Gastrinoma excision for cure. A prospective analysis.

Abstract:

:The role of surgery in the treatment of gastrinoma is unclear. The purpose of this study was to determine prospectively the surgical cure rate using a controlled clinical trial. Eleven patients who fit the entry criteria underwent abdominal exploration and attempted tumor resection for cure. A historical control group was used for comparison. Cure was defined as: (1) normal serum gastrin level, (2) no response to intravenous secretin, (3) no symptoms when antisecretory medications are stopped, and (4) no tumor recurrence on follow-up examination. Tumors found in both groups tended to be small (1.5 cm vs. 2.2 cm), multiple (71% vs. 40%), and in lymph nodes (70% vs. 70%). All tumors identified were located anatomically within the gastrinoma triangle. Tumors were found in 10 of 11 patients (91%) in the study group, and significantly more patients had their tumors excised for cure as compared to controls (82% vs. 27%, p less than 0.05). The current prospective cure rate for gastrinoma is higher than previously appreciated and tumors within lymph nodes do not preclude curative resection.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Howard TJ,Zinner MJ,Stabile BE,Passaro E Jr

doi

10.1097/00000658-199001000-00002

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

9-14

issue

1

eissn

0003-4932

issn

1528-1140

journal_volume

211

pub_type

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