Distribution of hematoporphyrin derivative in canine glioma following intraneoplastic and intraperitoneal injection.

Abstract:

:Hematoporphyrin derivative (HPD) is a photosensitizing agent that has been used to locate and kill tumors. The distribution of tritiated (3H)-HPD was studied in a transplantable canine glioma model following intraperitoneal or direct intraneoplastic injection. Compared to intraperitoneal administration of 3H-HPD, direct injection resulted in levels that were more than 2.5 times higher in tumor tissue and approximately 10 times lower in skin. Dose-corrected analysis of the data indicated that outside the central nervous system (CNS) the distribution of 3H-HPD is dose-related, regardless of route of injection. Within the CNS, direct injection leads to more efficient uptake of 3H-HPD, especially at the tumor periphery. Fluorescence microscopy confirmed the selective biodistribution of HPD fluorescence within the cytoplasm of tumor cells.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Steichen JD,Dashner K,Martuza RL

doi

10.3171/jns.1986.65.3.0364

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

364-9

issue

3

eissn

0022-3085

issn

1933-0693

journal_volume

65

pub_type

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