Nucleolar organizer regions in various human brain tumors.

Abstract:

:Nucleolar organizer regions (NOR's) are loops of deoxyribonucleic acid (DNA) which transcribe to ribosomal ribonucleic acid (RNA) by RNA polymerase I. They possess vital significance in the ultimate synthesis of cellular proteins. A silver colloid staining technique for demonstration of NOR-associated proteins (Ag-NOR's) was applied to paraffin-embedded sections from 128 varied brain tumors and to chromosomal preparations from cultured brain-tumor cells. There was a statistically significant difference in the mean number of Ag-NOR's per nucleus between low-grade tumors (1.98/nucleus) and high-grade tumors (2.95/nucleus). It is suggested that the mean number of Ag-NOR's may represent the proliferative potential of brain tumors. Furthermore, high-grade tumors usually showed relatively large Ag-NOR's in a scattered distribution. In chromosomal preparations, the cultured cells displayed five to 12 Ag-NOR's on acrocentric chromosomes. Five of eight cell lines examined demonstrated ectopic Ag-NOR's. This simple staining technique can be easily applied to routinely processed paraffin-embedded sections and will become a useful tool for quick estimation of the proliferative potential of human brain tumors.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Shiraishi T,Tabuchi K,Mineta T,Momozaki N,Takagi M

doi

10.3171/jns.1991.74.6.0979

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

979-84

issue

6

eissn

0022-3085

issn

1933-0693

journal_volume

74

pub_type

杂志文章
  • Chemotherapy of pediatric brain-stem tumors.

    abstract::Forty-five children harboring brain-stem tumors were treated at the University of California, San Francisco, between 1969 and 1979. Pathological diagnoses were made in 19 patients. All patients received radiation therapy (RT). Thirteen patients received chemotherapy before, during, or immediately after RT. Twenty-four...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1981.54.6.0721

    authors: Fulton DS,Levin VA,Wara WM,Edwards MS,Wilson CB

    更新日期:1981-06-01 00:00:00

  • Reflections on the contributions of Harvey Cushing to the surgery of peripheral nerves.

    abstract::By the time Harvey Cushing entered medical school, nerve reconstruction techniques had been developed, but peripheral nerve surgery was still in its infancy. As an assistant surgical resident influenced by Dr. William Halsted, Cushing wrote a series of reports on the use of cocaine for nerve blocks. Following his resi...

    journal_title:Journal of neurosurgery

    pub_type: 传,历史文章,杂志文章

    doi:10.3171/2010.11.JNS10804

    authors: Tubbs RS,Patel N,Nahed BV,Cohen-Gadol AA,Spinner RJ

    更新日期:2011-05-01 00:00:00

  • Conducted somatosensory evoked potentials during spinal surgery. Part 1: control conduction velocity measurements.

    abstract::Intraoperative recordings of conducted bipolar epidural somatosensory evoked potentials (SEP's) generated by unilateral common peroneal nerve stimulation have been obtained in 27 patients. The SEP's were multiphasic, 0.3 to 1.5 microV in amplitude, and recorded in 100% of patients with normal cords or in patients with...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1982.57.3.0349

    authors: Macon JB,Poletti CE

    更新日期:1982-09-01 00:00:00

  • Magnetic resonance demonstration of vertebral artery dissection. Report of two cases.

    abstract::Vertebral artery dissection may be spontaneous or related to some traumatic event. Diagnosis has usually been made by angiography, an invasive procedure with certain well-known risks. The authors describe the magnetic resonance (MR) appearance (both on conventional spin-echo and on gradient refocused "flow" sequences)...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1990.72.6.0964

    authors: Quint DJ,Spickler EM

    更新日期:1990-06-01 00:00:00

  • Thalamic syndrome caused by unruptured cerebral aneurysm. Case report.

    abstract::A case is reported of a 63-year-old woman with thalamic syndrome as the presenting feature of an unruptured cerebral aneurysm. Unruptured aneurysm is a rare cause of thalamic syndrome; the possible mechanisms of production of the sensory disturbance are discussed. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.82.2.0291

    authors: Stoodley MA,Warren JD,Oatey PE

    更新日期:1995-02-01 00:00:00

  • Intradural extramedullary tuberculoma of the cervical spine. Case report.

    abstract::A case is reported of a 45-year-old man who developed quadriplegia following a trivial motor-vehicle accident. Investigation including computerized tomography (CT) of the cervical spine revealed a large calcified lesion displacing the spinal cord and nerve roots, which proved to be a tuberculoma. The case is unusual i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.1.0200

    authors: Compton JS,Dorsch NW

    更新日期:1984-01-01 00:00:00

  • Long-term survival of patients treated with BCNU for brain tumors.

    abstract::The authors present three patients who, after excision and irradiation of their brain tumors, were treated with BCNU for recurrence. All three patients responded well and now are without evidence of tumor, 37, 30, and 36 months after BCNU was stopped. Although these patients represent only a small fraction of those tr...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1975.43.2.0191

    authors: Calogero J,Crafts DC,Wilson CB,Boldrey EB,Rosenberg A,Enot KJ

    更新日期:1975-08-01 00:00:00

  • Gamma Knife surgery for glossopharyngeal neuralgia.

    abstract::Gamma Knife surgery (GKS) is widely recognized as an effective, minimally invasive treatment for intractable trigeminal neuralgia, but the role of GKS in glossopharyngeal neuralgia (GPN) remains unclear. This study involved 2 patients with medically intractable GPN who were treated using GKS. One patient required 2 tr...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2008.8.17641

    authors: Yomo S,Arkha Y,Donnet A,Régis J

    更新日期:2009-03-01 00:00:00

  • Gamma surgery for melanoma metastases in the brain.

    abstract:OBJECT:The aim of this study was to evaluate the usefulness and limitations of gamma surgery (GS) in the treatment of brain metastases from melanoma. METHODS:Imaging and clinical outcomes in 45 patients treated for 92 brain metastases from melanoma between October 1989 and October 1999 were retrospectively analyzed. F...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2002.96.3.0544

    authors: Mingione V,Oliveira M,Prasad D,Steiner M,Steiner L

    更新日期:2002-03-01 00:00:00

  • Three-dimensional helical computerized tomography angiography in the diagnosis, characterization, and management of middle cerebral artery aneurysms: comparison with conventional angiography and intraoperative findings.

    abstract:OBJECT:Middle cerebral artery (MCA) aneurysms can be difficult to detect and characterize. The authors describe the utility and impact of helical computerized tomography (CT) angiography for the evaluation of aneurysms in this location, and compare this modality with digital subtraction (DS) angiography and intraoperat...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.3171/jns.2002.97.6.1322

    authors: Villablanca JP,Hooshi P,Martin N,Jahan R,Duckwiler G,Lim S,Frazee J,Gobin YP,Sayre J,Bentson J,Viñuela F

    更新日期:2002-12-01 00:00:00

  • Ischemic complications associated with resection of opercular glioma.

    abstract:OBJECT:Opercular glioma inferolateral to the hand/digit sensorimotor area can be resected safely using a neuronavigation system and functional brain mapping techniques. However, the surgery can still sometimes cause postoperative ischemic complications, the character of which remains unclear. The authors of this study ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2007.106.2.263

    authors: Kumabe T,Higano S,Takahashi S,Tominaga T

    更新日期:2007-02-01 00:00:00

  • Factors influencing the complication rate of subduroperitoneal shunt placement for the treatment of subdural hematomas in infants.

    abstract:OBJECT:In this study the authors' goal was to identify the complication rate of subduroperitoneal (SDP) shunts for the treatment of subdural hematomas (SDHs) in infants and to determine the influences on and predictive factors for these complications. METHODS:The authors present a case series spanning the years 1994 t...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2007.106.3.172

    authors: Kurschel S,Puget S,Bourgeois M,Zerah M,Ofner P,Renier D

    更新日期:2007-03-01 00:00:00

  • Speech changes induced by deep brain stimulation of the subthalamic nucleus in Parkinson disease: involvement of the dentatorubrothalamic tract.

    abstract::OBJECTIVE Patients with Parkinson disease (PD) who undergo subthalamic nucleus (STN) deep brain stimulation (DBS) often develop a deterioration in speech performance, but there is no clear consensus on the specific effects seen or the mechanism involved and little description of the impact of DBS on conversational spe...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2016.5.JNS16243

    authors: Fenoy AJ,McHenry MA,Schiess MC

    更新日期:2017-06-01 00:00:00

  • Choroid plexus papillomas and human choroid plexus. A light and electron microscopic study.

    abstract::Choroid plexus papillomas and mature human choroid plexus were studied by light and electron microscopic techniques. The mature choroid plexus has three types of cells: Type I cells are cuboidal or columnar cells and line the villi; Type II cells are flat cells lining connective tissue adjacent to neural tissue; and T...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1983.59.6.1054

    authors: Matsushima T

    更新日期:1983-12-01 00:00:00

  • Engorged epidural venous plexus and cervical myelopathy due to cerebrospinal fluid overdrainage: a rare complication of ventricular shunts. Case report.

    abstract::The authors report on a 17-year-old boy with cervical myelopathy from dilated epidural veins due to cerebrospinal fluid (CSF) overdrainage. The patient had a long-standing subdural-peritoneal shunt and presented with incapacitating spastic tetraparesis. Magnetic resonance imaging revealed significant cervical spinal c...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2007.106.3.227

    authors: Wolfe SQ,Bhatia S,Green B,Ragheb J

    更新日期:2007-03-01 00:00:00

  • Diffuse cerebral swelling following head injuries in children: the syndrome of "malignant brain edema".

    abstract::The commonest initial computerized tomography (CT) finding in head-injured children is bilateral diffuse cerebral swelling. Cerebral blood flow and CT density studies suggest that this swelling is due to cerebral hyperemia and increased blood volume, not to edema. The clinical history, course, and outcome of 63 childr...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1981.54.2.0170

    authors: Bruce DA,Alavi A,Bilaniuk L,Dolinskas C,Obrist W,Uzzell B

    更新日期:1981-02-01 00:00:00

  • Quantification of thermal asymmetry. Part 2: Application in low-back pain and sciatica.

    abstract::Temperature differences between the lower extremities were measured using a computerized thermometric scanning system in order to compare the degree of thermal asymmetry in 144 patients with low-back pain. The patients displayed highly significant thermal asymmetries, with the involved limb being cooler (p less than 0...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1988.69.4.0556

    authors: Uematsu S,Jankel WR,Edwin DH,Kim W,Kozikowski J,Rosenbaum A,Long DM

    更新日期:1988-10-01 00:00:00

  • Brain injury from a spent bullet descending vertically. Report of five cases.

    abstract::This is a report of five cases in which a bullet penetrated the vertex of the skull and brain, apparently during its vertical descent after having been fired into the air. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1971.34.2part1.0222

    authors: Hanieh A

    更新日期:1971-02-01 00:00:00

  • Arteriovenous malformations in the posterior fossa.

    abstract::We have operated on 12 of 14 cases of arteriovenous malformation (AVM) in the posterior fossa since 1968, with one death. The lesions were in the cerebellum in 10 cases (three anteromedial, one central, three lateral, and three posteromedial), and in the cerebellopontine angle in two; in two cases the lesions were dir...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1977.47.1.0050

    authors: Matsumura H,Makita Y,Someda K,Kondo A

    更新日期:1977-07-01 00:00:00

  • Effect of subarachnoid hemorrhage on the extracellular microenvironment.

    abstract::Local experimental subarachnoid hemorrhage (SAH) was produced over the cerebral cortex in 15 cats. The cellular response was monitored using ion-specific electrodes for extracellular potassium (K+) and calcium (Ca++) activity, DC cortical potential, and electrocorticogram. The response was characterized by a profound ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1982.56.2.0216

    authors: Hubschmann OR,Kornhauser D

    更新日期:1982-02-01 00:00:00

  • Endovascular placement of a ventriculoatrial shunt. Technical note.

    abstract::Atrial shunt revision surgeries are sometimes difficult due to venous occlusion and neck scarring. A direct approach guided by venography facilitates exposure and guarantees accurate placement of the distal catheter. Five patients with complicated histories of shunt malfunction were treated using an endoscope-assisted...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2007.106.4.319

    authors: Gonzalez LF,Kim L,Rekate HL,McDougall CG,Albuquerque FC

    更新日期:2007-04-01 00:00:00

  • Does adjuvant external-beam radiotherapy improve outcomes for nonbenign meningiomas? A Surveillance, Epidemiology, and End Results (SEER)-based analysis.

    abstract:OBJECT:The aim of this study was to examine the effect of postoperative external-beam radiation therapy (EBRT) on disease-specific survival in patients with nonbenign meningiomas. METHODS:The Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2007 was queried for cases of resected Grades II (atyp...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2012.7.JNS111439

    authors: Stessin AM,Schwartz A,Judanin G,Pannullo SC,Boockvar JA,Schwartz TH,Stieg PE,Wernicke AG

    更新日期:2012-10-01 00:00:00

  • Subcutaneous bone flap storage after emergency craniectomy: cost-effectiveness and rate of resorption.

    abstract::OBJECTIVEDecompressive craniectomy is used for uncontrolled intracranial pressure in traumatic brain injury and malignant hemispheric stroke. Subcutaneous preservation of the autologous bone flap in the abdomen is a simple, portable technique but has largely been abandoned due to perceived concerns of resorption. The ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2017.6.JNS17943

    authors: Ernst G,Qeadan F,Carlson AP

    更新日期:2018-12-01 00:00:00

  • A randomized placebo-controlled double-blind trial of nimodipine after SAH in monkeys. Part 1: Clinical and radiological findings.

    abstract::The authors have developed a method to induce chronic cerebral vasospasm after subarachnoid hemorrhage (SAH) in monkeys. With microsurgical techniques, 33 monkeys had a frontotemporal craniectomy and unilateral opening of the subarachnoid cisterns. Cerebrospinal fluid was drained and a fresh hematoma, obtained from an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.6.1167

    authors: Espinosa F,Weir B,Overton T,Castor W,Grace M,Boisvert D

    更新日期:1984-06-01 00:00:00

  • Corpus callosotomy performed with laser interstitial thermal therapy.

    abstract:OBJECTIVE:Corpus callosotomy is a palliative procedure that is effective at reducing seizure burden in patients with medically refractory epilepsy. The procedure is traditionally performed via open craniotomy with interhemispheric microdissection to divide the corpus callosum. Concerns for morbidity associated with cra...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2019.9.JNS191769

    authors: Roland JL,Akbari SHA,Salehi A,Smyth MD

    更新日期:2019-12-13 00:00:00

  • Arachnoid membranes in the posterior half of the incisural space: an inverted Liliequist membrane-like arachnoid complex.

    abstract:OBJECT:The aim of this study was to describe the similarity of configuration between the arachnoid complex in the posterior half of the incisural space and the Liliequist membrane. METHODS:Microsurgical dissection and anatomical observation were performed in 20 formalin-fixed adult cadaver heads. The origin, distribut...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.3.JNS132206

    authors: Zhang XA,Qi ST,Fan J,Huang GL,Peng JX

    更新日期:2014-08-01 00:00:00

  • Preservation of olfaction in anterior craniofacial approaches.

    abstract::Through the combined efforts of neurosurgeons, head and neck surgeons, and craniofacial surgeons, the standard transbasal approach to the frontal fossa has been modified to include removal of the orbital roofs, nasion, and ethmoid sinuses. This approach has been combined further with facial disassembly procedures to p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1993.79.1.0048

    authors: Spetzler RF,Herman JM,Beals S,Joganic E,Milligan J

    更新日期:1993-07-01 00:00:00

  • A new model of transient hindbrain ischemia in gerbils.

    abstract::A model of transient hindbrain ischemia in Mongolian gerbils is described. The vertebrobasilar junction of gerbils was exposed by a transcervical approach through the space between the atlas and occipital bone. The origin of the basilar artery was occluded by a clip, and the local cerebral blood flow (CBF) was measure...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.5.1054

    authors: Yamada K,Hayakawa T,Yoshimine T,Ushio Y

    更新日期:1984-05-01 00:00:00

  • Origin of somatosensory evoked responses recorded from the cervical skin surface.

    abstract::Somatosensory evoked response from the cervical skin surface over the spine (the cervical SER) was recorded, and compared with the cord dorsum potential (CDP) simultaneously recorded from the posterior epidural space at the same segment. The cervical SER evoked by segmental nerve stimulation consisted of an initially ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1978.48.6.0980

    authors: Shimoji K,Shimizu H,Maruyama Y

    更新日期:1978-06-01 00:00:00

  • Endoscopic endonasal resection of Rathke cleft cysts: clinical outcomes and surgical nuances.

    abstract:OBJECT:Rathke cleft cysts (RCCs) are benign lesions that can be diagnosed as an incidental finding associated with headaches, pituitary dysfunction, or vision deterioration. Typically, they occur in a sellar or suprasellar location. The aim of this study was to review the clinical presentation and outcomes associated w...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2009.10.JNS09348

    authors: Madhok R,Prevedello DM,Gardner P,Carrau RL,Snyderman CH,Kassam AB

    更新日期:2010-06-01 00:00:00