Abstract:
:Intractable epilepsies pose a therapeutic challenge. Precise localization of the epileptic focus is imperative before planning surgical intervention. Functional imaging is an important component of presurgical work-up. Positron emission tomography is unavailable in developing countries; hence, the need to evaluate the available imaging modality, single photon emission computed tomography (SPECT), was felt. We investigated 61 children with intractable epilepsy, identified by predefined criteria, by performing electroencephalography (EEG), magnetic resonance imaging (MRI), computed tomography (CT), and ictal and interictal SPECT. The localizing value of ictal and interictal SPECT imaging for epileptic foci was correlated with clinical, electrophysiologic, and anatomic neuroimaging data. An ictal SPECT was obtained in 9, and interictal SPECT was performed in all (61). Ictal SPECT was localizing in 8 of 9 (88.8%). Interictal SPECT was localizing in a significantly higher proportion of patients (47.54%) than either the scalp EEG (16.39%) (P = .0003) or CT scan (21.56%) (P = .0046). Our data demonstrated that interictal and ictal SPECT identified more focal changes in children with intractable epilepsy than interictal EEG, CT, and probably MRI. The definitive proof of the SPECT-based findings being epileptogenic foci awaits correlation with intraoperative monitoring and postoperative follow-up.
journal_name
J Child Neuroljournal_title
Journal of child neurologyauthors
Kalra V,Gulati S,Rana KS,Bal CS,Bhatia Mdoi
10.1177/088307380101600405subject
Has Abstractpub_date
2001-04-01 00:00:00pages
257-63issue
4eissn
0883-0738issn
1708-8283journal_volume
16pub_type
杂志文章abstract::We reported a case of an 8-year-old boy who was presented to the emergency department with left-sided hemiparesis. Computed tomography showed hypodense areas in the territory of the right middle cerebral artery, indicating acute cerebral infarct. Diagnostic evaluation was performed to identify the etiology. On the eig...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738050200071401
更新日期:2005-07-01 00:00:00
abstract::Morvan syndrome is a rare autoimmune disease named after the French physician Augustin Marie Morvan. It is characterized by multiple, irregular contractions of the long muscles, weakness, pruritus, hyperhidrosis, insomnia, and delirium. Here, we describe a 17-year-old young man, previously diagnosed with B-cell lympho...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073809356108
更新日期:2010-08-01 00:00:00
abstract::We describe a 13-year-old female with abrupt onset urinary retention progressing rapidly to pandysautonomia with symptoms of postural orthostatic tachycardia syndrome, gastroparesis, anhidrosis, pupillary dysfunction, and abdominal pain. Pandysautonomia has been reported frequently in adults, but is less commonly desc...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073812474099
更新日期:2013-12-01 00:00:00
abstract::Seizures occur in 25% to 40% of children with supratentorial tumors and are the presenting complaint in 10% to 15%. However, when divided by age, only 2% of children with seizures as the presenting complaint of brain tumors were less than 1 year of age. Three children, ranging in age from 20 days to 7 months and seen ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307388700200308
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:Metagenomic next-generation sequencing offers an unbiased approach to identifying viral pathogens in cerebrospinal fluid of patients with meningoencephalitis of unknown etiology. METHODS:In an 11-month case series, we investigated the use of cerebrospinal fluid metagenomic next-generation sequencing to diag...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820972232
更新日期:2020-11-18 00:00:00
abstract::There is increased necessity to focus research on school-aged athletes with sports-related concussion (SRC). This study assessed differences in symptom reporting and neurocognitive performance in youth athletes who sustained a sports-related concussion. A total of 1345 concussed and 3529 nonconcussed athletes (ages 8-...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073818766815
更新日期:2018-06-01 00:00:00
abstract::We recruited 128 neonates with hyperbilirubinemia over a 5-year period (1995-2000) to study the short- and long-term effects of hemolytic hyperbilirubinemia on the auditory brainstem pathway and neurodevelopmental status. These children were divided into two groups: (1) a hemolytic group (n = 29; ABO incompatibility [...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738060210061301
更新日期:2006-06-01 00:00:00
abstract::To report the authors' experience with diagnosis and management of Dravet syndrome, or severe myoclonic epilepsy in infancy, in the era of commercially available genetic testing, the authors performed a retrospective study of 16 patients diagnosed with Dravet syndrome at a tertiary care pediatric epilepsy center. They...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073807300294
更新日期:2007-02-01 00:00:00
abstract::Lissencephaly is a brain malformation manifested by a smooth cerebral surface and caused by incomplete neuronal migration. Clinical sequellae include minor craniofacial changes (bitemporal hollowing, small jaw), severe mental retardation, and other neurological abnormalities. Patients with classical or type I lissence...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389000500113
更新日期:1990-01-01 00:00:00
abstract::The level of parental stress in families of children with autism and other developmental disabilities and its association with child comorbid symptoms was studied in an ethnically diverse population, in a cross-sectional study with structured interview. The sample included 50 families of children with autism and 50 fa...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073815579705
更新日期:2015-11-01 00:00:00
abstract::Ischemic stroke in the young is uncommon, but we currently evaluate at least one young stroke patient at our institutions each week. We undertook this chart review of strokes in patients between the ages of 6 months and 39 years to review all conditions associated with, and thus possibly contributory to, the stroke. W...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389300800311
更新日期:1993-07-01 00:00:00
abstract::If behavior results from brain function, some evidence of dysfunction could be expected in children with major behavioral problems. Yet, neurophysiologic studies in these children are frequently normal. We hypothesized a relationship between maturational asymmetry and behavior, given the role of hemispheric imbalance ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389901400206
更新日期:1999-02-01 00:00:00
abstract::Spongy degeneration of the central nervous system in infancy (Van Bogaert-Bertrand disease) is a disorder usually thought to occur in Ashkenazi Jewish infants. We report a case occurring in an Arab infant of consanguineous parents. ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307388600100111
更新日期:1986-01-01 00:00:00
abstract::The clinical label attention deficit hyperactivity disorder (ADHD) suggests that this syndrome is a disorder of attention. However, the presumed attentional deficits have not been linked either to specific cognitive operations or to specific neural systems. To provide this link, theories of the cognitive anatomy of at...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073891006001s12
更新日期:1991-01-01 00:00:00
abstract::We report the clinical, electroencephalographic, neurophysiologic, and neuroimaging findings in eight children with infant-onset progressive myoclonus epilepsy, all of whom had muscle biopsies performed as as part of the diagnostic evaluation. Each child had myoclonic seizures, generalized tonic-clonic seizures, and n...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389100600207
更新日期:1991-04-01 00:00:00
abstract::The diagnosis of anterior spinal artery syndrome can be made with high accuracy by thorough clinical examination in combination with typical magnetic resonance imaging findings. Sudden onset of tetra- or paraparesis and dissociated sensory loss with bladder dysfunction are the leading clinical signs. We discuss clinic...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380101600213
更新日期:2001-02-01 00:00:00
abstract::We reviewed cranial sonographic studies done on 108 normal newborn infants to determine the prevalence and variability in size of the cavum septi pellucidi (CSP). Infants were classified according to gestational age by 2-week intervals. At 24 weeks, only four normal scans were identified. Between 26 and 34 weeks, ten ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389200700106
更新日期:1992-01-01 00:00:00
abstract::This study presents a large multicenter cohort of children with cerebral venous thrombosis from 5 centers in the United States and analyzes their clinical findings and risk factors. Seventy patients were included in the study (25 neonates, 35%). The age ranged from 6 days to 12 years. Thirty-eight (55%) were younger t...
journal_title:Journal of child neurology
pub_type: 杂志文章,多中心研究
doi:10.1177/0883073807307976
更新日期:2008-01-01 00:00:00
abstract::More than half of neonatal stroke survivors have long-term sequelae, including seizures and neurological deficits. Although the immature brain has tremendous potential for recovery, mechanisms governing repair are essentially unexplored. We investigated whether magnetic resonance imaging (MRI) early or late after tran...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811408308
更新日期:2011-09-01 00:00:00
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journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738060210021601
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Acute flaccid myelitis has emerged as the leading cause of acute flaccid paralysis in children. Acute flaccid myelitis leads to significant physical disability; hence, objective outcome measures to study disease severity and progression are desirable. In addition, nerve transfer to improve motor function in ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820939392
更新日期:2020-11-01 00:00:00
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journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073812470000
更新日期:2014-03-01 00:00:00
abstract::Idiopathic dystonia with onset in the first year of life has been described as a transient movement disorder, in contrast to other forms of idiopathic dystonia We report on a girl who showed, from her 5th month, episodes of dystonic postures of her neck and arm, which lasted for seconds and occurred several times a da...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380001501212
更新日期:2000-12-01 00:00:00
abstract::Spinal muscular atrophy is one of the most heterogeneous of the single-gene neuromuscular disorders. The broad spectrum of severity, with onset from the prenatal period to adulthood, presents unique challenges in the design and implementation of clinical trials. The clinical classification of subjects into severe (typ...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073807305665
更新日期:2007-08-01 00:00:00
abstract::This study explored verbal, visual, motor, and tactile humor appreciation and comprehension among preschool children with epilepsy as compared with healthy children. Participants included 32 children with focal epilepsy, as well as 70 healthy controls. The results suggest that children with epilepsy assess humor dicho...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811419259
更新日期:2012-03-01 00:00:00
abstract::Two children are described who suddenly developed an encephalitic illness with intractable bilateral facial seizures. The seizures subsided over several days, but the children were left with the signs of pseudobulbar palsy and are unable to speak or swallow effectively. Bilateral destructive lesions in the opercular r...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307388900400213
更新日期:1989-04-01 00:00:00
abstract::The goal of the research was to point out the importance of early prespeech therapy for babies suffering from at-birth-acquired unilateral or bilateral lesion in the prespeech period of development. On the basis of existing studies and experience in the field, a protocol and methodology for the observation of the phon...
journal_title:Journal of child neurology
pub_type: 临床试验,杂志文章
doi:10.1177/0883073807299970
更新日期:2007-01-01 00:00:00
abstract::Sydenham's chorea results from group A streptococcus infection and subsequent generation of antineuronal antibodies directed at the caudate nucleus and putamen. Predominantly bilateral, in up to 30% of cases the chorea can be unilaterally restricted. Imaging studies, both structural (magnetic resonance imaging) and fu...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389901400805
更新日期:1999-08-01 00:00:00
abstract::This study aimed to identify the indications in which electroencephalography in the pediatric emergency department is most useful. We retrospectively reviewed the influence that the results of the emergent electroencephalogram had on the eventual disposition of patients at our pediatric emergency department. Sixty-eig...
journal_title:Journal of child neurology
pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
abstract::Childhood disintegrative disorder, a rare, relentlessly progressive neurologic disorder, first described by Heller in 1908, remains a condition of great interest. It has long been debated whether it is a discrete disorder or simply a late-onset variant of childhood autism. We have studied 6 cases of childhood disinteg...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073812472391
更新日期:2013-12-01 00:00:00