Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation?

Abstract:

OBJECTIVE:The effects of interleukin (IL)-6 in the injured patient are examined in an attempt to clarify the potential pathophysiologic role of IL-6 in the response to injury. SUMMARY BACKGROUND DATA:Interleukin-6 is an integral cytokine mediator of the acute phase response to injury and infection. However, prolonged and excessive elevations of circulating IL-6 levels in patients after trauma, burns, and elective surgery have been associated with complications and mortality. The mechanistic role of IL-6 in mediating these effects is unclear. METHODS:A review of current literature is performed to summarize the origins, mechanisms of action, and biologic effects of IL-6 and to characterize the IL-6 response to injury. RESULTS:Interleukin-6 is a multifunctional cytokine expressed by a variety of cells after a multitude of stimuli, under complex regulatory control mechanisms. The IL-6 response to injury is uniquely consistent and related to the magnitude of the insult. Moreover, the early postinjury IL-6 response correlates with complications as well as mortality. CONCLUSIONS:Interleukin-6 appears to play an active role in the postinjury immune response, making it an attractive therapeutic target in attempts to control hyperinflammatory provoked organ injury.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Biffl WL,Moore EE,Moore FA,Peterson VM

doi

10.1097/00000658-199611000-00009

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

647-64

issue

5

eissn

0003-4932

issn

1528-1140

journal_volume

224

pub_type

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