Long-term results of intestinal transplantation for pseudo-obstruction in children.

Abstract:

PURPOSE:The aim of this study was to determine long-term results of intestinal transplantation in children with pseudo-obstruction, particularly when stomach and colon are not part of the allograft. METHODS:The authors conducted a case-record review of all children who underwent transplantation at our center for a primary diagnosis of pseudo-obstruction. Supplementary information was obtained from outpatient charts, computerized database, and telephone survey of parents. RESULTS:Six small bowel and 3 liver-small bowel transplants were carried out in 8 patients between 1993 and 1999. Median follow-up is 40 months (range, 13 to 73 months). Median age at transplantation was 2.7 years (range, 0.7 to 12.8 years). Median graft survival in this series is 15 months (range, 1 day to 71 months). Stomach and colon were excluded from all allografts. Two children died 5 and 368 days after transplant and 2 graft losses occurred in 1 patient. Two children had lymphoproliferative disease; both are alive with functioning grafts. Five survivors with functioning grafts receive full enteral feedings at home. Four of the 5 have had ileostomies closed, and 3 have normal bowel movements. CONCLUSIONS:Intestinal transplantation without stomach or colon provides children with chronic intestinal pseudo-obstruction with a good quality of life. The underlying disease poses special challenges in management.

journal_name

J Pediatr Surg

authors

Iyer K,Kaufman S,Sudan D,Horslen S,Shaw B,Fox I,Langnas A

doi

10.1053/jpsu.2001.20046

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

174-7

issue

1

eissn

0022-3468

issn

1531-5037

pii

S0022346801775975

journal_volume

36

pub_type

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