Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy.

Abstract:

BACKGROUND:Combined deficiency of vitamin K-dependent coagulation factors (II, VII, IX, X) is an uncommon challenge for the expectant gravida. CASE:A 34-year-old primigravida had congenital combined deficiency of factors II, VII, IX, and X that were incompletely sensitive to vitamin K. She had an altered form of vitamin K-dependent factors that retained immunologic activity but lacked coagulant activity and the normal complement of gamma-carboxyglutamic acid residues. She required vitamin K supplementation throughout her life. After an uneventful pregnancy she had postpartum hemorrhage resulting from an episiotomy. Fresh frozen plasma was administered to achieve hemostasis. The remainder of her postpartum course was normal. CONCLUSION:Combined congenital deficiency of factors II, VII, IX, and X can be managed in pregnancy with the use of vitamin K and fresh frozen plasma.

journal_name

Obstet Gynecol

authors

McMahon MJ,James AH

doi

10.1016/s0029-7844(00)01214-x

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

808-9

issue

5 Pt 2

eissn

0029-7844

issn

1873-233X

pii

S002978440001214X

journal_volume

97

pub_type

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