Occlusion of the pancreatic duct versus pancreaticojejunostomy: a prospective randomized trial.

Abstract:

OBJECTIVE:Using a prospective randomized study to assess postoperative morbidity and pancreatic function after pancreaticoduodenectomy with pancreaticojejunostomy and duct occlusion without pancreaticojejunostomy. SUMMARY BACKGROUND DATA:Postoperative complications after pancreaticoduodenectomy are largely due to leakage of the pancreaticoenterostomy. Pancreatic duct occlusion without anastomosis of the pancreatic remnant may prevent these complications. METHODS:A prospective randomized study was performed in a nonselected series of 169 patients with suspected pancreatic and periampullary cancer. In 86 patients the pancreatic duct was occluded without anastomosis to pancreatic remnant, and in 83 patients a pancreaticojejunostomy was performed after pancreaticoduodenectomy. Postoperative complications were the endpoint of the study. All relevant data concerning patient demographics and postoperative morbidity and mortality as well as endocrine and exocrine function were analyzed. At 3 and 12 months after surgery, evaluation of weight loss, stools, and the use of antidiabetics and pancreatic enzyme was repeated. RESULTS:Patient characteristics were comparable in both groups. There were no differences in median blood loss, duration of operation, and hospital stay. No significant difference was noted in postoperative complications, mortality, and exocrine insufficiency. The incidence of diabetes mellitus was significantly higher in patients with duct occlusion. CONCLUSIONS:Duct occlusion without pancreaticojejunostomy does not reduce postoperative complications but significantly increases the risk of endocrine pancreatic insufficiency after duct occlusion.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Tran K,Van Eijck C,Di Carlo V,Hop WC,Zerbi A,Balzano G,Jeekel H

doi

10.1097/00000658-200210000-00004

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

422-8; discussion 428

issue

4

eissn

0003-4932

issn

1528-1140

journal_volume

236

pub_type

临床试验,杂志文章,随机对照试验
  • Omega-3 Fatty Acids Protect Fatty and Lean Mouse Livers After Major Hepatectomy.

    abstract:OBJECTIVE:The aim of this study was to assess the effect of Ω3 fatty acids (Ω3FA) on fatty and lean liver in hepatic surgery. BACKGROUND:The global spread of energy-dense diets has led to an endemic rise in fatty liver disease and obesity. Besides metabolic pathologies, steatosis enhances hepatic sensitivity to ischem...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001968

    authors: Linecker M,Limani P,Kambakamba P,Kron P,Tschuor C,Calo N,Foti M,Dufour JF,Graf R,Humar B,Clavien PA

    更新日期:2017-08-01 00:00:00

  • Accelerated wound healing with stapled enteric suture lines. An experimental study comparing traditional sewing techniques and a stapling device.

    abstract::The healing of 3-cm longitudinal colotomies closed with either Czerny-Lembert suture lines (CLSL) or TA-30 staple lines (SSL) were studied in 28 mongrel dogs using bursting strength (BS) measurements. Dogs from each group were sacrificed on postoperative days (POD) 1 through 7. Mean BS for the SSL in all 14 dogs was 1...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198503000-00019

    authors: Ballantyne GH,Burke JB,Rogers G,Lampert EG,Boccia J

    更新日期:1985-03-01 00:00:00

  • Variation in practice and resource utilization associated with the diagnosis and management of appendicitis at freestanding children's hospitals: implications for value-based comparative analysis.

    abstract:OBJECTIVE:To characterize the scope and magnitude of practice variation associated with the diagnosis and treatment of appendicitis at freestanding children's hospitals. BACKGROUND:Variation in care has been associated with poor outcomes and is believed to be a key driver of excess health care spending. METHODS:Retro...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000000246

    authors: Rice-Townsend S,Barnes JN,Hall M,Baxter JL,Rangel SJ

    更新日期:2014-06-01 00:00:00

  • Neuropeptide Y and the development of cancer anorexia.

    abstract:OBJECTIVE:The authors determined whether radioligand binding of neuropeptide Y (NPY) to hypothalamus taken from nonanorectic and anorectic tumor-bearing rats was altered as compared with similar tissue taken from freely-feeding and food-restricted control rats. SUMMARY BACKGROUND DATA:Previous results indicate that tu...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199505000-00016

    authors: Chance WT,Balasubramaniam A,Fischer JE

    更新日期:1995-05-01 00:00:00

  • Evaluation of splenic injury by computed tomography and its impact on treatment.

    abstract::We reviewed 37 consecutive, hemodynamically stable patients (16 adults, 21 children) who had splenic injuries diagnosed by computed tomography (CT) scan to compare the CT evaluation with operative assessment of injury and eventual treatment. Computed tomographic scans and operative findings were graded by a splenic in...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199005000-00009

    authors: Malangoni MA,Cué JI,Fallat ME,Willing SJ,Richardson JD

    更新日期:1990-05-01 00:00:00

  • Defining lower limb lymphedema after inguinal or ilio-inguinal dissection in patients with melanoma using classification and regression tree analysis.

    abstract:OBJECTIVE:This study aims to objectively define the criteria for assessing the presence of lymphedema and to report the prevalence of lymphedema after inguinal and ilio-inguinal (inguinal and pelvic) lymph node dissection for metastatic melanoma. SUMMARY BACKGROUND DATA:Lymphedema of the lower limb is a common problem...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31817ed7c3

    authors: Spillane AJ,Saw RP,Tucker M,Byth K,Thompson JF

    更新日期:2008-08-01 00:00:00

  • Is carcinoma of the gallbladder a curable lesion?

    abstract::Carcinoma of the gallbladder is an uncommon, but not rare tumor that is associated with a 5% five-year survival rate after resection and this rate has not appreciably improved over the last decades in most series. Nevin et al.(20) however have reported that favorably staged gallbladder cancers (according to histologic...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198205000-00012

    authors: Wanebo HJ,Castle WN,Fechner RE

    更新日期:1982-05-01 00:00:00

  • Cholangitis with acute renal failure: priorities in therapeutics.

    abstract::Obstructive cholangitis with acute renal failure is a dramatic syndrome which merits individual definition. Twenty-one patients with acute suppurative cholangitis complicated by rapidly developing renal insufficiency were studied, and the severity of the renal failure, an acute interstitial tubulopathy, bore no signif...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197506000-00022

    authors: Bismuth H,Kuntziger H,Corlette MB

    更新日期:1975-06-01 00:00:00

  • Long-term Results of a Randomized Double-blinded Prospective Trial of a Lightweight (Ultrapro) Versus a Heavyweight Mesh (Prolene) in Laparoscopic Total Extraperitoneal Inguinal Hernia Repair (TULP-trial).

    abstract:OBJECTIVE:The aim of the randomized clinical trial was to compare the 2 years of clinical outcomes of a lightweight (Ultrapro) vs a heavyweight (Prolene) mesh for laparoscopic total extraperitoneal (TEP) inguinal hernia repair. BACKGROUND:Lightweight meshes reduce postoperative pain and stiffness in open anterior ingu...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000001579

    authors: Burgmans JP,Voorbrood CE,Simmermacher RK,Schouten N,Smakman N,Clevers G,Davids PH,Verleisdonk EM,Hamaker ME,Lange JF,van Dalen T

    更新日期:2016-05-01 00:00:00

  • Release of cholecystokinin and gallbladder contraction before and after gastrectomy.

    abstract::The contraction of the gallbladder by ultrasonography and release of cholecystokinin (CCK) by specific radioimmunoassay in response to the ingestion of oral fatty meal before and 1 month after gastrectomy in five patients with early gastric cancer was studied. Before gastrectomy, basal concentrations of CCK (13.4 +/- ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:

    authors: Inoue K,Fuchigami A,Hosotani R,Kogire M,Huang YS,Miyashita T,Suzuki T,Tsuda K,Seino Y,Rayford PL

    更新日期:1987-01-01 00:00:00

  • Liver transplantation for hereditary hemorrhagic telangiectasia: Report of the European liver transplant registry.

    abstract:BACKGROUND:Hereditary hemorrhagic telangiectasia (HHT) or Rendu-Osler-Weber disease is a rare disease characterized by the presence of arteriovenous malformations. Hepatic involvement can lead to life-threatening conditions. MATERIAL AND METHODS:Forty patients, reported to the European Liver Transplant Registry, were ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000247258.35406.a4

    authors: Lerut J,Orlando G,Adam R,Sabbà C,Pfitzmann R,Klempnauer J,Belghiti J,Pirenne J,Thevenot T,Hillert C,Brown CM,Gonze D,Karam V,Boillot O,European Liver Transplant Association.

    更新日期:2006-12-01 00:00:00

  • Longitudinal pancreaticojejunostomy in chronic relapsing pancreatitis with onset in childhood.

    abstract::Despite the rarity of chronic relapsing pancreatitis in children, in the last 15 years at Vanderbilt University Medical Center and its Children's Hospital we have used longitudinal pancreaticojejunostomy in treatment of eight patients whose symptoms began in childhood. Duration of symptoms ranged from 2 to 36 years. S...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198405000-00017

    authors: Scott HW Jr,Neblett WW,O'Neill JA Jr,Sawyers JL,Avant GS,Starnes VA

    更新日期:1984-05-01 00:00:00

  • Surgery, trauma and immune suppression. Evolving the mechanism.

    abstract::A major surgical procedure can impair the delayed hypersensitivity response. This impairment is associated with suppressor cell activity that can alter either afferent or efferent responses. Using the third party mixed leukocyte culture to define cell types involved, major immune impairment was seen with the combinati...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198304000-00010

    authors: Lundy J,Ford CM

    更新日期:1983-04-01 00:00:00

  • Cryopreservation of isolated primary rat hepatocytes: enhanced survival and long-term hepatospecific function.

    abstract:OBJECTIVE:To investigate the long-term effect of cryopreservation on hepatocyte function, as well as attempt to improve cell viability and function through the utilization of the hypothermic preservation solution, HypoThermosol (HTS), as the carrier solution. SUMMARY BACKGROUND DATA:Advances in the field of bioartific...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000149303.48692.0f

    authors: Sosef MN,Baust JM,Sugimachi K,Fowler A,Tompkins RG,Toner M

    更新日期:2005-01-01 00:00:00

  • Metastatic carcinoid to the liver treated by hepatic dearterialization.

    abstract::A historical review of work bearing on the rationale for hepatic artery ligation in the treatment of malignant disease in the liver is presented, particularly the early work showing that malignant disease of the liver is supplied primarily by the arterial circulation and not by the portal. A review is presented of som...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197409000-00008

    authors: McDermott WV Jr,Hensle TW

    更新日期:1974-09-01 00:00:00

  • The Impact of Clinical and Pathological Features on Intraductal Papillary Mucinous Neoplasm Recurrence After Surgical Resection: Long-Term Follow-Up Analysis.

    abstract:OBJECTIVE:This study aimed to identify risk factors for recurrence after pancreatic resection for intraductal papillary mucinous neoplasm (IPMN). SUMMARY BACKGROUND DATA:Long-term follow-up data on recurrence after surgical resection for IPMN are currently lacking. Previous studies have presented mixed results on the ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004427

    authors: Pflüger MJ,Griffin JF,Hackeng WM,Kawamoto S,Yu J,Chianchiano P,Shin E,Lionheart G,Tsai HL,Wang H,Rezaee N,Burkhart RA,Cameron JL,Thompson ED,Wolfgang CL,He J,Brosens LAA,Wood LD

    更新日期:2020-11-17 00:00:00

  • Surgical correction of posttransplant renovascular hypertension.

    abstract::The incidence of renovascular hypertension in the transplanted kidney is reported to range between 5 and 15%. A review of 391 consecutive renal transplant patients revealed 16 patients (5.4%) with hypertension secondary to partial obstruction of renal arterial blood flow. The clinical course of this group of patients ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198011000-00010

    authors: Dickerman RM,Peters PC,Hull AR,Curry TS,Atkins C,Fry WJ

    更新日期:1980-11-01 00:00:00

  • Influence of Depression on Recovery After Major Noncardiac Surgery: A Prospective Cohort Study.

    abstract:OBJECTIVES:To determine the influence of patient depression (and anxiety) on postoperative outcome and surgeons' consideration of it. BACKGROUND:Patients' mental state influences the course of nonpsychiatric diseases. Evidence in the surgical setting comes mainly from cardiac-surgery patients and no predictive-model o...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000001448

    authors: Orri M,Boleslawski E,Regimbeau JM,Barry C,Hassler C,Gregoire E,Bachellier P,Scatton O,Mabrut JY,Adham M,Vibert E,Revah-Levy A,Farges O

    更新日期:2015-11-01 00:00:00

  • Improving the AJCC/TNM staging for adenocarcinomas of the appendix: the prognostic impact of histological grade.

    abstract:PURPOSE:Though histological grade is known to have a major prognostic impact in metastatic mucinous appendiceal adenocarcinomas, the prognostic impact of grade in localized disease, and the validity of the American Joint Committee on Cancer AJCC Staging Manual 7th edition's decision to combine moderately and poorly dif...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318269d680

    authors: Overman MJ,Fournier K,Hu CY,Eng C,Taggart M,Royal R,Mansfield P,Chang GJ

    更新日期:2013-06-01 00:00:00

  • Analysis of reduced death and complication rates after esophageal resection.

    abstract:OBJECTIVE:To identify factors that have contributed to reduced rates of death and complications after esophageal resection in a 17-year period at a tertiary referral center. SUMMARY BACKGROUND DATA:There has been an evolving refinement in surgical technique and perioperative management of patients undergoing esophagea...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200103000-00006

    authors: Whooley BP,Law S,Murthy SC,Alexandrou A,Wong J

    更新日期:2001-03-01 00:00:00

  • Effect of resection margins on the recurrence of Crohn's disease in the small bowel. A randomized controlled trial.

    abstract:OBJECTIVE:The authors assess the effect of surgical margin width on recurrence rates after intestinal resection of Crohn's Disease (CD). BACKGROUND:The optimal width of margins when resecting DC of the small bowel is controversial. Most studies have been retrospective and have had conflicting results. METHODS:Patient...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-199610000-00014

    authors: Fazio VW,Marchetti F,Church M,Goldblum JR,Lavery C,Hull TL,Milsom JW,Strong SA,Oakley JR,Secic M

    更新日期:1996-10-01 00:00:00

  • Surgical management of bleeding chronic peptic ulcer. A 10-year prospective study.

    abstract::Analysis of experience with chronic bleeding peptic ulcer in 504 patients, admitted from 1960 to 1971, shows a hospital mortality of 12%. This retrospective review suggested that early endoscopic diagnosis, adequate resuscitation and a policy of early selective surgery was necessary if mortality was to be reduced. Wit...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198401000-00008

    authors: Hunt PS

    更新日期:1984-01-01 00:00:00

  • Oncological Outcomes After Robotic Proctectomy for Rectal Cancer: Analysis of a Prospective Database.

    abstract:OBJECTIVE:The aim of this study is to evaluate the oncological outcomes of robotic total mesorectal excision (TME) at an NCI designated cancer center. SUMMARY BACKGROUND DATA:The effectiveness of laparoscopic TME could not be established, but the robotic-assisted approach may hold some promise, with improved visualiza...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002112

    authors: Sammour T,Malakorn S,Bednarski BK,Kaur H,Shin US,Messick C,You YN,Chang GJ

    更新日期:2018-03-01 00:00:00

  • Vaccinia virus GLV-1h153 is effective in treating and preventing metastatic triple-negative breast cancer.

    abstract:OBJECTIVE:This study aimed to investigate the therapeutic impact of a new oncolytic vaccinia virus in a triple-negative breast cancer (TNBC) murine model and its potential for treating distant metastatic disease. BACKGROUND:TNBCs are aggressive tumors associated with a high metastatic rate. Their lack of targets for h...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182654572

    authors: Gholami S,Chen CH,Lou E,De Brot M,Fujisawa S,Chen NG,Szalay AA,Fong Y

    更新日期:2012-09-01 00:00:00

  • Hypertonic saline resuscitation of hemorrhagic shock diminishes neutrophil rolling and adherence to endothelium and reduces in vivo vascular leakage.

    abstract:OBJECTIVE:To evaluate the in vivo effects of hypertonic saline (HTS) resuscitation on the interactions of endothelial cells (ECs) and polymorphonuclear neutrophils (PMNs) and vascular permeability after hemorrhagic shock. SUMMARY BACKGROUND DATA:The PMN has been implicated in the pathogenesis of EC damage and organ in...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200211000-00014

    authors: Pascual JL,Ferri LE,Seely AJ,Campisi G,Chaudhury P,Giannias B,Evans DC,Razek T,Michel RP,Christou NV

    更新日期:2002-11-01 00:00:00

  • The role of antiplatelet drugs in carotid reconstructive surgery.

    abstract::Neurologic events following carotid reconstructive surgery for symptomatic cerebral occlusive disease are generally reported to be one to two per cent. One of the events leading to this incidence is thrombosis of the endarterectomized internal carotid artery (ICA) after surgery. Since antiplatelet drugs have been foun...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198506000-00014

    authors: Edwards WH,Edwards WH Jr,Mulherin JL Jr,Jenkins JM

    更新日期:1985-06-01 00:00:00

  • Influence of the postoperative state on the intracellular free amino acids in human muscle tissue.

    abstract::Five patients were studied before and two to three days after major, uncomplicated abdominal operation. Muscle tissue was obtained by needle biopsy from m. quadriceps femoris after eight hours overnight fast. Plasma free amino acids were analyzed in simultaneously obtained samples. In the homogenized muscle samples th...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197512000-00001

    authors: Vinnars E,Bergstöm J,Fürst P

    更新日期:1975-12-01 00:00:00

  • When Do DCD Donors Die?: Outcomes and Implications of DCD at a High-volume, Single-center OPO in the United States.

    abstract:OBJECTIVE:The objective of this study was to determine the fate of patients who attempted to donate organs after circulatory death (DCD) using a standardized DCD protocol. BACKGROUND:Successful donation is not always possible after attempted DCD. METHODS:Data were collected for all DCD donors between 1/2011 and 9/201...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001298

    authors: Scalea JR,Redfield RR,Rizzari MD,Bennett R,Anderson ME,Anderson JE,Kaufman DB,Sollinger HW,Fernandez LA,D'Alessandro AM,Mezrich J

    更新日期:2016-02-01 00:00:00

  • Factors Predicting Response, Perioperative Outcomes, and Survival Following Total Neoadjuvant Therapy for Borderline/Locally Advanced Pancreatic Cancer.

    abstract:OBJECTIVE:To identify predictive factors associated with operative morbidity, mortality, and survival outcomes in patients with borderline resectable (BR) or locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC) undergoing total neoadjuvant therapy (TNT). BACKGROUND:The optimal preoperative treatment sequencin...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003284

    authors: Truty MJ,Kendrick ML,Nagorney DM,Smoot RL,Cleary SP,Graham RP,Goenka AH,Hallemeier CL,Haddock MG,Harmsen WS,Mahipal A,McWilliams RR,Halfdanarson TR,Grothey AF

    更新日期:2021-02-01 00:00:00

  • Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study. Lymphadenectomy Study Group.

    abstract:OBJECTIVE:The study was conducted to determine whether the performance of an extended lymphadenectomy and retroperitoneal soft-tissue clearance in association with a pancreatoduodenal resection improves the long-term survival of patients with a potentially curable adenocarcinoma of the head of the pancreas. SUMMARY BA...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00000658-199810000-00007

    authors: Pedrazzoli S,DiCarlo V,Dionigi R,Mosca F,Pederzoli P,Pasquali C,Klöppel G,Dhaene K,Michelassi F

    更新日期:1998-10-01 00:00:00