Carcinoembryonic antigen (CEA) as a prognostic and monitoring test in clinically complete resection of colorectal carcinoma.

Abstract:

:The prognostic and postoperative monitoring capabilities of the CEA assay were compared to pathological staging of the operative specimens, clinical followup including endoscopy, radiology and scanning techniques, as well as DNCB skin testing and laboratory enzyme determinations (alkaline phosphatase and transaminase). A total of 46 patients with curative resection for colorectal carcinoma were studied. This included 23 patients with recurrent tumors compared to 23 long-term survivors without signs of recurrence at the time of the study. Preoperative CEA determinations were a good prognostic tool comparable to pathological staging of the specimen. Post operative CEA monitoring was the earliest sign of recurrence in 14 of 23 patients and was positive at the time of recurrence determined by other methods in 20; it was negative in only three cases. The incidence of false positive results among the non recurrent group became a lesser problem when repeated elevated values were required before considering the patient as having a recurrence. From these data, it seems reasonable to propose the use of a second-look operation in patients with maintained elevation of circulating CEA and no clinical signs of tumor presence, if we are to treat recurrence at an early stage. Chemotherapy would be an alternative way to deal with this problem, since the absence of clinical signs in general correlate with small bulk of tumor which at this time may be more susceptible to chemotherapeutic agents.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Herrera MA,Chu TM,Holyoke ED

doi

10.1097/00000658-197601000-00002

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

5-9

issue

1

eissn

0003-4932

issn

1528-1140

journal_volume

183

pub_type

杂志文章
  • Vein replacement with fresh vital veins: a comparison of transplantation in RT-1-different rat strain combinations.

    abstract::Transplantation of the intrathoracic inferior vena cava into the abdominal inferior vena cava of the recipient was performed in inbred rat strains of the following combinations: Syngeneic F344 leads to F344, RT-1-identical allogeneic LEW leads to F344, and RT-1-different allogeneic CAP leads to F344. In the RT-1-diffe...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198103000-00006

    authors: Thiede A,Engemann R,Korner HH,Deltz E,Muller-Ruchholtz W

    更新日期:1981-03-01 00:00:00

  • The comparative survivals of alcoholics versus nonalcoholics after distal splenorenal shunt.

    abstract::Survival after distal splenorenal shunt in appreciably better in nonalcoholic patients than in alcoholics. This increase in survival does not appear to be dependent upon the state of biochemical liver function or the severity of changes in liver histology since these latter were similar for both groups. We suggest tha...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197805000-00008

    authors: Zeppa R,Hensley GT,Levi JU,Bergstresser PR,Hutson DG Sr,Livingstone AS,Schiff ER,Fink P

    更新日期:1978-05-01 00:00:00

  • Risk and location of cancer in patients with preoperative colitis-associated dysplasia undergoing proctocolectomy.

    abstract:OBJECTIVE:To evaluate the influence of preoperative dysplasia grade, appearance, and site on risk and location of cancer in patients with colitis. BACKGROUND:The ability to predict the presence and location of cancer in colitis patients with dysplasia is essential to facilitate recommendations regarding the necessity ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31828e7417

    authors: Kiran RP,Ahmed Ali U,Nisar PJ,Khoury W,Gu J,Shen B,Remzi FH,Hammel JP,Lavery IC,Fazio VW,Goldblum JR

    更新日期:2014-02-01 00:00:00

  • Mucosal damage in the esophageal remnant after esophagectomy and gastric transposition.

    abstract:OBJECTIVE:To assess development of mucosal damage in the esophageal remnant in regard to the level of the esophagogastrostomy reconstruction either in a right chest or in a left neck position. SUMMARY BACKGROUND DATA:Esophagectomy with gastric interposition creates an in vivo human model of pathologic esophageal reflu...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31818eec06

    authors: D'Journo XB,Martin J,Rakovich G,Brigand C,Gaboury L,Ferraro P,Duranceau A

    更新日期:2009-02-01 00:00:00

  • The relationship between extent of thyroid cancer surgery and use of radioactive iodine.

    abstract:UNLABELLED:By linking surgeon surveys to the National Cancer Database, we found that surgeons' tendency to perform more extensive thyroid resection is associated with greater use of radioactive iodine for stage I thyroid cancer. OBJECTIVE:To determine the relationships between surgeon recommendations for extent of res...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31826c8915

    authors: Haymart MR,Banerjee M,Yang D,Stewart AK,Doherty GM,Koenig RJ,Griggs JJ

    更新日期:2013-08-01 00:00:00

  • The effect of renin angiotensin system genetic variants in acute pancreatitis.

    abstract:OBJECTIVES:We sought association of genetic variants in the renin-angiotensin system (RAS) and vitamin D system with acute pancreatitis (AP) development and severity. BACKGROUND:The endocrine RAS is involved in circulatory homeostasis through the pressor action of angiotensin II at its AT1 receptor. However, local RAS...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000655

    authors: Skipworth JR,Nijmeijer RM,van Santvoort HC,Besselink MG,Schulz HU,Kivimaki M,Kumari M,Cooper JA,Acharya J,Shankar A,Malago M,Humphries SE,Olde Damink SW,Montgomery HE

    更新日期:2015-01-01 00:00:00

  • Normoxic wound fluid contains high levels of vascular endothelial growth factor.

    abstract:OBJECTIVE:To examine the temporal integration of vascular endothelial growth factor (VEGF), which has been shown to be present in wound fluid, with the putatively related processes of wound fluid oxygen content, wound angiogenesis, and granulation tissue formation. SUMMARY BACKGROUND DATA:During cutaneous wound repair...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199811000-00011

    authors: Howdieshell TR,Riegner C,Gupta V,Callaway D,Grembowicz K,Sathyanarayana,McNeil PL

    更新日期:1998-11-01 00:00:00

  • Influence of modest endotoxemia on postoperative antithrombin deficiency and circulating secretory immunoglobulin a levels.

    abstract:OBJECTIVE:To evaluate the influence of modest endotoxemia on postoperative antithrombin deficiency and cholestasis. SUMMARY BACKGROUND DATA:It has not been determined whether endotoxin translocation in small amounts is a physiological phenomenon or whether it is a potential health hazard. METHODS:Blood endotoxin, ant...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000082711.77096.71

    authors: Fujita T,Imai T,Anazawa S

    更新日期:2003-08-01 00:00:00

  • Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver.

    abstract:OBJECTIVE:Metabolic activity of transformed human liver (Hep G2) cells and primary rat hepatocytes were compared during in vitro application of a gel entrapment bioartificial liver. BACKGROUND:Clinical trials of bioartificial liver devices containing either transformed liver cells or primary hepatocytes have been init...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:

    authors: Nyberg SL,Remmel RP,Mann HJ,Peshwa MV,Hu WS,Cerra FB

    更新日期:1994-07-01 00:00:00

  • Morbidity and mortality after pelvic exenteration for colorectal adenocarcinoma.

    abstract::A retrospective analysis was made of the complications from pelvic exenterations performed over the past 30 years for colorectal adenocarcinoma at the Roswell Park Cancer Institute. Seventy-five patients underwent exenteration, 51 for primary disease (PD) and 24 for recurrent disease (RD). Both total and posterior exe...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199201000-00009

    authors: Hafner GH,Herrera L,Petrelli NJ

    更新日期:1992-01-01 00:00:00

  • Role of arteriography in rectal hemorrhage due to arteriovenous malformations and diverticulosis.

    abstract::Nine patients with arteriographic right colon arteriovenous malformations (AVM's) are reviewed. Even though five of the eight surviving patients had diverticulosis in remaining colon, right colectomy with removal of the AVM effectively controlled bleeding in seven of the eight patients in follow-up intervals of 14-66 ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197908000-00013

    authors: Talman EA,Dixon DS,Gutierrez FE

    更新日期:1979-08-01 00:00:00

  • A prospective, randomized, controlled trial of preoperative transarterial chemoembolization for resectable large hepatocellular carcinoma.

    abstract:OBJECTIVE:To evaluate the effect of preoperative transarterial chemoembolization (TACE) for resectable large hepatocellular carcinoma (HCC). SUMMARY BACKGROUND DATA:Resection of HCC is potentially curative, but local recurrence is very common. There is currently no effective neoadjuvant or adjuvant therapy. METHODS:F...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0b013e3181961c16

    authors: Zhou WP,Lai EC,Li AJ,Fu SY,Zhou JP,Pan ZY,Lau WY,Wu MC

    更新日期:2009-02-01 00:00:00

  • Management of secondary peritonitis.

    abstract:OBJECTIVE:The authors review current definition, classification, scoring, microbiology, inflammatory response, and goals of management of secondary peritonitis. SUMMARY BACKGROUND DATA:Despite improved diagnostic modalities, potent antibiotics, modern intensive care, and aggressive surgical treatment, up to one third ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-199607000-00003

    authors: Wittmann DH,Schein M,Condon RE

    更新日期:1996-07-01 00:00:00

  • Prevalence and Risk Factors for Bariatric Surgery Readmissions: Findings From 130,007 Admissions in the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program.

    abstract:OBJECTIVE:To evaluate readmissions following laparoscopic adjustable gastric banding (LAGB), laparoscopic sleeve gastrectomy (LSG), and laparoscopic Roux-en-Y gastric bypass (LRYGB). BACKGROUND:Few studies have evaluated national readmission rates for primary bariatric surgery with national, bariatric-specific data. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000002079

    authors: Berger ER,Huffman KM,Fraker T,Petrick AT,Brethauer SA,Hall BL,Ko CY,Morton JM

    更新日期:2018-01-01 00:00:00

  • SM22 a Plasma Biomarker for Human Transmural Intestinal Ischemia.

    abstract:OBJECTIVE:To evaluate the diagnostic potential of smooth muscle protein of 22 kDa (SM22) as plasma biomarker for the detection of transmural intestinal ischemia. BACKGROUND:Acute mesenteric ischemia is an abdominal emergency requiring rapid diagnosis and treatment. Especially, detection of transmural damage is imperat...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002278

    authors: Schellekens DHSM,Reisinger KW,Lenaerts K,Hadfoune M,Olde Damink SW,Buurman WA,Dejong CHC,Derikx JPM

    更新日期:2018-07-01 00:00:00

  • Clinical significance of the mesorectal extension of rectal cancer: a Japanese multi-institutional study.

    abstract:OBJECTIVE:The aim of this study was to emphasize the importance of a subclassification in the TNM staging system of rectal cancer. BACKGROUND:The clinical significance of the mesorectal extension of rectal cancer is unclear. PATIENTS AND METHODS:Data from 463 consecutive patients with stage IIa disease (T3N0) undergo...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0b013e3182119331

    authors: Shirouzu K,Akagi Y,Fujita S,Ueno H,Takii Y,Komori K,Ito M,Sugihara K,Japanese Society for Cancer of the Colon and Rectum (JSCCR) on Clinical Significance of the Mesorectal Extension of Rectal Cancer.

    更新日期:2011-04-01 00:00:00

  • Gastrin release by ethanol in man and in dogs.

    abstract::In man, oral or intravenous administration of ethanol caused a small but definite increase in peripheral serum gastrin concentration (measured by radioimmunoassay). In dogs, perfusion of the antrum with 10% ethanol caused an immediate increase in gastrin levels in the antral venous outflow. Acidification of the perfus...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197406000-00015

    authors: Becker HD,Reeder DD,Thompson JC

    更新日期:1974-06-01 00:00:00

  • Observations on preservation, bile drainage and rejection in 64 human orthotopic liver allografts.

    abstract::The combined Cambridge/King's College Hospital series of 64 orthotopic liver grafts' experience dates back to 1968. Many patients were referred for liver grafting late in the course of their diseases and were operated on when they were too ill or died before suitable livers could be found. Complications of biliary dra...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197709000-00006

    authors: Calne RY,McMaster P,Portmann B,Wall WJ,Williams R

    更新日期:1977-09-01 00:00:00

  • A Propensity-matched Analysis Comparing Survival After Esophagectomy Followed by Adjuvant Chemoradiation to Surgery Alone for Esophageal Squamous Cell Carcinoma.

    abstract:BACKGROUND:The role of adjuvant chemoradiation in esophageal cancer has been underestimated in the literature. This study was undertaken to determine whether adjuvant chemoradiation improves survival compared with surgery alone. METHODS:Data of 1095 esophageal squamous cell carcinoma (ESCC) patients, including 679 in ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001410

    authors: Hwang JY,Chen HS,Hsu PK,Chao YK,Wang BY,Huang CS,Liu CC,Wu SC

    更新日期:2016-07-01 00:00:00

  • A Novel Method to Improve Perfusion of Ex Vivo Pumped Human Kidneys.

    abstract:OBJECTIVE:To determine if addition of the S-nitrosylating agent ethyl nitrite (ENO) to the preservation solution can improve perfusion parameters in pumped human kidneys. BACKGROUND:A significant percentage of actively stored kidneys experience elevations in resistance and decreases in flow rate during the ex vivo sto...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003702

    authors: Zhu L,Qureshi A,Awad M,Hausladen A,Perez-Protto S,Latifi SQ,Lebovitz DJ,Chavin K,Stamler JS,Reynolds JD

    更新日期:2019-12-05 00:00:00

  • Complications of vagotomy in the treatment of hiatal hernia.

    abstract::Inclusion of vagotomy and pyloroplasty in the surgical treatment of gastroesophageal reflux associated with hiatal hernia has long been controversial. To evaluate the morbidity of vagotomy in the treatment of reflux esophagitis, a retrospective study of 311 patients treated by the Hill posterior gastropexy technique o...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197606000-00003

    authors: Vansant JH,Baker JW Jr

    更新日期:1976-06-01 00:00:00

  • Infrarenal abdominal aortic aneurysm: factors influencing survival after operation performed over a 25-year period.

    abstract::This report is concerned with the factors influencing survival in 920 consecutive patients submitted to operation for infrarenal abdominal aortic aneurysm during the past 25 years. Rupture had occurred in 60 patients (6.5%) and survival was 77%, which did not vary during the period of study. Of the 860 patients (93.5%...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198106000-00005

    authors: Crawford ES,Saleh SA,Babb JW 3rd,Glaeser DH,Vaccaro PS,Silvers A

    更新日期:1981-06-01 00:00:00

  • Survival and Scoliosis Following Resection of Chest Wall Tumors in Children and Adolescents: A Single-center Retrospective Analysis.

    abstract:OBJECTIVE:We reviewed our experience with pediatric chest wall tumors (CWTs) to identify variables associated with survival, scoliosis development, and need for corrective scoliosis surgery. BACKGROUND:Chest wall neoplasms in children or adolescents are rare. Consequently, there are few large series that detail surviv...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003495

    authors: Saltsman JA,Danzer E,Hammond WJ,Rhee D,Berhe S,Monteagudo J,Price AP,Heaton TE,Jones DR,LaQuaglia MP

    更新日期:2019-07-25 00:00:00

  • Thromboresistant surface coatings for the measurement of cardiac output through continuous low flow peripheral A-V shunts.

    abstract::The dilution technique for determining cardiac output using indocyanine green dye is limited in patients weighing less than 20 kg because of the obligatory volume loss. Reproducible achieved using the green dye dilution method by the establishment of a low flow peripheral arteriovenous shunt. The shunt materials were ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198001000-00020

    authors: Deeb GM,Borovetz HS,Griffith BP,Hardesty RL

    更新日期:1980-01-01 00:00:00

  • Desmoid tumors in familial polyposis coli.

    abstract::Desmoid tumors are locally invasive, nonmetastasizing fibrous tumors most frequently seen in patients with familial polyposis coli (FPC). Of 325 patients with FPC treated at the Cleveland Clinic, 29 (8.9%) were found to have a total of 36 desmoid tumors. These tumors occur in young patients (mean age: 29.8 years), par...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198607000-00014

    authors: Jones IT,Jagelman DG,Fazio VW,Lavery IC,Weakley FL,McGannon E

    更新日期:1986-07-01 00:00:00

  • Regional intestinal blood flow and nitric oxide synthase inhibition during sepsis in the rat.

    abstract:OBJECTIVE:Regional circulatory changes in intestinal mucosa were evaluated after the onset of septic shock and the effect of nitric oxide (NO) inhibition on mucosal blood flow was investigated at different locations along the intestine. SUMMARY BACKGROUND DATA:The response of intestinal blood flow to different physiol...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199801000-00018

    authors: Klemm K,Moody FG

    更新日期:1998-01-01 00:00:00

  • The impact of neural invasion severity in gastrointestinal malignancies: a clinicopathological study.

    abstract:OBJECTIVES:Because neural invasion (NI) is still inconsistently reported and not well characterized within gastrointestinal malignancies (GIMs), our aim was to determine the exact prevalence and severity of NI and to elucidate the true impact of NI on patient's prognosis. BACKGROUND:The union internationale contre le ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000968

    authors: Liebl F,Demir IE,Mayer K,Schuster T,DʼHaese JG,Becker K,Langer R,Bergmann F,Wang K,Rosenberg R,Novotny AR,Feith M,Reim D,Friess H,Ceyhan GO

    更新日期:2014-11-01 00:00:00

  • The prevalence and prognostic value of BRAF mutation in thyroid cancer.

    abstract:OBJECTIVE:To examine the prevalence of BRAF mutation among thyroid cancer histologic subtypes and determine the association of BRAF mutation with indicators of poor prognosis for papillary thyroid cancer and patient outcome. SUMMARY BACKGROUND DATA:The appropriate extent of surgical treatment, adjuvant therapy and fol...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318148563d

    authors: Kebebew E,Weng J,Bauer J,Ranvier G,Clark OH,Duh QY,Shibru D,Bastian B,Griffin A

    更新日期:2007-09-01 00:00:00

  • Video-based peer feedback through social networking for robotic surgery simulation: a multicenter randomized controlled trial.

    abstract:OBJECTIVE:To examine the feasibility and outcomes of video-based peer feedback through social networking to facilitate robotic surgical skill acquisition. BACKGROUND:The acquisition of surgical skills may be challenging for novel techniques and/or those with prolonged learning curves. METHODS:Randomized controlled tr...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000000756

    authors: Carter SC,Chiang A,Shah G,Kwan L,Montgomery JS,Karam A,Tarnay C,Guru KA,Hu JC

    更新日期:2015-05-01 00:00:00

  • Complete versus partial atrioventricular canal: equal risks of repair in the modern era.

    abstract:OBJECTIVE:To assess the authors' hypothesis that with modern techniques, the current risks of repair for both complete and partial atrioventricular canal (AVC) are equal. SUMMARY BACKGROUND DATA:Repair of complete AVC in infancy has traditionally carried a substantial mortality. In contrast, partial AVC has been consi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200210000-00014

    authors: Cope JT,Fraser GD,Kouretas PC,Kron IL

    更新日期:2002-10-01 00:00:00