Chemotherapy of pediatric brain-stem tumors.


:Forty-five children harboring brain-stem tumors were treated at the University of California, San Francisco, between 1969 and 1979. Pathological diagnoses were made in 19 patients. All patients received radiation therapy (RT). Thirteen patients received chemotherapy before, during, or immediately after RT. Twenty-four patients were treated with chemotherapy at the time of tumor progression, after initial treatment with RT alone. No statistically significant difference in time to tumor progression or survival was found for treatment with chemotherapy as an adjuvant to RT compared to treatment with RT alone followed by chemotherapy administered at the time of tumor progression. There were, however, more long-term survivors in the group that was first treated with chemotherapy at the time of tumor progression. There was no statistically significant correlation between survival and tumor pathology or location, although there were more long-term survivors among patients harboring low-grade gliomas and among patients with tumors confined to the midbrain. The authors documented the response of some brain-stem tumors to chemotherapy; however, cooperative controlled studies will be required to determine the optimum treatment for this disease.


J Neurosurg


Journal of neurosurgery


Fulton DS,Levin VA,Wara WM,Edwards MS,Wilson CB




Has Abstract


1981-06-01 00:00:00












  • Surgical management of camptocormia in Parkinson's disease: systematic review and meta-analysis.

    abstract:OBJECTIVE:Camptocormia is a potentially debilitating condition in the progression of Parkinson's disease (PD). It is described as an abnormal forward flexion while standing that resolves when lying supine. Although the condition is relatively common, the underlying pathophysiology and optimal treatment strategy are unc...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,meta分析


    authors: Chan AK,Chan AY,Lau D,Durcanova B,Miller CA,Larson PS,Starr PA,Mummaneni PV

    更新日期:2018-09-14 00:00:00

  • Analysis of intra- and intercellular calcium signaling in a mouse malignant glioma cell line.

    abstract::Intra- and intercellular calcium signaling in glioma cells was examined by mechanical stimulation of a monolayer cell line of methylcholanthrene-induced mouse ependymoblastoma, 203-glioma, with a fine round-tip glass needle. A fura-2 fluorescence image of the glioma revealed a four- to eightfold increase in the cytoso...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Yamasaki T,Enomoto K,Moritake K,Maeno T

    更新日期:1994-09-01 00:00:00

  • Assessment of the difference in posterior circulation involvement between pediatric and adult patients with moyamoya disease.

    abstract:OBJECT:There is no description of the change in the posterior cerebral artery (PCA) in the diagnostic criteria of moyamoya disease (MMD). However, PCAs are often involved in the clinical setting, and an understanding of the significance of PCA lesions is therefore of great importance when evaluating the disease progres...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Hishikawa T,Tokunaga K,Sugiu K,Date I

    更新日期:2013-10-01 00:00:00

  • Treatment of spontaneous carotid-cavernous fistula in Ehlers-Danlos syndrome by transvenous occlusion with Guglielmi detachable coils. Case report and review of the literature.

    abstract::The authors report on a young woman with Ehlers-Danlos syndrome (EDS) Type IV in whom a spontaneous direct carotid-cavernous fistula (CCF) was treated by transvenous occlusion with regular and fiber-coated Guglielmi detachable coils. To the authors' knowledge, this is the first time this approach has been used in a pa...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: Kanner AA,Maimon S,Rappaport ZH

    更新日期:2000-10-01 00:00:00

  • Gamma knife radiosurgery for trigeminal neuralgia associated with multiple sclerosis.

    abstract:OBJECT:The authors assessed the efficacy and complications from gamma knife radiosurgery (GKS) for multiple sclerosis (MS)-associated trigeminal neuralgia (TN). METHODS:There were 15 patients with MS-associated TN (MS-TN). Treatment involved three sequential protocols, 70 to 90-Gy maximum dose, using a single 4-mm iso...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章


    authors: Rogers CL,Shetter AG,Ponce FA,Fiedler JA,Smith KA,Speiser BL

    更新日期:2002-12-01 00:00:00

  • Extended transsphenoidal approach.

    abstract::The authors have developed an extended transsphenoidal approach with submucosal posterior ethmoidectomy for resection of tumors located in the cavernous sinus or the suprasellar region that are difficult to remove via the conventional transsphenoidal approach. Surgery was performed using this approach in 14 patients w...

    journal_title:Journal of neurosurgery

    pub_type: 评论,信件


    authors: Frank G,Pasquini E,Mazzatenta D

    更新日期:2001-11-01 00:00:00

  • Holoventricular glioma in a child. Case report.

    abstract::An intraventricular glioma occupying all four ventricles of the brain in children is very uncommon. The authors report a unique case of a tetraventricular Grade II astrocytoma with evidence of extension into the basal cisterns in a 5-year-old boy who had a 1-month history of headache. There was no neurological deficit...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Hercules SA,Ramesh VG,Paramasivan S,Kodiarasan P,Kumar MS

    更新日期:2007-02-01 00:00:00

  • Microsurgical anatomy of the hippocampal arteries.

    abstract::An anatomical study of the vascularization of the hippocampus was performed on 30 hemispheres. There were a total of 140 arteries supplying the hippocampi, for an average of 4.7 arteries per hemisphere (range three to seven arteries). Based on the origin and caliber of the arteries supplying the hippocampus, the hemis...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Erdem A,Yaşargil G,Roth P

    更新日期:1993-08-01 00:00:00

  • The nonsurgical nature of patients with subarachnoid or intraparenchymal hemorrhage associated with mild traumatic brain injury.

    abstract:OBJECT:Mild traumatic brain injury (mTBI), as defined by Glasgow Coma Scale (GCS) score of 13 or higher, is a common problem in the United States and worldwide, estimated to affect more than 1 million patients yearly. When associated with intracranial hemorrhage, it is a common reason for neurosurgical consultation and...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Ditty BJ,Omar NB,Foreman PM,Patel DM,Pritchard PR,Okor MO

    更新日期:2015-09-01 00:00:00

  • Thyrotropin-producing pituitary adenomas.

    abstract::To evaluate the biology of thyrotropin (TSH)-producing pituitary adenomas, the authors reviewed the charts of 19 patients who underwent transsphenoidal surgery within a 15-year period at the University of California, San Francisco (UCSF). Between 1989 and 1991, the period during which immunostaining techniques were us...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Mindermann T,Wilson CB

    更新日期:1993-10-01 00:00:00

  • Polymorphism rs42524 of COL1A2 and sporadic intracranial aneurysms in the Chinese population.

    abstract:OBJECT:The COL1A2 gene at 7q22.1 has been shown to be associated with familial intracranial aneurysms (IAs) in the Japanese population. In the present study, the authors investigated the correlation between the presence of the rs42524 polymorphism in COL1A2 and the occurrence of sporadic IAs in Chinese patients. METHO...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Zhu Y,Li W,Ge M,Xu S,Zhao G,Wang H,Qian H,Zhu N,Pang Q

    更新日期:2008-12-01 00:00:00

  • Liposomes coupled with monoclonal antibodies against glioma-associated antigen for targeting chemotherapy of glioma.

    abstract::Liposomes have a variety of attributes as a drug delivery system. Targeting of liposomes to specific cells has been investigated by using appropriate cytophilic ligands such as monoclonal antibodies (MAb's). In the present study, liposomes with selective cytotoxicity toward glioma cells were obtained. An MAb which rea...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kito A,Yoshida J,Kageyama N,Kojima N,Yagi K

    更新日期:1989-09-01 00:00:00

  • Irving S. Cooper (1922-1985): a pioneer in functional neurosurgery.

    abstract::Irving S. Cooper (1922-1985), the son of a salesman, worked his way through high school, college, and medical school to become one of the pioneers in functional neurosurgery. He developed several novel techniques for the surgical management of Parkinson's disease and other crippling movement disorders. A keen interest...

    journal_title:Journal of neurosurgery

    pub_type: 传,历史文章,杂志文章


    authors: Das K,Benzil DL,Rovit RL,Murali R,Couldwell WT

    更新日期:1998-11-01 00:00:00

  • Intraoperative localization using an armless, frameless stereotactic wand. Technical note.

    abstract::A technique of "frameless" stereotaxy that allows real-time intraoperative neurosurgical localization is described. The system is composed of four components: a hand-held probe containing two ultrasonic emitters, a microphone array that is rigidly affixed to the operating table in proximity to the surgical field, hard...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Barnett GH,Kormos DW,Steiner CP,Weisenberger J

    更新日期:1993-03-01 00:00:00

  • Cysts of the atlantoaxial joint: excellent long-term outcome after posterolateral surgical decompression. Report of two cases.

    abstract::Articular cysts of the atlantoaxial joint are infrequently described and probably an underreported cause of upper cervical spinal cord compression. The authors report on two patients with cysts located posteriorly of the dens in whom a C-1 and partial C-2 hemilaminectomy with subtotal resection of the cyst provided ad...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Zorzon M,Skrap M,Diodato S,Nasuelli D,Lucci B

    更新日期:2001-07-01 00:00:00

  • Malignant progression in meningioma: documentation of a series and analysis of cytogenetic findings.

    abstract:OBJECT:The malignant progression of benign tumors is well documented in gliomas and other systemic lesions. It is also well known that some meningiomas become progressively aggressive despite their original benign status. The theory of clonal evolution is widely believed to explain malignant progression in meningioma; ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Al-Mefty O,Kadri PA,Pravdenkova S,Sawyer JR,Stangeby C,Husain M

    更新日期:2004-08-01 00:00:00

  • Diffuse bilateral cerebral astrocytomas with atypical neuroimaging studies.

    abstract::The authors describe the clinical behavior of eight patients with cerebral astrocytomas, in whom computerized tomography (CT) or magnetic resonance (MR) imaging of the brain was characterized by diffuse bilateral cerebral hemisphere tissue density abnormalities and minimal focal mass effect. Five patients were newly d...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Rogers LR,Weinstein MA,Estes ML,Cairncross JG,Strachan T

    更新日期:1994-12-01 00:00:00

  • Correlation between the efferent venous drainage of the tumor and peritumoral edema in intracranial meningiomas: superselective angiographic analysis of 25 cases.

    abstract:OBJECT:The extent of peritumoral brain edema (PTBE) associated with meningiomas can be highly variable. The authors studied the correlation between the development of efferent venous drainage from the tumor and the degree of PTBE that occurs in intracranial meningiomas. METHODS:Twenty-five patients with 27 intracrania...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Tanaka M,Imhof HG,Schucknecht B,Kollias S,Yonekawa Y,Valavanis A

    更新日期:2006-03-01 00:00:00

  • Hemorrhage after particle embolization of hemangioblastomas: comparison of outcomes in spinal and cerebellar lesions.

    abstract:OBJECT:In this study the authors compare the clinical outcomes after particle embolization of hemangioblastomas in the cerebellum and spinal cord. They also review the literature of similar cases. METHODS:Seven patients with hemangioblastomas in the spinal cord (four patients) and cerebellum (three patients) underwent...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Cornelius JF,Saint-Maurice JP,Bresson D,George B,Houdart E

    更新日期:2007-06-01 00:00:00

  • Tenascin-C-coated platinum coils for acceleration of organization of cavities and reduction of lumen size in a rat aneurysm model.

    abstract:OBJECT:Detachable platinum coils are widely used in the endovascular treatment of intracranial aneurysms. The use of coil placement produces a higher incidence of aneurysm recurrence compared with surgical clipping. To reduce the incidence of recurrence by promoting clot organization, the authors designed a platinum co...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Toma N,Imanaka-Yoshida K,Takeuchi T,Matsushima S,Iwata H,Yoshida T,Taki W

    更新日期:2005-10-01 00:00:00

  • Induction of tolerance against ischemia/reperfusion injury in the rat brain by preconditioning with the endotoxin analog diphosphoryl lipid A.

    abstract:OBJECT:Inflammatory responses and oxygen free radicals have increasingly been implicated in the development of ischemic brain injury. In some cases, an attenuation of inflammation or free-radical injury can provide tissue protection. Diphosphoryl lipid A (DPL) is a detoxified derivative of a lipopolysaccharide (endotox...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Toyoda T,Kassell NF,Lee KS

    更新日期:2000-03-01 00:00:00

  • Spontaneous involution of a large pineal region hemorrhagic cyst in an infant. Case report.

    abstract::The authors report the case of a newborn presenting at birth with macrocephaly and a large pineal region hemorrhagic cyst without neurological deficit. No neurosurgical intervention was performed, and subsequent imaging studies demonstrated complete involution of the cyst. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Nimmagadda A,Sandberg DI,Ragheb J

    更新日期:2006-04-01 00:00:00

  • Normalization of hindbrain morphology after decompression of Chiari malformation Type I.

    abstract:OBJECT:Chiari malformation Type I (CM-I) is characterized by hindbrain deformity. We investigated the effects of craniocervical decompression surgery on the anatomical features of hindbrain deformity with a prospective MRI study of patients with CM-I. METHODS:A prospective longitudinal study was conducted in 48 patien...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Heiss JD,Suffredini G,Bakhtian KD,Sarntinoranont M,Oldfield EH

    更新日期:2012-11-01 00:00:00

  • Occlusion of cerebral artery due to metastasis of chorioepithelioma. Case report.

    abstract::A case of cerebral metastasis of chorioepithelioma with an occlusion of the angular artery is presented. The occlusion was verified angiographically, surgically, and microscopically. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Nakagawa Y,Tashiro K,Isu T,Tsuru M

    更新日期:1979-08-01 00:00:00

  • Thalamic deep brain stimulation for writer's cramp.

    abstract:OBJECT:Writer's cramp is a type of idiopathic focal hand dystonia characterized by muscle cramps that accompany execution of the writing task specifically. In this report, the authors describe the clinical outcome after thalamic deep brain stimulation (DBS) therapy in patients with writer's cramp and present an illustr...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Fukaya C,Katayama Y,Kano T,Nagaoka T,Kobayashi K,Oshima H,Yamamoto T

    更新日期:2007-11-01 00:00:00

  • Comparison of spinal cord gray matter and white matter softness: measurement by pipette aspiration method.

    abstract:OBJECT:Although the gray matter of the spinal cord has been thought to be softer than the white matter, there is no evidence to support this belief. Because the spinal cord is extremely soft, it has been difficult to measure the mechanical properties of the gray and white matter. The modulis of elasticity of the gray a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Ozawa H,Matsumoto T,Ohashi T,Sato M,Kokubun S

    更新日期:2001-10-01 00:00:00

  • Intraoperative subcortical stimulation mapping for hemispherical perirolandic gliomas located within or adjacent to the descending motor pathways: evaluation of morbidity and assessment of functional outcome in 294 patients.

    abstract:OBJECT:Intraoperative stimulation mapping of subcortical white matter tracts during the resection of gliomas has become a valuable surgical adjunct that is used to reduce morbidity associated with tumor removal. The purpose of this retrospective analysis was to assess the morbidity and functional outcome associated wit...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Keles GE,Lundin DA,Lamborn KR,Chang EF,Ojemann G,Berger MS

    更新日期:2004-03-01 00:00:00

  • MicroRNA and gene expression changes in unruptured human cerebral aneurysms.

    abstract::OBJECTIVE The molecular mechanisms behind cerebral aneurysm formation and rupture remain poorly understood. In the past decade, microRNAs (miRNAs) have been shown to be key regulators in a host of biological processes. They are noncoding RNA molecules, approximately 21 nucleotides long, that posttranscriptionally inhi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Bekelis K,Kerley-Hamilton JS,Teegarden A,Tomlinson CR,Kuintzle R,Simmons N,Singer RJ,Roberts DW,Kellis M,Hendrix DA

    更新日期:2016-12-01 00:00:00

  • Effects of intracranial meningioma location, size, and surgery on neurocognitive functions: a 3-year prospective study.

    abstract::OBJECT Current recommendations stress the need for cognitive parameters to be integrated in the evaluation of outcomes for intracranial meningioma surgery. The aim of this prospective study was to examine neurocognitive function in meningioma patients pre- and postoperatively. METHODS Patients with skull base (anterio...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Liouta E,Koutsarnakis C,Liakos F,Stranjalis G

    更新日期:2016-06-01 00:00:00

  • Early surgical removal of migrated coil/stent after failed embolization of intracranial aneurysm.

    abstract:OBJECT:Distal coil or stent migration is a rare, but potentially morbid complication of intracranial aneurysm embolization. At present, there is no established standard of surgical evacuation of displaced material-in particular, there is no consensus on the optimum time for such intervention. The authors report their p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Turek G,Kochanowicz J,Lewszuk A,Lyson T,Zielinska-Turek J,Chwiesko J,Mariak Z

    更新日期:2015-10-01 00:00:00