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Diaphragmatic hernia in the fetus: prenatal diagnosis and outcome in 94 cases.

Abstract：

:Most babies born with congenital diaphragmatic hernia (CDH) die after birth. The natural course of CDH in the human fetus is not known. We found 94 cases of fetal CDH in the records of surgeons and obstetricians surveyed in the United States and Canada. We found the following: (1) prenatal diagnosis of CDH is accurate and current techniques can detect lethal nonpulmonary anomalies and prevent diagnostic errors; (2) despite optimal conventional therapy, most fetuses with detectable CDH will die in the neonatal period (80% mortality); (3) polyhydramnios is both a common prenatal marker for CDH (present in 76% of fetuses) and a predictor for poor clinical outcome (only 11% survived); (4) fetal CDH is a dynamic process--nonsurvivors have larger defects and may have more viscera displaced into the chest at an earlier stage of development. Surgical intervention before birth may be necessary to improve survival of the fetus with CDH and polyhydramnios.

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

Adzick NS,Harrison MR,Glick PL,Nakayama DK,Manning FA,deLorimier AA

doi

10.1016/s0022-3468(85)80219-0

subject

Has Abstract

pub_date

1985-08-01 00:00:00

pages

357-61

issue

4

eissn

0022-3468

issn

1531-5037

pii

S0022346885000835

journal_volume

20

pub_type

杂志文章

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