Phase II clinical study on intraoperative photodynamic therapy with talaporfin sodium and semiconductor laser in patients with malignant brain tumors.


OBJECT:The objective of the present study was to perform a prospective evaluation of the potential efficacy and safety of intraoperative photodynamic therapy (PDT) using talaporfin sodium and irradiation using a 664-nm semiconductor laser in patients with primary malignant parenchymal brain tumors. METHODS:In 27 patients with suspected newly diagnosed or recurrent primary malignant parenchymal brain tumors, a single intravenous injection of talaporfin sodium (40 mg/m(2)) was administered 1 day before resection of the neoplasm. The next day after completion of the tumor removal, the residual lesion and/or resection cavity were irradiated using a 664-nm semiconductor laser with a radiation power density of 150 mW/cm(2) and a radiation energy density of 27 J/cm(2). The procedure was performed 22-27 hours after drug administration. The study cohort included 22 patients with a histopathologically confirmed diagnosis of primary malignant parenchymal brain tumor. Thirteen of these neoplasms (59.1%) were newly diagnosed glioblastomas multiforme (GBM). RESULTS:Among all 22 patients included in the study cohort, the 12-month overall survival (OS), 6-month progression-free survival (PFS), and 6-month local PFS rates after surgery and PDT were 95.5%, 91%, and 91%, respectively. Among patients with newly diagnosed GBMs, all these parameters were 100%. Side effects on the skin, which could be attributable to the administration of talaporfin sodium, were noted in 7.4% of patients and included rash (2 cases), blister (1 case), and erythema (1 case). Skin photosensitivity test results were relatively mild and fully disappeared within 15 days after administration of photosensitizer in all patients. CONCLUSIONS:Intraoperative PDT using talaporfin sodium and a semiconductor laser may be considered as a potentially effective and sufficiently safe option for adjuvant management of primary malignant parenchymal brain tumors. The inclusion of intraoperative PDT in a combined treatment strategy may have a positive impact on OS and local tumor control, particularly in patients with newly diagnosed GBMs. Clinical trial registration no.: JMA-IIA00026 (


J Neurosurg


Journal of neurosurgery


Muragaki Y,Akimoto J,Maruyama T,Iseki H,Ikuta S,Nitta M,Maebayashi K,Saito T,Okada Y,Kaneko S,Matsumura A,Kuroiwa T,Karasawa K,Nakazato Y,Kayama T




Has Abstract


2013-10-01 00:00:00












  • Evaluation of prognostic factors and clinical outcome in elderly patients in whom expansive laminoplasty is performed for cervical myelopathy due to multisegmental spondylotic canal stenosis. A retrospective comparison with younger patients.

    abstract:OBJECT:It remains unclear whether elderly patients with compressive cervical myelopathy can be expected to experience a promising surgery-related outcome after undergoing expansive laminoplasty. The purposes of this study were to evaluate the efficacy of expansive laminoplasty in elderly patients with cervical myelopat...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Handa Y,Kubota T,Ishii H,Sato K,Tsuchida A,Arai Y

    更新日期:2002-03-01 00:00:00

  • Long-term outcome after resection of brainstem hemangioblastomas in von Hippel-Lindau disease.

    abstract:OBJECT:Brainstem hemangioblastomas are frequently encountered in patients with von Hippel-Lindau (VHL) disease. These tumors can cause significant morbidity, and their optimal management has not been defined. To better define the outcome and management of these tumors, the authors analyzed the long-term results in pati...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Wind JJ,Bakhtian KD,Sweet JA,Mehta GU,Thawani JP,Asthagiri AR,Oldfield EH,Lonser RR

    更新日期:2011-05-01 00:00:00

  • Trigeminal neuralgia resulting from auditory brainstem implant cable compression.

    abstract::The authors report a case of neurofibromatosis Type 2 presenting with symptoms of trigeminal neuralgia refractory to medical management following placement of an auditory brainstem implant (ABI). Physical examination and history revealed trigeminal neuralgia. A 3D FIESTA (fast imaging employing steady-state acquisitio...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Schwartz MS,Brackmann DE,Wilkinson EP,Go JL,Santos F

    更新日期:2011-01-01 00:00:00

  • Cost analysis of awake versus asleep deep brain stimulation: a single academic health center experience.

    abstract::OBJECT The objective of this study was to compare the cost of deep brain stimulation (DBS) performed awake versus asleep at a single US academic health center and to compare costs across the University HealthSystem Consortium (UHC) Clinical Database. METHODS Inpatient and outpatient demographic and hospital financial ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Jacob RL,Geddes J,McCartney S,Burchiel KJ

    更新日期:2016-05-01 00:00:00

  • Do tumor and ventricular volume predict the need for postresection shunting in colloid cyst patients?

    abstract::OBJECTIVE Many colloid cyst patients present with obstructive hydrocephalus that resolves after resection of the cyst. However, a proportion of patients with these cysts will require cerebrospinal fluid shunting after tumor resection, despite resolution of the obstruction at the foramina of Monro. The goal of this stu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Weaver KJ,McCord M,Neal D,Bova F,Rajon D,Quinones-Hinojosa A,Rahman M

    更新日期:2016-09-01 00:00:00

  • Cerebellar stimulation in man. Quantitative changes in spasticity.

    abstract::The effects of chronic anterior lobe cerebellar stimulation on patients with cerebral palsy have been investigated using a new method of quanitfying muscle rigidity and stretch reflexes. The ankle is oscillated sinusoidally, compliance is measured at several frequencies, and electromyographic activity of the extensor ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Penn RD,Gottlieb GL,Agarwal GC

    更新日期:1978-05-01 00:00:00

  • Natural course of intracranial arterial dissections.

    abstract:OBJECT:Noninvasive neuroimaging techniques are increasingly identifying unruptured intracranial arterial dissections (IADs) at examination for headache or ischemic symptoms. Approximately 3% of cases of aneurysmal subarachnoid hemorrhage (SAH) are caused by IADs in Japan, but the natural history of unruptured IADs is n...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Mizutani T

    更新日期:2011-04-01 00:00:00

  • Outcomes and complications of different surgical treatments for idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis.

    abstract::OBJECTIVEDifferent CSF diversion procedures (ventriculoperitoneal, ventriculoatrial, and lumboperitoneal shunting) have been utilized for the treatment of idiopathic normal pressure hydrocephalus. More recently, endoscopic third ventriculostomy has been suggested as a reasonable alternative in some studies. The purpos...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: Giordan E,Palandri G,Lanzino G,Murad MH,Elder BD

    更新日期:2018-11-01 00:00:00

  • Radiotherapy and CCNU in the treatment of high-grade supratentorial astrocytomas.

    abstract::Forty-one consecutive patients with supratentorial primary brain tumors (38 Grade III and IV astrocytomas, one giant-cell astrocytoma, and two cases with insufficient tissue for diagnosis) were randomly allocated within 2 weeks of surgery to one of three therapeutic groups. Group 1 (15 patients) received radiation the...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Weir B,Band P,Urtasun R,Blain G,Mclean D,Wilson F,Mielke B,Grace M

    更新日期:1976-08-01 00:00:00

  • Acquired Chiari I malformation secondary to spontaneous spinal cerebrospinal fluid leakage and chronic intracranial hypotension syndrome in seven cases.

    abstract:OBJECT:Spontaneous spinal cerebrospinal fluid (CSF) leakage with development of the intracranial hypotension syndrome and acquired Chiari I malformation due to lumbar spinal CSF diversion procedures have both been well described. However, concomitant presentation of both syndromes has rarely been reported. The object o...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Atkinson JL,Weinshenker BG,Miller GM,Piepgras DG,Mokri B

    更新日期:1998-02-01 00:00:00

  • Thalamic syndrome caused by unruptured cerebral aneurysm. Case report.

    abstract::A case is reported of a 63-year-old woman with thalamic syndrome as the presenting feature of an unruptured cerebral aneurysm. Unruptured aneurysm is a rare cause of thalamic syndrome; the possible mechanisms of production of the sensory disturbance are discussed. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Stoodley MA,Warren JD,Oatey PE

    更新日期:1995-02-01 00:00:00

  • A refined experimental model of fusiform aneurysms in a rabbit carotid artery.

    abstract:OBJECTIVE:Reliable animal models are an important aspect of translational research, especially for relatively uncommon clinical entities such as fusiform aneurysms. While several animal models exist, very few are tailored to cerebral fusiform aneurysms, which have unique attributes compared to abdominal fusiform aneury...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Avery MB,Alaqeel A,Bromley AB,Chen YX,Wong JH,Eesa M,Mitha AP

    更新日期:2018-07-27 00:00:00

  • A leap forward in the endovascular management of acute basilar artery occlusion since the appearance of stent retrievers: a single-center comparative study.

    abstract::OBJECTIVE Contrary to acute ischemic stroke involving the anterior circulation, no randomized trial has yet demonstrated the safety and effectiveness of endovascular management in acute basilar artery occlusion (BAO). Recently developed thrombectomy devices, such as stentrievers and aspiration systems, have helped in ...

    journal_title:Journal of neurosurgery

    pub_type: 评论,杂志文章


    authors: Fahed R,Di Maria F,Rosso C,Sourour N,Degos V,Deltour S,Baronnet-Chauvet F,Léger A,Crozier S,Gabrieli J,Samson Y,Chiras J,Clarençon F

    更新日期:2017-05-01 00:00:00

  • Acute hydrocephalus and death one month after non-surgical treatment for acute cerebellar hemorrhage. Case report.

    abstract::Acute cerebellar hemorrhages, treated medically with subsequent complete recovery, have been designated "benign cerebellar hemorrhages." Ordinarily, acute cerebellar hemorrhage does require early surgical intervention and reported surgical mortality is relatively low (17%) in awake patients with this lesion. Clinical ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Brillman J

    更新日期:1979-03-01 00:00:00

  • Regional cerebrovascular and metabolic effects of hyperventilation after severe traumatic brain injury.

    abstract:OBJECT:Recently, concern has been raised that hyperventilation following severe traumatic brain injury (TBI) could lead to cerebral ischemia. In acute ischemic stroke, in which the baseline metabolic rate is normal, reduction in cerebral blood flow (CBF) below a threshold of 18 to 20 ml/100 g/min is associated with ene...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Diringer MN,Videen TO,Yundt K,Zazulia AR,Aiyagari V,Dacey RG Jr,Grubb RL,Powers WJ

    更新日期:2002-01-01 00:00:00

  • Dabigatran bleed risk with closed head injuries: are we prepared?

    abstract:OBJECT:The direct thrombin inhibitor dabigatran has recently been approved in the US as an alternative to warfarin. The lack of guidelines, protocols, and an established specific antidote to reverse the anticoagulation effect of dabigatran potentially increases the rates of morbidity and mortality in patients with clos...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Parra MW,Zucker L,Johnson ES,Gullett D,Avila C,Wichner ZA,Kokaram CR

    更新日期:2013-09-01 00:00:00

  • Hydroxyurea for treatment of unresectable and recurrent meningiomas. II. Decrease in the size of meningiomas in patients treated with hydroxyurea.

    abstract::In this paper the authors present the first evidence that meningiomas respond to treatment with hydroxyurea. Hydroxyurea was administered as an adjunct chemotherapeutic treatment in patients with recurrent and unresectable meningiomas. Hydroxyurea was used because experimental data demonstrated that it inhibits growth...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章


    authors: Schrell UM,Rittig MG,Anders M,Koch UH,Marschalek R,Kiesewetter F,Fahlbusch R

    更新日期:1997-05-01 00:00:00

  • Hook-rod with pedicle screw fixation for unstable spinal fracture. Technical note.

    abstract::A technique is described in which spinal fracture repositioning, decompression, and stabilization are achieved by a combination of hook-rod and pedicle screw fixation. This straightforward technique is useful for performing acute decompression in patients with partial neurological deficits and multisystem injuries. A ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Stancić MF,Mićović V,Potocnjak M

    更新日期:2000-01-01 00:00:00

  • Low-grade gliomas in children: tumor volume response to radiation.

    abstract:OBJECT:The authors conducted a retrospective review to examine and document the frequency, degree, and timing of the radiologically confirmed response to radiotherapy of low-grade gliomas in children. METHODS:Between 1963 and 1995, 80 patients 17 years of age or younger were referred to the London Regional Cancer Cent...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Fisher BJ,Bauman GS,Leighton CE,Stitt L,Cairncross JG,Macdonald DR

    更新日期:1998-06-01 00:00:00

  • Hemorrhage after particle embolization of hemangioblastomas: comparison of outcomes in spinal and cerebellar lesions.

    abstract:OBJECT:In this study the authors compare the clinical outcomes after particle embolization of hemangioblastomas in the cerebellum and spinal cord. They also review the literature of similar cases. METHODS:Seven patients with hemangioblastomas in the spinal cord (four patients) and cerebellum (three patients) underwent...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Cornelius JF,Saint-Maurice JP,Bresson D,George B,Houdart E

    更新日期:2007-06-01 00:00:00

  • Synergistic effect of basic fibroblast growth factor and methylprednisolone on neurological function after experimental spinal cord injury.

    abstract::The authors evaluated the effects of exogenous basic fibroblast growth factor (bFGF) in combination with intravenous methylprednisolone on neurological function and cord angiogenesis in a model of spinal cord injury. Cord injury was produced by extradural clip compression through a T-1 laminectomy. Rats were randomize...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Baffour R,Achanta K,Kaufman J,Berman J,Garb JL,Rhee S,Friedmann P

    更新日期:1995-07-01 00:00:00

  • Hemiparesis caused by vertebral artery compression of the medulla oblongata. Case report.

    abstract::The case is reported of a patient with progressive left hemiparesis due to vascular compression of the medulla oblongata. Metrizamide computerized tomography cisternography revealed that the left vertebral artery was compressing and distorting the left lateral surface of the medulla. Compression was surgically relieve...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kim P,Ishijima B,Takahashi H,Shimizu H,Yokochi M

    更新日期:1985-03-01 00:00:00

  • Magnetic resonance imaging-monitored conservative management of traumatic spinal epidural hematomas. Report of four cases.

    abstract::Spinal epidural hematomas (SEHs) are uncommon complications of traumatic injury to the spine. Emergency surgical evacuation is the standard treatment. Although it is recognized in the literature, the possibility of nonsurgical treatment of traumatic SEH is far from being codified. The authors report excellent outcomes...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: La Rosa G,d'Avella D,Conti A,Cardali S,La Torre D,Cacciola F,Longo M,Tomasello F

    更新日期:1999-07-01 00:00:00

  • Multimodality treatment of posterior fossa arteriovenous malformations.

    abstract:OBJECT:Posterior fossa arteriovenous malformations (AVMs) are relatively uncommon and often difficult to treat. The authors present their experience with multimodality treatment of 76 posterior fossa AVMs, with an emphasis on Spetzler-Martin Grades III-V AVMs. METHODS:Seventy-six patients with posterior fossa AVMs tre...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kelly ME,Guzman R,Sinclair J,Bell-Stephens TE,Bower R,Hamilton S,Marks MP,Do HM,Chang SD,Adler JR,Levy RP,Steinberg GK

    更新日期:2008-06-01 00:00:00

  • Factors involved in long-term efficacy of deep brain stimulation of the thalamus for essential tremor.

    abstract:OBJECT:Although nucleus ventralis intermedius stimulation has been shown to be safe and efficacious in the treatment of essential tremor, there is a subset of patients who eventually lose benefit from their stimulation. Proposed causes for this phenomenon include tolerance, disease progression, and suboptimal location....

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Pilitsis JG,Metman LV,Toleikis JR,Hughes LE,Sani SB,Bakay RA

    更新日期:2008-10-01 00:00:00

  • Neurosurgery and consciousness: historical sketch and future possibilities.

    abstract::Neurosurgery has played an important role in the development of neuroscience and the science of consciousness. In this paper, the authors reflect on some of the historical contributions of neurosurgeons to the science of consciousness and discuss the ways in which clinical neurosurgery can contribute to the science of...

    journal_title:Journal of neurosurgery

    pub_type: 历史文章,杂志文章


    authors: Hasegawa H,Jamieson GA,Ashkan K

    更新日期:2012-09-01 00:00:00

  • Dural involvement in primary extradural meningiomas of the cranial vault.

    abstract:OBJECT:The authors retrospectively analyzed a consecutive series of patients with cranial vault primary extradural meningioma (PEM), with particular regard to the tumor's dural involvement. The pertinent literature was reviewed. METHODS:Clinical data were retrospectively obtained in a consecutive series of 16 patients...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Bassiouni H,Asgari S,Hübschen U,König HJ,Stolke D

    更新日期:2006-07-01 00:00:00

  • Ventricular pressure monitoring during bilateral decompression with dural expansion.

    abstract:OBJECT:The management of massive brain swelling remains an unsolved problem in neurosurgery. Despite newly developed medical and pharmacological therapy, the rates of mortality and morbidity caused by massive brain swelling remain high. According to many recent reports, surgical decompression with dural expansion is su...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Yoo DS,Kim DS,Cho KS,Huh PW,Park CK,Kang JK

    更新日期:1999-12-01 00:00:00

  • Posterior plates in the management of cervical instability: long-term results in 44 patients.

    abstract::Although posterior plates are increasingly used to manage cervical spinal instability, long-term follow-up evaluation of patients with a critical analysis of efficacy and complications has not been reported. The authors have retrospectively analyzed the outcome in 44 consecutive patients (37 males and seven females, a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Fehlings MG,Cooper PR,Errico TJ

    更新日期:1994-09-01 00:00:00

  • Cerebral sparganosis diagnosed and treated with stereotactic techniques. Report of two cases.

    abstract::Infestation of the central nervous system with sparganum, the larva of Spirometra mansoni, is rare. Only 27 cases have been reported in the literature; however, the true incidence might be underestimated. Two cases are reported that were definitively diagnosed by stereotactic biopsy techniques. Without a positive hist...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Tsai MD,Chang CN,Ho YS,Wang AD

    更新日期:1993-01-01 00:00:00