for surgical trajectory alignment. METHODS:Betwee...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2001.94.1.0067

    authors: Hall WA,Liu H,Martin AJ,Maxwell RE,Truwit CL

    更新日期:2001-01-01 00:00:00

  • Intracranial phosphaturic mesenchymal tumors: report of 2 cases.

    abstract::Hypophosphatemia with osteomalacia may be due to a neoplasm that produces fibroblast growth factor 23 (FGF-23), which inhibits phosphate reabsorption in the kidneys. Most of these tumors occur in bone or soft tissue and occasionally in the head, although intracranial occurrence is very rare. This report describes a tu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/2012.12.JNS12598

    authors: Mathis DA,Stehel EJ Jr,Beshay JE,Mickey BE,Folpe AL,Raisanen J

    更新日期:2013-04-01 00:00:00

  • Gamma Knife surgery of vestibular schwannomas: longitudinal changes in vestibular function and measurement of the Dizziness Handicap Inventory.

    abstract:OBJECT:Gamma Knife surgery (GKS) is one of the methods available to treat vestibular schwannomas (VSs), in addition to microsurgical resection; however, clear information regarding balance function outcomes and the impact of treatment on patients' quality of life over time remains an important clinical need. The purpos...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/109/12/S21

    authors: Wackym PA,Hannley MT,Runge-Samuelson CL,Jensen J,Zhu YR

    更新日期:2008-12-01 00:00:00

  • Optochiasmal arachnoiditis following muslin wrapping of ruptured anterior communicating artery aneurysms.

    abstract::Optochiasmal arachnoiditis has been reported following treatment of ruptured intracranial aneurysms, particularly arising from the anterior communicating artery. It has been suggested that the accompanying loss of vision is due to a muslin-induced optic neuropathy. This paper considers five cases of this condition; th...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1991.75.3.0393

    authors: McFadzean RM,Hadley DM,McIlwaine GG

    更新日期:1991-09-01 00:00:00

  • Efficacy of intraarterial superselective indocyanine green videoangiography in cerebral arteriovenous malformation surgery in a hybrid operating room.

    abstract:OBJECTIVE:Although intravenous indocyanine green (ICG) videoangiography has been reported to be useful when applied to cerebral arteriovenous malformation (AVM) surgery, the ICG that remains after the procedure makes it difficult to understand the anatomy, to evaluate nidus blood flow changes, and to repeat ICG videoan...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2020.3.JNS20319

    authors: Shimada K,Yamaguchi T,Miyamoto T,Sogabe S,Korai M,Okazaki T,Kanematsu Y,Satomi J,Nagahiro S,Takagi Y

    更新日期:2020-05-22 00:00:00

  • Nucleolar organizer regions in various human brain tumors.

    abstract::Nucleolar organizer regions (NOR's) are loops of deoxyribonucleic acid (DNA) which transcribe to ribosomal ribonucleic acid (RNA) by RNA polymerase I. They possess vital significance in the ultimate synthesis of cellular proteins. A silver colloid staining technique for demonstration of NOR-associated proteins (Ag-NOR...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1991.74.6.0979

    authors: Shiraishi T,Tabuchi K,Mineta T,Momozaki N,Takagi M

    更新日期:1991-06-01 00:00:00

  • Fracture of S1-2 after L4-S1 decompression and fusion. Case report and review of the literature.

    abstract::The author describes a woman in whom an S1-2 fracture developed after L4-S1 decompression and fusion. Osteoporosis was not present, but the lesion failed to respond to conservative therapy, necessitating surgical extension of the spinal fusion. Although biomechanical complications of lumbosacral fusion are uncommon, p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.2003.99.3.0310

    authors: Bose B

    更新日期:2003-10-01 00:00:00

  • Intravenous digital subtraction angiography and duplex ultrasonography in postoperative assessment of carotid endarterectomy.

    abstract::Seventy-four consecutive patients who had undergone carotid endarterectomy procedures were examined with intravenous digital subtraction angiography (IV-DSA) and duplex ultrasonography (DUS) at intervals ranging from 1 to 14 months postoperatively. Ninety-one percent of the DUS and 74% of the DSA images were of diagno...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1987.66.1.0088

    authors: Pelz D,Rankin RN,Ferguson GG

    更新日期:1987-01-01 00:00:00